LOCUS       NM_022112                750 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens tumor protein p53 regulated apoptosis inducing protein
            1 (TP53AIP1), transcript variant 1, mRNA.
ACCESSION   NM_022112
VERSION     NM_022112.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 750)
  AUTHORS   Liu,S., Xu,T., Chen,X., Tang,L., Li,L., Zhang,L., Yang,Y. and
            Huang,J.
  TITLE     TP53AIP1 induce autophagy via the AKT/mTOR signaling pathway in the
            breast cancer cells
  JOURNAL   Cancer Biol Ther 25 (1), 2398297 (2024)
   PUBMED   39223776
  REMARK    GeneRIF: TP53AIP1 induce autophagy via the AKT/mTOR signaling
            pathway in the breast cancer cells.
REFERENCE   2  (bases 1 to 750)
  AUTHORS   Fang,H., Liu,Y., He,Y., Jiang,Y., Wei,Y., Liu,H., Gong,Y. and An,G.
  TITLE     Extracellular vesicle-delivered miR-505-5p, as a diagnostic
            biomarker of early lung adenocarcinoma, inhibits cell apoptosis by
            targeting TP53AIP1
  JOURNAL   Int J Oncol 54 (5), 1821-1832 (2019)
   PUBMED   30864684
  REMARK    GeneRIF: Bioinformatic analysis identified TP53AIP1 as a direct
            target for miR-505.
REFERENCE   3  (bases 1 to 750)
  AUTHORS   Benfodda,M., Gazal,S., Descamps,V., Basset-Seguin,N., Deschamps,L.,
            Thomas,L., Lebbe,C., Saiag,P., Zanetti,R., Sacchetto,L.,
            Chiorino,G., Scatolini,M., Grandchamp,B., Bensussan,A. and
            Soufir,N.
  TITLE     Truncating mutations of TP53AIP1 gene predispose to cutaneous
            melanoma
  JOURNAL   Genes Chromosomes Cancer 57 (6), 294-303 (2018)
   PUBMED   29359367
  REMARK    GeneRIF: results show that constitutional truncating TP53AIP1
            mutations predispose to CMM in the French population
REFERENCE   4  (bases 1 to 750)
  AUTHORS   Lin,X., Zhao,Q., Yin,X., Tian,R., Li,F., Gao,J. and Yu,J.
  TITLE     [Effect of p53-regulated apoptosis-inducing protein 1 transfection
            on the biological characteristics of PC-3M human prostate cancer
            cells]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30 (8), 819-823 (2014)
   PUBMED   25108434
  REMARK    GeneRIF: Data indicate that p53-regulated apoptosis-inducing
            protein 1 (p53AIP1) inhibits the proliferation of PC-3M cells,
            arrests cell cycle at S/G2-M phase, decreases the abilities of
            invasion and migration and promotes cell apoptosis.
REFERENCE   5  (bases 1 to 750)
  AUTHORS   Igarashi,H., Hirano,H., Yahagi,A., Saika,T. and Ishihara,K.
  TITLE     Anti-apoptotic roles for the mutant p53R248Q through suppression of
            p53-regulated apoptosis-inducing protein 1 in the RA-derived
            fibroblast-like synoviocyte cell line MH7A
  JOURNAL   Clin Immunol 150 (1), 12-21 (2014)
   PUBMED   24316591
  REMARK    GeneRIF: These studies indicate the critical role of p53AIP1 under
            DNA damaging stresses for cell fate determination in rheumatoid
            arthritis-fibroblast-like synovioctes containing the p53R248Q
            mutation.
REFERENCE   6  (bases 1 to 750)
  AUTHORS   Wesierska-Gadek,J., Gueorguieva,M. and Horky,M.
  TITLE     Roscovitine-induced up-regulation of p53AIP1 protein precedes the
            onset of apoptosis in human MCF-7 breast cancer cells
  JOURNAL   Mol Cancer Ther 4 (1), 113-124 (2005)
   PUBMED   15657359
  REMARK    GeneRIF: Roscovitine induced up-regulation of p53AIP1 protein and
            the depolarization of mitochondrial potential.
            Erratum:[Mol Cancer Ther. 2005 Mar;4(3):503]
REFERENCE   7  (bases 1 to 750)
  AUTHORS   Chan,K.T. and Lung,M.L.
  TITLE     Mutant p53 expression enhances drug resistance in a hepatocellular
            carcinoma cell line
  JOURNAL   Cancer Chemother Pharmacol 53 (6), 519-526 (2004)
   PUBMED   15004724
  REMARK    GeneRIF: expression of the p53 mutant, R248Q, in liver cancer cells
            may enhance their drug resistance and upregulation of
            P-glycoprotein activity may contribute to this protective effect.
REFERENCE   8  (bases 1 to 750)
  AUTHORS   Kovesi,G. and Szende,B.
  TITLE     Changes in apoptosis and mitotic index, p53 and Ki67 expression in
            various types of oral leukoplakia
  JOURNAL   Oncology 65 (4), 331-336 (2003)
   PUBMED   14707453
  REMARK    GeneRIF: The expression of Ki67 and p53 in various forms of
            leukoplakia point to the increasing instability of the genome in
            parallel with the severity of leukoplakia.
REFERENCE   9  (bases 1 to 750)
  AUTHORS   Matsuda,K., Yoshida,K., Taya,Y., Nakamura,K., Nakamura,Y. and
            Arakawa,H.
  TITLE     p53AIP1 regulates the mitochondrial apoptotic pathway
  JOURNAL   Cancer Res 62 (10), 2883-2889 (2002)
   PUBMED   12019168
  REMARK    GeneRIF: p53AIP1 regulates the mitochondrial apoptotic pathway.
REFERENCE   10 (bases 1 to 750)
  AUTHORS   Oda,K., Arakawa,H., Tanaka,T., Matsuda,K., Tanikawa,C., Mori,T.,
            Nishimori,H., Tamai,K., Tokino,T., Nakamura,Y. and Taya,Y.
  TITLE     p53AIP1, a potential mediator of p53-dependent apoptosis, and its
            regulation by Ser-46-phosphorylated p53
  JOURNAL   Cell 102 (6), 849-862 (2000)
   PUBMED   11030628
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB045830.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_022112.2.
            
            Summary: This gene is specifically expressed in the thymus, and
            encodes a protein that is localized to the mitochondrion. The
            expression of this gene is inducible by p53, and it is thought to
            play an important role in mediating p53-dependent apoptosis.
            Alternatively spliced transcript variants encoding different
            isoforms have been described for this gene. [provided by RefSeq,
            Oct 2011].
            
            Transcript Variant: This variant (1, also known as alpha)
            represents the longest transcript and encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB045830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000531399.6/
                                                  ENSP00000432743.1
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-750               AB045830.1         57-806
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..750
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /note="tumor protein p53 regulated apoptosis inducing
                     protein 1"
                     /db_xref="GeneID:63970"
                     /db_xref="HGNC:HGNC:29984"
                     /db_xref="MIM:605426"
     exon            1..78
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            79..295
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..529
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="p53-regulated apoptosis-inducing protein 1
                     isoform a"
                     /protein_id="NP_071395.2"
                     /db_xref="CCDS:CCDS8480.2"
                     /db_xref="GeneID:63970"
                     /db_xref="HGNC:HGNC:29984"
                     /db_xref="MIM:605426"
                     /translation="MGSSSEASFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQTHT
                     PGWVSDPLVLGAQVHGGCRGIEALSVSSGSWSSATVWILTGLGLGLSRPFLPGATVLR
                     DRPLGSAFELSYDQKKAPLRLQ"
     exon            296..407
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..750
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      732..737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /note="hexamer: AATAAA"
     polyA_site      750
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /note="major polyA site"
ORIGIN      
        1 agacctgcac ccagtcacag cagcacagat gtgcaggagg agaccatttc cacggaccct
       61 ccgactccta ggaggcagtc ccttagggac tggccctaac aacaaatgag gagaagccaa
      121 gttctctgct ttctgcagac agggcctccc ctggatggga tcttcctctg aggcgagctt
      181 cagatctgct caagcttcct gcagtggggc caggaggcag ggcctgggca ggggagacca
      241 gaacctctcg gtgatgcctc cgaatggcag ggctcagaca cacacacctg gctgggtttc
      301 agatccctta gttttgggtg cccaagttca cggagggtgc cggggaatag aagctctgtc
      361 agtctcgtct ggatcttggt cctcagcaac tgtctggatc ctgacaggcc ttggtctagg
      421 tctctccagg cctttccttc ctggagccac agtgcttaga gacaggccac tggggtcagc
      481 atttgagctc agctatgatc agaaaaaagc accgttgagg ttgcagtgag ccgagatcac
      541 gccactgcac tccagcctgg gcgacagaga gagactccat ctcaaaacaa aaacaaacaa
      601 acaaacagaa agcaccgtcg agaaatggct ccagcgctga ctagcggcca cctcatttcc
      661 ccccttgacc actgggccag ttgggtggct aggttgcctc attttgcatc cttctgtatc
      721 cccaaatctg aaataaaagc tggaaaaaaa
//
