LOCUS       NM_001318903            2254 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TPD52 like 1 (TPD52L1), transcript variant 7, mRNA.
ACCESSION   NM_001318903
VERSION     NM_001318903.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2254)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2254)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2254)
  AUTHORS   Couzens,A.L., Knight,J.D., Kean,M.J., Teo,G., Weiss,A.,
            Dunham,W.H., Lin,Z.Y., Bagshaw,R.D., Sicheri,F., Pawson,T.,
            Wrana,J.L., Choi,H. and Gingras,A.C.
  TITLE     Protein interaction network of the mammalian Hippo pathway reveals
            mechanisms of kinase-phosphatase interactions
  JOURNAL   Sci Signal 6 (302), rs15 (2013)
   PUBMED   24255178
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2254)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   5  (bases 1 to 2254)
  AUTHORS   Cao,Q., Chen,J., Zhu,L., Liu,Y., Zhou,Z., Sha,J., Wang,S. and Li,J.
  TITLE     A testis-specific and testis developmentally regulated tumor
            protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52
            family proteins
  JOURNAL   Biochem Biophys Res Commun 344 (3), 798-806 (2006)
   PUBMED   16631610
REFERENCE   6  (bases 1 to 2254)
  AUTHORS   Nourse,C.R., Mattei,M.G., Gunning,P. and Byrne,J.A.
  TITLE     Cloning of a third member of the D52 gene family indicates
            alternative coding sequence usage in D52-like transcripts
  JOURNAL   Biochim Biophys Acta 1443 (1-2), 155-168 (1998)
   PUBMED   9838088
REFERENCE   7  (bases 1 to 2254)
  AUTHORS   Byrne,J.A., Nourse,C.R., Basset,P. and Gunning,P.
  TITLE     Identification of homo- and heteromeric interactions between
            members of the breast carcinoma-associated D52 protein family using
            the yeast two-hybrid system
  JOURNAL   Oncogene 16 (7), 873-881 (1998)
   PUBMED   9484778
REFERENCE   8  (bases 1 to 2254)
  AUTHORS   Byrne,J.A., Mattei,M.G., Basset,P. and Gunning,P.
  TITLE     Identification and in situ hybridization mapping of a mouse Tpd52l1
            (D53) orthologue to chromosome 10A4-B2
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 199-201 (1998)
   PUBMED   9730602
REFERENCE   9  (bases 1 to 2254)
  AUTHORS   Byrne,J.A., Mattei,M.G. and Basset,P.
  TITLE     Definition of the tumor protein D52 (TPD52) gene family through
            cloning of D52 homologues in human (hD53) and mouse (mD52)
  JOURNAL   Genomics 35 (3), 523-532 (1996)
   PUBMED   8812487
REFERENCE   10 (bases 1 to 2254)
  AUTHORS   Byrne,J.A., Tomasetto,C., Garnier,J.M., Rouyer,N., Mattei,M.G.,
            Bellocq,J.P., Rio,M.C. and Basset,P.
  TITLE     A screening method to identify genes commonly overexpressed in
            carcinomas and the identification of a novel complementary DNA
            sequence
  JOURNAL   Cancer Res 55 (13), 2896-2903 (1995)
   PUBMED   7796418
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB114736.1, BM546629.1,
            U44429.1, AL121938.10 and AI222450.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001318903.1.
            
            Summary: This gene encodes a member of a family of proteins that
            contain coiled-coil domains and may form hetero- or homomers. The
            encoded protein is involved in cell proliferation and calcium
            signaling. It also interacts with the mitogen-activated protein
            kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates
            MAP3K5-induced apoptosis. Multiple alternatively spliced transcript
            variants have been observed. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (7) contains an alternate in-frame
            exon in the 3' coding region compared to variant 1. The encoded
            isoform (7) is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.496387.1,
                                           SRR1803617.446312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               CB114736.1         45-188
            145-843             BM546629.1         62-760
            844-1688            U44429.1           219-1063
            1689-1804           AL121938.10        85540-85655
            1805-2251           U44429.1           1180-1626
            2252-2254           AI222450.1         16-18               c
FEATURES             Location/Qualifiers
     source          1..2254
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..2254
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /note="TPD52 like 1"
                     /db_xref="GeneID:7164"
                     /db_xref="HGNC:HGNC:12006"
                     /db_xref="MIM:604069"
     exon            1..198
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..809
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /note="isoform 7 is encoded by transcript variant 7; tumor
                     protein D53; tumor protein D52 like 1"
                     /codon_start=1
                     /product="tumor protein D53 isoform 7"
                     /protein_id="NP_001305832.1"
                     /db_xref="CCDS:CCDS83122.1"
                     /db_xref="GeneID:7164"
                     /db_xref="HGNC:HGNC:12006"
                     /db_xref="MIM:604069"
                     /translation="MEAQAQGLLETEPLQGTDEDAVASADFSSMLSEEEKEELKAELV
                     QLEDEITTLRQVLSAKERHLVEIKQKLGMNLMNELKQNFSKSWHDMQTTTAYKKTHET
                     LSHAGQKATAAFSNVGTAISKKFGDMRSHSIGYSIRHSISMPAMRNSPTFKSFEERVE
                     TTVTSLKTKVGGTNPNGGSFEEVLSSTAHASAQSLAGGSRRTKEEELQC"
     exon            199..314
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     exon            315..463
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     exon            464..565
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     exon            566..580
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     exon            581..619
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     exon            620..680
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     exon            681..2254
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1322..1327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /note="hexamer: ATTAAA"
     polyA_site      1341
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /note="major polyA site"
     regulatory      2224..2229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
                     /note="hexamer: AGTAAA"
     polyA_site      2254
                     /gene="TPD52L1"
                     /gene_synonym="D53; TPD53"
ORIGIN      
        1 agaagcggct agtggcggct gcctgcgtcc ccaaccccct ccgcgcagcg ctcgcgacac
       61 gcgtgccagg agtgggagcg agcggcgggg ccagctgcgt tctgagcctg ggcgcagctg
      121 ccatctgctc tgggaagcac cagggtgtcc ccgccgccct cagctcgaag tcagccacca
      181 tggaggcgca ggcacaaggt ttgttggaga ctgaaccgtt gcaaggaaca gacgaagatg
      241 cagtagccag tgctgacttc tctagcatgc tctctgagga ggaaaaggaa gagttaaaag
      301 cagagttagt tcagctagaa gacgaaatta caacactacg acaagttttg tcagcgaaag
      361 aaaggcatct agttgagata aaacaaaaac tcggcatgaa cctgatgaat gaattaaaac
      421 agaacttcag caaaagctgg catgacatgc agactaccac tgcctacaag aaaacacatg
      481 aaaccctgag tcacgcaggg caaaaggcaa ctgcagcttt cagcaacgtt ggaacggcca
      541 tcagcaagaa gttcggagac atgaggtctc actccatcgg ttactccatt cgccattcca
      601 taagtatgcc tgctatgagg aattctccta ctttcaaatc atttgaggag agggttgaga
      661 caactgtcac aagcctcaag acgaaagtag gcggtacgaa ccctaatgga ggcagttttg
      721 aggaggtcct cagctccacg gcccatgcca gtgcccagag cttggcagga ggctcccggc
      781 ggaccaagga ggaggagctg cagtgctaag tccagccagc gtgcagctgc atccagaaac
      841 cggccactac ccagcccatc tctgcctgtg cttatccaga taagaagacc aaaatcccgc
      901 tgggaaaaac ccaggccttg acattgttat tcaaatggcc cctccagaaa gtttaatgat
      961 ttccatttgt atttgtgttg atgatggacc acttgaccat cacatttcag tattcataga
     1021 tgactgtcac attttaaaat gttcccactt gagcaggtac acaactggtc ataattcctg
     1081 tctgtgtaat tcgatgtata tttttccaaa catgtagcta ttgtttgctt tgatttttgc
     1141 ttggcctcct ttatgatgtg catgtccttg aaggctgaat gaacagtccc tttcagttca
     1201 gcagatcaac aggatggagc tcttcatgac tgtctccagc aataggatga tttactataa
     1261 atttcatcca actacttgtg atctctctca cctacatcaa ttatgtatgt taatttcagc
     1321 aattaaaaga attgatttta atgactttga attcttaatt tctttgtctt aaaagttgct
     1381 agttatgatt ttacagatgc aattttaaat caacttttag ccaggtgcgg cggctcacac
     1441 ctgtaatccc aactattttg gatgccaagg tgagaggatt gcttgaggcc aggagttaaa
     1501 gatcagcctg ggcaacacag accctgtctc tacaaaaaaa gaaaaaaatt agccagacat
     1561 agtgttgctt gcctgtagtc ccagctactc tagaggctga ggcaggagga ttgcatgagc
     1621 ctaggagttc gaaactgcag tgagctatga ttgcaccact gcactactcc agcctgggtg
     1681 acagagtggg acactgtctc caaaaatagt aataataagt agtcaacttt tactgctaat
     1741 ttggtgaaca tgagagagga tatgaaaata aatattacct cagctatcct aggatgttaa
     1801 aataatctcc aattttaaaa ttctctccaa tctacataca gtagtagtta gtcagataaa
     1861 ggatatccaa aaaagagata gctagaaaat gggagaagca gagttctgca acccctttca
     1921 gtttgtaaat tgttcacatg tatgaaaata actggtattt atcaatccac tcagatttct
     1981 gcactaactt ttatcttata tatcatatgt atctcttttc tttttctaaa tgggaacata
     2041 tatttgttat taggtggcag agatatagcc ttaagatata tttgtaaaat gcacactgaa
     2101 tagacatcca acctaaaaaa aatcactatt taaaaagccc atataatata tacatatttg
     2161 ttagcatgct aattgttcat gttttgtgtt tattaaatag aagtgatata tatgacattt
     2221 tgaagtaaag cacatctgaa aaattctact caaa
//
