LOCUS       NM_014729               4076 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens thymocyte selection associated high mobility group box
            (TOX), mRNA.
ACCESSION   NM_014729 XM_376776
VERSION     NM_014729.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4076)
  AUTHORS   Burg,M.M.L., Visser,L. and Diepstra,A.
  TITLE     TOX as a new diagnostic marker for T cell large granular
            lymphocytic leukaemia
  JOURNAL   Histopathology 84 (4), 697-701 (2024)
   PUBMED   38087646
  REMARK    GeneRIF: TOX as a new diagnostic marker for T cell large granular
            lymphocytic leukaemia.
REFERENCE   2  (bases 1 to 4076)
  AUTHORS   Ornek,S., Ozekinci,S., Ipin,T. and Kocaturk,E.
  TITLE     TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage
            mycosis fungoides
  JOURNAL   J Cutan Pathol 51 (3), 232-238 (2024)
   PUBMED   37932931
  REMARK    GeneRIF: TOX, TWIST1, STAT4, and SATB1 protein expressions in
            early-stage mycosis fungoides.
REFERENCE   3  (bases 1 to 4076)
  AUTHORS   Mohammadi,M., Asgarian-Omran,H., Najafi,B., Najafi,A., Valadan,R.,
            Karami,H., Naderisoraki,M., Alizadeforoutan,M., Shekarriz,R. and
            Tehrani,M.
  TITLE     Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in
            Acute Leukemia
  JOURNAL   Iran J Immunol 20 (4), 438-445 (2023)
   PUBMED   37961948
  REMARK    GeneRIF: Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T
            cells in Acute Leukemia.
REFERENCE   4  (bases 1 to 4076)
  AUTHORS   Niu,H., Yan,L., Yang,L., Zhang,M., Liu,M., Ren,J., Shao,Z., Fu,R.,
            Xing,L. and Wang,H.
  TITLE     High TOX expression on CD8+ T cells in pure red cell aplasia
  JOURNAL   Ann Hematol 102 (5), 1247-1255 (2023)
   PUBMED   36933041
  REMARK    GeneRIF: High TOX expression on CD8[+] T cells in pure red cell
            aplasia.
REFERENCE   5  (bases 1 to 4076)
  AUTHORS   Niu,H. and Wang,H.
  TITLE     TOX regulates T lymphocytes differentiation and its function in
            tumor
  JOURNAL   Front Immunol 14, 990419 (2023)
   PUBMED   36969216
  REMARK    GeneRIF: TOX regulates T lymphocytes differentiation and its
            function in tumor.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4076)
  AUTHORS   Sebastiani,P., Wang,L., Nolan,V.G., Melista,E., Ma,Q., Baldwin,C.T.
            and Steinberg,M.H.
  TITLE     Fetal hemoglobin in sickle cell anemia: Bayesian modeling of
            genetic associations
  JOURNAL   Am J Hematol 83 (3), 189-195 (2008)
   PUBMED   17918249
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4076)
  AUTHORS   Stacey,S.N., Manolescu,A., Sulem,P., Rafnar,T., Gudmundsson,J.,
            Gudjonsson,S.A., Masson,G., Jakobsdottir,M., Thorlacius,S.,
            Helgason,A., Aben,K.K., Strobbe,L.J., Albers-Akkers,M.T.,
            Swinkels,D.W., Henderson,B.E., Kolonel,L.N., Le Marchand,L.,
            Millastre,E., Andres,R., Godino,J., Garcia-Prats,M.D., Polo,E.,
            Tres,A., Mouy,M., Saemundsdottir,J., Backman,V.M., Gudmundsson,L.,
            Kristjansson,K., Bergthorsson,J.T., Kostic,J., Frigge,M.L.,
            Geller,F., Gudbjartsson,D., Sigurdsson,H., Jonsdottir,T.,
            Hrafnkelsson,J., Johannsson,J., Sveinsson,T., Myrdal,G.,
            Grimsson,H.N., Jonsson,T., von Holst,S., Werelius,B., Margolin,S.,
            Lindblom,A., Mayordomo,J.I., Haiman,C.A., Kiemeney,L.A.,
            Johannsson,O.T., Gulcher,J.R., Thorsteinsdottir,U., Kong,A. and
            Stefansson,K.
  TITLE     Common variants on chromosomes 2q35 and 16q12 confer susceptibility
            to estrogen receptor-positive breast cancer
  JOURNAL   Nat Genet 39 (7), 865-869 (2007)
   PUBMED   17529974
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4076)
  AUTHORS   Aliahmad,P., O'Flaherty,E., Han,P., Goularte,O.D., Wilkinson,B.,
            Satake,M., Molkentin,J.D. and Kaye,J.
  TITLE     TOX provides a link between calcineurin activation and CD8 lineage
            commitment
  JOURNAL   J Exp Med 199 (8), 1089-1099 (2004)
   PUBMED   15078895
  REMARK    GeneRIF: expression of the HMG box protein TOX is sufficient to
            induce changes in coreceptor gene expression associated with
            beta-selection, including CD8 gene demethylation
REFERENCE   9  (bases 1 to 4076)
  AUTHORS   O'Flaherty,E. and Kaye,J.
  TITLE     TOX defines a conserved subfamily of HMG-box proteins
  JOURNAL   BMC Genomics 4 (1), 13 (2003)
   PUBMED   12697058
REFERENCE   10 (bases 1 to 4076)
  AUTHORS   Wilkinson,B., Chen,J.Y., Han,P., Rufner,K.M., Goularte,O.D. and
            Kaye,J.
  TITLE     TOX: an HMG box protein implicated in the regulation of thymocyte
            selection
  JOURNAL   Nat Immunol 3 (3), 272-280 (2002)
   PUBMED   11850626
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB018351.1, CA439630.1 and
            AC091195.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014729.2.
            
            Summary: The protein encoded by this gene contains a HMG box DNA
            binding domain. HMG boxes are found in many eukaryotic proteins
            involved in chromatin assembly, transcription and replication. This
            protein may function to regulate T-cell development.[provided by
            RefSeq, Apr 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018351.1, SRR1660809.135967.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361421.2/ ENSP00000354842.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3279              AB018351.1         64-3342
            3280-3298           CA439630.1         646-664
            3299-4070           AB018351.1         3362-4133
            4071-4076           AC091195.6         36714-36719
FEATURES             Location/Qualifiers
     source          1..4076
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.1"
     gene            1..4076
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /note="thymocyte selection associated high mobility group
                     box"
                     /db_xref="GeneID:9760"
                     /db_xref="HGNC:HGNC:18988"
                     /db_xref="MIM:606863"
     exon            1..262
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1741
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /note="thymus high mobility group box protein TOX"
                     /codon_start=1
                     /product="thymocyte selection-associated high mobility
                     group box protein TOX"
                     /protein_id="NP_055544.1"
                     /db_xref="CCDS:CCDS34897.1"
                     /db_xref="GeneID:9760"
                     /db_xref="HGNC:HGNC:18988"
                     /db_xref="MIM:606863"
                     /translation="MDVRFYPPPAQPAAAPDAPCLGPSPCLDPYYCNKFDGENMYMSM
                     TEPSQDYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNH
                     NGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRP
                     RGQPADIRQQPGMMPHGQLTTINQSQLSAQLGLNMGGSNVPHNSPSPPGSKSATPSPS
                     SSVHEDEGDDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQ
                     AAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVS
                     KSYSEPVDVKTSQPPQLINSKPSVFHGPSQAHSALYLSSHYHQQPGMNPHLTAMHPSL
                     PRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLNMQQHQPLTMQQPLGNQLP
                     MQVQSALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWN
                     NDYCSSGGMQRDKALYLT"
     exon            263..328
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            329..571
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..853
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1084
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1165
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1552
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1704
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..4076
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2684..2689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /note="hexamer: AATATA"
     polyA_site      2705
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /note="major polyA site"
     regulatory      2812..2817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /note="hexamer: AATAAA"
     polyA_site      2851
                     /gene="TOX"
                     /gene_synonym="TOX1"
     regulatory      3781..3786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /note="hexamer: AATATA"
     polyA_site      3803
                     /gene="TOX"
                     /gene_synonym="TOX1"
     regulatory      4033..4038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /note="hexamer: AAGAAA"
     regulatory      4049..4054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOX"
                     /gene_synonym="TOX1"
                     /note="hexamer: AATAAA"
     polyA_site      4055
                     /gene="TOX"
                     /gene_synonym="TOX1"
     polyA_site      4076
                     /gene="TOX"
                     /gene_synonym="TOX1"
ORIGIN      
        1 ctcttcttct taaacaaacc acaaacggat gtgagggaag gaaggtgttt cttttactcc
       61 tgagcccaga cacctcactc tgttccgtct aagcttgttt tgctgaacac ttttttttaa
      121 aaaaggaaaa agaaaaggag ttgcttgatg tgagagtgaa atggacgtaa gattttatcc
      181 acctccagcc cagcccgccg ctgcgcccga cgctccctgt ctgggacctt ctccctgcct
      241 ggacccctac tattgcaaca agtttgacgg tgagaacatg tatatgagca tgacagagcc
      301 gagccaggac tatgtgccag ccagccagtc ctaccctggt ccaagcctgg aaagtgaaga
      361 cttcaacatt ccaccaatta ctcctccttc cctcccagac cactcgctgg tgcacctgaa
      421 tgaagttgag tctggttacc attctctgtg tcaccccatg aaccataatg gcctgctacc
      481 atttcatcca caaaacatgg acctccctga aatcacagtc tccaatatgc tgggccagga
      541 tggaacactg ctttctaatt ccatttctgt gatgccagat atacgaaacc cagaaggaac
      601 tcagtacagt tcccatcctc agatggcagc catgagacca aggggccagc ctgcagacat
      661 caggcagcag ccaggaatga tgccacatgg ccagctgact accattaacc agtcacagct
      721 aagtgctcaa cttggtttga atatgggagg aagcaatgtt ccccacaact caccatctcc
      781 acctggaagc aagtctgcaa ctccttcacc atccagttca gtgcatgaag atgaaggcga
      841 tgatacctct aagatcaatg gtggagagaa gcggcctgcc tctgatatgg ggaaaaaacc
      901 aaaaactccc aaaaagaaga agaagaagga tcccaatgag ccccagaagc ctgtgtctgc
      961 ctatgcgtta ttctttcgtg atactcaggc cgccatcaag ggccaaaatc caaacgctac
     1021 ctttggcgaa gtctctaaaa ttgtggcttc aatgtgggac ggtttaggag aagagcaaaa
     1081 acaggtctat aaaaagaaaa ccgaggctgc gaagaaggag tacctgaagc aactcgcagc
     1141 atacagagcc agccttgtat ccaagagcta cagtgaacct gttgacgtga agacatctca
     1201 acctcctcag ctgatcaatt cgaagccgtc ggtgttccat gggcccagcc aggcccactc
     1261 ggccctgtac ctaagttccc actatcacca acaaccggga atgaatcctc acctaactgc
     1321 catgcatcct agtctcccca ggaacatagc ccccaagccg aataaccaaa tgccagtgac
     1381 tgtctctata gcaaacatgg ctgtgtcccc tcctcctccc ctccagatca gcccgcctct
     1441 tcaccagcat ctcaacatgc agcagcacca gccgctcacc atgcagcagc cccttgggaa
     1501 ccagctcccc atgcaggtcc agtctgcctt acactcaccc accatgcagc aaggatttac
     1561 tcttcaaccc gactatcaga ctattatcaa tcctacatct acagctgcac aagttgtcac
     1621 ccaggcaatg gagtatgtgc gttcggggtg cagaaatcct cccccacaac cggtggactg
     1681 gaataacgac tactgcagta gtgggggcat gcagagggac aaagcactgt accttacttg
     1741 agaatctgaa cacctcttct ttccactgag gaattcaggg aagtgttttc accatggatt
     1801 gctttgtaca gtcaaggcag ttctccattt tattagaaaa tacaagttgc taagcactta
     1861 ggaccatttg agcttgtggg tcacccactc tggaagaaat agtcatgctt ctttattatt
     1921 tttttaatcc tttatggaca ttgtttttct tcttccctga aggaaatttg gaccattcag
     1981 attttatgtt ggttttttgc tgtgaagtgc tgcgctctag taactgcctt agcaactgta
     2041 gatgtctcgg ataaaagtcc tggattttcc attggttttc ataatgggtg tttatatgaa
     2101 actactaaag actttttaaa tggcttgatg tagcagtcat agcaagtttg taaatagcat
     2161 ctatgttaca ctctcctaga gtataaaatg tgaatgtttt tgtagctaaa ttgtaattga
     2221 aactggctca ttccagttta ttgatttcac aataggggtt aaattggcaa acattcatat
     2281 ttttacttca tttttaaaac aactgactga tagttctata ttttcaaaat atttgaaaat
     2341 aaaaagtatt cccaagtgat tttaatttaa aaacaaattg gctttgtctc attgatcaga
     2401 caaaaagaaa ctagtattaa gggaagcgca aacacattta ttttgtactg cagaaaaatt
     2461 gcttttttgt atcacttttt gtgtaatggt tagtaaatgt catttaagtc cttttatgta
     2521 taaaactgcc aaatgcttac ctggtatttt attagatgca gaaacagatt ggaaacagct
     2581 aaattacaac ttttacatat ggctctgtct tattgtttct tcatactgtg tctgtattta
     2641 atcttttttt atggaacctg ttgcgcctat ttatgaaata ataaatatag gtgtttgtaa
     2701 gtaaatttgt tagtatttga aagaggtttc tttgatgttt taacttttgc tggcaaaaaa
     2761 aaattcacgc ttggtgtgaa tactttatta tttagttttt acagtaacat gaataaagcc
     2821 aaacctgctt ttcatttagc agcaaattaa agtaaccagt ccttatttct gcatttcttt
     2881 ggttgatgca aacaaaaaac tattatattt aagaacttta tttcttcata cgacataaca
     2941 gaattgccct ccaagtcaca caagctccaa gactaaacaa acagacaggt cctctgtctt
     3001 aaaaaggtta cttcttggtt ctcagctggt tctagtcaat tctgaaccac caccccccgc
     3061 cccccgcaaa aaagtaaaag tcaaaccaaa cttcctcaag ctgcatgctt ttcacaaaat
     3121 ccagaaagca tttaagaatt gaactagggg ctggaagaag tgaaagggaa gcatctaaaa
     3181 atgaaaggtg agtaaccaga tagcaaaaga aaagggaaag ccatccaaat ttgaaagctg
     3241 ttgatagaaa ttgagattct tgctgtcttt tgtgcctcta caagctacta ctcattccag
     3301 aattcctggg tcttccaaga ggattcttaa ggtaccagag atttgctagg gaaccaaaag
     3361 tgcttgagaa tctgcctgag ggcttgcata gctttcacat taaaaaaaga aaaagctagc
     3421 agatttactc ctttttaggg gatcatatca agaaagttag tctggttgga aaccaagaga
     3481 atggctgatg tctctttctt ggaatatgtg aaataaattt agcagtttaa ctaaatacaa
     3541 atatatgcat tgtgtaatcc actcagaatt aaacagacaa aaggtatgct tgctttggaa
     3601 tgattttagg cattgtacaa ccttgaatca cttgagcatg taataactaa taaataatgc
     3661 agatccatgt gattattaaa atgactgtag ctgagagctc taattttcct gtcttgaaac
     3721 tgtataagaa ctcatgtgat taagttcaca gtttattgtt tgtctgttta gtattttaga
     3781 aatataccag cactactaat taactaatgt cttttattta ttatattatg ataaagtaaa
     3841 aatttcactt gcattaagtc taaactgaga aggtaattac tgggaggaga atgagcagct
     3901 ttgactttga caggcggttt gtgcaggaaa gcacagtgcc gtgttgttta cagcttttct
     3961 agagcagctg tgcgaccagg gtagagagtg ttgaaattca ataccaaata cagtaaaaac
     4021 aaatgtaaat aaaagaaaac acatcatcaa taaaactgtt attatgcgtg accgta
//
