LOCUS       NM_033285               5605 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens tumor protein p53 inducible nuclear protein 1
            (TP53INP1), transcript variant 1, mRNA.
ACCESSION   NM_033285
VERSION     NM_033285.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5605)
  AUTHORS   Sweed,N.M., Dawoud,M.H.S., Aborehab,N.M. and Ezzat,S.M.
  TITLE     An approach for an enhanced anticancer activity of ferulic
            acid-loaded polymeric micelles via MicroRNA-221 mediated activation
            of TP53INP1 in caco-2 cell line
  JOURNAL   Sci Rep 14 (1), 2073 (2024)
   PUBMED   38267567
  REMARK    GeneRIF: An approach for an enhanced anticancer activity of ferulic
            acid-loaded polymeric micelles via MicroRNA-221 mediated activation
            of TP53INP1 in caco-2 cell line.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5605)
  AUTHORS   Luo,X., Xu,Y., Zhong,Z., Xiang,P., Wu,X. and Chong,A.
  TITLE     miR-8485 alleviates the injury of cardiomyocytes through TP53INP1
  JOURNAL   J Biochem Mol Toxicol 36 (10), e23159 (2022)
   PUBMED   35876212
  REMARK    GeneRIF: miR-8485 alleviates the injury of cardiomyocytes through
            TP53INP1.
REFERENCE   3  (bases 1 to 5605)
  AUTHORS   Liu,T., Liao,S., Mo,J., Bai,X., Li,Y., Zhang,Y., Zhang,D.,
            Cheng,R., Zhao,N., Che,N., Guo,Y., Dong,X. and Zhao,X.
  TITLE     LncRNA n339260 functions in hepatocellular carcinoma progression
            via regulation of miRNA30e-5p/TP53INP1 expression
  JOURNAL   J Gastroenterol 57 (10), 784-797 (2022)
   PUBMED   35802258
  REMARK    GeneRIF: LncRNA n339260 functions in hepatocellular carcinoma
            progression via regulation of miRNA30e-5p/TP53INP1 expression.
REFERENCE   4  (bases 1 to 5605)
  AUTHORS   Liu,Y., Zhao,X., Li,J., Zhou,L., Chang,W., Li,J., Hou,R., Li,J.,
            Yin,G., Li,X. and Zhang,K.
  TITLE     MiR-155 inhibits TP53INP1 expression leading to enhanced glycolysis
            of psoriatic mesenchymal stem cells
  JOURNAL   J Dermatol Sci 105 (3), 142-151 (2022)
   PUBMED   35164998
  REMARK    GeneRIF: MiR-155 inhibits TP53INP1 expression leading to enhanced
            glycolysis of psoriatic mesenchymal stem cells.
REFERENCE   5  (bases 1 to 5605)
  AUTHORS   Han,L., Huang,Z., Liu,Y., Ye,L., Li,D., Yao,Z., Wang,C., Zhang,Y.,
            Yang,H., Tan,Z., Tang,J. and Yang,Z.
  TITLE     MicroRNA-106a regulates autophagy-related cell death and EMT by
            targeting TP53INP1 in lung cancer with bone metastasis
  JOURNAL   Cell Death Dis 12 (11), 1037 (2021)
   PUBMED   34718338
  REMARK    GeneRIF: MicroRNA-106a regulates autophagy-related cell death and
            EMT by targeting TP53INP1 in lung cancer with bone metastasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5605)
  AUTHORS   Tomasini,R., Seux,M., Nowak,J., Bontemps,C., Carrier,A.,
            Dagorn,J.C., Pebusque,M.J., Iovanna,J.L. and Dusetti,N.J.
  TITLE     TP53INP1 is a novel p73 target gene that induces cell cycle arrest
            and cell death by modulating p73 transcriptional activity
  JOURNAL   Oncogene 24 (55), 8093-8104 (2005)
   PUBMED   16044147
  REMARK    GeneRIF: TP53INP1s are functionally associated with p73 to regulate
            cell cycle progression and apoptosis.
REFERENCE   7  (bases 1 to 5605)
  AUTHORS   Tomasini,R., Samir,A.A., Carrier,A., Isnardon,D., Cecchinelli,B.,
            Soddu,S., Malissen,B., Dagorn,J.C., Iovanna,J.L. and Dusetti,N.J.
  TITLE     TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are
            partners in regulating p53 activity
  JOURNAL   J Biol Chem 278 (39), 37722-37729 (2003)
   PUBMED   12851404
  REMARK    GeneRIF: TP53INP1s and HIPK2 could be partners in regulating p53
            activity.
REFERENCE   8  (bases 1 to 5605)
  AUTHORS   Tomasini,R., Samir,A.A., Pebusque,M.J., Calvo,E.L., Totaro,S.,
            Dagorn,J.C., Dusetti,N.J. and Iovanna,J.L.
  TITLE     P53-dependent expression of the stress-induced protein (SIP)
  JOURNAL   Eur J Cell Biol 81 (5), 294-301 (2002)
   PUBMED   12067065
  REMARK    GeneRIF: Data show that induction of the stress-induced proteins
            (SIPs) SIP18 and SIP27, in human- and mouse-derived cell lines, is
            absent from cells with deleted, mutated or inactive p53, suggesting
            that regulation of SIP gene expression is dependent on p53.
REFERENCE   9  (bases 1 to 5605)
  AUTHORS   Nowak,J., Tomasini,R., Mattei,M.G., Azizi Samir,L.A., Dagorn,J.C.,
            Dusetti,N., Iovanna,J.L. and Pebusque,M.J.
  TITLE     Assignment of tumor protein p53 induced nuclear protein 1
            (TP53INP1) gene to human chromosome band 8q22 by in situ
            hybridization
  JOURNAL   Cytogenet Genome Res 97 (1-2), 140E (2002)
   PUBMED   12438758
  REMARK    GeneRIF: Assignment of tumor protein p53 induced nuclear protein 1
            (TP53INP1) gene to human chromosome band 8q22 by in situ
            hybridization.
REFERENCE   10 (bases 1 to 5605)
  AUTHORS   Okamura,S., Arakawa,H., Tanaka,T., Nakanishi,H., Ng,C.C., Taya,Y.,
            Monden,M. and Nakamura,Y.
  TITLE     p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis
  JOURNAL   Mol Cell 8 (1), 85-94 (2001)
   PUBMED   11511362
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB086880.1, AF409115.1 and AB017926.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033285.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.26768.1, AF409115.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342697.5/ ENSP00000344215.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-545               DB086880.1         10-554
            546-5144            AF409115.1         527-5125
            5145-5605           AB017926.1         4839-5299
FEATURES             Location/Qualifiers
     source          1..5605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..5605
                     /gene="TP53INP1"
                     /gene_synonym="p53DINP1; SIP; Teap; TP53DINP1; TP53INP1A;
                     TP53INP1B"
                     /note="tumor protein p53 inducible nuclear protein 1"
                     /db_xref="GeneID:94241"
                     /db_xref="HGNC:HGNC:18022"
                     /db_xref="MIM:606185"
     exon            1..225
                     /gene="TP53INP1"
                     /gene_synonym="p53DINP1; SIP; Teap; TP53DINP1; TP53INP1A;
                     TP53INP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            226..487
                     /gene="TP53INP1"
                     /gene_synonym="p53DINP1; SIP; Teap; TP53DINP1; TP53INP1A;
                     TP53INP1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..1098
                     /gene="TP53INP1"
                     /gene_synonym="p53DINP1; SIP; Teap; TP53DINP1; TP53INP1A;
                     TP53INP1B"
                     /note="isoform a is encoded by transcript variant 1;
                     p53-inducible p53DINP1; stress-induced protein;
                     p53-dependent damage-inducible nuclear protein 1"
                     /codon_start=1
                     /product="tumor protein p53-inducible nuclear protein 1
                     isoform a"
                     /protein_id="NP_150601.1"
                     /db_xref="CCDS:CCDS6265.1"
                     /db_xref="GeneID:94241"
                     /db_xref="HGNC:HGNC:18022"
                     /db_xref="MIM:606185"
                     /translation="MFQRLNKMFVGEVSSSSNQEPEFNEKEDDEWILVDFIDTCTGFS
                     AEEEEEEEDISEESPTEHPSVFSCLPASLECLADTSDSCFLQFESCPMEESWFITPPP
                     CFTAGGLTTIKVETSPMENLLIEHPSMSVYAVHNSCPGLSEATRGTDELHSPSSPRVE
                     AQNEMGQHIHCYVAALAAHTTFLEQPKSFRPSQWIKEHSERQPLNRNSLRRQNLTRDC
                     HPRQVKHNGWVVHQPCPRQYNY"
     exon            488..848
                     /gene="TP53INP1"
                     /gene_synonym="p53DINP1; SIP; Teap; TP53DINP1; TP53INP1A;
                     TP53INP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            849..5605
                     /gene="TP53INP1"
                     /gene_synonym="p53DINP1; SIP; Teap; TP53DINP1; TP53INP1A;
                     TP53INP1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5584..5589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TP53INP1"
                     /gene_synonym="p53DINP1; SIP; Teap; TP53DINP1; TP53INP1A;
                     TP53INP1B"
                     /note="hexamer: AATAAA"
     polyA_site      5605
                     /gene="TP53INP1"
                     /gene_synonym="p53DINP1; SIP; Teap; TP53DINP1; TP53INP1A;
                     TP53INP1B"
                     /note="major polyA site"
ORIGIN      
        1 gttgcgagcg ctgcacaaca acaaaaggac ttggactggc cggcctgggc gcagcgaccc
       61 gagggctgga gccggccccg cgcctgccgt ctgggtacct gaacgaggtg cagcgcagcc
      121 cggccccacc gcagctacct cagcagtccc gccccgcccg cgtccttccc cgccgagccg
      181 gcggccgctc ccttccccgc gcagccccgc acggcccggg cccacgtaca atgactcttc
      241 ttgcttttca cctaagttga ataagcaccc tgtgcacttt aatctcctgt cggtaccatt
      301 gggccaacta aagacaaggt tttgaaatct cagctataaa agacatccag ccaaactctc
      361 agtcttgcct taacaatgtt ccagaggctg aataaaatgt ttgtgggtga agtcagttct
      421 tcctccaacc aagaaccaga attcaatgag aaagaagatg atgaatggat tcttgttgac
      481 ttcatagata cttgcactgg tttctcagca gaagaagaag aagaagagga ggacatcagt
      541 gaagagtcac ctactgagca cccttcagtc ttttcctgtt taccggcatc tcttgagtgc
      601 ttggctgata caagtgattc ctgctttctc cagtttgagt catgtccaat ggaggagagc
      661 tggtttatca ccccaccccc atgttttact gcaggtggat taaccactat caaggtggaa
      721 acaagtccta tggaaaacct tctcattgaa catcccagca tgtctgtcta tgctgtgcat
      781 aactcctgcc ctggtctcag tgaggccacc cgtgggactg atgaattaca tagcccaagt
      841 agtcccagag tggaagctca aaatgaaatg gggcagcata ttcattgtta tgttgcagct
      901 cttgctgctc atacaacttt tctggaacaa cccaagagct ttcgcccttc ccagtggata
      961 aaagaacaca gtgaaagaca gcctcttaac agaaatagcc ttcgtcgcca aaatcttacc
     1021 agggattgcc accctcggca agtcaagcac aatggctggg ttgttcatca gccctgcccg
     1081 cgtcagtaca attactaata gtttcaagtt ttgttggttg gtttctcttg gtttgtgctt
     1141 acatgtatgg atgtgtgtat atgtacagtg aaaatgttgt ctctttacaa ccaattgata
     1201 accaatcaca tagttttatc agtgtattta gacactatct tgaaaatcag atttatatgc
     1261 tgtgtatcac ataatgcctt gcctttaaca tttacttttt ttgtacactt tttcagatta
     1321 tttctggaaa catatcaata taattacagt gtttgggggt gtctttaaat atattaggtt
     1381 atacattagt cagcatttta aagacatttc ttcccaagta cgagaatagg catctttcat
     1441 tttcatttta ttttgtatta cttaatcttt taagcaagca aaaatttatt ctcagggtca
     1501 gctgtacact ttattgacca gtacttgata atctctctgt atatgatgaa tacattttta
     1561 cacactaaca ttagcattaa caggtgatag ttgccatgga tataatggaa ttatggctgg
     1621 actttctttt gaaagaaaac ttgatgtatt ctgtgtgtat ggtttttccc cagattagtc
     1681 atacagttca tttggaattc aggtacatta agctttagtg aagagtgcat gcagtaattc
     1741 caatgtgact gcatgacgtg gtacagacat tacaggtgtt gtagacagag gcacttgtct
     1801 cgtgcagagg gattaaatta gacctgtgag attatatttg gaaaaattca tgtctgtaac
     1861 taacccatta gtgcagtatt taatttgtta ctattccttc ccgccaattc tgtccactcc
     1921 tcacctcgca tcagctataa atttggaagt acttgtccag gcactcaagt gacttcatat
     1981 ttctctctgc ccatgggaaa agagataggc tttatatttc cacagagtga aaaatcctct
     2041 gtcatggagc ctgtcctgcc aagtggcaag agtgtgggga ctgtctggtg atgatgtctt
     2101 tcatggcatc tgagtgaaga gtgacaggtt ggctcaactt ttttcttttt ttttttttaa
     2161 ttgccttgta ttgtaagtat tcttccctgc agtccaagtg acttttcatt ttttgtttta
     2221 acttcaggca aaatctttaa ccactctggc ctctgtttcc cccaccaacg gggagcagtg
     2281 acatttacct ccctcacaga gtcactgtga ggattctata ctgatttgaa gtggagctgt
     2341 tcagaactga accttgtagg aaattccaag ggcctttcta ctgaatctgg tgatggggtg
     2401 gggccgtggc actttctctg ccacagctgt tcttcacagt gttggtgcta atgaggccag
     2461 ggtgcagggt tcgattcaca cgtaggccag ttaacttaga gaaaatctat ttccttacct
     2521 ctagccagtc acttcctttt tccgcagttg tgatgggttt tgctgagcca tccactctga
     2581 ctgatttcct ctgaagtaaa catatttaca atccaaagca attctactga cagaagtgtt
     2641 gccttcataa tcaaacagct tgtttttcca tctcctctgc aaccctaatt aaatgagtac
     2701 aggtctacaa aatgttttca aggagaaaag cagcatatcc ttaagtgaag tattatattt
     2761 ttcaataacc ctgtagtggc ttgatgcagg gaaccctggg ggactttcag cgaagagctg
     2821 tgctcttttc tgactagatt agagcgtttg gagtggaaga cgtcaaatgt gtagtgagat
     2881 ggaggtttta cattgttctt ctactggctg tgatgaagtg ccagaatgtc tctttagaac
     2941 aagagttaga ttcccccttt ctccttattg ccccttccgt tttgacttcc cctttattta
     3001 tttgttgtct aattaggggc caagtctgta aagttttgtc aaagtgagtt agaagttgtt
     3061 ttctcttact atttgtgttt accagagttg ggagataaga tagtttccat gaaggtgtgt
     3121 atgttttata cgatgtttgt tatagggcca tgcattggta acttgaaaat agaccagctt
     3181 aatgtcttca ggatgtaaaa ctctgaatac acggcgtctc tttttcatac attgcatgta
     3241 agttgttagt acctcacaag ctacagaagt tcagccatga gattttgttt ggcaacatga
     3301 acagatttgt gtataactgc aatggccttt ttttccagat ttccttattg actttttgtt
     3361 tgccttacct ggggctagtt ttttatgctt tgtacctaga aaacaaaaaa ttacattcgt
     3421 tgggcttttt ttcaaggttg ggattaccac accacctgga atatcatact gtggtttctg
     3481 cctaaaattg gcacatgtaa gtattgaaga aaatggttat ataattcagt tgaaactctt
     3541 ggttattaga tgttaggcat ctcctgtatg taagacacaa ggccaaccac aacacagaac
     3601 gatgttgacc tgttaagtat tctctgaaac atggccaaaa tgcattttat gagctttttt
     3661 ttttgctatt gtaaatatta gtggtttaca atgcgcttta gacatatttc tttaaaatgc
     3721 aagcagtgag aaataagacc tctctgaatt agtagctcta aactgttaac atagaatgtt
     3781 acttggaaaa agtctggaat atgtggtgta cacaagcagt gcttcgtgaa tgagtttctt
     3841 agcttttata gtgcgccatg tttctcaaag tttgtttttg ttgacaaaac attttataat
     3901 atatatctta tgtttatttt ttttctcaac taattgtgta ctgcactgta aggtgaaaat
     3961 tagccatcca ttatttatct tctgtggcaa tgcatttata tggttgattg ggtggggaat
     4021 tttttgcaga aagatgcaaa gtgattgggt tttcgacttc ctatcgcagg gagcttttaa
     4081 gaaatattaa tttcctatac atttttccaa tccccatgca aactgttcct gtttacatac
     4141 cttctctgtt gtatcagtac tttgagtgag aagacagttt atttaaaact tgagcaggct
     4201 gttcagcatt gtttctgctt ctgaaatctg tatagtacac tggtttgtaa tcattatgtc
     4261 ttcattgaaa tccttgctac ttctcttcct cctcaatgaa atacattata tattatcttt
     4321 atgtactctt aagaaaaacg agcaaggaag agtatcttca ttattctcat tttctctgag
     4381 ttggaaacaa aaacatgaag gactccaact agaagacaga tatttacatt taaatagatt
     4441 agtgggaaaa ctttaagagt ttccacatat tagttttcat tttttgagtc aagagactgc
     4501 tccttgtact gggagacact agtagtatat gtttgtaatg ttactttaaa attatctttt
     4561 tattttataa ggcccataaa tactggttaa actctgttaa aagtgggcct tctatcttgg
     4621 atggtttcac tgccatcagc catgctgata tattagaaat ggcatcccta tctacttact
     4681 ttaatgctta aaattataca taaaatgctt tatttagaaa acctacatga tacagtggtg
     4741 tcagccttgc catgtatcag tttcacttga aatttgagac caattaaatt tcaactgttt
     4801 agggtggaga aagaggtact ggaaaacatg cagatgagga tatcttttat gtgcaacagt
     4861 atcctttgca tgggaggaga gttactcttg aaaggcaggc agcttaagtg gacaatgttt
     4921 tgtatatagt tgagaatttt acgacacttt taaaaattgt gtaattgtta aatgtccagt
     4981 tttgctctgt tttgcctgaa gttttagtat ttgttttcta ggtggacctc tgaaaaccaa
     5041 accagtacct ggggaggtta gatgtgtgtt tcaggcttgg agtgtatgag tggttttgct
     5101 tgtattttcc tccagagatt ttgaacttta ataattgcgt gtgttttttt tttttttaag
     5161 tggctttgtt tttttttctc aagtaaaatt gtgaacatat ttcctttata ggggcagggc
     5221 atgagttagg gagactgaag agtattgtag actgtacatg tgccttctta atgtgtttct
     5281 cgacacattt tttttcagta acttgaaaat tcaaaaggga catttggtta ggttactgta
     5341 catcaatcta tgcataaatg gcagcttgtt ttcttgagcc acggtctaaa ttttgttttt
     5401 atagaaattt tttatactga ttggttcata gatggtcagt tttgtacaca gactgaacaa
     5461 tacagcactt tgccaaaaat gagtgtagca ttgtttaaac attgtgtgtt aacacctgtt
     5521 ctttgtaatt gggttgtggt gcattttgca ctacctggag ttacagtttt caatctgtca
     5581 gtaaataaag tgtcctttaa cttca
//
