LOCUS       NM_021202               4127 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens tumor protein p53 inducible nuclear protein 2
            (TP53INP2), transcript variant 1, mRNA.
ACCESSION   NM_021202
VERSION     NM_021202.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4127)
  AUTHORS   Sebastian,D., Beltra,M., Irazoki,A., Sala,D., Aparicio,P., Aris,C.,
            Alibakhshi,E., Rubio-Valera,M., Palacin,M., Castellanos,J.,
            Lores,L. and Zorzano,A.
  TITLE     TP53INP2-dependent activation of muscle autophagy ameliorates
            sarcopenia and promotes healthy aging
  JOURNAL   Autophagy 20 (8), 1815-1824 (2024)
   PUBMED   38545813
  REMARK    GeneRIF: TP53INP2-dependent activation of muscle autophagy
            ameliorates sarcopenia and promotes healthy aging.
REFERENCE   2  (bases 1 to 4127)
  AUTHORS   Shi,K., Shan,Y., Sun,X., Chen,K., Luo,Q. and Xu,Q.
  TITLE     TP53INP2 modulates the malignant progression of colorectal cancer
            by reducing the inactive form of beta-catenin
  JOURNAL   Biochem Biophys Res Commun 690, 149275 (2024)
   PUBMED   37995453
  REMARK    GeneRIF: TP53INP2 modulates the malignant progression of colorectal
            cancer by reducing the inactive form of beta-catenin.
REFERENCE   3  (bases 1 to 4127)
  AUTHORS   Li,B., Ren,B., Ma,G., Cai,F., Wang,P., Zeng,Y., Liu,Y., Zhang,L.,
            Yang,Y., Liang,H., Zhang,R. and Deng,J.
  TITLE     Inactivation of ZSCAN18 by promoter hypermethylation drives the
            proliferation via attenuating TP53INP2-mediated autophagy in
            gastric cancer cells
  JOURNAL   Clin Epigenetics 15 (1), 10 (2023)
   PUBMED   36650573
  REMARK    GeneRIF: Inactivation of ZSCAN18 by promoter hypermethylation
            drives the proliferation via attenuating TP53INP2-mediated
            autophagy in gastric cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4127)
  AUTHORS   Huang,J., Sun,M., Tao,Y., Ren,J., Peng,M., Jing,Y., Xiao,Q.,
            Yang,J., Lin,C., Lei,L., Yang,Z. and Zhang,L.
  TITLE     Cytoplasmic Expression of TP53INP2 Modulated by Demethylase FTO and
            Mutant NPM1 Promotes Autophagy in Leukemia Cells
  JOURNAL   Int J Mol Sci 24 (2), 1624 (2023)
   PUBMED   36675134
  REMARK    GeneRIF: Cytoplasmic Expression of TP53INP2 Modulated by
            Demethylase FTO and Mutant NPM1 Promotes Autophagy in Leukemia
            Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4127)
  AUTHORS   Cui,Y., Yang,H., Shi,S., Ping,X., Zheng,S., Tang,X., Yu,X. and
            Shentu,X.
  TITLE     TP53INP2 Contributes to TGF-beta2-Induced Autophagy during the
            Epithelial-Mesenchymal Transition in Posterior Capsular
            Opacification Development
  JOURNAL   Cells 11 (15), 2385 (2022)
   PUBMED   35954230
  REMARK    GeneRIF: TP53INP2 Contributes to TGF-beta2-Induced Autophagy during
            the Epithelial-Mesenchymal Transition in Posterior Capsular
            Opacification Development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4127)
  AUTHORS   Linares,G.R., Xing,W., Burghardt,H., Baumgartner,B., Chen,S.T.,
            Ricart,W., Fernandez-Real,J.M., Zorzano,A. and Mohan,S.
  TITLE     Role of diabetes- and obesity-related protein in the regulation of
            osteoblast differentiation
  JOURNAL   Am J Physiol Endocrinol Metab 301 (1), E40-E48 (2011)
   PUBMED   21467300
  REMARK    GeneRIF: DOR plays an important role in thyroid hormone-mediated
            osteoblast differentiation, and a DOR SNP associates with plasma
            osteocalcin in men.
REFERENCE   7  (bases 1 to 4127)
  AUTHORS   Moran-Jones,K., Grindlay,J., Jones,M., Smith,R. and Norman,J.C.
  TITLE     hnRNP A2 regulates alternative mRNA splicing of TP53INP2 to control
            invasive cell migration
  JOURNAL   Cancer Res 69 (24), 9219-9227 (2009)
   PUBMED   19934309
  REMARK    GeneRIF: Alternative splicing of an exon in the 5' untranslated
            region of a gene termed TP53INP2 is a key event downstream of hnRNP
            A2 that is necessary for cells to invade the extracellular matrix.
REFERENCE   8  (bases 1 to 4127)
  AUTHORS   Nowak,J., Archange,C., Tardivel-Lacombe,J., Pontarotti,P.,
            Pebusque,M.J., Vaccaro,M.I., Velasco,G., Dagorn,J.C. and
            Iovanna,J.L.
  TITLE     The TP53INP2 protein is required for autophagy in mammalian cells
  JOURNAL   Mol Biol Cell 20 (3), 870-881 (2009)
   PUBMED   19056683
  REMARK    GeneRIF: TP53INP2 is a novel gene involved in the autophagy of
            mammalian cells.
REFERENCE   9  (bases 1 to 4127)
  AUTHORS   Bennetts,J.S., Rendtorff,N.D., Simpson,F., Tranebjaerg,L. and
            Wicking,C.
  TITLE     The coding region of TP53INP2, a gene expressed in the developing
            nervous system, is not altered in a family with autosomal recessive
            non-progressive infantile ataxia on chromosome 20q11-q13
  JOURNAL   Dev Dyn 236 (3), 843-852 (2007)
   PUBMED   17238154
REFERENCE   10 (bases 1 to 4127)
  AUTHORS   Nowak,J., Depetris,D., Iovanna,J.L., Mattei,M.G. and Pebusque,M.J.
  TITLE     Assignment of the tumor protein p53 induced nuclear protein 2
            (TP53INP2) gene to human chromosome band 20q11.2 by in situ
            hybridization
  JOURNAL   Cytogenet Genome Res 108 (4), 362 (2005)
   PUBMED   15628030
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY422170.1 and CA310159.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021202.2.
            
            Summary: The protein encoded by this gene promotes autophagy and is
            essential for proper autophagosome formation and processing. In
            addition, the encoded protein can enhance rDNA transcription by
            helping in the assembly of the POLR1/RNA polymerase I preinitiation
            complex. Finally, this protein serves as a transcriptional
            activator for some genes. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript (1). All four variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY422170.1, AJ297792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374810.8/ ENSP00000363943.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4124              AY422170.1         1-4124
            4125-4127           CA310159.1         19-21               c
FEATURES             Location/Qualifiers
     source          1..4127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..4127
                     /gene="TP53INP2"
                     /gene_synonym="C20orf110; dJ1181N3.1; DOR; PIG-U; PIGU;
                     PINH"
                     /note="tumor protein p53 inducible nuclear protein 2"
                     /db_xref="GeneID:58476"
                     /db_xref="HGNC:HGNC:16104"
                     /db_xref="MIM:617549"
     exon            1..169
                     /gene="TP53INP2"
                     /gene_synonym="C20orf110; dJ1181N3.1; DOR; PIG-U; PIGU;
                     PINH"
                     /inference="alignment:Splign:2.1.0"
     exon            170..286
                     /gene="TP53INP2"
                     /gene_synonym="C20orf110; dJ1181N3.1; DOR; PIG-U; PIGU;
                     PINH"
                     /inference="alignment:Splign:2.1.0"
     exon            287..459
                     /gene="TP53INP2"
                     /gene_synonym="C20orf110; dJ1181N3.1; DOR; PIG-U; PIGU;
                     PINH"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..998
                     /gene="TP53INP2"
                     /gene_synonym="C20orf110; dJ1181N3.1; DOR; PIG-U; PIGU;
                     PINH"
                     /note="p53-inducible protein U; diabetes and
                     obesity-regulated"
                     /codon_start=1
                     /product="tumor protein p53-inducible nuclear protein 2"
                     /protein_id="NP_067025.1"
                     /db_xref="CCDS:CCDS13240.1"
                     /db_xref="GeneID:58476"
                     /db_xref="HGNC:HGNC:16104"
                     /db_xref="MIM:617549"
                     /translation="MFQRLSSLFFSTPSPPEDPDCPRAFVSEEDEVDGWLIIDLPDSY
                     AAPPSPGAAPAPAGRPPPAPSLMDESWFVTPPACFTAEGPGLGPARLQSSPLEDLLIE
                     HPSMSVYVTGSTIVLEPGSPSPLPDAALPDGDLSEGELTPARREPRAARHAAPLPARA
                     ALLEKAGQVRRLQRARQRAERHALSAKAVQRQNRARESRPRRSKNQSSFIYQPCQRQF
                     NY"
     exon            460..748
                     /gene="TP53INP2"
                     /gene_synonym="C20orf110; dJ1181N3.1; DOR; PIG-U; PIGU;
                     PINH"
                     /inference="alignment:Splign:2.1.0"
     exon            749..4127
                     /gene="TP53INP2"
                     /gene_synonym="C20orf110; dJ1181N3.1; DOR; PIG-U; PIGU;
                     PINH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4105..4110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TP53INP2"
                     /gene_synonym="C20orf110; dJ1181N3.1; DOR; PIG-U; PIGU;
                     PINH"
                     /note="hexamer: AATAAA"
     polyA_site      4127
                     /gene="TP53INP2"
                     /gene_synonym="C20orf110; dJ1181N3.1; DOR; PIG-U; PIGU;
                     PINH"
                     /note="major polyA site"
ORIGIN      
        1 gcacagactc aaagccccgc gggcgagctc agcagcccgg agcgaccgcg gccccgccgc
       61 ctcccccgcg agtcccggcg atgcggcccg gcctgtgagc ggccggcgac cctgggacgc
      121 cccgccgcac aactacctca acgccgtgcc gcccccctcc cgcccccagg gaatctctgg
      181 agattggttc accttttgtg gtcctgaccc cttctgtcct cactgtacct tgaagtccta
      241 gagtccaata aaatcgctgc ctcccagctg tttggatcac agagaggttt ttgcactgcc
      301 atagggcgcc cccgtgaggc gcttcgcccc ccaccatgtt ccagcgcctc tccagcctct
      361 tcttcagcac cccctcgccc cccgaagacc ccgactgccc ccgcgccttc gtgtcggagg
      421 aggatgaagt ggacggctgg ctcatcattg acctgccgga cagctacgcg gctccaccca
      481 gccccggggc cgcccctgcc cccgcgggcc gccctccgcc cgcgccctcc ttgatggacg
      541 agagctggtt tgttacccct cccgcctgtt ttacggcaga ggggcctgga ctcggtcccg
      601 cccgcctcca gagcagtccc ctggaggacc tcctcatcga gcaccccagc atgtccgttt
      661 acgtcaccgg cagcaccata gtgctagagc ccgggtcccc ttccccgctc ccggacgcgg
      721 ccctgcctga cggcgacctc agcgaagggg aattgacgcc cgcccgccgc gagccgcggg
      781 ccgcgcgcca cgccgctcct ctcccagcgc gggcggcgct gctggagaag gcgggccagg
      841 tgcggcggct gcagcgggcc cggcagcggg cagagcgcca cgcgctgagc gccaaggcgg
      901 tgcagcggca gaaccgagcc cgcgagagcc gtccgcgccg gtccaagaac cagagcagct
      961 tcatctacca gccgtgccag cgccagttca actactgagc gtccaccggc cgcgccacga
     1021 accccttgcc gatcccgatc cctgtcgggc tcctccgact cctcgggctg gacaccgaaa
     1081 cctcccttct taaagcgtgt gaggttgggt gatagccgtt ccttccccga caccctcaat
     1141 ttccccatct ctgatcctct aatctgcctc tgaacccatt cacccttcac cctcactcct
     1201 ggtccccata cccagcatct aatcatccat gccccctact cctggcccct ccatcctttc
     1261 ttctctggtc cccatccctg tctctccctt tcacccttgc cctccagtcc tctacctctg
     1321 gcctgcccct atttctgaaa gcttcttcca gtccctgatc tggctcattc cccaccttca
     1381 actcccacct tacatgtctc acactatccc atggttggca ttacactcac tcctgttccc
     1441 ttattcttca ttcccagtaa ttccctacca aatggtgggg accctgagcc cagctctgac
     1501 caggtagagc ctgtgcagcc tgggctgctg tcattgccct ccagtaaggg ctcagggttt
     1561 tgcttttagt ctccccttcc ttctgccttg ggggcggtac tctgtggagc tgcttaggcc
     1621 tggaaaggta cagtatgtag aagaggactg tgagacgtga gttagaggga gaagatggag
     1681 ggaatctagg gaacgaggca gcctattgga gatgcggaca ggacagacac gttgagaagc
     1741 tgcagggagc agggcaccaa gggagtgtgc actgtgcttg ctcagagagg ccaaaccctg
     1801 ctcccaggct gaagcctgga gtctgccccc acttcccttt tctataatcc acccttctgc
     1861 aggccctgaa atctgaaggg cttagttagt accttgccac tctaccccca acacgtcacc
     1921 cgagtagaag ctgggcaagg ccctaccatc ctggccgtct gttcacaagc ccaaggtgct
     1981 agaactagct taggagacat gcaggccaca gggcttctag gcagggaaag ggcacacacc
     2041 ctaggtcagc gtgcagagca gtgatgctgg aggacacacc atggggtgaa gccatcccaa
     2101 ggctgacagc tcagtcttca ccttgcctct ggccttgtat ttcacaccct gctcagtatg
     2161 gctagccagc agtcctgagt aggagtccag gactcccact gtctcaatct gcaaattgtt
     2221 cctatccagg ttcagggcct tcagggggcc tcttttcatt ttctcccaca ggcctctctt
     2281 tctttctagg ttgctgggga gaaatgggta ccctatgatc cccctcccct tctcctccag
     2341 taaatacctg gaagagggaa cctgaatccc tgggggagac agaaggggca ggggccacca
     2401 gcctcccctt cttgtggtga gactgaattt tgggctcaga caccagcaac agcctcttgg
     2461 gatgccctga gttgcttccc atttcctctt tctagccgtc cttttctagt gtgtgctcac
     2521 tcttcctagg aacttttaag acttcttggt acctatgaac ataggtcctc ccctcacccc
     2581 aactctaggt ttccaggcct cacagccaag ctgaagcttg gagaaaactc tgcattccca
     2641 tgagggcaaa ggcagctgcc ctccctgacc ctatagcccc aggcctcatg gggggtatgt
     2701 ggggaaggga tggggtatcc ccatggatgc tgggatgagg acagaggaag acctgatggg
     2761 gtctcctatt ccagggaata agccaaatta acactaaaaa cggatcaaag ctcccacgcc
     2821 agtccactag ggccccagta gttgacagcc ttgctcctct cccaagttct ccttcagaac
     2881 ctagttgctt ttattcttcc agctaccact tgggcacttc acagccagcc tagggtcttc
     2941 ggcacctcca agagctgaat ctccctccaa cccttcttgc ctactcctca ctgccagctg
     3001 ggacctaggc tcagtcctgt gtggtgccca tgatccttct ggtgggggaa gagtttaagt
     3061 tatagggcat ttggctcaaa ttttaaaagg ccttttgttt acctatattt ctggaggctc
     3121 ctgtattcta gaacccaatc tctcacctgc ttggttgcaa ggctcatatt tttttgtacc
     3181 tttcctatag attctgtagc atttgagtgt ggcaatattt taattgtgta tagatttcta
     3241 agaaccaaca ctactcagtc tcctgctagt ctgactcctg aagcatcagc ccttgtcata
     3301 ctgtattgac tgtgtacgtg cctttcacct tgagcatgct tcaggatttt tttttaaacc
     3361 acagaacttg aatacatgag ggaaccagag ttcaaagtcc tatgcaacct taggaggggg
     3421 ttagagagtc tgttttgatt gatgttttct gaggccctag aggagtttgt atcaatttgt
     3481 gagtattaat gtcagtacta ccagcacttt gccaaaactg tcagagggac ccgtttctag
     3541 agtgagtccc agttacatca aacagtgact tccagttatt ccccagtaag tctgagtggt
     3601 tccttcaagc tgggtgtctt tccagccttt gccagtctag ccccagcagg gcaccgtgta
     3661 tgaatgcagt ttggtgctgt tttagagtat gcctgctccc cagccccctg cctggaaccc
     3721 tctgagcaac ttgctctgac ctataatgtc ttaggtgcaa cacggacccc accagagctc
     3781 ttggataccc ccctagatcc atgtggcttt atgtgagggg actgaatgca gacacaccat
     3841 agcccccttc tactactttc cctctcgccc tgccacctag ttccacatgg aaccaacaag
     3901 ttgagtgcat ccctgttggg tgttttgtgt tgagactggc tgaaatgagg agactttgac
     3961 catgtgacgt gtcaacagac tcaaggagac aaccacctca actgggtcat gtggcatgcc
     4021 tgtgtatgtg tgtaacagaa ttctgattgt tagactgtaa tgctattcct ctatgggaga
     4081 aaaaaattaa tataaagaaa aacaaataaa aatatattta aagcaca
//
