LOCUS       NM_001025253            4116 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens tumor protein D52 (TPD52), transcript variant 2, mRNA.
ACCESSION   NM_001025253
VERSION     NM_001025253.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4116)
  AUTHORS   Zhang,J., Li,Z., Han,J., Tian,Z., Meng,Q. and Niu,W.
  TITLE     KLF7 enhances the invasion and migration of colorectal cancer cells
            via the miR-139-5p/TPD52 axis
  JOURNAL   Cancer Biol Ther 25 (1), 2385172 (2024)
   PUBMED   39097779
  REMARK    GeneRIF: KLF7 enhances the invasion and migration of colorectal
            cancer cells via the miR-139-5p/TPD52 axis.
REFERENCE   2  (bases 1 to 4116)
  AUTHORS   Li,Y., Zhu,X., Zhang,C., Yin,Y., Chen,L., Liu,Y., He,A. and Xia,F.
  TITLE     Long noncoding RNA FTX promotes epithelial-mesenchymal transition
            of epithelial ovarian cancer through modulating miR-7515/TPD52 and
            activating Met/Akt/mTOR
  JOURNAL   Histol Histopathol 38 (12), 1487-1498 (2023)
   PUBMED   37140169
  REMARK    GeneRIF: Long noncoding RNA FTX promotes epithelial-mesenchymal
            transition of epithelial ovarian cancer through modulating
            miR-7515/TPD52 and activating Met/Akt/mTOR.
REFERENCE   3  (bases 1 to 4116)
  AUTHORS   Khan,K., Zafar,S., Badshah,Y., Ashraf,N.M., Rafiq,M., Danish,L.,
            Shabbir,M., Trembley,J.H., Afsar,T., Almajwal,A. and Razak,S.
  TITLE     Cross talk of tumor protein D52 (TPD52) with KLF9, PKCepsilon, and
            MicroRNA 223 in ovarian cancer
  JOURNAL   J Ovarian Res 16 (1), 202 (2023)
   PUBMED   37833790
  REMARK    GeneRIF: Cross talk of tumor protein D52 (TPD52) with KLF9,
            PKCepsilon, and MicroRNA 223 in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4116)
  AUTHORS   Liu,S., Hu,C., Li,M., Zhou,W., Wang,R. and Xiao,Y.
  TITLE     Androgen receptor suppresses lung cancer invasion and increases
            cisplatin response via decreasing TPD52 expression
  JOURNAL   Int J Biol Sci 19 (12), 3709-3725 (2023)
   PUBMED   37564195
  REMARK    GeneRIF: Androgen receptor suppresses lung cancer invasion and
            increases cisplatin response via decreasing TPD52 expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4116)
  AUTHORS   Shi,Q., Ma,Y., Zhang,X. and Yin,C.
  TITLE     Circ_0060551 promotes the migration and invasion of cervical cancer
            by upregulating TPD52
  JOURNAL   Am J Reprod Immunol 88 (3), e13586 (2022)
   PUBMED   35716110
  REMARK    GeneRIF: Circ_0060551 promotes the migration and invasion of
            cervical cancer by upregulating TPD52.
REFERENCE   6  (bases 1 to 4116)
  AUTHORS   Wang,R., He,H., Sun,X., Xu,J., Marshall,F.F., Zhau,H., Chung,L.W.,
            Fu,H. and He,D.
  TITLE     Transcription variants of the prostate-specific PrLZ gene and their
            interaction with 14-3-3 proteins
  JOURNAL   Biochem Biophys Res Commun 389 (3), 455-460 (2009)
   PUBMED   19732746
  REMARK    GeneRIF: Alternative splicing may contribute to abnormally enhanced
            PrLZ levels in prostate cancer, and interaction with 14-3-3
            proteins may be a mechanism by which PrLZ promotes cell
            proliferation and survival during prostate cancer development and
            progression.
REFERENCE   7  (bases 1 to 4116)
  AUTHORS   Byrne,J.A., Nourse,C.R., Basset,P. and Gunning,P.
  TITLE     Identification of homo- and heteromeric interactions between
            members of the breast carcinoma-associated D52 protein family using
            the yeast two-hybrid system
  JOURNAL   Oncogene 16 (7), 873-881 (1998)
   PUBMED   9484778
REFERENCE   8  (bases 1 to 4116)
  AUTHORS   Byrne,J.A., Mattei,M.G. and Basset,P.
  TITLE     Definition of the tumor protein D52 (TPD52) gene family through
            cloning of D52 homologues in human (hD53) and mouse (mD52)
  JOURNAL   Genomics 35 (3), 523-532 (1996)
   PUBMED   8812487
REFERENCE   9  (bases 1 to 4116)
  AUTHORS   Chen,S.L., Maroulakou,I.G., Green,J.E., Romano-Spica,V., Modi,W.,
            Lautenberger,J. and Bhat,N.K.
  TITLE     Isolation and characterization of a novel gene expressed in
            multiple cancers
  JOURNAL   Oncogene 12 (4), 741-751 (1996)
   PUBMED   8632896
REFERENCE   10 (bases 1 to 4116)
  AUTHORS   Byrne,J.A., Tomasetto,C., Garnier,J.M., Rouyer,N., Mattei,M.G.,
            Bellocq,J.P., Rio,M.C. and Basset,P.
  TITLE     A screening method to identify genes commonly overexpressed in
            carcinomas and the identification of a novel complementary DNA
            sequence
  JOURNAL   Cancer Res 55 (13), 2896-2903 (1995)
   PUBMED   7796418
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC331087.1, AK295468.1, U18914.1, DA079836.1, CB128067.1,
            BU071387.1 and AC009686.14.
            
            On Jun 2, 2019 this sequence version replaced NM_001025253.2.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon and it thus differs in its 5' UTR and 5' coding
            region, compared to variant 4. The encoded isoform (2) has a
            distinct N-terminus and is shorter than isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.70288.1,
                                           SRR1660807.62935.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518937.6/ ENSP00000429915.1
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DC331087.1         96-133
            39-1460             AK295468.1         1-1422
            1461-2360           U18914.1           1362-2261
            2361-2761           DA079836.1         169-569
            2762-3347           U18914.1           2662-3247
            3348-3634           CB128067.1         367-653
            3635-3993           BU071387.1         13-371              c
            3994-4116           AC009686.14        31025-31147         c
FEATURES             Location/Qualifiers
     source          1..4116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..4116
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /note="tumor protein D52"
                     /db_xref="GeneID:7163"
                     /db_xref="HGNC:HGNC:12005"
                     /db_xref="MIM:604068"
     exon            1..140
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..745
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /EC_number="2.7.1.21"
                     /note="isoform 2 is encoded by transcript variant 2;
                     prostate and colon associated protein; prostate leucine
                     zipper; protein N8"
                     /codon_start=1
                     /product="tumor protein D52 isoform 2"
                     /protein_id="NP_001020424.1"
                     /db_xref="CCDS:CCDS47879.1"
                     /db_xref="GeneID:7163"
                     /db_xref="HGNC:HGNC:12005"
                     /db_xref="MIM:604068"
                     /translation="MDRGEQGLLRTDPVPEEGEDVAATISATETLSEEEQEELRRELA
                     KVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQDVTATSAYKKTSET
                     LSQAGQKASAAFSSVGSVITKKLEDVKLQAFSHSFSIRSIQHSISMPAMRNSPTFKSF
                     EEKVENLKSKVGGTKPAGGDFGEVLNSAANASATTTEPLPEKTQESL"
     exon            141..256
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     exon            257..405
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     exon            406..507
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     exon            508..534
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     exon            535..576
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     exon            577..625
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     exon            626..4116
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2251..2256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /note="hexamer: AATAAA"
     polyA_site      2271
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /note="major polyA site"
     regulatory      3969..3974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /note="hexamer: AATAAA"
     polyA_site      3993
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
     regulatory      4089..4094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
                     /note="hexamer: AATACA"
     polyA_site      4116
                     /gene="TPD52"
                     /gene_synonym="D52; hD52; N8L; PC-1; PrLZ"
ORIGIN      
        1 gacttcgcgg gagtcgccgg cggaggcgag gaggagctct gcgcggcgcg gcgggcgatc
       61 cgagccggga cgggctgcag gcgggggtgc tgcagaggac acgaggcggc gggctggaga
      121 catggaccgc ggcgagcaag gtctgctgag aacagaccca gtccctgagg aaggagaaga
      181 tgttgctgcc acgatcagtg ccacagagac cctctcggaa gaggagcagg aagagctaag
      241 aagagaactt gcaaaggtag aagaagaaat ccagactctg tctcaagtgt tagcagcaaa
      301 agagaagcat ctagcagaga tcaagcggaa acttggaatc aattctctac aggaactaaa
      361 acagaacatt gccaaagggt ggcaagacgt gacagcaaca tctgcttaca agaagacatc
      421 tgaaacctta tcccaggctg gacagaaggc ctcagctgct ttttcgtctg ttggctcagt
      481 catcaccaaa aagctggaag atgtaaaatt gcaagccttt tcacattcct ttagtatacg
      541 ttccattcag cattcaatta gcatgcctgc tatgagaaac tccccaactt ttaaatcatt
      601 tgaagaaaag gtcgaaaact taaagtctaa agtaggggga accaagcctg ctggtggtga
      661 ttttggagaa gtcttgaatt cggctgcaaa tgctagtgcc accaccacgg agcctcttcc
      721 agaaaagaca caggagagcc tgtgagattc ctacctttgt tctgctaccc actgccagat
      781 gctgcaagcg aggtccaagc acatcttgtc aacatgcatt gccatgaatt tctaccagat
      841 gtgcttttat ttagctttac atattccttt gaccaaatag tttgtgggtt aaacaaaatg
      901 aaaatatctt cacctctatt cttgggaaac accctttagt gtacatttat gttcctttat
      961 ttaggaaaca ccattataaa aacacttata gtaaatgggg acattcacta taatgatcta
     1021 agaagctaca gattgtcata gttgttttcc tgctttacaa aattgctcca gatctggaat
     1081 gccagtttga cctttgtctt ctataatatt tccttttttt cccctctttg aatctctgta
     1141 tatttgattc ttaactaaaa ttgttctctt aaatattctg aatcctggta attaaaagtt
     1201 tgggtgtatt ttctttacct ccaaggaaag aactactagc tacaaaaaat attttggaat
     1261 aagcattgtt ttggtataag gtacatattt tggttgaaga caccagactg aagtaaacag
     1321 ctgtgcatcc aatttattat agttttgtaa gtaacaatat gtaatcaaac ttctaggtga
     1381 cttgagagtg gaacctccta tatcattatt tagcaccgtt tgtgacagta accatttcag
     1441 tgtattgttt attataccac ttatatcaac ttatttttca ccaggttaaa attttaattt
     1501 ctacaaaata acattctgaa tcaagcacac tgtatgttca gtaggttgaa ctatgaacac
     1561 tgtcatcaat gttcagttca aaagcctgaa agtttagatc tagaagctgg taaaaatgac
     1621 aatatcaatc acattagggg aaccattgtt gtcttcactt aatccattta gcactattta
     1681 aaataagcac accaagttat atgactaata taacttgaaa attttttata ctgaggggtt
     1741 ggtgataact cttgaggatg taatgcatta ataaaaatca actcatcatt ttctacttgt
     1801 tttcaatgtg ttggaaactg taaaatgata ctgtagaacc tgtctcctac tttgaaaact
     1861 gaatgtcagg gctgagtgaa tcaaagtgtc tagacatatt tgcatagagg ccaaggtatt
     1921 ctattctaat aactgcttac tcaacactac caccttttcc ttatactgta tatgattatg
     1981 gcctacaatg ttgtatttgt tatttattaa attgtgattg ttttattatt gtttatgcca
     2041 aatgttaact gccaagcttg gagtgaccta aagcattttt taaaagcatg gctagattta
     2101 cttcagtata aattatctta tgaaaaccaa attttaaaag ccacaggtgt tgattgttat
     2161 aaaataacat gctgccattc ttgattgcta gagtttttgt tagtactttg gatgcaatta
     2221 aaactatgtg ctatcacatg tgaaaagctt aataaattcc atctatcagt agtataggtc
     2281 tcaatattta ttatgagacc agtggtctgg aaacagcttg ttgtaccgaa tcaactggag
     2341 tctatgctta aaaaaaaaaa attttttttt aaccatcctt aaattattgc ttaatggtat
     2401 catattaaca tattctaaat aagggcttta aggcacaggc tgttgaagca ttttctcaga
     2461 ggagtggatc tgtagaagtc tgtctttcta tagaaatatt gtgcttactc aagtgttaaa
     2521 ttattttttc tatgaactag tctacttctt aaaattcaaa catattcttt tgatcacatt
     2581 gtttcttgag catcctgccc tgctactaac ttttcaacaa ggcaaaatgg agtaaagtgg
     2641 caatttcttt agatgagtga aataccctca agtctctttt ctgcccaaaa agggaaaagt
     2701 gatagaaatg ggggtggcaa gtggggtgag tggatgaagg tgggtattgg gggtggctgt
     2761 gaaagaaaat aatggagaat cacttttcta gacatctacc tatacttaat ctaagaaaca
     2821 aagtaatcta ctgtaaagta ctctgcccct tgaaagaagt attaaaaaga gtgaggatgg
     2881 atttagaaaa aaacatgaat ttagaaatat tcaaaatggt ttttgtggca gattcaatat
     2941 tatgaattca cagatattta aagaatgaga aacatagtaa ttagtagaaa tgccagaaac
     3001 agttcctggt tcctcttgtg tttgacacta agaaaatagc aagagtgtga aatctcagat
     3061 acttatgaaa tctcacagat gtaaggactc aagtgtagaa gaaaatatcc ccttcttaca
     3121 aaaagaaatg tcaatttatg gagtttgtgg gaaatagggc aagaattctt atgcttatga
     3181 gagccaagta gtcagtggaa gagagtagag ctcaaaactg gattatcacc ttagcaactt
     3241 agaatagttt gaaatagaaa aaaagtattt aatttggatc tggatctgtt aagatatgca
     3301 cagtctattt tttgtatagt attggaaaat aaaaatgcta taatttgggt atgggttctt
     3361 ttgtatacat tacctgccca ttgaggaaag gggcaagtcc attatgcaac ttctctccaa
     3421 acccttcata ttctggatat gatacttaaa gagccatgag cagctacatt ctgcctatca
     3481 gaaggcattt attaaatgac tgcttgctga agatgtgtcc aaagagatcc tacattaagg
     3541 tcatttgtca gaatgatgtt tgtgtttgtt tagagttggc tgacctccaa ctcctggggt
     3601 caaggaatcc tactgcctta gcttcccaaa tagctaggac tataggcatg cacccggcca
     3661 tgtgttttat ttatagctct taaagcccag atgaagaaat cacatttttg cccatagtga
     3721 agaaacattt ggccattgat tagtccttat tttcagtgac tgtcctgttt tcattagatt
     3781 agagagaccc tgtgtgggcc acagttaata taaaccatta tcacttttaa gtaaacctgc
     3841 acatcttaga tttcataatt tccttattgt tctgactcaa aatgaactaa gagcttttca
     3901 ctttttgttt gtaagttctc agagagtcgg gtctgcaagt gcttttgcct gccaggattt
     3961 tgtactcaaa taaatgctat ttggcaacta aaattcttgc cagctctcat gtaattttga
     4021 tgttactgag gttggttggt agtttatttt attaattttg tggttcttct atcatataga
     4081 aaaagccaaa tacagttttg tttgaatatt tgtaaa
//
