LOCUS       NM_006034               3344 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tumor protein p53 inducible protein 11 (TP53I11),
            transcript variant 6, mRNA.
ACCESSION   NM_006034
VERSION     NM_006034.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3344)
  AUTHORS   Xie,J., Ning,Y., Zhang,L., Lin,Y., Guo,R. and Wang,S.
  TITLE     Overexpression of hsa_circ_0006470 inhibits the malignant behavior
            of gastric cancer cells <em>via</em> regulation of miR-1234/TP53I11
            axis
  JOURNAL   Eur J Histochem 66 (4), 3477 (2022)
   PUBMED   36190397
  REMARK    GeneRIF: Overexpression of hsa_circ_0006470 inhibits the malignant
            behavior of gastric cancer cells <em>via</em> regulation of
            miR-1234/TP53I11 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3344)
  AUTHORS   Zhu,B., Tian,T. and Zhao,M.
  TITLE     MiR-645 promotes proliferation and migration of non-small cell lung
            cancer cells by targeting TP53I11
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 6150-6156 (2020)
   PUBMED   32572880
  REMARK    GeneRIF: MiR-645 promotes proliferation and migration of non-small
            cell lung cancer cells by targeting TP53I11.
REFERENCE   3  (bases 1 to 3344)
  AUTHORS   Xiao,T., Xu,Z., Zhang,H., Geng,J., Qiao,Y., Liang,Y., Yu,Y.,
            Dong,Q. and Suo,G.
  TITLE     TP53I11 suppresses epithelial-mesenchymal transition and metastasis
            of breast cancer cells
  JOURNAL   BMB Rep 52 (6), 379-384 (2019)
   PUBMED   30940320
  REMARK    GeneRIF: Findings showed that hypoxic treatment upregulated the
            expression of HIF1alpha, but reduced TP53I11 protein levels and
            TP53I11 overexpression reduced HIF1alpha expression under normal
            culture and hypoxicconditions, and in xenografts of MDA-MB-231
            cells.
REFERENCE   4  (bases 1 to 3344)
  AUTHORS   Xiao,T., Xu,Z., Zhou,Y., Zhang,H., Geng,J., Liang,Y., Qiao,H. and
            Suo,G.
  TITLE     Loss of TP53I11 Enhances the Extracellular Matrix-independent
            Survival by Promoting Activation of AMPK
  JOURNAL   IUBMB Life 71 (2), 183-191 (2019)
   PUBMED   30376610
  REMARK    GeneRIF: TP53I11 functions as a mediator to balance activation of
            AKT and AMPK to adapt cells to different cellular contexts such as
            extracellular matrix-attachment and -detachment.
REFERENCE   5  (bases 1 to 3344)
  AUTHORS   Wu,Y., Liu,X.M., Wang,X.J., Zhang,Y., Liang,X.Q. and Cao,E.H.
  TITLE     PIG11 is involved in hepatocellular carcinogenesis and its
            over-expression promotes Hepg2 cell apoptosis
  JOURNAL   Pathol Oncol Res 15 (3), 411-416 (2009)
   PUBMED   19096915
  REMARK    GeneRIF: PIG11 is considered to be a new candidate liver tumour
            suppressor gene.
REFERENCE   6  (bases 1 to 3344)
  AUTHORS   Xiong,X.F., Li,H. and Cao,E.H.
  TITLE     PIG11 protein binds to DNA in sequence-independent manner in vitro
  JOURNAL   Biochem Biophys Res Commun 358 (1), 29-34 (2007)
   PUBMED   17482569
  REMARK    GeneRIF: PIG11 protein may play an important role by interaction
            with other biological molecules in the regulation of apoptosis and
            provided us a novel angel of view to explore the possible function
            of PIG11 in vivo.
REFERENCE   7  (bases 1 to 3344)
  AUTHORS   Fingrut,O., Reischer,D., Rotem,R., Goldin,N., Altboum,I.,
            Zan-Bar,I. and Flescher,E.
  TITLE     Jasmonates induce nonapoptotic death in high-resistance mutant
            p53-expressing B-lymphoma cells
  JOURNAL   Br J Pharmacol 146 (6), 800-808 (2005)
   PUBMED   16170329
  REMARK    GeneRIF: Jasmonates can circumvent drug resistance induced by p53
            mutations.
REFERENCE   8  (bases 1 to 3344)
  AUTHORS   Liang,X.Q., Cao,E.H., Zhang,Y. and Qin,J.F.
  TITLE     A P53 target gene, PIG11, contributes to chemosensitivity of cells
            to arsenic trioxide
  JOURNAL   FEBS Lett 569 (1-3), 94-98 (2004)
   PUBMED   15225615
  REMARK    GeneRIF: Overexpression of PIG11 could induce cell apoptosis in the
            low levels and enhanced the apoptotic effects of arsenic trioxide
REFERENCE   9  (bases 1 to 3344)
  AUTHORS   Liang,X.Q., Cao,E.H., Zhang,Y. and Qin,J.F.
  TITLE     P53-induced gene 11 (PIG11) involved in arsenic trioxide-induced
            apoptosis in human gastric cancer MGC-803 cells
  JOURNAL   Oncol Rep 10 (5), 1265-1269 (2003)
   PUBMED   12883691
  REMARK    GeneRIF: PIG11, as a downstream target of p53, is involved in
            apoptosis of gastric cancer cells
REFERENCE   10 (bases 1 to 3344)
  AUTHORS   Polyak,K., Xia,Y., Zweier,J.L., Kinzler,K.W. and Vogelstein,B.
  TITLE     A model for p53-induced apoptosis
  JOURNAL   Nature 389 (6648), 300-305 (1997)
   PUBMED   9305847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068858.10 and AC092733.18.
            
            On Jun 3, 2019 this sequence version replaced NM_006034.4.
            
            Transcript Variant: This variant (6) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 all encode the
            same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026607.1, SRR11853565.4824.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000525680.6/ ENSP00000433474.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AC068858.10        105223-105429
            208-367             AC092733.18        185463-185622       c
            368-426             AC092733.18        184811-184869       c
            427-475             AC092733.18        184560-184608       c
            476-572             AC092733.18        184059-184155       c
            573-674             AC092733.18        182817-182918       c
            675-3344            AC092733.18        179604-182273       c
FEATURES             Location/Qualifiers
     source          1..3344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..3344
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /note="tumor protein p53 inducible protein 11"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
     exon            1..207
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /inference="alignment:Splign:2.1.0"
     exon            208..367
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..808
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /note="isoform a is encoded by transcript variant 6;
                     p53-induced gene 11 protein"
                     /codon_start=1
                     /product="tumor protein p53-inducible protein 11 isoform
                     a"
                     /protein_id="NP_006025.2"
                     /db_xref="CCDS:CCDS7911.1"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
                     /translation="MAAKQPPPLMKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKI
                     SQVLGNEIKFTIREPLGLRVWQFVSAVLFSGIAIMALAFPDQLYDAVFDGAQVTSKTP
                     IRLYGGALLSISLIMWNALYTAEKVIIRWTLLTEACYFGVQFLVVTATLAETGLMSLG
                     ILLLLVSRLLFVVISIYYYYQVGRRPKKA"
     exon            368..426
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /inference="alignment:Splign:2.1.0"
     exon            427..475
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /inference="alignment:Splign:2.1.0"
     exon            476..572
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /inference="alignment:Splign:2.1.0"
     exon            573..674
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /inference="alignment:Splign:2.1.0"
     exon            675..3344
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3310..3315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /note="hexamer: AAGAAA"
     polyA_site      3344
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /note="major polyA site"
ORIGIN      
        1 agactcggta agccccggcc gcgcagggcg ccgcgcgcag tccagccggc ccggccctgc
       61 cctgccctgc cctgtcctgc cctgccctgc cctgccctgc cctgcactgc ccggcccggc
      121 acgggcggcg cgatgtgagg cgtccgagcc cggagcctcc gcctggcatc agctccacgt
      181 agcccagcgc cggcacgcgc gaggcccccc ttctgcagag gccgggctgg aggagaagat
      241 ggcggccaag cagcccccgc ctctgatgaa gaagcacagc cagacggacc tcgtgagccg
      301 cctgaagacc cgcaagatcc tcggcgtggg cggggaggat gacgacgggg aggtgcatcg
      361 ctccaagatc agccaggtct taggcaatga aatcaagttt accattcggg agcctttggg
      421 gctcagggtc tggcagttcg tctctgctgt gctcttctcc ggcattgcca tcatggcgct
      481 tgccttccct gaccagctct atgatgcggt ctttgatgga gcccaggtga ccagcaagac
      541 ccccatccgc ctctacggcg gtgccctcct cagcatctcc ctgatcatgt ggaacgctct
      601 ctacacggct gagaaggtca tcattcgatg gaccctgctc accgaagctt gctatttcgg
      661 ggtccagttc ttggtggtca ctgccacgct agctgagacg ggcctcatgt ccctggggat
      721 cctgctgctc ctggtcagcc gcctcctttt tgtcgtcatc agcatttact actattacca
      781 agtcggccga agacccaaga aggcctagtt gcccgctggg cctggggccc tgcccatgcc
      841 tgggccagag tggcgctggg gcctcggctt ccctttggct cctggaaggc aggagggtcc
      901 cctgccctgc cccagtcctg ccccagggag gcagggggtg gggggccttc ctttcctcct
      961 gggcaccccg tgtgctgtga tctcctgggc tttcaggctt gacatgctgg tctggggaga
     1021 gacagggcct ctgctgccct gttcttcacc ctcacagtga tacctccttt ccttgggtct
     1081 cttggcctcc agaccccctc aatagacact gactaaagtc aggctggagt catgagggta
     1141 gtgggctaag tcgagggtcc agcctcttct gccaggaagc ccttcttgct tttgagagag
     1201 gctgtgacca ccccccatcc ttctccctac actcccagcc aacctagtgc ccaagcagct
     1261 aaacttggct tccttctaat cctggaaaac cctgtacccc tcctcctcaa tctggccctc
     1321 tccacatgca caccctgaaa acacacacag acacacaaca cacacacata cacacccctg
     1381 aacacacaca cagacacaca tacacccatg atgtgagcaa acacacacac gtgcgccttc
     1441 atagcccagc caagggcatg caggcagggt gtgctgcctg agatggcacc tccctttcag
     1501 ccattcttca agaatgggcc acacacagct agaagtcctc tcccagctag aagtcctgtc
     1561 cccactctcc tggcctgaca agatgagctc tcctgggacc ttgctctagg gcactctgcc
     1621 tctaccctag gacactggaa tgccctggga gccccctccc tgcaaccagc ctgagttcag
     1681 ccccacggac aaagggacac acagccccca atggagacca ttgtaagtgg tggggctggg
     1741 agaggaggaa cagaaggaaa gccatagcgc tctcttgccc cttggcatgt accccaaggc
     1801 ctgatggcca ctgggctcag cctgtccccc actcctgcct gcttcccggt gagctgcccc
     1861 ccacacgtgc agcccgggct gcctccaggg tctggctgag tgggatcagg tggccctcca
     1921 actcagcaca ggaaataagt agaaacattt cagcaggcca cctcccctca tcttccccgc
     1981 cctgtccagc gccctggcaa aggctgacaa ctggctgtct tggggccgaa cagcccctgc
     2041 cctgcctctg agggcccacc agcctgtgct gcatacccac cgcccagctt ctccctgagg
     2101 gcccaccagc ctgtgctgca tacccaccgc ccagcttctc cctgagggcc caccagcctg
     2161 tgctgtacac cccgttagtc cctgatccca accttctccc tcctgccagc acaccgatgc
     2221 acacaccgga agtggcgagc ccaagccctg gggacaggtg tagggagaaa agcagcccca
     2281 ggcctcagac tcgcttccca tcctggcata gagtggggga tggctggagg gtgtctatag
     2341 gtacagcccg ctctggctgc tgccaggtgg gcccctgcca ggggtcctca cccctgtcca
     2401 ccctgtgcct ggctgtccct gcacccagat acagcaacat ggcctgtacc cagcagagtg
     2461 gtggcaccac catggttaca gcggatgccc cgagactctg cttggtaaac gtggcagagc
     2521 agaatgggag gctggaccct gaggaagggc ccctctcctg gcatctgtct cttgctacct
     2581 aagcctgtgc ctctccctaa agagctgcct ccctgctgcc gagccctggt ctggccacga
     2641 gccaccactg cctcccgctg ctgcccacag gtggtgccgc caatgggcag tgccctcagg
     2701 ccgaagcctc aatcccccat ctgagccagg cctaatcctc taatagtgat ggttggtttg
     2761 tcctcccata actgcaggtg gattccacct ggggaatgag gctgcgtgtc gggcgtctgc
     2821 tggccctgag acatccagtc ttccacactc aactgtggga tgggagggtg gcgtggcctt
     2881 accccatgag gctgtccagg ctctggcaca cagctgtgct cacaaaatac tgggtggctt
     2941 ggttagagct aattgtagtg gagcctgcag gtgagggtga gggagggggc tgcaggtcag
     3001 gtaagatctg gaagacagac gtacagcttg gagggcaggg ggactctaag gcaaggagat
     3061 ttacagttgg gaaggaggca gtggcagagg ggtgagggac aggggccctt aagtccagcg
     3121 aggaaagctc ggtgtgggcc cgctctacgc tccgtttggg gtgacctgga acgcctcttc
     3181 tcccagctcc ctccagccat cagcagcctc ttgtcaagct tctgcctcgc cccagtctat
     3241 ccccaacccc aaatcaagac cacctttctt cacggtcact atttattctt tgttcctttt
     3301 tctttttgta agaaacattc acaaaaacca gtgcaaaacc atca
//
