LOCUS       NP_006025                189 aa            linear   PRI 29-APR-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform a [Homo sapiens].
ACCESSION   NP_006025
VERSION     NP_006025.2
DBSOURCE    REFSEQ: accession NM_006034.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 189)
  AUTHORS   Xie,J., Ning,Y., Zhang,L., Lin,Y., Guo,R. and Wang,S.
  TITLE     Overexpression of hsa_circ_0006470 inhibits the malignant behavior
            of gastric cancer cells <em>via</em> regulation of miR-1234/TP53I11
            axis
  JOURNAL   Eur J Histochem 66 (4), 3477 (2022)
   PUBMED   36190397
  REMARK    GeneRIF: Overexpression of hsa_circ_0006470 inhibits the malignant
            behavior of gastric cancer cells <em>via</em> regulation of
            miR-1234/TP53I11 axis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 189)
  AUTHORS   Zhu,B., Tian,T. and Zhao,M.
  TITLE     MiR-645 promotes proliferation and migration of non-small cell lung
            cancer cells by targeting TP53I11
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 6150-6156 (2020)
   PUBMED   32572880
  REMARK    GeneRIF: MiR-645 promotes proliferation and migration of non-small
            cell lung cancer cells by targeting TP53I11.
REFERENCE   3  (residues 1 to 189)
  AUTHORS   Xiao,T., Xu,Z., Zhang,H., Geng,J., Qiao,Y., Liang,Y., Yu,Y.,
            Dong,Q. and Suo,G.
  TITLE     TP53I11 suppresses epithelial-mesenchymal transition and metastasis
            of breast cancer cells
  JOURNAL   BMB Rep 52 (6), 379-384 (2019)
   PUBMED   30940320
  REMARK    GeneRIF: Findings showed that hypoxic treatment upregulated the
            expression of HIF1alpha, but reduced TP53I11 protein levels and
            TP53I11 overexpression reduced HIF1alpha expression under normal
            culture and hypoxicconditions, and in xenografts of MDA-MB-231
            cells.
REFERENCE   4  (residues 1 to 189)
  AUTHORS   Xiao,T., Xu,Z., Zhou,Y., Zhang,H., Geng,J., Liang,Y., Qiao,H. and
            Suo,G.
  TITLE     Loss of TP53I11 Enhances the Extracellular Matrix-independent
            Survival by Promoting Activation of AMPK
  JOURNAL   IUBMB Life 71 (2), 183-191 (2019)
   PUBMED   30376610
  REMARK    GeneRIF: TP53I11 functions as a mediator to balance activation of
            AKT and AMPK to adapt cells to different cellular contexts such as
            extracellular matrix-attachment and -detachment.
REFERENCE   5  (residues 1 to 189)
  AUTHORS   Wu,Y., Liu,X.M., Wang,X.J., Zhang,Y., Liang,X.Q. and Cao,E.H.
  TITLE     PIG11 is involved in hepatocellular carcinogenesis and its
            over-expression promotes Hepg2 cell apoptosis
  JOURNAL   Pathol Oncol Res 15 (3), 411-416 (2009)
   PUBMED   19096915
  REMARK    GeneRIF: PIG11 is considered to be a new candidate liver tumour
            suppressor gene.
REFERENCE   6  (residues 1 to 189)
  AUTHORS   Xiong,X.F., Li,H. and Cao,E.H.
  TITLE     PIG11 protein binds to DNA in sequence-independent manner in vitro
  JOURNAL   Biochem Biophys Res Commun 358 (1), 29-34 (2007)
   PUBMED   17482569
  REMARK    GeneRIF: PIG11 protein may play an important role by interaction
            with other biological molecules in the regulation of apoptosis and
            provided us a novel angel of view to explore the possible function
            of PIG11 in vivo.
REFERENCE   7  (residues 1 to 189)
  AUTHORS   Fingrut,O., Reischer,D., Rotem,R., Goldin,N., Altboum,I.,
            Zan-Bar,I. and Flescher,E.
  TITLE     Jasmonates induce nonapoptotic death in high-resistance mutant
            p53-expressing B-lymphoma cells
  JOURNAL   Br J Pharmacol 146 (6), 800-808 (2005)
   PUBMED   16170329
  REMARK    GeneRIF: Jasmonates can circumvent drug resistance induced by p53
            mutations.
REFERENCE   8  (residues 1 to 189)
  AUTHORS   Liang,X.Q., Cao,E.H., Zhang,Y. and Qin,J.F.
  TITLE     A P53 target gene, PIG11, contributes to chemosensitivity of cells
            to arsenic trioxide
  JOURNAL   FEBS Lett 569 (1-3), 94-98 (2004)
   PUBMED   15225615
  REMARK    GeneRIF: Overexpression of PIG11 could induce cell apoptosis in the
            low levels and enhanced the apoptotic effects of arsenic trioxide
REFERENCE   9  (residues 1 to 189)
  AUTHORS   Liang,X.Q., Cao,E.H., Zhang,Y. and Qin,J.F.
  TITLE     P53-induced gene 11 (PIG11) involved in arsenic trioxide-induced
            apoptosis in human gastric cancer MGC-803 cells
  JOURNAL   Oncol Rep 10 (5), 1265-1269 (2003)
   PUBMED   12883691
  REMARK    GeneRIF: PIG11, as a downstream target of p53, is involved in
            apoptosis of gastric cancer cells
REFERENCE   10 (residues 1 to 189)
  AUTHORS   Polyak,K., Xia,Y., Zweier,J.L., Kinzler,K.W. and Vogelstein,B.
  TITLE     A model for p53-induced apoptosis
  JOURNAL   Nature 389 (6648), 300-305 (1997)
   PUBMED   9305847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068858.10 and AC092733.18.
            
            On Aug 16, 2003 this sequence version replaced NP_006025.1.
            
            Transcript Variant: This variant (6) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 all encode the
            same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026607.1, SRR11853565.4824.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000525680.6/ ENSP00000433474.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     Protein         1..189
                     /product="tumor protein p53-inducible protein 11 isoform
                     a"
                     /note="p53-induced gene 11 protein"
                     /calculated_mol_wt=20923
     Region          10..188
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692;
                     propagated from UniProtKB/Swiss-Prot (O14683.2)"
     Site            64..84
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O14683.2)"
     Site            109..129
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O14683.2)"
     Site            131..151
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O14683.2)"
     Site            156..176
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O14683.2)"
     CDS             1..189
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="NM_006034.5:239..808"
                     /note="isoform a is encoded by transcript variant 6"
                     /db_xref="CCDS:CCDS7911.1"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lsislimwna
      121 lytaekviir wtllteacyf gvqflvvtat laetglmslg illllvsrll fvvisiyyyy
      181 qvgrrpkka
//
