LOCUS       NM_001080430            4959 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens TOX high mobility group box family member 3 (TOX3),
            transcript variant 1, mRNA.
ACCESSION   NM_001080430 XM_049037
VERSION     NM_001080430.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4959)
  AUTHORS   Yang,W., Wu,W., Liang,H., Chen,J. and Dong,X.
  TITLE     TOX3 regulates the proliferation and apoptosis of colorectal cancer
            by downregulating RhoB via the activation of the MAPK pathway
  JOURNAL   Cell Biol Int 46 (7), 1074-1088 (2022)
   PUBMED   35347804
  REMARK    GeneRIF: TOX3 regulates the proliferation and apoptosis of
            colorectal cancer by downregulating RhoB via the activation of the
            MAPK pathway.
REFERENCE   2  (bases 1 to 4959)
  AUTHORS   Solis-Coronado,O., Villarreal-Vela,M.P., Rodriguez-Gutierrez,H.F.,
            Gonzalez-Guerrero,J.F., Cerda-Flores,R.M., Alcorta-Nunez,F.,
            Camarillo-Cardenas,K.P., Perez-Ibave,D.C., Vidal-Gutierrez,O.,
            Ramirez-Correa,G.A. and Garza-Rodriguez,M.L.
  TITLE     Risk Association of TOX3 and MMP7 Gene Polymorphisms with Sporadic
            Breast Cancer in Mexican Women
  JOURNAL   Curr Oncol 29 (2), 1008-1017 (2022)
   PUBMED   35200585
  REMARK    GeneRIF: Risk Association of TOX3 and MMP7 Gene Polymorphisms with
            Sporadic Breast Cancer in Mexican Women.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4959)
  AUTHORS   Al-Khaykanee,A.M., Abdel-Rahman,A.A., Essa,A., Gadallah,A.A.,
            Ali,B.H., Al-Aqar,A.A., Badr,E.A.E. and Shehab-Eldeen,S.
  TITLE     Genetic polymorphism of fibroblast growth factor receptor 2 and
            trinucleotide repeat-containing 9 influence the susceptibility to
            HCV-induced hepatocellular carcinoma
  JOURNAL   Clin Res Hepatol Gastroenterol 45 (6), 101636 (2021)
   PUBMED   33740609
  REMARK    GeneRIF: Genetic polymorphism of fibroblast growth factor receptor
            2 and trinucleotide repeat-containing 9 influence the
            susceptibility to HCV-induced hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 4959)
  AUTHORS   Liang,X.S., Mo,J.L., Hu,L.M., Gong,C.M., Liu,T., Hong,W.X.,
            Yin,J.Y., Liu,Z.Q. and Zhou,H.H.
  TITLE     Association between CASC16 rs4784227 polymorphism and breast cancer
            susceptibility: A meta-analysis
  JOURNAL   Medicine (Baltimore) 100 (28), e26215 (2021)
   PUBMED   34260521
  REMARK    GeneRIF: Association between CASC16 rs4784227 polymorphism and
            breast cancer susceptibility: A meta-analysis.
REFERENCE   5  (bases 1 to 4959)
  AUTHORS   Man,Y., Zhao,R., Gao,X., Liu,Y., Zhao,S., Lu,G., Chan,W.Y.,
            Leung,P.C.K. and Bian,Y.
  TITLE     TOX3 Promotes Ovarian Estrogen Synthesis: An RNA-Sequencing and
            Network Study
  JOURNAL   Front Endocrinol (Lausanne) 11, 615846 (2021)
   PUBMED   33716953
  REMARK    GeneRIF: TOX3 Promotes Ovarian Estrogen Synthesis: An
            RNA-Sequencing and Network Study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4959)
  AUTHORS   Stacey,S.N., Manolescu,A., Sulem,P., Rafnar,T., Gudmundsson,J.,
            Gudjonsson,S.A., Masson,G., Jakobsdottir,M., Thorlacius,S.,
            Helgason,A., Aben,K.K., Strobbe,L.J., Albers-Akkers,M.T.,
            Swinkels,D.W., Henderson,B.E., Kolonel,L.N., Le Marchand,L.,
            Millastre,E., Andres,R., Godino,J., Garcia-Prats,M.D., Polo,E.,
            Tres,A., Mouy,M., Saemundsdottir,J., Backman,V.M., Gudmundsson,L.,
            Kristjansson,K., Bergthorsson,J.T., Kostic,J., Frigge,M.L.,
            Geller,F., Gudbjartsson,D., Sigurdsson,H., Jonsdottir,T.,
            Hrafnkelsson,J., Johannsson,J., Sveinsson,T., Myrdal,G.,
            Grimsson,H.N., Jonsson,T., von Holst,S., Werelius,B., Margolin,S.,
            Lindblom,A., Mayordomo,J.I., Haiman,C.A., Kiemeney,L.A.,
            Johannsson,O.T., Gulcher,J.R., Thorsteinsdottir,U., Kong,A. and
            Stefansson,K.
  TITLE     Common variants on chromosomes 2q35 and 16q12 confer susceptibility
            to estrogen receptor-positive breast cancer
  JOURNAL   Nat Genet 39 (7), 865-869 (2007)
   PUBMED   17529974
REFERENCE   7  (bases 1 to 4959)
  AUTHORS   Easton,D.F., Pooley,K.A., Dunning,A.M., Pharoah,P.D., Thompson,D.,
            Ballinger,D.G., Struewing,J.P., Morrison,J., Field,H., Luben,R.,
            Wareham,N., Ahmed,S., Healey,C.S., Bowman,R., Meyer,K.B.,
            Haiman,C.A., Kolonel,L.K., Henderson,B.E., Le Marchand,L.,
            Brennan,P., Sangrajrang,S., Gaborieau,V., Odefrey,F., Shen,C.Y.,
            Wu,P.E., Wang,H.C., Eccles,D., Evans,D.G., Peto,J., Fletcher,O.,
            Johnson,N., Seal,S., Stratton,M.R., Rahman,N., Chenevix-Trench,G.,
            Bojesen,S.E., Nordestgaard,B.G., Axelsson,C.K., Garcia-Closas,M.,
            Brinton,L., Chanock,S., Lissowska,J., Peplonska,B., Nevanlinna,H.,
            Fagerholm,R., Eerola,H., Kang,D., Yoo,K.Y., Noh,D.Y., Ahn,S.H.,
            Hunter,D.J., Hankinson,S.E., Cox,D.G., Hall,P., Wedren,S., Liu,J.,
            Low,Y.L., Bogdanova,N., Schurmann,P., Dork,T., Tollenaar,R.A.,
            Jacobi,C.E., Devilee,P., Klijn,J.G., Sigurdson,A.J., Doody,M.M.,
            Alexander,B.H., Zhang,J., Cox,A., Brock,I.W., MacPherson,G.,
            Reed,M.W., Couch,F.J., Goode,E.L., Olson,J.E., Meijers-Heijboer,H.,
            van den Ouweland,A., Uitterlinden,A., Rivadeneira,F., Milne,R.L.,
            Ribas,G., Gonzalez-Neira,A., Benitez,J., Hopper,J.L., McCredie,M.,
            Southey,M., Giles,G.G., Schroen,C., Justenhoven,C., Brauch,H.,
            Hamann,U., Ko,Y.D., Spurdle,A.B., Beesley,J., Chen,X.,
            Mannermaa,A., Kosma,V.M., Kataja,V., Hartikainen,J., Day,N.E.,
            Cox,D.R. and Ponder,B.A.
  CONSRTM   SEARCH collaborators; kConFab; AOCS Management Group
  TITLE     Genome-wide association study identifies novel breast cancer
            susceptibility loci
  JOURNAL   Nature 447 (7148), 1087-1093 (2007)
   PUBMED   17529967
REFERENCE   8  (bases 1 to 4959)
  AUTHORS   Huijts,P.E., Vreeswijk,M.P., Kroeze-Jansema,K.H., Jacobi,C.E.,
            Seynaeve,C., Krol-Warmerdam,E.M., Wijers-Koster,P.M., Blom,J.C.,
            Pooley,K.A., Klijn,J.G., Tollenaar,R.A., Devilee,P. and van
            Asperen,C.J.
  TITLE     Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1,
            LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases
  JOURNAL   Breast Cancer Res 9 (6), R78 (2007)
   PUBMED   17997823
  REMARK    GeneRIF: Heterozygote carriers and minor allele homozygote carriers
            for SNP rs3803662 near the TNCR9 gene were more likely to be
            diagnosed before the age of 60 years (P = 0.025) relative to major
            allele homozygote carriers
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4959)
  AUTHORS   O'Flaherty,E. and Kaye,J.
  TITLE     TOX defines a conserved subfamily of HMG-box proteins
  JOURNAL   BMC Genomics 4 (1), 13 (2003)
   PUBMED   12697058
REFERENCE   10 (bases 1 to 4959)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum Genet 100 (1), 114-122 (1997)
   PUBMED   9225980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007490.7, BE501808.1, AK299202.1 and AI733227.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001080430.3.
            
            Summary: The protein encoded by this gene contains an HMG-box,
            indicating that it may be involved in bending and unwinding of DNA
            and alteration of chromatin structure. The C-terminus of the
            encoded protein is glutamine-rich due to CAG repeats in the coding
            sequence. A minor allele of this gene has been implicated in an
            elevated risk of breast cancer. Two transcript variants encoding
            different isoforms have been found for this gene.[provided by
            RefSeq, Apr 2009].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.76894.1,
                                           SRR1803617.378118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219746.14/ ENSP00000219746.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               AC007490.7         164769-165017       c
            250-828             BE501808.1         1-579
            829-3370            AK299202.1         582-3123
            3371-4462           AC007490.7         54788-55879         c
            4463-4959           AI733227.1         2-498               c
FEATURES             Location/Qualifiers
     source          1..4959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..4959
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /note="TOX high mobility group box family member 3"
                     /db_xref="GeneID:27324"
                     /db_xref="HGNC:HGNC:11972"
                     /db_xref="MIM:611416"
     exon            1..507
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..2151
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     trinucleotide repeat-containing gene 9 protein; CAG
                     trinucleotide repeat-containing gene F9 protein"
                     /codon_start=1
                     /product="TOX high mobility group box family member 3
                     isoform 1"
                     /protein_id="NP_001073899.2"
                     /db_xref="CCDS:CCDS54009.1"
                     /db_xref="GeneID:27324"
                     /db_xref="HGNC:HGNC:11972"
                     /db_xref="MIM:611416"
                     /translation="MDVRFYPAAAGDPASLDFAQCLGYYGYSKFGNNNNYMNMAEANN
                     AFFAASEQTFHTPSLGDEEFEIPPITPPPESDPALGMPDVLLPFQALSDPLPSQGSEF
                     TPQFPPQSLDLPSITISRNLVEQDGVLHSSGLHMDQSHTQVSQYRQDPSLIMRSIVHM
                     TDAARSGVMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSINE
                     EDADEANRAIGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQ
                     NPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAES
                     AEAQTIRSVQQTLASTNLTSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPKPLTMRL
                     PMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQ
                     QQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQLQQ
                     QLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQ
                     TQVLSQVSIF"
     exon            508..573
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            574..828
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1098
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1326
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1407
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..4959
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3278..3283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /note="hexamer: AATAAA"
     polyA_site      3299
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /note="major polyA site"
     regulatory      3348..3353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /note="hexamer: AATAAA"
     polyA_site      3371
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /note="major polyA site"
     regulatory      4936..4941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
                     /note="hexamer: AATAAA"
     polyA_site      4959
                     /gene="TOX3"
                     /gene_synonym="CAGF9; TNRC9"
ORIGIN      
        1 gtctccgcgg ctcgtctcct cagtccgccc ggggaggagg aggaggagcg gggccagccg
       61 ccgccgccgc cgccgtccca gcctcgccca gcgcacctga actcgcctcg ccgacccggg
      121 ccccagcgcc gcgccccgcg cccccggcgc ccggcccgcg cgcagcgctg cctcggtgcc
      181 ccggcggggc gcgtcccccc ggccgcctcc cgctctcccg cggctcgcgt ggccgcgcct
      241 ttgtgtgcgg cggccgcggc tcccgagctc ctcgggctct gggtcccggc gcccctccgg
      301 ccgcgagtcc cacgcgccac ccccgggcgc cctcgacggt ggatctagcg gcggcgagga
      361 ggcgggtccc ggccccggcg aaccccagtc ccggcccccg gccccgggcc cagcttcggc
      421 atggatgtga ggttctaccc cgcggcggcc ggggaccctg ccagcctgga cttcgcgcag
      481 tgcctggggt actacggcta cagcaagttt ggaaataata ataactatat gaatatggct
      541 gaggcgaaca atgcgttctt cgctgccagt gagcagacat tccacacacc aagccttggg
      601 gacgaggaat tcgaaattcc accaatcacg cctcctccag agtcagaccc tgccctaggc
      661 atgccggatg tactgctacc ctttcaagcc ctcagcgatc cattgccttc ccagggaagt
      721 gaattcacac cccagtttcc ccctcaaagc ctggacctcc cttccattac aatctcaaga
      781 aatctcgtgg aacaagatgg cgtgcttcat agcagtgggt tgcatatgga tcagagccac
      841 acacaagtgt cccagtaccg gcaggatccc tccctgatca tgcggtccat cgtccacatg
      901 accgatgctg cgcgttctgg ggtcatgcct cctgcccagc tcaccaccat caaccagtct
      961 cagctcagcg cccagttggg gttgaatttg ggaggtgcca gtatgcctca cacatctcct
     1021 tcacctccag caagcaaatc agccactccc tccccttcca gctccatcaa tgaagaggat
     1081 gctgatgaag ccaacagagc cattggagag aaaagagctg ctccagactc tggcaagaag
     1141 cccaagactc caaagaaaaa gaaaaagaaa gatcccaatg agccacagaa gccagtgtca
     1201 gcatatgccc tgtttttcag agacacacag gctgcaatta aaggtcaaaa ccccaatgca
     1261 acctttggag aggtctcaaa aattgtagca tctatgtggg acagccttgg agaagaacaa
     1321 aagcaggtat ataaaaggaa aacagaagct gccaaaaaag aatacctgaa ggccctggcg
     1381 gcatacaggg ccagcctcgt ttctaaggct gctgctgagt cagcagaagc ccagaccatc
     1441 cgttctgttc agcagaccct ggcgtcgacc aatctaacat cctctctcct tctcaacact
     1501 ccactgtctc aacatggaac agtgtcagca tcacctcaga ctctccagca atccctccct
     1561 aggtcaatcg ctcccaaacc cttaaccatg agactcccca tgaaccagat tgtcacatca
     1621 gtcaccattg cagccaacat gccctcgaac attggggctc cactgataag ctccatggga
     1681 acgaccatgg ttggctcagc accctccacc caagtgagtc cttcggtgca aacccagcag
     1741 catcagatgc aattgcagca gcagcagcag cagcaacaac aacagatgca acagatgcag
     1801 cagcagcaac tccagcagca ccaaatgcat cagcaaatcc agcagcagat gcagcagcag
     1861 catttccagc accacatgca gcagcacctg cagcagcagc agcagcatct ccagcagcaa
     1921 attaatcaac agcagctgca gcagcagctg cagcagcgcc tccagctgca gcagctgcaa
     1981 cacatgcagc accagtctca gccttctcct cggcagcact cccctgtcgc ctctcagata
     2041 acatccccca tccctgccat cgggagcccc cagccagcct ctcagcagca ccagtcgcaa
     2101 atacagtctc agacacagac tcaagtatta tcgcaggtca gtattttctg aagacgcata
     2161 tggcagacgg atttgcgtat accaaggaga gtggcatagg agggaaaagc atatgtggct
     2221 gaaacctgta agttggtgtt ggttatgcag aaatgtgtaa cagatcaaac ggtcctctca
     2281 agtgtctatt agataggcaa taagaactgc agtgtagctg agtaacatct tttagctgac
     2341 tataaatcac tttgttttta aacaagaaaa gctgtgctct tttatgtgat gcctttttta
     2401 tttattcagg ctatacctac aatatgtgaa tcaaactgtt taatgaatcc tgggacatac
     2461 tgatgactat aaactggcct ctctgagtca tagaaaaatg gccttatttc tccagaagtg
     2521 agtaaaccac acttccaggc tatctgaact cctgaagccc taaaaataaa aagcacagtt
     2581 gtaactacct gaaatatgaa gatccagttt catacaaaca tttgtatgac gtgaatagtt
     2641 gatggcattt ttttgtcatg aaaaaaataa tgtaaatcac agacttttgc caaagctctt
     2701 attttttttc ctaaatctct ccagaaaaaa aatgcaagtg actaaattca attattgact
     2761 aatttccact ttttatccat gacttctcca aatcaaacca cagtatatgt tgtaacaata
     2821 tctatgacca ctgttagccc attatattca ttccaattag aagaaatgtg aatactatat
     2881 tccgtgtttt gagtgacaag tttcgaaaaa taaaaacact gtatttttaa aagggaaatg
     2941 cacttaaatg aaaacagtta ttacaaaagt taagatttaa aaagaaaaag caagagtttt
     3001 tattatgatg taataccagt agaatattta aaaggcacac cacatctgaa taatcaatgt
     3061 aaatattttc tttcaaagtt gtaagttttc atatcatgtg ctgtaaagtt ttcctaaatg
     3121 aggctttaac gtaaacactg gtgacataaa ccattcattg ctacgttgct tattgtgttt
     3181 ttatgctgtt ttatactttt ttatgagtta tgatagcagc aattaagttg tttgtatttt
     3241 gcttaactaa aacaaaaatg cttttatctt gctatagaat aaacacattt cagtaaaaac
     3301 tgtggactgt attttgatgc aacaacaaag aaactgttca cttttcaaat aaaatgatat
     3361 gtcagatttc atttttggtt ccttgaatac atgtaagatg gggaaatatg ccacatacca
     3421 agtttcgttt tagcccaaac atcatcttcc atttttcaat tggaaatatg atatttatgg
     3481 ccaagaatat gcattgcata gcctgaaatg aagatccttg aaaaaaccaa aacaacgcat
     3541 tggaaatatt tgtgtaattg tctttttttt tttttttttt ttttttaaga tgcaagtaca
     3601 aggtaagtat agagaaaaaa gtaatcgctt ttttgagggg gctagaacta gctgggtatt
     3661 gtaatgttat tgcgattaaa atagatggtg aatgctaatt cttaagccaa aataattatt
     3721 tcggtgccca tttattcccc ccttttcttg ctctgtagcg gttcctcttt gagagcagtg
     3781 tgaccactat ccccagttgt cttgcatgat taattacagc atctgtcctg tcagaagcta
     3841 taatgaagag gtcttgataa aaattgcaaa ttaccactgg caacagtctt aaactgctta
     3901 tgataaaatg aaaattaaaa acagcaagtg tcaaccctga ccagaatcct aatctggaaa
     3961 gaatgagggt gtgcgtggtg cgctccacag ctactatgtg caagacattc aaaaataatg
     4021 gaatatggat ccctcaaagt tgttgtattt cagagattat ttactgtatg ttgtgggtta
     4081 tgaataatga attcagcttt caatatttca taatcctctc ctactctgta ttatgtacaa
     4141 atattgaaca gcaagagatt ctaattataa atttatggat ttcttgctgt agaaaaattt
     4201 atgtctaaat tgaagctttt cataagatgt attagttgac aggtatcagt gttcaaacag
     4261 ccttagaatg atgcctaatt acatctacaa gggagtgatt gtattccaca aagaaatgat
     4321 gtgctagcat cagatccttc agaagtagag ctcgaatggt aaaagatttt ctgtgaattg
     4381 aaactaacat tacataacaa taaccatttt atattctgtt gtgaaacctt tagacagatg
     4441 tcttcaaaat taattgctaa actacatgtg acagtaattg tgtattagtt ctgtaattgt
     4501 cattttgaaa acccatgaag tattgcttgg aaaaaaatgt cactagtgat aagacttaat
     4561 tgcaagtgaa gtctgttttc aactgtttgc agttagaagc aggtgttgta acatctatta
     4621 aatgatttta taaatcttgg gttttatcac atttgattaa atgctgctaa gccactgatg
     4681 gtcaattcca gaggaaaaaa aaagtttaat gactacagtt tataaaatta atcaccaggc
     4741 aaaactacat atttaaaatg tcaaaaggct tgaatcatga aaagaattcc tcaaccttgt
     4801 taccaaatta ttgttttcag gattcacaaa gcatgttata tatccattta tatttcagtt
     4861 tatacatatg actggtttct attcctgaga cttaagtaag tacttggtgc gctttttctt
     4921 ttgttacagg tcagaaataa atcaggataa tgaaaaata
//
