LOCUS       NM_004881               1653 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens tumor protein p53 inducible protein 3 (TP53I3),
            transcript variant 1, mRNA.
ACCESSION   NM_004881
VERSION     NM_004881.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1653)
  AUTHORS   Gu,M.M., Gao,D., Yao,P.A., Yu,L., Yang,X.D., Xing,C.G., Zhou,J.,
            Shang,Z.F. and Li,M.
  TITLE     p53-inducible gene 3 promotes cell migration and invasion by
            activating the FAK/Src pathway in lung adenocarcinoma
  JOURNAL   Cancer Sci 109 (12), 3783-3793 (2018)
   PUBMED   30281878
  REMARK    GeneRIF: Study found that PIG3 expression was positively associated
            with lymph node metastasis from lung adenocarcinoma (LUAD) but not
            from lung squamous cell carcinoma (LUSC). Further data revealed a
            role for PIG3 in inducing LUAD metastasis, and its role as a new
            FAK regulator, suggesting that it could be considered as a novel
            prognostic biomarker.
REFERENCE   2  (bases 1 to 1653)
  AUTHORS   Chu,Y., Li,D., Zhang,H., Ding,J., Xu,P., Qiu,X. and Zhang,H.
  TITLE     PIG3 suppresses gastric cancer proliferation by regulating p53-
            mediated apoptosis
  JOURNAL   J Biol Regul Homeost Agents 32 (5), 1185-1189 (2018)
   PUBMED   30334411
  REMARK    GeneRIF: expression of PIG3 is frequently reduced in gastric cancer
            (GC) tissue, and PIG3 suppressed human GC growth through p53-
            mediated apoptosis; PIG3 may act as a potential diagnostic marker
            and a potential therapeutic target of GC
REFERENCE   3  (bases 1 to 1653)
  AUTHORS   Li,M., Li,S., Liu,B., Gu,M.M., Zou,S., Xiao,B.B., Yu,L., Ding,W.Q.,
            Zhou,P.K., Zhou,J. and Shang,Z.F.
  TITLE     PIG3 promotes NSCLC cell mitotic progression and is associated with
            poor prognosis of NSCLC patients
  JOURNAL   J Exp Clin Cancer Res 36 (1), 39 (2017)
   PUBMED   28259183
  REMARK    GeneRIF: Results revealed that PIG3 expression levels positively
            correlated with poor prognosis of non-small cell lung cancer
            (NSCLC) patients and indicate that PIG3 promotes NSCLC progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1653)
  AUTHORS   Quan,J., Li,Y., Jin,M., Chen,D., Yin,X. and Jin,M.
  TITLE     Suppression of p53-inducible gene 3 is significant for glioblastoma
            progression and predicts poor patient prognosis
  JOURNAL   Tumour Biol 39 (3), 1010428317694572 (2017)
   PUBMED   28351326
  REMARK    GeneRIF: our data suggest that high expression of p53-inducible
            gene 3 is significant for glioblastoma inhibition and p53-inducible
            gene 3 independently indicates good prognosis in patients, which
            might be a novel prognostic biomarker or potential therapeutic
            target in glioblastoma.
REFERENCE   5  (bases 1 to 1653)
  AUTHORS   Chen,G., Xu,J.Y., Chen,J., Zhang,J.X., Zhou,J., Liang,Y. and
            Ding,X.F.
  TITLE     Loss of PIG3 increases HIF-1alpha level by promoting protein
            synthesis via mTOR pathway in renal cell carcinoma cells
  JOURNAL   Oncotarget 7 (19), 27176-27184 (2016)
   PUBMED   27029070
  REMARK    GeneRIF: Data suggest that PIG3 was involved in HIF-1alpha
            regulation, and indicate a signaling pathway of PIG3/HIF-1alpha in
            the regulation of cell migration in renal cell carcinoma.
REFERENCE   6  (bases 1 to 1653)
  AUTHORS   Nicholls,C.D., Shields,M.A., Lee,P.W., Robbins,S.M. and
            Beattie,T.L.
  TITLE     UV-dependent alternative splicing uncouples p53 activity and PIG3
            gene function through rapid proteolytic degradation
  JOURNAL   J Biol Chem 279 (23), 24171-24178 (2004)
   PUBMED   15067011
  REMARK    GeneRIF: p53 activity and PIG3 gene function are uncoupled by
            UV-dependent alternative splicing through rapid proteolytic
            degradation
REFERENCE   7  (bases 1 to 1653)
  AUTHORS   Pospisilova,S., Siligan,C., Ban,J., Jug,G. and Kovar,H.
  TITLE     Constitutive and DNA damage inducible activation of pig3 and MDM2
            genes by tumor-derived p53 mutant C277Y
  JOURNAL   Mol Cancer Res 2 (5), 296-304 (2004)
   PUBMED   15192123
  REMARK    GeneRIF: suppression of p53-C277Y by RNAi reduced pig3 promoter
            activity, RNA, and protein expression
REFERENCE   8  (bases 1 to 1653)
  AUTHORS   Contente,A., Dittmer,A., Koch,M.C., Roth,J. and Dobbelstein,M.
  TITLE     A polymorphic microsatellite that mediates induction of PIG3 by p53
  JOURNAL   Nat Genet 30 (3), 315-320 (2002)
   PUBMED   11919562
REFERENCE   9  (bases 1 to 1653)
  AUTHORS   Flatt,P.M., Polyak,K., Tang,L.J., Scatena,C.D., Westfall,M.D.,
            Rubinstein,L.A., Yu,J., Kinzler,K.W., Vogelstein,B., Hill,D.E. and
            Pietenpol,J.A.
  TITLE     p53-dependent expression of PIG3 during proliferation, genotoxic
            stress, and reversible growth arrest
  JOURNAL   Cancer Lett 156 (1), 63-72 (2000)
   PUBMED   10840161
REFERENCE   10 (bases 1 to 1653)
  AUTHORS   Polyak,K., Xia,Y., Zweier,J.L., Kinzler,K.W. and Vogelstein,B.
  TITLE     A model for p53-induced apoptosis
  JOURNAL   Nature 389 (6648), 300-305 (1997)
   PUBMED   9305847
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK223382.1, BT007149.1 and
            CN285566.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004881.4.
            
            Summary: The protein encoded by this gene is similar to
            oxidoreductases, which are enzymes involved in cellular responses
            to oxidative stresses and irradiation. This gene is induced by the
            tumor suppressor p53 and is thought to be involved in p53-mediated
            cell death. It contains a p53 consensus binding site in its
            promoter region and a downstream pentanucleotide microsatellite
            sequence. P53 has been shown to transcriptionally activate this
            gene by interacting with the downstream pentanucleotide
            microsatellite sequence. The microsatellite is polymorphic, with a
            varying number of pentanucleotide repeats directly correlated with
            the extent of transcriptional activation by p53. It has been
            suggested that the microsatellite polymorphism may be associated
            with differential susceptibility to cancer. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223382.1, AF010309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159080 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238721.9/ ENSP00000238721.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1294              AK223382.1         219-1512
            1295-1505           BT007149.1         787-997
            1506-1653           CN285566.1         329-476
FEATURES             Location/Qualifiers
     source          1..1653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..1653
                     /gene="TP53I3"
                     /gene_synonym="PIG3"
                     /note="tumor protein p53 inducible protein 3"
                     /db_xref="GeneID:9540"
                     /db_xref="HGNC:HGNC:19373"
                     /db_xref="MIM:605171"
     exon            1..646
                     /gene="TP53I3"
                     /gene_synonym="PIG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             509..1507
                     /gene="TP53I3"
                     /gene_synonym="PIG3"
                     /EC_number="1.6.5.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     quinone oxidoreductase homolog; p53-induced gene 3
                     protein; quinone oxidoreductase PIG3; NADPH:quinone
                     reductase PIG3"
                     /codon_start=1
                     /product="quinone oxidoreductase PIG3 isoform 1"
                     /protein_id="NP_004872.2"
                     /db_xref="CCDS:CCDS1708.1"
                     /db_xref="GeneID:9540"
                     /db_xref="HGNC:HGNC:19373"
                     /db_xref="MIM:605171"
                     /translation="MLAVHFDKPGGPENLYVKEVAKPSPGEGEVLLKVAASALNRADL
                     MQRQGQYDPPPGASNILGLEASGHVAELGPGCQGHWKIGDTAMALLPGGGQAQYVTVP
                     EGLLMPIPEGLTLTQAAAIPEAWLTAFQLLHLVGNVQAGDYVLIHAGLSGVGTAAIQL
                     TRMAGAIPLVTAGSQKKLQMAEKLGAAAGFNYKKEDFSEATLKFTKGAGVNLILDCIG
                     GSYWEKNVNCLALDGRWVLYGLMGGGDINGPLFSKLLFKRGSLITSLLRSRDNKYKQM
                     LVNAFTEQILPHFSTEGPQRLLPVLDRIYPVTEIQEAHKYMEANKNIGKIVLELPQ"
     exon            647..914
                     /gene="TP53I3"
                     /gene_synonym="PIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1127
                     /gene="TP53I3"
                     /gene_synonym="PIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1324
                     /gene="TP53I3"
                     /gene_synonym="PIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1653
                     /gene="TP53I3"
                     /gene_synonym="PIG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1635..1640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TP53I3"
                     /gene_synonym="PIG3"
                     /note="hexamer: AATAAA"
     polyA_site      1653
                     /gene="TP53I3"
                     /gene_synonym="PIG3"
                     /note="major polyA site"
ORIGIN      
        1 agaggcagtc ctggggctct ggggctcggg ctttgtcacc gggacccgca ggagccagaa
       61 ccactcggcg ccgcctggtg catgggaggg gagccgggcc aggagtaagt aactcatacg
      121 ggcgccgggg acccgggtcg ggctgggggc ttccaactca gagggagtgt gatttgcctg
      181 atcctcttcg gcgttgtcct gctctgccgc atccagccct gtaccgccat cccacttccc
      241 gccgttccca tctgtgttcc gggtgggatc ggtctggagg cggccgagga cttcccaggc
      301 aggagctcgg ggcggaggcc gggtccgcgg cagaccaggg cagcgaggcg ctggccggca
      361 gggggcgctg cggtgccagc ctgaggctgg gctgctccgc gaggatacag cggcccctgc
      421 cctgtcctgt cctgccctgc cctgtcctgt cctgccctgc cctgccctgt cctgtcctgc
      481 cctgccctgc cctgtgtcct cagacaatat gttagccgtg cactttgaca agccgggagg
      541 accggaaaac ctctacgtga aggaggtggc caagccgagc ccgggggagg gtgaagtcct
      601 cctgaaggtg gcggccagcg ccctgaaccg ggcggactta atgcagagac aaggccagta
      661 tgacccacct ccaggagcca gcaacatttt gggacttgag gcatctggac atgtggcaga
      721 gctggggcct ggctgccagg gacactggaa gatcggggac acagccatgg ctctgctccc
      781 cggtgggggc caggctcagt acgtcactgt ccccgaaggg ctcctcatgc ctatcccaga
      841 gggattgacc ctgacccagg ctgcagccat cccagaggcc tggctcaccg ccttccagct
      901 gttacatctt gtgggaaatg ttcaggctgg agactatgtg ctaatccatg caggactgag
      961 tggtgtgggc acagctgcta tccaactcac ccggatggct ggagctattc ctctggtcac
     1021 agctggctcc cagaagaagc ttcaaatggc agaaaagctt ggagcagctg ctggattcaa
     1081 ttacaaaaaa gaggatttct ctgaagcaac gctgaaattc accaaaggtg ctggagttaa
     1141 tcttattcta gactgcatag gcggatccta ctgggagaag aacgtcaact gcctggctct
     1201 tgatggtcga tgggttctct atggtctgat gggaggaggt gacatcaatg ggcccctgtt
     1261 ttcaaagcta ctttttaagc gaggaagtct gatcaccagt ttgctgaggt ctagggacaa
     1321 taagtacaag caaatgctgg tgaatgcttt cacggagcaa attctgcctc acttctccac
     1381 ggagggcccc caacgtctgc tgccggttct ggacagaatc tacccagtga ccgaaatcca
     1441 ggaggcccat aagtacatgg aggccaacaa gaacataggc aagatcgtcc tggaactgcc
     1501 ccagtgaagg aggatggggc aggacaggac gcggccaccc caggcctttc cagagcaaac
     1561 ctggagaaga ttcacaatag acaggccaag aaacccggtg cttcctccag agccgtttaa
     1621 agctgatatg aggaaataaa gagtgaactg gaa
//
