LOCUS       NM_014828               4514 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens TOX high mobility group box family member 4 (TOX4),
            transcript variant 1, mRNA.
ACCESSION   NM_014828 XM_375045
VERSION     NM_014828.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4514)
  AUTHORS   Pan,Z., Chen,C., Huang,X., Xiong,Y., Kang,X., Zhou,J., Guo,X.,
            Zheng,S., Wang,C., Zheng,F. and Hu,W.
  TITLE     Migration-inducing gene-7 promotes glioma cell proliferation and
            invasiveness via activating the MAPK signaling pathway
  JOURNAL   Neoplasma 70 (4), 534-544 (2023)
   PUBMED   37789777
  REMARK    GeneRIF: Migration-inducing gene-7 promotes glioma cell
            proliferation and invasiveness via activating the MAPK signaling
            pathway.
REFERENCE   2  (bases 1 to 4514)
  AUTHORS   Liu,Z., Wu,A., Wu,Z., Wang,T., Pan,Y., Li,B., Zhang,X. and Yu,M.
  TITLE     TOX4 facilitates promoter-proximal pausing and C-terminal domain
            dephosphorylation of RNA polymerase II in human cells
  JOURNAL   Commun Biol 5 (1), 300 (2022)
   PUBMED   35365735
  REMARK    GeneRIF: TOX4 facilitates promoter-proximal pausing and C-terminal
            domain dephosphorylation of RNA polymerase II in human cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4514)
  AUTHORS   Wang,L., Yu,J., Zhou,Q., Wang,X., Mukhanova,M., Du,W., Sun,L.,
            Pajvani,U.B. and Accili,D.
  TITLE     TOX4, an insulin receptor-independent regulator of hepatic glucose
            production, is activated in diabetic liver
  JOURNAL   Cell Metab 34 (1), 158-170 (2022)
   PUBMED   34914893
  REMARK    GeneRIF: TOX4, an insulin receptor-independent regulator of hepatic
            glucose production, is activated in diabetic liver.
REFERENCE   4  (bases 1 to 4514)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4514)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4514)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 4514)
  AUTHORS   Lee,S.J., Lee,J.K., Maeng,Y.S., Kim,Y.M. and Kwon,Y.G.
  TITLE     Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus:
            implications for this complex in transcriptional regulation
  JOURNAL   Exp Mol Med 41 (3), 189-200 (2009)
   PUBMED   19293638
  REMARK    GeneRIF: the coordinated spatial and temporal regulation of LCP1
            and PNUTS may be a novel mechanism to control the expression of
            genes that are critical for certain physiological and pathological
            processes.
REFERENCE   8  (bases 1 to 4514)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   9  (bases 1 to 4514)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   10 (bases 1 to 4514)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA334895.1, BC020292.1, AL161747.5 and N63399.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014828.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.255590.1,
                                           SRR1803611.262124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448790.7/ ENSP00000393080.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                DA334895.1         20-101
            83-2311             BC020292.1         40-2268
            2312-4355           AL161747.5         113205-115248
            4356-4514           N63399.1           13-171              c
FEATURES             Location/Qualifiers
     source          1..4514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..4514
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /note="TOX high mobility group box family member 4"
                     /db_xref="GeneID:9878"
                     /db_xref="HGNC:HGNC:20161"
                     /db_xref="MIM:614032"
     exon            1..90
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1950
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     migration-inducing protein 7; epidermal Langerhans cell
                     protein LCP1"
                     /codon_start=1
                     /product="TOX high mobility group box family member 4
                     isoform 1"
                     /protein_id="NP_055643.1"
                     /db_xref="CCDS:CCDS32043.1"
                     /db_xref="GeneID:9878"
                     /db_xref="HGNC:HGNC:20161"
                     /db_xref="MIM:614032"
                     /translation="MEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISL
                     DSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSG
                     GLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGG
                     TILPPAQSPEDRLSTTPSPTSSLHEDGVEDFRRQLPSQKTVVVEAGKKQKAPKKRKKK
                     DPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKT
                     EAAKKEYLKALAAYKDNQECQATVETVELDPAPPSQTPSPPPMATVDPASPAPASIEP
                     PALSPSIVVNSTLSSYVANQASSGAGGQPNITKLIITKQMLPSSITMSQGGMVTVIPA
                     TVVTSRGLQLGQTSTATIQPSQQAQIVTRSVLQAAAAAAAAASMQLPPPRLQPPPLQQ
                     MPQPPTQQQVTILQQPPPLQAMQQPPPQKVRINLQQQPPPLQIKSVPLPTLKMQTTLV
                     PPTVESSPERPMNNSPEAHTVEAPSPETICEMITDVVPEVESPSQMDVELVSGSPVAL
                     SPQPRCVRSGCENPPIVSKDWDNEYCSNECVVKHCRDVFLAWVASRNSNTVVFVK"
     exon            91..159
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /inference="alignment:Splign:2.1.0"
     exon            160..402
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /inference="alignment:Splign:2.1.0"
     exon            403..663
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /inference="alignment:Splign:2.1.0"
     exon            664..894
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /inference="alignment:Splign:2.1.0"
     exon            895..975
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1725
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1889
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..4514
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2288..2293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /note="hexamer: ATTAAA"
     polyA_site      2331
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /note="major polyA site"
     regulatory      4230..4235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /note="hexamer: AATACA"
     polyA_site      4254
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
     regulatory      4488..4493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
                     /note="hexamer: AATAAA"
     polyA_site      4514
                     /gene="TOX4"
                     /gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
ORIGIN      
        1 cttgcggaag tgacggcagt tccgagtcca gtgggggcgg tgggagcgat gagggtctga
       61 gacggtggga gcggttgtgt gaagatggag tttcccggag gaaatgacaa ttacctgacg
      121 atcacagggc cttcgcaccc cttcctgtca ggggccgaga cattccatac accaagcttg
      181 ggtgatgagg aatttgaaat cccacctatc tccttggatt ctgatccctc attggctgtc
      241 tcagatgtgg ttggccactt tgatgacctg gcagaccctt cctcttcaca ggatggcagt
      301 ttttcagccc agtatggggt ccagacattg gacatgcctg tgggcatgac ccatggcttg
      361 atggagcagg gcggggggct cctgagtggg ggcttgacca tggacttgga ccactctata
      421 ggaactcagt atagtgccaa cccacctgtt acaattgatg taccaatgac agacatgaca
      481 tctggcttga tggggcatag ccagttgacc accattgatc agtcagaact gagttcccag
      541 ctgggtttga gcctaggggg tggcaccatc ctgccacctg cccagtcacc tgaagatcgt
      601 ctttcaacca ccccttcacc tactagttca cttcacgagg atggtgttga ggatttccgg
      661 aggcaacttc ccagccagaa gacagtcgtg gtggaagcag ggaaaaagca gaaggcccca
      721 aagaagagaa aaaagaaaga tcctaatgaa cctcagaaac cagtttcagc atatgcttta
      781 ttctttcgtg atacacaggc tgccatcaag ggacagaatc ctaatgccac ttttggtgag
      841 gtttcaaaaa ttgtggcctc catgtgggat agtcttggag aggagcaaaa acaggtatat
      901 aagaggaaaa ctgaggctgc caagaaagag tatctgaagg cactggctgc ttacaaagac
      961 aaccaggagt gtcaggccac tgtggaaaca gtggaattgg atccagcacc accatcacaa
     1021 actccttctc cacctcctat ggctactgtt gacccagcat ctccagcacc agcttcaata
     1081 gagccccctg ccctgtcccc atccattgtt gttaactcca ccctttcatc ctatgtggca
     1141 aaccaggcat cttctggagc tgggggtcag cccaatatca ccaagttgat tattaccaaa
     1201 caaatgttgc cctcttctat tactatgtct caaggaggga tggttactgt tatcccagcc
     1261 acagtggtga cctcccgggg gctccaacta ggccaaacca gtacagctac tatccagccc
     1321 agtcaacaag cccagattgt cactcggtca gtgttgcagg cagcagcagc tgctgctgct
     1381 gctgcttcta tgcaactgcc tccaccccga ctacagcccc ctccattaca acagatgcca
     1441 cagcccccga ctcagcagca agttaccatt ctgcagcagc ctcctccact ccaggccatg
     1501 caacagcctc cacctcagaa agttcgaatc aatttacagc aacagcctcc tcctctgcag
     1561 atcaagagtg tgcctctacc cactttgaaa atgcagacta ccttagtccc accaactgtg
     1621 gaaagtagtc ctgagcggcc tatgaacaac agccctgagg cccatacagt ggaggcacct
     1681 tctcctgaga ctatctgtga gatgatcaca gatgtagttc ctgaggttga gtctccttct
     1741 cagatggatg ttgaattggt gagtgggtct cctgtggcac tctcacccca gcctcgatgt
     1801 gtgaggtctg gttgtgagaa ccctcccatt gtgagtaagg actgggacaa tgaatactgc
     1861 agcaatgagt gtgtggtgaa gcactgcagg gatgtattct tggcctgggt agcctctaga
     1921 aattcaaaca cagtggtgtt tgtgaaatag tccttcctgt tctccaagcc agtgaagagt
     1981 tatctgctgg gaaagtgtcc aagagcctgt ttttgaaaca caagctgggc ttctggtagt
     2041 gcctcatcac aacccatgat ggctgttcat gtttcacccc ttttcttcct tcagcagagg
     2101 ccaggctatg gagcagggcc actgaatttg ctgtaatctg gagatgcttt ttactttcaa
     2161 ccataagcgg taatagcaga ggaaagggtg aagggagtct gggcaagcaa agcatagaga
     2221 tggtggggtg gtggtggggt tgaagaaact tgttggtata attgtcatag gacttgccta
     2281 aaatattatt aaaattacgg gagtgtactc agctttgagc ctaggagaaa atgccactgt
     2341 gtgcatccat tttaaagggt tccctcataa aaaaatgtta ttccccatta tcacatcagt
     2401 acactgcttt gaaaacaaaa cttttcaaca tgggcatact gggctacatg gaaaatgaca
     2461 tcacccagga gtgatttctc tttatatata ttatttctgc agttaccatc cttatctgag
     2521 ttatcacagt tcatgaatct aagaggcgga actctacatc attagtaaga ggttccacca
     2581 aagtctaaag ttgtattcac ttgtgtttga tgaactatct ttaaaagacc ataggtctat
     2641 cattatttct tagacataat ctaaagaaaa acagactaga gaagccacct ggttgtaaca
     2701 gaataagcag aagtttacag catgatagtc caagtggtga taactttaaa taaaactcaa
     2761 atttttactg tttgtagaca ggaatgctgt cctagagaac ctcctcctca accagctacg
     2821 tacatagttt tatcctatgc attcctgttt tctgtgtgtt ttttgttttt tttttttttt
     2881 tttttttttg agacagagtc tcgctctgtc acccaggctg gagtgcagtg gtgcgacctc
     2941 agctcactga aacctctgcc tcccgggttc aagcgattct cctgcatcag cctcccgagt
     3001 agctaggatt acaggcgccc gccactacgc ccagctaatt tgtggtattt ttagtagaga
     3061 cagggtttca ccatgttggc caggctggtc tcgaactcct gacctcatga tccgcccgcc
     3121 ttgacctccc aaagtgctgg gattacaggc atgagccacc gcacccagcc tgcattcctg
     3181 tttttttaat ggttttggag ggtagcagta gagatggggt ctcactatgt tgcccagtct
     3241 agtcttgaac tcctgggcta cagttaccct cctacctcgg cttcccaaag tgctcggatt
     3301 acaggtgtga gccactgtgc ctagcctata atgatcattt taatgtttcc catgcactca
     3361 tttagtttga accttcacag caacccaatg aggtaatact cccatttcac atataatact
     3421 gagagatgag ttgcacaaga ttatacactg ttaagtagca gagccagaat ggacttcaga
     3481 atcccaacta caatacaaat gtttatttaa ataaagaaga aagctattgt acaaatatca
     3541 ctcttcaggt ttagcttaca gagccatggc tatggattct tagctctgta aggaagtgct
     3601 tctataaatt cttaggttta gagatgatac catctgggta cctttgcttg aaccgtgcaa
     3661 ccacatctgg gtctagtagg tggatcccat ccagttggtt tccaagggtg atcctgaaac
     3721 agtgtaaaag gaggggcaaa ccagaaatcc tggaattaga gggtttaata ttgttaaaaa
     3781 atgcatacca aatgaagact gcctatcatc atatcaaata tgccaattct aaaaagagct
     3841 taacattaga atagtatatg gtagaattac tagttcagaa ttggcataga ttctggtgtt
     3901 aaaatagact ggatctgtat tatctgaggg ttagtaacta atgcttagcc aggcctgctt
     3961 cacagagttg ctaccaggga gtattctttg gataagcaaa atgctagcag catgtgtttt
     4021 aagctctgtt aaggggtgaa agatgtaatt attgacagat taaatagata acttcgtaac
     4081 caccaggggg cagattcaat acatcacaga atggctgagg aagatccttg ggttgtgaag
     4141 agagtagaaa ccctagggag cagtgctttt gggtcctaga acctgttgag tttctaatga
     4201 atatttgtag aatctcataa aacagtttaa atacaagctt aagtggctta tgaatcctgt
     4261 gaagctcatt tatggactag tgtaaaacaa tgtgaagctc tactaagttc tgtccttaat
     4321 cataaataat agccccttga ggactagcct gttctctggt caccttacca gttgggttgc
     4381 acattgtgtg gtcgtccaaa taactcaatc ttgcgagtgc caggagatag tctttcaatc
     4441 atgccataga tttcatctgg tttatgactg gtggaacgaa cctaggaaat aaaaactagc
     4501 tgctttttaa gtta
//
