LOCUS       NM_017723               4171 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens torsin family 4 member A (TOR4A), mRNA.
ACCESSION   NM_017723 XM_001130541
VERSION     NM_017723.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4171)
  AUTHORS   Wang,Q., Li,Y., Li,J., Yao,Z., Ma,X. and Ma,J.W.
  TITLE     Delta and Notch-like epidermal growth factor-related receptor
            suppresses human glioma growth by inhibiting oncogene TOR4A
  JOURNAL   J Cancer Res Ther 18 (5), 1372-1379 (2022)
   PUBMED   36204885
  REMARK    GeneRIF: Delta and Notch-like epidermal growth factor-related
            receptor suppresses human glioma growth by inhibiting oncogene
            TOR4A.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX255925.17, AK000252.1 and AK000392.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017723.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000252.1, DB226617.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357503.3/ ENSP00000350102.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               BX255925.17        73106-73207
            103-1285            AK000252.1         5-1187
            1286-1400           AK000392.1         90-204
            1401-2862           AK000252.1         1303-2764
            2863-4171           BX255925.17        76713-78021
FEATURES             Location/Qualifiers
     source          1..4171
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..4171
                     /gene="TOR4A"
                     /gene_synonym="C9orf167"
                     /note="torsin family 4 member A"
                     /db_xref="GeneID:54863"
                     /db_xref="HGNC:HGNC:25981"
     exon            1..182
                     /gene="TOR4A"
                     /gene_synonym="C9orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            183..4171
                     /gene="TOR4A"
                     /gene_synonym="C9orf167"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1491
                     /gene="TOR4A"
                     /gene_synonym="C9orf167"
                     /note="torsin family protein C9orf167"
                     /codon_start=1
                     /product="torsin-4A"
                     /protein_id="NP_060193.2"
                     /db_xref="CCDS:CCDS7041.1"
                     /db_xref="GeneID:54863"
                     /db_xref="HGNC:HGNC:25981"
                     /translation="MDRGQPSLEPAAAAPRASGRCVIAPVRAVLRLRRRVCVLRKRRL
                     LQPGGGPDVGTGAPRPGCSPRAPRADLDQPKFFTFDSPAELPSRTPRKKRRRSRLVLY
                     PETSRKYRPRVEHRSRAQRCLLLLVAIVGFQVLNAIENLDDNAQRYDLDGLEKALQRA
                     VFGQPAAVSRIVALMRDYLATHVHSRPLLLALHGPSGVGKSHVGRLLARHFRSVLEDS
                     ALVLQYHARHHCPEARAAQDCREELARRVADVVARAEAEEKTPLLVLDDVELMPRPLL
                     DELHGFLQPQRSHHFHNAIYVLLSGAGGAEVTRFVLQNASRALPLRPDGFRSAEAAAA
                     QAEEDLRASLLAVLSREHPLWQAAAIVPFLLLDKRDVVSCFRDEMAGEGFFPDQARAE
                     NLAAQLSFYRVAGREFAVTGCKQVVATVNLL"
     regulatory      4147..4152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOR4A"
                     /gene_synonym="C9orf167"
                     /note="hexamer: AATAAA"
     polyA_site      4171
                     /gene="TOR4A"
                     /gene_synonym="C9orf167"
                     /note="major polyA site"
ORIGIN      
        1 actccggccg gccgctccct ggggacccac aggtgtcgct gcccctccag gccgaagctg
       61 gcccaggagg cccctggccc accccctcgc cctgggaggc gcatttcctg cttggagtct
      121 caggccccag cgtctggcac aggcaggggc ctgcggagct gagggcagtg gaccagctgc
      181 agggagggcg acctgtatgc ggagcgccgt tcctgcgaca tggaccgcgg ccagcccagc
      241 ctggagcctg ctgccgcggc cccccgagcc tcgggccggt gcgtgatcgc gcccgtgcgc
      301 gctgtgctcc gcctgcgccg ccgggtgtgt gtcctacgca aacggcgcct cctgcagccg
      361 ggtggggggc ccgacgtcgg gaccggggcg cccaggccgg gctgcagccc ccgggcaccg
      421 cgcgcggacc tggaccagcc aaagttcttc accttcgaca gccccgcgga gctaccctcc
      481 aggacgccac gcaagaagcg ccggcgcagc cgcctggtgc tttacccgga gacctcgcgc
      541 aagtatcggc cgcgcgtgga gcacaggagc cgcgcgcagc gctgccttct gctgctagtc
      601 gccatcgtgg gcttccaagt tctcaacgct atcgagaacc tggacgataa cgcgcagcgc
      661 tatgacctcg acgggctgga gaaagcgctg cagcgcgcgg tgttcggcca gcccgctgcc
      721 gtatcgcgca tcgtggcgct gatgcgggac tacctggcca cgcatgtgca cagtcgtccg
      781 ctcctcctgg cgctgcacgg gcccagtggc gtgggcaaga gccacgtggg ccgcctgctg
      841 gcgcgccact tccgctcggt gctggaggac agcgcgctcg tgctgcaata ccatgcgcgg
      901 caccactgcc ccgaggcgcg cgccgcacag gactgccgcg aggagctggc gcggcgcgtg
      961 gccgacgtgg tggcgcgggc cgaagcggag gagaagaccc cactcttggt gctggacgac
     1021 gtggagctca tgccgcggcc gctgctggac gagctgcacg gcttcctgca gccgcagcgc
     1081 tcccaccact tccacaacgc catctacgtg ctcctcagtg gcgcgggtgg cgccgaggtc
     1141 acgcgcttcg tgctgcagaa cgcgtcccgc gcgctgcccc tgcgccccga cggcttccgc
     1201 agtgccgagg ccgcagcggc gcaggcggaa gaagacctgc gcgccagcct gctggctgtg
     1261 ctgtcccggg agcatccgct gtggcaggcc gcggccatcg tgccgtttct gctgctggac
     1321 aagcgggatg tggtcagctg cttccgggac gagatggcgg gtgagggctt ctttcctgac
     1381 caggcccgcg cggagaacct ggccgcgcag ctcagcttct accgcgtggc tggccgcgag
     1441 tttgccgtca ccggctgcaa gcaggtggtg gccacggtga acctcctgta gtggaggcgc
     1501 aggacgggac gtttgggttg atggcggcag taggagggcg accagggacc ttgtgggctg
     1561 gtgcaggccc ctgaggtttc tagtgaattt gtggctgccc ggctggtggg tgcggatcag
     1621 cttggagctc tgcttccagg tccacacccg cctcagagtc cggagtctgt ccctgggggc
     1681 ggcaggacag cagccacctc cctcccaaac ttgcccattg ccctgctggg cgtcccaggc
     1741 atggtctggt gcgttctccc tgtggcccca agaggtgggt tcccatggta caaggatgat
     1801 ctcagggcca acaattcccg gggtcacaca gctgggacgt gaccccgcct cttgggggtg
     1861 gtcgcgtgtt gctcagtgct gaagtggggt tctcattccg gcccccctgg agatgacccc
     1921 ggaggaggcc acagccaacc atgacagtgc tggggctctg gctgccttct ccacccaccc
     1981 cacccctcac tcaggtcgtg ttttcaggag ctcaaggctg gagtgtcttg acagtaaggg
     2041 gaggggagcg gaggcggagg cgcctcaggc agcctctccc cctccttcct ggacccccca
     2101 accccgggcc cgccagccct ggcttgggct tactgggtga ccgagagccc gcggggcaag
     2161 cgggaggtgc ctaggcctct ccccatcccc ctcttctccg cacgtgggac ccttagcccg
     2221 tggccagtcc cctggtcacc acgattgcgc gacctccctt tccctggggc cttttgtgcc
     2281 ccgagttccg cccacccgca ccctctgcgc agagcgccct ccccacgcca gtcgacccca
     2341 caccccacac tccccacgcg ccgcctcccg gaagccctcc tggacgcctc ccgtggatgg
     2401 gcccaccgcg cccacggggg ctttagggga aggtgctttg ggcgtttttt gcgccatgtc
     2461 tcctcggggc cggcggttgc ctcgggacgg ttctcgcctc ctcccacagc cccggtgtct
     2521 gggacgcacc cggcagcccc gctgctgccg ccttgtggcg cgcccggccc agccggtggc
     2581 ttctgtggtc gccgggggct gagcgcgcgg ctgggccctg agtcccccag gccgccccga
     2641 tcctctgtcc ccgccgccgg ccccgctgca gtcccaaccc gggcctgccc gggaggagcg
     2701 caggggcggc gatgaccagt cccgaaaggg gctcagaggg cagcgaggag gtttcacgcc
     2761 ggtgcggggc gccgtcgagg tgggggcacc gcgaaggtgg aggcggggcc gcgccggaag
     2821 ccccgagtcg agcgcacacg gcgggcgccc ctggcaagtg ggactcctcc ggccccgagg
     2881 cctgaactca gcccggagac cgcgcccacc agcgccggtg tccccggagg ggccccgcta
     2941 gttccctgag cagaggtcct gcggcttccc ggagggtgtc ctgttctctc ccccgcctcg
     3001 catccattct cgccctggtg gttggtgtct gtggtcgggg gcgagggccg tctagtggag
     3061 acggggattc aggccgcttg aaagtctggg atctctgggc ggatggcagc ggctccgcgg
     3121 agctcgagct cggcgcgcag gtcctgggcc cagggcggga gcgctagcga gagggctgcc
     3181 ccgtcctgcc cagagggtcc tgaggactcc cgctgctcct ggagtcttgg ggaggggtcc
     3241 ggctccacgg ggtgggggtg ggggctacca ggaaaccttt gcctcctggg gctgtgcagg
     3301 accggctagc cagcgctggg aaccagggct gagttcagcc cagctctgtc caccccaacc
     3361 ccagggctag gggaaggagc tgggagaagg agccccacct ctcccaggcg agtatctgtc
     3421 ccaggagccc acacagaggg acacccagct ctggtctggc cttcgtgttg gcttcaaggt
     3481 ggtaacagag agagctgcag agtgggggtg tgtttgccag tccctgcatg ggtgaatgtt
     3541 ggggtgccca ctgctcccca ggcaggaccc ccaggactgt cagctcccct tcccacagag
     3601 cacccacctg gaggtgtcac ctgccggcaa gcgtgggcca ttcatccacc tgtcagtcaa
     3661 caacacccgc tgagcatcgg cttgtatcaa aaggtccaga cctaagggga aattttatct
     3721 ctttctttct ttctttcttt tttttttgac acagagtttt gctcttgttg cccaggctgg
     3781 agtgcaatga cacgatctcg gttcactgca acctctgcct cctgggttca agcgattctc
     3841 ctgcctcagc ctcccgagta gctgggatta caggcgcccg ccatcacgcc cgggtaattt
     3901 ttttgtattg ttggtagaga cggtgattca ctatgttggc caggctagtc acgaactcct
     3961 gacctcgtga tccgcccacc tcggcctccc aaagtgctgg gattacaggt gtgagccacc
     4021 gtgcccggcc tctttttatt tattcctaaa atattacctt gaggccaaat tctgcgctta
     4081 aggagaatgt gcaccaagtg ctggggtggg ggctggtaat aaacgaggcc acaaatcatg
     4141 cttgttaata aattgtgtgg ttcaaatctg a
//
