LOCUS       NM_001098797            2491 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens TOX high mobility group box family member 2 (TOX2),
            transcript variant 1, mRNA.
ACCESSION   NM_001098797
VERSION     NM_001098797.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2491)
  AUTHORS   Li,A., Zhang,J., Zhan,L., Liu,X., Zeng,X., Zhu,Q., Wang,Z. and
            Li,J.
  TITLE     TOX2 nuclear-cytosol translocation is linked to leukemogenesis of
            acute T-cell leukemia by repressing TIM3 transcription
  JOURNAL   Cell Death Differ 31 (11), 1506-1518 (2024)
   PUBMED   39080376
  REMARK    GeneRIF: TOX2 nuclear-cytosol translocation is linked to
            leukemogenesis of acute T-cell leukemia by repressing TIM3
            transcription.
REFERENCE   2  (bases 1 to 2491)
  AUTHORS   Collins,S.M., Alexander,K.A., Lundh,S., Dimitri,A.J., Zhang,Z.,
            Good,C.R., Fraietta,J.A. and Berger,S.L.
  TITLE     TOX2 coordinates with TET2 to positively regulate central memory
            differentiation in human CAR T cells
  JOURNAL   Sci Adv 9 (29), eadh2605 (2023)
   PUBMED   37467321
  REMARK    GeneRIF: TOX2 coordinates with TET2 to positively regulate central
            memory differentiation in human CAR T cells.
REFERENCE   3  (bases 1 to 2491)
  AUTHORS   Veldman,J., Rodrigues Placa,J., Chong,L., Terpstra,M.M., Mastik,M.,
            van Kempen,L.C., Kok,K., Aoki,T., Steidl,C., van den Berg,A.,
            Visser,L. and Diepstra,A.
  TITLE     CD4+ T cells in classical Hodgkin lymphoma express exhaustion
            associated transcription factors TOX and TOX2: Characterizing CD4+
            T cells in Hodgkin lymphoma
  JOURNAL   Oncoimmunology 11 (1), 2033433 (2022)
   PUBMED   35111387
  REMARK    GeneRIF: CD4+ T cells in classical Hodgkin lymphoma express
            exhaustion associated transcription factors TOX and TOX2:
            Characterizing CD4+ T cells in Hodgkin lymphoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2491)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2491)
  AUTHORS   Zeng,Y., Navarro,P., Shirali,M., Howard,D.M., Adams,M.J.,
            Hall,L.S., Clarke,T.K., Thomson,P.A., Smith,B.H., Murray,A.,
            Padmanabhan,S., Hayward,C., Boutin,T., MacIntyre,D.J., Lewis,C.M.,
            Wray,N.R., Mehta,D., Penninx,B.W.J.H., Milaneschi,Y., Baune,B.T.,
            Air,T., Hottenga,J.J., Mbarek,H., Castelao,E., Pistis,G.,
            Schulze,T.G., Streit,F., Forstner,A.J., Byrne,E.M., Martin,N.G.,
            Breen,G., Muller-Myhsok,B., Lucae,S., Kloiber,S., Domenici,E.,
            Deary,I.J., Porteous,D.J., Haley,C.S. and McIntosh,A.M.
  CONSRTM   Major Depressive Disorder Working Group of the Psychiatric Genomics
            Consortium
  TITLE     Genome-wide Regional Heritability Mapping Identifies a Locus Within
            the TOX2 Gene Associated With Major Depressive Disorder
  JOURNAL   Biol Psychiatry 82 (5), 312-321 (2017)
   PUBMED   28153336
  REMARK    GeneRIF: A haplotype block across a 24-kb region within the TOX2
            gene reached genome-wide significance in haplotype-block-based
            regional heritability mapping. Single-SNP- and haplotype-based
            association tests demonstrated that five of nine genotyped SNPs and
            two haplotypes within this block were significantly associated with
            major depressive disorder.
REFERENCE   6  (bases 1 to 2491)
  AUTHORS   Tessema,M., Yingling,C.M., Grimes,M.J., Thomas,C.L., Liu,Y.,
            Leng,S., Joste,N. and Belinsky,S.A.
  TITLE     Differential epigenetic regulation of TOX subfamily high mobility
            group box genes in lung and breast cancers
  JOURNAL   PLoS One 7 (4), e34850 (2012)
   PUBMED   22496870
  REMARK    GeneRIF: A novel aberrantly hypermethylated CpG island in cancer
            was discovered within the TOX2 promoter. TOX2 was unmethylated in
            normal cells. Expression of two novel TOX2 transcripts was
            significantly reduced in primary lung tumors.
REFERENCE   7  (bases 1 to 2491)
  AUTHORS   Dick,D.M., Aliev,F., Krueger,R.F., Edwards,A., Agrawal,A.,
            Lynskey,M., Lin,P., Schuckit,M., Hesselbrock,V., Nurnberger,J. Jr.,
            Almasy,L., Porjesz,B., Edenberg,H.J., Bucholz,K., Kramer,J.,
            Kuperman,S. and Bierut,L.
  TITLE     Genome-wide association study of conduct disorder symptomatology
  JOURNAL   Mol Psychiatry 16 (8), 800-808 (2011)
   PUBMED   20585324
REFERENCE   8  (bases 1 to 2491)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2491)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   10 (bases 1 to 2491)
  AUTHORS   Kajitani,T., Mizutani,T., Yamada,K., Yazawa,T., Sekiguchi,T.,
            Yoshino,M., Kawata,H. and Miyamoto,K.
  TITLE     Cloning and characterization of granulosa cell high-mobility group
            (HMG)-box protein-1, a novel HMG-box transcriptional regulator
            strongly expressed in rat ovarian granulosa cells
  JOURNAL   Endocrinology 145 (5), 2307-2318 (2004)
   PUBMED   14764631
  REMARK    GeneRIF: Identification and functional analysis of the rat Gcx1
            ortholog.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB989964.1 and BC007636.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001098797.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341197.9/ ENSP00000344724.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               CB989964.1         28-603
            577-2491            BC007636.1         605-2519
FEATURES             Location/Qualifiers
     source          1..2491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..2491
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /note="TOX high mobility group box family member 2"
                     /db_xref="GeneID:84969"
                     /db_xref="HGNC:HGNC:16095"
                     /db_xref="MIM:611163"
     exon            1..139
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1561
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /note="isoform a is encoded by transcript variant 1;
                     granulosa cell HMG box 1"
                     /codon_start=1
                     /product="TOX high mobility group box family member 2
                     isoform a"
                     /protein_id="NP_001092267.1"
                     /db_xref="CCDS:CCDS46603.1"
                     /db_xref="GeneID:84969"
                     /db_xref="HGNC:HGNC:16095"
                     /db_xref="MIM:611163"
                     /translation="MDVRLYPSAPAVGARPGAEPAGLAHLDYYHGGKFDGDSAYVGMS
                     DGNPELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPN
                     GLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGR
                     PAMLASHMSALSQSQLISQMGIRSSIAHSSPSPPGSKSATPSPSSSTQEEESEVHFKI
                     SGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDV
                     SKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSSPDQGETKSTQAN
                     PPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKSLLPGLSASPPP
                     PPSFPLSPTLHQQLSLPPHAQGALLSPPVSMSPAPQPPVLPTPMALQVQLAMSPSPPG
                     PQDFPHISEFPSSSGSCSPGPSNPTSSGDWDSSYPSGECGISTCSLLPRDKSLYLT"
     exon            140..205
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..451
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..691
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..919
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1000
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1396
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1524
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..2491
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2467..2472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /note="hexamer: AATAAA"
     polyA_site      2491
                     /gene="TOX2"
                     /gene_synonym="C20orf100; dJ1108D11.2; dJ495O3.1; GCX-1;
                     GCX1"
                     /note="major polyA site"
ORIGIN      
        1 actgcccgcg ggagccgccg ccgccgccgc cgcgcccgcc atggacgtcc gcctgtaccc
       61 ctcggcgccc gcggtgggcg cgcggcccgg ggccgagccg gccggcctgg cgcacctgga
      121 ctattaccac ggcggcaagt ttgatggtga cagtgcctac gtggggatga gtgacggaaa
      181 cccagagctc ctgtcaacca gccagaccta caacggccag agcgagaaca acgaagacta
      241 tgagatcccc ccgataacac ctcccaacct cccggagcca tccctcctgc acctggggga
      301 ccacgaagcc agctaccact cgctgtgcca cggcctcacc cccaacggtc tgctccctgc
      361 ctactcctat caggccatgg acctcccagc catcatggtg tccaacatgc tagcacagga
      421 cagccacctg ctgtcgggcc agctgcccac gatccaggag atggtccact cggaagtggc
      481 tgcctatgac tcgggccggc ccgggcccct gctgggtcgc ccggcaatgc tggccagcca
      541 catgagtgcc ctcagccagt cccagctcat ctcgcagatg ggcatccgga gcagcatcgc
      601 ccacagctcc ccatcaccgc cggggagcaa gtcagcgacc ccctctccct ccagctccac
      661 tcaggaagag gagtcggaag tgcatttcaa gatctcggga gaaaagagac cttcagccga
      721 cccaggaaaa aaggccaaga acccgaagaa gaagaaaaag aaggacccca atgagccgca
      781 gaagcctgtg tcggcctacg cactcttctt cagagacact caggccgcca tcaagggtca
      841 gaaccccagt gccactttcg gtgacgtgtc caaaatcgtg gcctccatgt gggacagcct
      901 gggagaggaa cagaagcagg cctacaagag gaagacagaa gcagcaaaga aggaatatct
      961 gaaggccctg gcagcctacc gggctagcct cgtctccaag agctccccag atcaaggtga
     1021 gaccaagagc actcaggcaa acccaccagc caaaatgctc ccacccaagc agcccatgta
     1081 tgccatgcca ggcctggcct ccttcctgac gccgtcggac ctgcaggcct tccgcagtgg
     1141 ggcctcccct gccagcctcg cccggacgct gggctccaag tctctgctgc caggcctcag
     1201 tgcgtccccg ccgccgccac cctccttccc gctcagcccc acactgcacc agcagctgtc
     1261 actgccccct cacgcccagg gcgccctcct cagtccacct gttagcatgt ccccagcccc
     1321 ccagccccct gtcctgccca cccccatggc actccaggtg cagctggcga tgagcccctc
     1381 acctccaggg ccacaggact tcccgcacat ctctgagttc cccagcagct cgggatcctg
     1441 ctcacctggc ccatccaacc ccaccagcag cggggactgg gacagcagct accccagtgg
     1501 ggagtgtggc atcagcacct gcagcctgct ccccagggac aaatcgctct acctcaccta
     1561 atcccgcctc cctaccatcc ctgaggctcg ctggaaggca ctgctcagag cctgaagggc
     1621 tgacagcaga aaagaggccc tggccagagg cagggtggcc catcggagag agcagtgaca
     1681 cacccattgc ccgggggctg agtctcttcc tcaacctccc accagactct gcagaggcag
     1741 cccactgccc accaccagcc caaagaacct gcaggaacct tccgcccgct gacctgcttg
     1801 ctccagggta actgtggacc ctgtcctcgc cctgcgcacg gtaccctatg tctggacacc
     1861 cggccccagc tccagcccca gcccaggtgg gccgcccctg gcggggtcgc ttaccaacgg
     1921 acacccaccc cagatgcatg ggccagaggg ccggcccccg gcatagatgt gcacatcggt
     1981 tttccagtgt gaacaaaaga ttacgaaacc tagaaactgt tggttccgtg taagtagttg
     2041 actacgtgtt ttagaactgt gctgaagaca tctgtaagac tattttgtgg gggaaaaaag
     2101 tagtttcctt taaggtaaaa agcattttat atgatcctta gcacattttt aagttttatc
     2161 ttaagggaga cgcgcacaaa agcggctgcc aaaccgtttc gtcatcctca cagcaaggac
     2221 cggacgcttg ctagccaccc cggagcactg ctctcctttt aatcatgtat tcatctattt
     2281 taaattgccg gcgacgactt ttgtctattt atgaagaaac cttgagaacg aagttacagc
     2341 ttatcctacc gtgtgtgtgg ttttggggtt tcgtttgggt ttgggttctt gacgtcgttt
     2401 gcagctgttt cctggccctg gcgagtgtct gtcttggtgc ccagtgcttc tctcaaatct
     2461 ctttataata aaacttctga aaagctgaaa a
//
