LOCUS       NM_001387778            1170 bp    mRNA    linear   PRI 17-JUL-2023
DEFINITION  Homo sapiens TPD52-MRPS28 readthrough (TPD52-MRPS28), mRNA.
ACCESSION   NM_001387778
VERSION     NM_001387778.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009686.14, AC018952.9 and AC036214.9.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring TPD52 (tumor protein D52) and
            MRPS28 (mitochondrial ribosomal protein S28) genes on chromosome 8.
            The readthrough transcript encodes a fusion protein that shares
            sequence identity with each individual gene product. [provided by
            RefSeq, Feb 2022].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142348
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 7163, 28957
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC009686.14        167705-167844       c
            141-256             AC009686.14        60758-60873         c
            257-405             AC009686.14        49562-49710         c
            406-507             AC009686.14        47807-47908         c
            508-556             AC009686.14        38900-38948         c
            557-738             AC018952.9         157812-157993       c
            739-1170            AC036214.9         58933-59364
FEATURES             Location/Qualifiers
     source          1..1170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..1170
                     /gene="TPD52-MRPS28"
                     /note="TPD52-MRPS28 readthrough"
                     /db_xref="GeneID:124188259"
     exon            1..140
                     /gene="TPD52-MRPS28"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..907
                     /gene="TPD52-MRPS28"
                     /codon_start=1
                     /product="TPD52-MRPS28 protein"
                     /protein_id="NP_001374707.1"
                     /db_xref="GeneID:124188259"
                     /translation="MDRGEQGLLRTDPVPEEGEDVAATISATETLSEEEQEELRRELA
                     KVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQDVTATSAYKKTSET
                     LSQAGQKASAAFSSVGSVITKKLEDVKNSPTFKSFEEKVENLKGSPKNVESFASMLRH
                     SPLTQMGPAKDKLVIGRIFHIVENDLYIDFGGKFHCVCRRPEVDGEKYQKGTRVRLRL
                     LDLELTSRFLGATTDTTVLEANAVLLGIQESKDSRSKEEHHEK"
     exon            141..256
                     /gene="TPD52-MRPS28"
                     /inference="alignment:Splign:2.1.0"
     exon            257..405
                     /gene="TPD52-MRPS28"
                     /inference="alignment:Splign:2.1.0"
     exon            406..507
                     /gene="TPD52-MRPS28"
                     /inference="alignment:Splign:2.1.0"
     exon            508..556
                     /gene="TPD52-MRPS28"
                     /inference="alignment:Splign:2.1.0"
     exon            557..738
                     /gene="TPD52-MRPS28"
                     /inference="alignment:Splign:2.1.0"
     exon            739..1170
                     /gene="TPD52-MRPS28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1009..1014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPD52-MRPS28"
                     /note="hexamer: AATAAA"
     polyA_site      1032
                     /gene="TPD52-MRPS28"
     regulatory      1145..1150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TPD52-MRPS28"
                     /note="hexamer: AATAAA"
     polyA_site      1170
                     /gene="TPD52-MRPS28"
                     /note="major polyA site"
ORIGIN      
        1 gacttcgcgg gagtcgccgg cggaggcgag gaggagctct gcgcggcgcg gcgggcgatc
       61 cgagccggga cgggctgcag gcgggggtgc tgcagaggac acgaggcggc gggctggaga
      121 catggaccgc ggcgagcaag gtctgctgag aacagaccca gtccctgagg aaggagaaga
      181 tgttgctgcc acgatcagtg ccacagagac cctctcggaa gaggagcagg aagagctaag
      241 aagagaactt gcaaaggtag aagaagaaat ccagactctg tctcaagtgt tagcagcaaa
      301 agagaagcat ctagcagaga tcaagcggaa acttggaatc aattctctac aggaactaaa
      361 acagaacatt gccaaagggt ggcaagacgt gacagcaaca tctgcttaca agaagacatc
      421 tgaaacctta tcccaggctg gacagaaggc ctcagctgct ttttcgtctg ttggctcagt
      481 catcaccaaa aagctggaag atgtaaaaaa ctccccaact tttaaatcat ttgaagaaaa
      541 ggtcgaaaac ttaaagggtt ctccaaaaaa tgtggaatcc tttgcatcta tgctgagaca
      601 ttctcctctt acacagatgg gacctgcaaa ggataaactg gtcattggac ggatctttca
      661 tattgtggag aatgatctgt acatagattt tggtggaaag tttcattgtg tatgtagaag
      721 accagaagtg gatggagaga aataccagaa aggaaccagg gtccggttgc ggctattaga
      781 tcttgaactt acgtctaggt tcctgggagc aacaacagat acaactgtac tagaggctaa
      841 tgcagttctc ttgggaatcc aggagagtaa agactcaaga tcgaaagaag aacatcatga
      901 aaaataaatg aactttgctt agtggattga ctcctttgct gaagtcagtt attcatcaag
      961 aatgcaatta gactaattgt gaataaatga ttgaatgaag atataataaa taaaagctat
     1021 aattatagat aactcttatt agaattttct ttagcaatat tcccaccccc caccccttgt
     1081 tttgctctta atgttttttt cctttggtgg ggatagtata cactgtacta agaaattgtc
     1141 attcaataaa tacgttttga gtgctgtcta
//
