LOCUS       NM_001114979            2916 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens tumor protein p63 (TP63), transcript variant 3, mRNA.
ACCESSION   NM_001114979
VERSION     NM_001114979.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2916)
  AUTHORS   Zhang,Y., Karagiannis,D., Liu,H., Lin,M., Fang,Y., Jiang,M.,
            Chen,X., Suresh,S., Huang,H., She,J., Shi,F., Liu,J., Luo,D.,
            Angel,J.C., Lin,G., Yang,P., El-Rifai,W., Zaika,A., Oro,A.E.,
            Liu,K., Rustgi,A.K., Wang,T.C., Lu,C. and Que,J.
  TITLE     Epigenetic regulation of p63 blocks squamous-to-neuroendocrine
            transdifferentiation in esophageal development and malignancy
  JOURNAL   Sci Adv 10 (41), eadq0479 (2024)
   PUBMED   39383220
  REMARK    GeneRIF: Epigenetic regulation of p63 blocks
            squamous-to-neuroendocrine transdifferentiation in esophageal
            development and malignancy.
REFERENCE   2  (bases 1 to 2916)
  AUTHORS   Zhao,J., Williams,M.D., Hernandez,M., Kuang,G., Goldberg,H.,
            Fan,J., Ning,J., Ferrarotto,R. and Esmaeli,B.
  TITLE     Prognostic Impact of Notch1 Intracellular Domain, P63, and c-MYC in
            Lacrimal Gland Adenoid Cystic Carcinoma
  JOURNAL   Invest Ophthalmol Vis Sci 65 (11), 4 (2024)
   PUBMED   39230995
  REMARK    GeneRIF: Prognostic Impact of Notch1 Intracellular Domain, P63, and
            c-MYC in Lacrimal Gland Adenoid Cystic Carcinoma.
REFERENCE   3  (bases 1 to 2916)
  AUTHORS   Chen,Z., Cai,H., Ye,W., Wu,J., Liu,J., Xie,Y., Feng,S., Jin,Y.,
            Lv,Y., Ye,H., Cai,C. and Cai,G.
  TITLE     TP63 transcriptionally regulates SLC7A5 to suppress ferroptosis in
            head and neck squamous cell carcinoma
  JOURNAL   Front Immunol 15, 1445472 (2024)
   PUBMED   39234254
  REMARK    GeneRIF: TP63 transcriptionally regulates SLC7A5 to suppress
            ferroptosis in head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2916)
  AUTHORS   Rouleau,M., Medawar,A., Hamon,L., Shivtiel,S., Wolchinsky,Z.,
            Zhou,H., De Rosa,L., Candi,E., de la Forest Divonne,S.,
            Mikkola,M.L., van Bokhoven,H., Missero,C., Melino,G., Puceat,M. and
            Aberdam,D.
  TITLE     TAp63 is important for cardiac differentiation of embryonic stem
            cells and heart development
  JOURNAL   Stem Cells 29 (11), 1672-1683 (2011)
   PUBMED   21898690
REFERENCE   5  (bases 1 to 2916)
  AUTHORS   Liu,M. and Eiden,M.V.
  TITLE     Role of human endogenous retroviral long terminal repeats (LTRs) in
            maintaining the integrity of the human germ line
  JOURNAL   Viruses 3 (6), 901-905 (2011)
   PUBMED   21994760
REFERENCE   6  (bases 1 to 2916)
  AUTHORS   Beyer,U., Moll-Rocek,J., Moll,U.M. and Dobbelstein,M.
  TITLE     Endogenous retrovirus drives hitherto unknown proapoptotic p63
            isoforms in the male germ line of humans and great apes
  JOURNAL   Proc Natl Acad Sci U S A 108 (9), 3624-3629 (2011)
   PUBMED   21300884
  REMARK    GeneRIF: Human p63 transcripts with unique 5'-ends derived from
            incorporated exons upstream of the currently mapped TP63 gene, were
            identified.
REFERENCE   7  (bases 1 to 2916)
  AUTHORS   Crum,C.P. and McKeon,F.D.
  TITLE     p63 in epithelial survival, germ cell surveillance, and neoplasia
  JOURNAL   Annu Rev Pathol 5, 349-371 (2010)
   PUBMED   20078223
  REMARK    Review article
REFERENCE   8  (bases 1 to 2916)
  AUTHORS   Bian,J. and Sun,Y.
  TITLE     p53CP, a putative p53 competing protein that specifically binds to
            the consensus p53 DNA binding sites: a third member of the p53
            family?
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14753-14758 (1997)
   PUBMED   9405685
REFERENCE   9  (bases 1 to 2916)
  AUTHORS   Robinson,A., Gibbins,J., Rodriguez-Linares,B., Finan,P.M.,
            Wilson,L., Kellie,S., Findell,P. and Watson,S.P.
  TITLE     Characterization of Grb2-binding proteins in human platelets
            activated by Fc gamma RIIA cross-linking
  JOURNAL   Blood 88 (2), 522-530 (1996)
   PUBMED   8695800
REFERENCE   10 (bases 1 to 2916)
  AUTHORS   Sutton,V.R. and van Bokhoven,H.
  TITLE     TP63-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20556892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078809.9, AB016072.1,
            AC117486.3, AF075428.1 and AC063939.15.
            
            On May 31, 2019 this sequence version replaced NM_001114979.1.
            
            Summary: This gene encodes a member of the p53 family of
            transcription factors. The functional domains of p53 family
            proteins include an N-terminal transactivation domain, a central
            DNA-binding domain and an oligomerization domain. Alternative
            splicing of this gene and the use of alternative promoters results
            in multiple transcript variants encoding different isoforms that
            vary in their functional properties. These isoforms function during
            skin development and maintenance, adult stem/progenitor cell
            regulation, heart development and premature aging. Some isoforms
            have been found to protect the germline by eliminating oocytes or
            testicular germ cells that have suffered DNA damage. Mutations in
            this gene are associated with ectodermal dysplasia, and cleft
            lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4
            (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT
            syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary
            syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.
            [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (3) differs in the 3' UTR and
            coding region, compared to variant 1. The resulting isoform (3,
            also known as TAp63gamma, TA-gamma, and p51A) is shorter and has a
            distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB016072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMN03465413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC078809.9         70643-70680         c
            39-99               AC078809.9         70582-70642         c
            100-189             AB016072.1         1-90
            190-244             AC117486.3         43785-43839         c
            245-1591            AF075428.1         1-1347
            1592-2908           AC063939.15        100601-101917
            2909-2916           AC063939.15        101918-101925
FEATURES             Location/Qualifiers
     source          1..2916
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q28"
     gene            1..2916
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /note="tumor protein p63"
                     /db_xref="GeneID:8626"
                     /db_xref="HGNC:HGNC:15979"
                     /db_xref="MIM:603273"
     exon            1..189
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1591
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /note="isoform 3 is encoded by transcript variant 3; tumor
                     protein p53-competing protein; amplified in squamous cell
                     carcinoma; chronic ulcerative stomatitis protein;
                     transformation-related protein 63; keratinocyte
                     transcription factor KET; tumor protein 63"
                     /codon_start=1
                     /product="tumor protein 63 isoform 3"
                     /protein_id="NP_001108451.1"
                     /db_xref="CCDS:CCDS46977.1"
                     /db_xref="GeneID:8626"
                     /db_xref="HGNC:HGNC:15979"
                     /db_xref="MIM:603273"
                     /translation="MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQST
                     QTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSD
                     LSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALS
                     PSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP
                     PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYV
                     EDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQV
                     LGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKK
                     RRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKH
                     LLSACFRNELVEPRRETPKQSDVFFRHSKPPNRSVYP"
     exon            190..318
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            319..451
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            452..706
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            707..893
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1009
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1119
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1256
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1339
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1476
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..2916
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2886..2891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /note="hexamer: AATAAA"
     polyA_site      2916
                     /gene="TP63"
                     /gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
                     OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
                     TP53CP; TP53L; TP73L"
                     /note="major polyA site"
ORIGIN      
        1 ctatgtctga tagcatttga ccctattgct tttagcctcc cggctttata tctatatata
       61 cacaggtata tgtgtatatt ttatataatt gttctccgtt cgttgatatc aaagacagtt
      121 gaaggaaatg aattttgaaa cttcacggtg tgccacccta cagtactgcc ctgaccctta
      181 catccagcgt ttcgtagaaa ccccagctca tttctcttgg aaagaaagtt attaccgatc
      241 caccatgtcc cagagcacac agacaaatga attcctcagt ccagaggttt tccagcatat
      301 ctgggatttt ctggaacagc ctatatgttc agttcagccc attgacttga actttgtgga
      361 tgaaccatca gaagatggtg cgacaaacaa gattgagatt agcatggact gtatccgcat
      421 gcaggactcg gacctgagtg accccatgtg gccacagtac acgaacctgg ggctcctgaa
      481 cagcatggac cagcagattc agaacggctc ctcgtccacc agtccctata acacagacca
      541 cgcgcagaac agcgtcacgg cgccctcgcc ctacgcacag cccagctcca ccttcgatgc
      601 tctctctcca tcacccgcca tcccctccaa caccgactac ccaggcccgc acagtttcga
      661 cgtgtccttc cagcagtcga gcaccgccaa gtcggccacc tggacgtatt ccactgaact
      721 gaagaaactc tactgccaaa ttgcaaagac atgccccatc cagatcaagg tgatgacccc
      781 acctcctcag ggagctgtta tccgcgccat gcctgtctac aaaaaagctg agcacgtcac
      841 ggaggtggtg aagcggtgcc ccaaccatga gctgagccgt gaattcaacg agggacagat
      901 tgcccctcct agtcatttga ttcgagtaga ggggaacagc catgcccagt atgtagaaga
      961 tcccatcaca ggaagacaga gtgtgctggt accttatgag ccaccccagg ttggcactga
     1021 attcacgaca gtcttgtaca atttcatgtg taacagcagt tgtgttggag ggatgaaccg
     1081 ccgtccaatt ttaatcattg ttactctgga aaccagagat gggcaagtcc tgggccgacg
     1141 ctgctttgag gcccggatct gtgcttgccc aggaagagac aggaaggcgg atgaagatag
     1201 catcagaaag cagcaagttt cggacagtac aaagaacggt gatggtacga agcgcccgtt
     1261 tcgtcagaac acacatggta tccagatgac atccatcaag aaacgaagat ccccagatga
     1321 tgaactgtta tacttaccag tgaggggccg tgagacttat gaaatgctgt tgaagatcaa
     1381 agagtccctg gaactcatgc agtaccttcc tcagcacaca attgaaacgt acaggcaaca
     1441 gcaacagcag cagcaccagc acttacttca gaaacatctc ctttcagcct gcttcaggaa
     1501 tgagcttgtg gagccccgga gagaaactcc aaaacaatct gacgtcttct ttagacattc
     1561 caagccccca aaccgatcag tgtacccata gagccctatc tctatatttt aagtgtgtgt
     1621 gttgtatttc catgtgtata tgtgagtgtg tgtgtgtgta tgtgtgtgcg tgtgtatcta
     1681 gccctcataa acaggacttg aagacacttt ggctcagaga cccaactgct caaaggcaca
     1741 aagccactag tgagagaatc ttttgaaggg actcaaacct ttacaagaaa ggatgttttc
     1801 tgcagatttt gtatccttag accggccatt ggtgggtgag gaaccactgt gtttgtctgt
     1861 gagctttctg ttgtttcctg ggagggaggg gtcaggtggg gaaaggggca ttaagatgtt
     1921 tattggaacc cttttctgtc ttcttctgtt gtttttctaa aattcacagg gaagcttttg
     1981 agcaggtctc aaacttaaga tgtcttttta agaaaaggag aaaaaagttg ttattgtctg
     2041 tgcataagta agttgtaggt gactgagaga ctcagtcaga cccttttaat gctggtcatg
     2101 taataatatt gcaagtagta agaaacgaag gtgtcaagtg tactgctggg cagcgaggtg
     2161 atcattacca aaagtaatca actttgtggg tggagagttc tttgtgagaa cttgcattat
     2221 ttgtgtcctc ccctcatgtg taggtagaac atttcttaat gctgtgtacc tgcctctgcc
     2281 actgtatgtt ggcatctgtt atgctaaagt ttttcttgta catgaaaccc tggaagacct
     2341 actacaaaaa aactgttgtt tggcccccat agcaggtgaa ctcattttgt gcttttaata
     2401 gaaagacaaa tccaccccag taatattgcc cttacgtagt tgtttaccat tattcaaagc
     2461 tcaaaataga atttgaagcc ctctcacaaa atctgtgatt aatttgctta attagagctt
     2521 ctatccctca agcctaccta ccataaaacc agccatatta ctgatactgt tcagtgcatt
     2581 tagccaggag acttacgttt tgagtaagtg agatccaagc agacgtgtta aaatcagcac
     2641 tcctggactg gaaattaaag attgaaaggg tagactactt ttcttttttt tactcaaaag
     2701 tttagagaat ctctgtttct ttccatttta aaaacatatt ttaagataat agcataaaga
     2761 ctttaaaaat gttcctcccc tccatcttcc cacacccagt caccagcact gtattttctg
     2821 tcaccaagac aatgatttct tgttattgag gctgttgctt ttgtggatgt gtgattttaa
     2881 ttttcaataa acttttgcat cttggtttat cttgca
//
