LOCUS       NM_005427               5192 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tumor protein p73 (TP73), transcript variant 1, mRNA.
ACCESSION   NM_005427
VERSION     NM_005427.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5192)
  AUTHORS   Pastor-Morate,D., Amigo-Moran,L., Garranzo-Asensio,M.,
            Rejas-Gonzalez,R., Carnicero,P., Rodriguez,N., Perez-Robledo,J.P.,
            Barderas,R., Prieto-Nieto,I. and Dominguez,G.
  TITLE     DeltaNp73 and its effector targets promote colorectal peritoneal
            carcinosis and predict survival
  JOURNAL   J Pathol 263 (3), 328-337 (2024)
   PUBMED   38629257
  REMARK    GeneRIF: DeltaNp73 and its effector targets promote colorectal
            peritoneal carcinosis and predict survival.
REFERENCE   2  (bases 1 to 5192)
  AUTHORS   Li,D., Kok,C.Y.L., Wang,C., Ray,D., Osterburg,S., Dotsch,V.,
            Ghosh,S. and Sabapathy,K.
  TITLE     Dichotomous transactivation domains contribute to growth inhibitory
            and promotion functions of TAp73
  JOURNAL   Proc Natl Acad Sci U S A 121 (21), e2318591121 (2024)
   PUBMED   38739802
  REMARK    GeneRIF: Dichotomous transactivation domains contribute to growth
            inhibitory and promotion functions of TAp73.
REFERENCE   3  (bases 1 to 5192)
  AUTHORS   Motamedinasab,M., Karimi-Zarchi,M., Marzbanrad,Z.,
            Mirmohammadi,S.R., Vakili-Ojarood,M., Azizi,S., Barahman,M.,
            Yeganegy,M., Aghasipour,M., Khajehnoori,S., Aghili,K. and
            Neamatzadeh,H.
  TITLE     Lack of Association between TP73 G4C14-A4T14 Polymorphism and
            Cervical Cancer Risk in Overall and Asian Women: A Meta-Analysis
  JOURNAL   Asian Pac J Cancer Prev 25 (2), 661-670 (2024)
   PUBMED   38415554
  REMARK    GeneRIF: Lack of Association between TP73 G4C14-A4T14 Polymorphism
            and Cervical Cancer Risk in Overall and Asian Women: A
            Meta-Analysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5192)
  AUTHORS   Richmond,B.W., Marshall,C.B., Blackburn,J.B., Tufenkjian,T.S.,
            Lehmann,B.D., Han,W., Newcomb,D., Gutor,S.S., Hunt,R.P.,
            Michell,D.L., Vickers,K.C., Polosukhin,V.V., Blackwell,T.S. and
            Pietenpol,J.A.
  TITLE     Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary
            Disease
  JOURNAL   Am J Respir Crit Care Med 209 (2), 153-163 (2024)
   PUBMED   37931077
  REMARK    GeneRIF: Loss of p73 Expression Contributes to Chronic Obstructive
            Pulmonary Disease.
REFERENCE   5  (bases 1 to 5192)
  AUTHORS   Hiramatsu,H., Yokomori,R., Shengyi,L., Tanaka,N., Mori,S.,
            Kiyotani,K., Gotoh,O., Kusumoto,S., Nakano,N., Suehiro,Y., Ito,A.,
            Choi,I., Ohtsuka,E., Hidaka,M., Nosaka,K., Yoshimitsu,M.,
            Imaizumi,Y., Iida,S., Utsunomiya,A., Noda,T., Nishikawa,H.,
            Ueda,R., Sanda,T. and Ishida,T.
  TITLE     Clinical landscape of TP73 structural variants in ATL patients
  JOURNAL   Leukemia 37 (12), 2502-2506 (2023)
   PUBMED   37864123
  REMARK    GeneRIF: Clinical landscape of TP73 structural variants in ATL
            patients.
REFERENCE   6  (bases 1 to 5192)
  AUTHORS   Mai,M., Qian,C., Yokomizo,A., Tindall,D.J., Bostwick,D.,
            Polychronakos,C., Smith,D.I. and Liu,W.
  TITLE     Loss of imprinting and allele switching of p73 in renal cell
            carcinoma
  JOURNAL   Oncogene 17 (13), 1739-1741 (1998)
   PUBMED   9796703
REFERENCE   7  (bases 1 to 5192)
  AUTHORS   Mai,M., Huang,H., Reed,C., Qian,C., Smith,J.S., Alderete,B.,
            Jenkins,R., Smith,D.I. and Liu,W.
  TITLE     Genomic organization and mutation analysis of p73 in
            oligodendrogliomas with chromosome 1 p-arm deletions
  JOURNAL   Genomics 51 (3), 359-363 (1998)
   PUBMED   9721206
REFERENCE   8  (bases 1 to 5192)
  AUTHORS   Nomoto,S., Haruki,N., Kondo,M., Konishi,H., Takahashi,T.,
            Takahashi,T. and Takahashi,T.
  TITLE     Search for mutations and examination of allelic expression
            imbalance of the p73 gene at 1p36.33 in human lung cancers
  JOURNAL   Cancer Res 58 (7), 1380-1383 (1998)
   PUBMED   9537234
REFERENCE   9  (bases 1 to 5192)
  AUTHORS   Jost,C.A., Marin,M.C. and Kaelin,W.G. Jr.
  TITLE     p73 is a simian [correction of human] p53-related protein that can
            induce apoptosis
  JOURNAL   Nature 389 (6647), 191-194 (1997)
   PUBMED   9296498
  REMARK    Erratum:[Nature 1999 Jun 24;399(6738):817]
REFERENCE   10 (bases 1 to 5192)
  AUTHORS   Kaghad,M., Bonnet,H., Yang,A., Creancier,L., Biscan,J.C.,
            Valent,A., Minty,A., Chalon,P., Lelias,J.M., Dumont,X., Ferrara,P.,
            McKeon,F. and Caput,D.
  TITLE     Monoallelically expressed gene related to p53 at 1p36, a region
            frequently deleted in neuroblastoma and other human cancers
  JOURNAL   Cell 90 (4), 809-819 (1997)
   PUBMED   9288759
  REMARK    GeneRIF: TP73 gene is imprinted, with monoallelic expression likely
            from the maternal allele.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136528.11, Y11416.1 and
            AI094238.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005427.3.
            
            Summary: This gene encodes a member of the p53 family of
            transcription factors involved in cellular responses to stress and
            development. It maps to a region on chromosome 1p36 that is
            frequently deleted in neuroblastoma and other tumors, and thought
            to contain multiple tumor suppressor genes. The demonstration that
            this gene is monoallelically expressed (likely from the maternal
            allele), supports the notion that it is a candidate gene for
            neuroblastoma. Many transcript variants resulting from alternative
            splicing and/or use of alternate promoters have been found for this
            gene, but the biological validity and the full-length nature of
            some variants have not been determined. [provided by RefSeq, Feb
            2011].
            
            Transcript Variant: This variant (1), encodes isoform a, also known
            as TA p73 alpha.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.521257.1,
                                           SRR11853559.141.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 9288759
            MANE Ensembl match     :: ENST00000378295.9/ ENSP00000367545.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AL136528.11        116667-116715       c
            50-677              Y11416.1           1-628
            678-678             AL136528.11        47121-47121         c
            679-2283            Y11416.1           630-2234
            2284-5170           AL136528.11        33052-35938         c
            5171-5192           AI094238.1         12-33               c
FEATURES             Location/Qualifiers
     source          1..5192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..5192
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /note="tumor protein p73"
                     /db_xref="GeneID:7161"
                     /db_xref="HGNC:HGNC:12003"
                     /db_xref="MIM:601990"
     exon            1..126
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     exon            127..224
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2070
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /note="isoform a is encoded by transcript variant 1;
                     p53-related protein; p53-like transcription factor"
                     /codon_start=1
                     /product="tumor protein p73 isoform a"
                     /protein_id="NP_005418.1"
                     /db_xref="CCDS:CCDS49.1"
                     /db_xref="GeneID:7161"
                     /db_xref="HGNC:HGNC:12003"
                     /db_xref="MIM:601990"
                     /translation="MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGG
                     TDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQP
                     SSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCP
                     IQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVE
                     GNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIIT
                     LEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSP
                     PAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQ
                     QQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGP
                     GMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEY
                     FTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNA
                     ATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQ
                     PIKEEFTEAEIH"
     exon            225..345
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     exon            346..588
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     exon            589..775
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     exon            776..891
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1001
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1144
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1233
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1355
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1504
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1643
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1737
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..5192
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2875..2880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /note="hexamer: GATAAA"
     polyA_site      2896
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /note="major polyA site"
     regulatory      5171..5176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /note="hexamer: AATAAA"
     polyA_site      5192
                     /gene="TP73"
                     /gene_synonym="CILD47; P73"
                     /note="major polyA site"
ORIGIN      
        1 gccctgcctc cccgcccgcg cacccgcccg gaggctcgcg cgcccgcgaa ggggacgcag
       61 cgaaaccggg gcccgcgcca ggccagccgg gacggacgcc gatgcccggg gctgcgacgg
      121 ctgcagagcg agctgccctc ggaggccggc gtggggaaga tggcccagtc caccgccacc
      181 tcccctgatg ggggcaccac gtttgagcac ctctggagct ctctggaacc agacagcacc
      241 tacttcgacc ttccccagtc aagccggggg aataatgagg tggtgggcgg aacggattcc
      301 agcatggacg tcttccacct ggagggcatg actacatctg tcatggccca gttcaatctg
      361 ctgagcagca ccatggacca gatgagcagc cgcgcggcct cggccagccc ctacacccca
      421 gagcacgccg ccagcgtgcc cacccactcg ccctacgcac aacccagctc caccttcgac
      481 accatgtcgc cggcgcctgt catcccctcc aacaccgact accccggacc ccaccacttt
      541 gaggtcactt tccagcagtc cagcacggcc aagtcagcca cctggacgta ctccccgctc
      601 ttgaagaaac tctactgcca gatcgccaag acatgcccca tccagatcaa ggtgtccacc
      661 ccgccacccc caggcaccgc catccgggcc atgcctgttt acaagaaagc ggagcacgtg
      721 accgacgtcg tgaaacgctg ccccaaccac gagctcggga gggacttcaa cgaaggacag
      781 tctgctccag ccagccacct catccgcgtg gaaggcaata atctctcgca gtatgtggat
      841 gaccctgtca ccggcaggca gagcgtcgtg gtgccctatg agccaccaca ggtggggacg
      901 gaattcacca ccatcctgta caacttcatg tgtaacagca gctgtgtagg gggcatgaac
      961 cggcggccca tcctcatcat catcaccctg gagatgcggg atgggcaggt gctgggccgc
     1021 cggtcctttg agggccgcat ctgcgcctgt cctggccgcg accgaaaagc tgatgaggac
     1081 cactaccggg agcagcaggc cctgaacgag agctccgcca agaacggggc cgccagcaag
     1141 cgtgccttca agcagagccc ccctgccgtc cccgcccttg gtgccggtgt gaagaagcgg
     1201 cggcatggag acgaggacac gtactacctt caggtgcgag gccgggagaa ctttgagatc
     1261 ctgatgaagc tgaaagagag cctggagctg atggagttgg tgccgcagcc actggtggac
     1321 tcctatcggc agcagcagca gctcctacag aggccgagtc acctacagcc cccgtcctac
     1381 gggccggtcc tctcgcccat gaacaaggtg cacgggggca tgaacaagct gccctccgtc
     1441 aaccagctgg tgggccagcc tcccccgcac agttcggcag ctacacccaa cctggggccc
     1501 gtgggccccg ggatgctcaa caaccatggc cacgcagtgc cagccaacgg cgagatgagc
     1561 agcagccaca gcgcccagtc catggtctcg gggtcccact gcactccgcc acccccctac
     1621 cacgccgacc ccagcctcgt cagtttttta acaggattgg ggtgtccaaa ctgcatcgag
     1681 tatttcacct cccaagggtt acagagcatt taccacctgc agaacctgac cattgaggac
     1741 ctgggggccc tgaagatccc cgagcagtac cgcatgacca tctggcgggg cctgcaggac
     1801 ctgaagcagg gccacgacta cagcaccgcg cagcagctgc tccgctctag caacgcggcc
     1861 accatctcca tcggcggctc aggggaactg cagcgccagc gggtcatgga ggccgtgcac
     1921 ttccgcgtgc gccacaccat caccatcccc aaccgcggcg gcccaggcgg cggccctgac
     1981 gagtgggcgg acttcggctt cgacctgccc gactgcaagg cccgcaagca gcccatcaag
     2041 gaggagttca cggaggccga gatccactga gggcctcgcc tggctgcagc ctgcgccacc
     2101 gcccagagac ccaagctgcc tcccctctcc ttcctgtgtg tccaaaactg cctcaggagg
     2161 caggaccttc gggctgtgcc cggggaaagg caaggtccgg cccatcccca ggcacctcac
     2221 aggccccagg aaaggcccag ccaccgaagc cgcctgtgga cagcctgagt cacctgcaga
     2281 accttctgga gctgccctag tgctgggctt gtggggcggg ggctggccca ctctcagccc
     2341 tgccactgcc ccggcgtgct ccatggcagg cgtgggtggg gaccgcagcg tcggctccga
     2401 cttccaggct tcatcctaga gactgtcatc tcccaaccag gcgaggtcct tccaaaggaa
     2461 aggatcctct ttgctgatgg actgccaaaa agtattttgc gacatctttt ggttctggat
     2521 agtagtgagc agccaagtga ctgtgtctga aacaccagtg tattttcagg gaatgtccct
     2581 aactgcgtct tgcccgcgcc gggggctggg gactctctct gctggacttg ggactggcct
     2641 ctgcccccag cacgctgtat tctgcaggac cgcctccttc ctgcccctaa caacaaccac
     2701 agtgttgctg aaattggaga aaactgggga gggcgcaacc ccccccaggc gcggggaagc
     2761 atgtggtacc gcctcagcca gtgcccctca gcctggccac agtcgcctct cctcggggac
     2821 ccctcagcag aaagggacag cctgtcctta gaggactgga aattgtcaat atttgataaa
     2881 atgataccct tttctacatg gtgggtcagc tttttttttt ttttttttaa ctttctttct
     2941 cagcattctc tttggagttc aacctagcgc ccatgagcca ggctgaggaa gctgagtgag
     3001 aagccaggtg ggcgggactt gttcccagga aggccgggtg gggaggaagc ctagagggaa
     3061 ccccaggaag ggcaaatcca ggcaaatctg caggaatgct ctgccatggg agcagctcct
     3121 cccttgccac ggccaccttc tctagcactg caaggtccac agggcattgc tttcctttct
     3181 aggcggtggc agtcagggaa cagactgagg taggtgtagg ggggtctagg ccttcgtgga
     3241 gcaccccagg gagttagtag gccccgggga gacagagtct gcacaggccc tttctggggc
     3301 cacctccatc cacgaggagc agcctgagcc ttggtggccg aaccttgacc gtcccggagc
     3361 acagcttcag ggcagggaac cggagcccct ggggggcctc acgggtgtga cgaggccctt
     3421 cattgcaggc aggtgggcca atgggagccc tcacccacgc aagccgagac accacccaga
     3481 gtgcaggctg cctggcccct tctggcacgg ccagctccac accccctgcc tagggtatgt
     3541 gtggtcctaa gggctaggag cttcccctac taacatctcc cagaaaaagc agttaagccc
     3601 ctcagggcac agcaaggtta gacacagccc ccatccccag atcaggactc catcttgcta
     3661 agtggcatca ccgtcaccag cctcccctta tttaaaagca gcgactggtg ttgccgcagg
     3721 tacctggtct acgaagacgc aggcatccct ctcccaccgt ccacctcccc gggggccgct
     3781 gacagcacag tcgcctgggt gcacgcttgt gggggcagca ggaacggggc tgtcggctct
     3841 caggggatct ggctgcagcc agggcgaggg cctggccctt ccttccagct ccttccggct
     3901 ccttccagct gaagggcagg aagctctggc cgcttagctt ctagggttcc atctccctag
     3961 aaaggtgccc acgcccaggg catcagtcag tagcggcagc agcagcagac tcggggcttt
     4021 cccagggtgg cgcagccacc ccagctgcat gtcacctcag ctctccatct tattgccatt
     4081 ttgtagatga ggaagctgag accagaaagg ctaagaccca tgccccaggc accacaccca
     4141 tctcttgggg gctgggcacc tgctacccga ggccacctcc tgaagccccc actcttcccc
     4201 catgttccac ttcaggagcc gcgggggccc atcctgacac ccggggttcc tcagcccagc
     4261 gcagatgtgc ttcagttcca gagggcttgt tgatttgttt cttaggtacg ttacctgtcc
     4321 accctgagtc cagtgaggct gtcccaagag cccctgtagt gtgctcctgg gaagggctgg
     4381 gggggctggg ggggctggga gaggcccagg ggcagctgtc actggaaccc cagccagatg
     4441 tccaaggaag ccggccagaa cacggagcag ccagatggcc ccagctgcac ctgtctaggg
     4501 agcccatgca gcctccttgc actggagaag cagctgtgaa agtagacaga gttgagactt
     4561 cgccgtggtc aggagaaaat gcaaattccc aggaacaaga atcctttaag tgatatgttt
     4621 ttataaaact aaacaaatca acaaataaat cttgaaggcg gatggttttc ccagcagtgc
     4681 aggggttgga gggaggctgc tggcactcct ggggccaagg gggacaggca gtggtcctga
     4741 gtctgctcag agaggcaagg cagaaggagc tcgccaggca ggtcagctca catctgtcca
     4801 agtcgctctg gtcagaaaca gcgactctcc cccattcccc cagcgttccc accaggcctg
     4861 ggctgctggg aagcccttgc tgtacccagg agcccgaccc gcagtatcct ggcacagagc
     4921 cacttgtcac tcagaacagt cagtgtctcc aacgcacaaa catccactcc tctgttacca
     4981 gttaaagcac tttaatgctt taaggtgaaa acgaaatccc atccgtgttt ttcgtgtaag
     5041 atcgtgcttc tccgagcagt attaatggac gccctccaat gacataacaa ctgtttttgg
     5101 taatgtaatc ttgggaaaat gtgttatttt tttagctgtg tttcagtggg gatttttgtt
     5161 tttgtaacat aataaagtgt atgttccaat ga
//
