LOCUS       NM_003722               4944 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens tumor protein p63 (TP63), transcript variant 1, mRNA.
ACCESSION   NM_003722
VERSION     NM_003722.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4944)
  AUTHORS   Zhang,Y., Karagiannis,D., Liu,H., Lin,M., Fang,Y., Jiang,M.,
            Chen,X., Suresh,S., Huang,H., She,J., Shi,F., Liu,J., Luo,D.,
            Angel,J.C., Lin,G., Yang,P., El-Rifai,W., Zaika,A., Oro,A.E.,
            Liu,K., Rustgi,A.K., Wang,T.C., Lu,C. and Que,J.
  TITLE     Epigenetic regulation of p63 blocks squamous-to-neuroendocrine
            transdifferentiation in esophageal development and malignancy
  JOURNAL   Sci Adv 10 (41), eadq0479 (2024)
   PUBMED   39383220
  REMARK    GeneRIF: Epigenetic regulation of p63 blocks
            squamous-to-neuroendocrine transdifferentiation in esophageal
            development and malignancy.
REFERENCE   2  (bases 1 to 4944)
  AUTHORS   Zhao,J., Williams,M.D., Hernandez,M., Kuang,G., Goldberg,H.,
            Fan,J., Ning,J., Ferrarotto,R. and Esmaeli,B.
  TITLE     Prognostic Impact of Notch1 Intracellular Domain, P63, and c-MYC in
            Lacrimal Gland Adenoid Cystic Carcinoma
  JOURNAL   Invest Ophthalmol Vis Sci 65 (11), 4 (2024)
   PUBMED   39230995
  REMARK    GeneRIF: Prognostic Impact of Notch1 Intracellular Domain, P63, and
            c-MYC in Lacrimal Gland Adenoid Cystic Carcinoma.
REFERENCE   3  (bases 1 to 4944)
  AUTHORS   Chen,Z., Cai,H., Ye,W., Wu,J., Liu,J., Xie,Y., Feng,S., Jin,Y.,
            Lv,Y., Ye,H., Cai,C. and Cai,G.
  TITLE     TP63 transcriptionally regulates SLC7A5 to suppress ferroptosis in
            head and neck squamous cell carcinoma
  JOURNAL   Front Immunol 15, 1445472 (2024)
   PUBMED   39234254
  REMARK    GeneRIF: TP63 transcriptionally regulates SLC7A5 to suppress
            ferroptosis in head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4944)
  AUTHORS   Rouleau,M., Medawar,A., Hamon,L., Shivtiel,S., Wolchinsky,Z.,
            Zhou,H., De Rosa,L., Candi,E., de la Forest Divonne,S.,
            Mikkola,M.L., van Bokhoven,H., Missero,C., Melino,G., Puceat,M. and
            Aberdam,D.
  TITLE     TAp63 is important for cardiac differentiation of embryonic stem
            cells and heart development
  JOURNAL   Stem Cells 29 (11), 1672-1683 (2011)
   PUBMED   21898690
REFERENCE   5  (bases 1 to 4944)
  AUTHORS   Liu,M. and Eiden,M.V.
  TITLE     Role of human endogenous retroviral long terminal repeats (LTRs) in
            maintaining the integrity of the human germ line
  JOURNAL   Viruses 3 (6), 901-905 (2011)
   PUBMED   21994760
REFERENCE   6  (bases 1 to 4944)
  AUTHORS   Beyer,U., Moll-Rocek,J., Moll,U.M. and Dobbelstein,M.
  TITLE     Endogenous retrovirus drives hitherto unknown proapoptotic p63
            isoforms in the male germ line of humans and great apes
  JOURNAL   Proc Natl Acad Sci U S A 108 (9), 3624-3629 (2011)
   PUBMED   21300884
  REMARK    GeneRIF: Human p63 transcripts with unique 5'-ends derived from
            incorporated exons upstream of the currently mapped TP63 gene, were
            identified.
REFERENCE   7  (bases 1 to 4944)
  AUTHORS   Crum,C.P. and McKeon,F.D.
  TITLE     p63 in epithelial survival, germ cell surveillance, and neoplasia
  JOURNAL   Annu Rev Pathol 5, 349-371 (2010)
   PUBMED   20078223
  REMARK    Review article
REFERENCE   8  (bases 1 to 4944)
  AUTHORS   Bian,J. and Sun,Y.
  TITLE     p53CP, a putative p53 competing protein that specifically binds to
            the consensus p53 DNA binding sites: a third member of the p53
            family?
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14753-14758 (1997)
   PUBMED   9405685
REFERENCE   9  (bases 1 to 4944)
  AUTHORS   Robinson,A., Gibbins,J., Rodriguez-Linares,B., Finan,P.M.,
            Wilson,L., Kellie,S., Findell,P. and Watson,S.P.
  TITLE     Characterization of Grb2-binding proteins in human platelets
            activated by Fc gamma RIIA cross-linking
  JOURNAL   Blood 88 (2), 522-530 (1996)
   PUBMED   8695800
REFERENCE   10 (bases 1 to 4944)
  AUTHORS   Sutton,V.R. and van Bokhoven,H.
  TITLE     TP63-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20556892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078809.9, BC039815.1 and
            AC063939.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003722.4.
            
            Summary: This gene encodes a member of the p53 family of
            transcription factors. The functional domains of p53 family
            proteins include an N-terminal transactivation domain, a central
            DNA-binding domain and an oligomerization domain. Alternative
            splicing of this gene and the use of alternative promoters results
            in multiple transcript variants encoding different isoforms that
            vary in their functional properties. These isoforms function during
            skin development and maintenance, adult stem/progenitor cell
            regulation, heart development and premature aging. Some isoforms
            have been found to protect the germline by eliminating oocytes or
            testicular germ cells that have suffered DNA damage. Mutations in
            this gene are associated with ectodermal dysplasia, and cleft
            lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4
            (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT
            syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary
            syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.
            [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) is the longest transcript and
            encodes the longest isoform (1, also known as TAp63alpha, TA-alpha,
            KET, and p51B). This isoform is expressed in female germ cells and
            acts to protect the germline by eliminating oocytes that have
            suffered DNA damage.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039815.1, Y16961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2158800
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264731.8/ ENSP00000264731.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC078809.9         70643-70680         c
            39-4514             BC039815.1         1-4476
            4515-4515           AC063939.15        117269-117269
            4516-4944           BC039815.1         4478-4906
FEATURES             Location/Qualifiers
     source          1..4944
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q28"
     gene            1..4944
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /note="tumor protein p63"
                     /db_xref="GeneID:8626"
                     /db_xref="HGNC:HGNC:15979"
                     /db_xref="MIM:603273"
     exon            1..189
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2170
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /note="isoform 1 is encoded by transcript variant 1; tumor
                     protein p53-competing protein; amplified in squamous cell
                     carcinoma; chronic ulcerative stomatitis protein;
                     transformation-related protein 63; keratinocyte
                     transcription factor KET; tumor protein 63"
                     /codon_start=1
                     /product="tumor protein 63 isoform 1"
                     /protein_id="NP_003713.3"
                     /db_xref="CCDS:CCDS3293.1"
                     /db_xref="GeneID:8626"
                     /db_xref="HGNC:HGNC:15979"
                     /db_xref="MIM:603273"
                     /translation="MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQST
                     QTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSD
                     LSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALS
                     PSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP
                     PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYV
                     EDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQV
                     LGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKK
                     RRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQ
                     TSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGT
                     HMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFT
                     TQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSAS
                     TVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE"
     exon            190..318
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            319..451
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            452..706
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            707..893
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1009
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1119
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1256
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1339
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1476
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1634
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1779
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1873
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..4944
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4925..4930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /note="hexamer: AATAAA"
     polyA_site      4944
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /note="major polyA site"
ORIGIN      
        1 ctatgtctga tagcatttga ccctattgct tttagcctcc cggctttata tctatatata
       61 cacaggtata tgtgtatatt ttatataatt gttctccgtt cgttgatatc aaagacagtt
      121 gaaggaaatg aattttgaaa cttcacggtg tgccacccta cagtactgcc ctgaccctta
      181 catccagcgt ttcgtagaaa ccccagctca tttctcttgg aaagaaagtt attaccgatc
      241 caccatgtcc cagagcacac agacaaatga attcctcagt ccagaggttt tccagcatat
      301 ctgggatttt ctggaacagc ctatatgttc agttcagccc attgacttga actttgtgga
      361 tgaaccatca gaagatggtg cgacaaacaa gattgagatt agcatggact gtatccgcat
      421 gcaggactcg gacctgagtg accccatgtg gccacagtac acgaacctgg ggctcctgaa
      481 cagcatggac cagcagattc agaacggctc ctcgtccacc agtccctata acacagacca
      541 cgcgcagaac agcgtcacgg cgccctcgcc ctacgcacag cccagctcca ccttcgatgc
      601 tctctctcca tcacccgcca tcccctccaa caccgactac ccaggcccgc acagtttcga
      661 cgtgtccttc cagcagtcga gcaccgccaa gtcggccacc tggacgtatt ccactgaact
      721 gaagaaactc tactgccaaa ttgcaaagac atgccccatc cagatcaagg tgatgacccc
      781 acctcctcag ggagctgtta tccgcgccat gcctgtctac aaaaaagctg agcacgtcac
      841 ggaggtggtg aagcggtgcc ccaaccatga gctgagccgt gaattcaacg agggacagat
      901 tgcccctcct agtcatttga ttcgagtaga ggggaacagc catgcccagt atgtagaaga
      961 tcccatcaca ggaagacaga gtgtgctggt accttatgag ccaccccagg ttggcactga
     1021 attcacgaca gtcttgtaca atttcatgtg taacagcagt tgtgttggag ggatgaaccg
     1081 ccgtccaatt ttaatcattg ttactctgga aaccagagat gggcaagtcc tgggccgacg
     1141 ctgctttgag gcccggatct gtgcttgccc aggaagagac aggaaggcgg atgaagatag
     1201 catcagaaag cagcaagttt cggacagtac aaagaacggt gatggtacga agcgcccgtt
     1261 tcgtcagaac acacatggta tccagatgac atccatcaag aaacgaagat ccccagatga
     1321 tgaactgtta tacttaccag tgaggggccg tgagacttat gaaatgctgt tgaagatcaa
     1381 agagtccctg gaactcatgc agtaccttcc tcagcacaca attgaaacgt acaggcaaca
     1441 gcaacagcag cagcaccagc acttacttca gaaacagacc tcaatacagt ctccatcttc
     1501 atatggtaac agctccccac ctctgaacaa aatgaacagc atgaacaagc tgccttctgt
     1561 gagccagctt atcaaccctc agcagcgcaa cgccctcact cctacaacca ttcctgatgg
     1621 catgggagcc aacattccca tgatgggcac ccacatgcca atggctggag acatgaatgg
     1681 actcagcccc acccaggcac tccctccccc actctccatg ccatccacct cccactgcac
     1741 acccccacct ccgtatccca cagattgcag cattgtcagt ttcttagcga ggttgggctg
     1801 ttcatcatgt ctggactatt tcacgaccca ggggctgacc accatctatc agattgagca
     1861 ttactccatg gatgatctgg caagtctgaa aatccctgag caatttcgac atgcgatctg
     1921 gaagggcatc ctggaccacc ggcagctcca cgaattctcc tccccttctc atctcctgcg
     1981 gaccccaagc agtgcctcta cagtcagtgt gggctccagt gagacccggg gtgagcgtgt
     2041 tattgatgct gtgcgattca ccctccgcca gaccatctct ttcccacccc gagatgagtg
     2101 gaatgacttc aactttgaca tggatgctcg ccgcaataag caacagcgca tcaaagagga
     2161 gggggagtga gcctcaccat gtgagctctt cctatccctc tcctaactgc cagcccccta
     2221 aaagcactcc tgcttaatct tcaaagcctt ctccctagct cctccccttc ctcttgtctg
     2281 atttcttagg ggaaggagaa gtaagaggct acctcttacc taacatctga cctggcatct
     2341 aattctgatt ctggctttaa gccttcaaaa ctatagcttg cagaactgta gctgccatgg
     2401 ctaggtagaa gtgagcaaaa aagagttggg tgtctcctta agctgcagag atttctcatt
     2461 gacttttata aagcatgttc acccttatag tctaagacta tatatataaa tgtataaata
     2521 tacagtatag atttttgggt ggggggcatt gagtattgtt taaaatgtaa tttaaatgaa
     2581 agaaaattga gttgcactta ttgaccattt tttaatttac ttgttttgga tggcttgtct
     2641 atactccttc ccttaagggg tatcatgtat ggtgataggt atctagagct taatgctaca
     2701 tgtgagtgac gatgatgtac agattctttc agttctttgg attctaaata catgccacat
     2761 caaacctttg agtagatcca tttccattgc ttattatgta ggtaagactg tagatatgta
     2821 ttcttttctc agtgttggta tattttatat tactgacatt tcttctagtg atgatggttc
     2881 acgttggggt gatttaatcc agttataaga agaagttcat gtccaaacgt cctctttagt
     2941 ttttggttgg gaatgaggaa aattcttaaa aggcccatag cagccagttc aaaaacaccc
     3001 gacgtcatgt atttgagcat atcagtaacc cccttaaatt taataccaga taccttatct
     3061 tacaatattg attgggaaaa catttgctgc cattacagag gtattaaaac taaatttcac
     3121 tactagattg actaactcaa atacacattt gctactgttg taagaattct gattgatttg
     3181 attgggatga atgccatcta tctagttcta acagtgaagt tttactgtct attaatattc
     3241 agggtaaata ggaatcattc agaaatgttg agtctgtact aaacagtaag atatctcaat
     3301 gaaccataaa ttcaactttg taaaaatctt ttgaagcata gataatattg tttggtaaat
     3361 gtttcttttg tttggtaaat gtttctttta aagaccctcc tattctataa aactctgcat
     3421 gtagaggctt gtttaccttt ctctctctaa ggtttacaat aggagtggtg atttgaaaaa
     3481 tataaaatta tgagattggt tttcctgtgg cataaattgc atcactgtat cattttcttt
     3541 tttaaccggt aagagtttca gtttgttgga aagtaactgt gagaacccag tttcccgtcc
     3601 atctccctta gggactaccc atagacatga aaggtcccca cagagcaaga gataagtctt
     3661 tcatggctgc tgttgcttaa accacttaaa cgaagagttc ccttgaaact ttgggaaaac
     3721 atgttaatga caatattcca gatctttcag aaatataaca catttttttg catgcatgca
     3781 aatgagctct gaaatcttcc catgcattct ggtcaagggc tgtcattgca cataagcttc
     3841 cattttaatt ttaaagtgca aaagggccag cgtggctcta aaaggtaatg tgtggattgc
     3901 ctctgaaaag tgtgtatata ttttgtgtga aattgcatac tttgtatttt gattattttt
     3961 tttttcttct tgggatagtg ggatttccag aaccacactt gaaacctttt tttatcgttt
     4021 ttgtattttc atgaaaatac catttagtaa gaataccaca tcaaataaga aataatgcta
     4081 caattttaag aggggaggga agggaaagtt tttttttatt atttttttaa aattttgtat
     4141 gttaaagaga atgagtcctt gatttcaaag ttttgttgta cttaaatggt aataagcact
     4201 gtaaacttct gcaacaagca tgcagctttg caaacccatt aaggggaaga atgaaagctg
     4261 ttccttggtc ctagtaagaa gacaaactgc ttcccttact ttgctgaggg tttgaataaa
     4321 cctaggactt ccgagctatg tcagtactat tcaggtaaca ctagggcctt ggaaattcct
     4381 gtactgtgtc tcatggattt ggcactagcc aaagcgaggc acccttactg gcttacctcc
     4441 tcatggcagc ctactctcct tgagtgtatg agtagccagg gtaaggggta aaaggatagt
     4501 aagcatagaa accactagaa agtgggctta atggagttct tgtggcctca gctcaatgca
     4561 gttagctgaa gaattgaaaa gtttttgttt ggagacgttt ataaacagaa atggaaagca
     4621 gagttttcat taaatccttt tacctttttt ttttcttggt aatcccctaa aataacagta
     4681 tgtgggatat tgaatgttaa agggatattt ttttctatta tttttataat tgtacaaaat
     4741 taagcaaatg ttaaaagttt tatatgcttt attaatgttt tcaaaaggta ttatacatgt
     4801 gatacatttt ttaagcttca gttgcttgtc ttctggtact ttctgttatg ggcttttggg
     4861 gagccagaag ccaatctaca atctcttttt gtttgccagg acatgcaata aaatttaaaa
     4921 aataaataaa aactaattaa gaaa
//
