LOCUS       NM_001199260            8319 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens torsin 1A interacting protein 2 (TOR1AIP2), transcript
            variant 3, mRNA.
ACCESSION   NM_001199260
VERSION     NM_001199260.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8319)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8319)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 8319)
  AUTHORS   Laudermilch,E., Tsai,P.L., Graham,M., Turner,E., Zhao,C. and
            Schlieker,C.
  TITLE     Dissecting Torsin/cofactor function at the nuclear envelope: a
            genetic study
  JOURNAL   Mol Biol Cell 27 (25), 3964-3971 (2016)
   PUBMED   27798237
REFERENCE   4  (bases 1 to 8319)
  AUTHORS   Demircioglu,F.E., Sosa,B.A., Ingram,J., Ploegh,H.L. and
            Schwartz,T.U.
  TITLE     Structures of TorsinA and its disease-mutant complexed with an
            activator reveal the molecular basis for primary dystonia
  JOURNAL   Elife 5, e17983 (2016)
   PUBMED   27490483
  REMARK    GeneRIF: A comparison of these structures shows, in atomic detail,
            the subtle differences in TorsinADeltaE-LULL1 activator
            interactions that separate the healthy from the diseased state.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8319)
  AUTHORS   Turner,E.M., Brown,R.S., Laudermilch,E., Tsai,P.L. and Schlieker,C.
  TITLE     The Torsin Activator LULL1 Is Required for Efficient Growth of
            Herpes Simplex Virus 1
  JOURNAL   J Virol 89 (16), 8444-8452 (2015)
   PUBMED   26041288
  REMARK    GeneRIF: The Torsin Activator LULL1 Is Required for Efficient
            Growth of Herpes Simplex Virus 1.
REFERENCE   6  (bases 1 to 8319)
  AUTHORS   Rose,A.E., Brown,R.S. and Schlieker,C.
  TITLE     Torsins: not your typical AAA+ ATPases
  JOURNAL   Crit Rev Biochem Mol Biol 50 (6), 532-549 (2015)
   PUBMED   26592310
  REMARK    Review article
REFERENCE   7  (bases 1 to 8319)
  AUTHORS   Rose,A.E., Zhao,C., Turner,E.M., Steyer,A.M. and Schlieker,C.
  TITLE     Arresting a Torsin ATPase reshapes the endoplasmic reticulum
  JOURNAL   J Biol Chem 289 (1), 552-564 (2014)
   PUBMED   24275647
REFERENCE   8  (bases 1 to 8319)
  AUTHORS   Zhao,C., Brown,R.S., Chase,A.R., Eisele,M.R. and Schlieker,C.
  TITLE     Regulation of Torsin ATPases by LAP1 and LULL1
  JOURNAL   Proc Natl Acad Sci U S A 110 (17), E1545-E1554 (2013)
   PUBMED   23569223
  REMARK    GeneRIF: LAP1 and LULL1 as regulatory cofactors that are
            responsible for the activation of TorA's ATPase activity.
REFERENCE   9  (bases 1 to 8319)
  AUTHORS   Vander Heyden,A.B., Naismith,T.V., Snapp,E.L., Hodzic,D. and
            Hanson,P.I.
  TITLE     LULL1 retargets TorsinA to the nuclear envelope revealing an
            activity that is impaired by the DYT1 dystonia mutation
  JOURNAL   Mol Biol Cell 20 (11), 2661-2672 (2009)
   PUBMED   19339278
  REMARK    GeneRIF: Data suggest that LULL1 regulates the distribution and
            activity of TorA within the ER and NE lumen and reveal functional
            defects in the mutant protein responsible for DYT1 dystonia.
REFERENCE   10 (bases 1 to 8319)
  AUTHORS   Goodchild,R.E. and Dauer,W.T.
  TITLE     The AAA+ protein torsinA interacts with a conserved domain present
            in LAP1 and a novel ER protein
  JOURNAL   J Cell Biol 168 (6), 855-862 (2005)
   PUBMED   15767459
  REMARK    GeneRIF: identifed a novel transmembrane protein, lumenal domain
            like LAP1 (LULL1), which appears to interact with torsinA; it
            resides in the main endoplasmic reticulum.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC094724.1 and AL359853.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001199260.1.
            
            Summary: One of the two protein isoforms encoded by this gene is a
            type II integral membrane protein found in the endoplasmic
            reticulum (ER). The encoded protein is a cofactor for the ATPase
            TorsinA, regulating the amount of TorsinA present in the ER
            compared to that found in the nuclear envelope. Defects in this
            protein are a cause of early onset primary dystonia, a
            neuromuscular disease. The other isoform encoded by this gene is an
            interferon alpha responsive protein whose cellular role has yet to
            be determined. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (3) contains the same 5'
            non-coding exons, but has a completely different set of coding
            exons compared to variant 1. This results in a longer isoform b
            (torsin-1A-interacting protein 2) distinct from isoform a, referred
            to as interferon alpha responsive protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094724.1, SRR11853561.2229.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000609928.6/ ENSP00000477486.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4364              BC094724.1         1-4364
            4365-8319           AL359853.18        133282-137236       c
FEATURES             Location/Qualifiers
     source          1..8319
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..8319
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /note="torsin 1A interacting protein 2"
                     /db_xref="GeneID:163590"
                     /db_xref="HGNC:HGNC:24055"
                     /db_xref="MIM:614513"
     exon            1..111
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /inference="alignment:Splign:2.1.0"
     exon            112..246
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /inference="alignment:Splign:2.1.0"
     exon            247..665
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /inference="alignment:Splign:2.1.0"
     exon            666..845
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /inference="alignment:Splign:2.1.0"
     CDS             812..2224
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /note="isoform b is encoded by transcript variant 3;
                     interferon responsive gene 15; lumenal domain like LAP1;
                     15 kDa interferon-responsive protein; torsin A interacting
                     protein 2"
                     /codon_start=1
                     /product="torsin-1A-interacting protein 2 isoform b"
                     /protein_id="NP_001186189.1"
                     /db_xref="CCDS:CCDS1334.1"
                     /db_xref="GeneID:163590"
                     /db_xref="HGNC:HGNC:24055"
                     /db_xref="MIM:614513"
                     /translation="MADSGLREPQEDSQKDLENDPSVNSQAQETTIIASNAEEAEILH
                     SACGLSKDHQEVETEGPESADTGDKSESPDEANVGKHPKDKTEDENKQSFLDGGKGHH
                     LPSENLGKEPLDPDPSHSPSDKVGRADAHLGSSSVALPKEASDGTGASQEPPTTDSQE
                     AQSPGHSSAGQEGEDTLRRRLLAPEAGSHPQQTQKLEEIKENAQDTMRQINKKGFWSY
                     GPVILVVLVVAVVASSVNSYYSSPAQQVPKNPALEAFLAQFSQLEDKFPGQSSFLWQR
                     GRKFLQKHLNASNPTEPATIIFTAAREGRETLKCLSHHVADAYTSSQKVSPIQIDGAG
                     RTWQDSDTVKLLVDLELSYGFENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDV
                     ALVLTVLLEEETLEASVGPRETEEKVRDLLWAKFTNSDTPTSFNHMDSDKLSGLWSRI
                     SHLVLPVQPVSSIEEQGCLF"
     exon            846..1364
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1466
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..8319
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7186..7191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /note="hexamer: AATAAA"
     polyA_site      7209
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /note="major polyA site"
     regulatory      7356..7361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /note="hexamer: AATAAA"
     polyA_site      7376
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /note="major polyA site"
     regulatory      8301..8306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
                     /note="hexamer: AATAAA"
     polyA_site      8319
                     /gene="TOR1AIP2"
                     /gene_synonym="IFRG15; LULL1; NET9"
ORIGIN      
        1 attcgggccg cggcggccgc tgggtgcagc cgagcggtgt ggagcggaga gaatactcga
       61 agggctctcc tgatactaac agttttacga tttaaaactt cgccagaatt tcgacagggt
      121 ctcactgtat tgcccaggtt ggtctcgaac tcctggcttc aagcgattct cccacctcag
      181 cctcccaaag tgctgggatt acaggcgtga gccaccacgc ctggcctcac tcaaacagta
      241 aacgaggtat gtgacgcatt cccagactct tcagccaact gagcatcagc ttcttcacag
      301 caattgggtc ctgattaatg tcctcccaag acagacttca ttggatccac gatcaagagg
      361 actctgccag gtttttctga cccctctaca ttgctataaa gtgccaaggc cttaagactt
      421 gggtacgtgt gttacaacgg caagagtgcc agcgccaaca aaagacccat tggacctgtc
      481 agctcctctg tttcaccaag cagacacaat aaccttacca acaaagcaga gtaagccaag
      541 tgcctctgtg tgacaccacc agcagctgat gacgcataag aaaaatataa ctaatttaga
      601 ctagagccct atctcttctt gagaagctgg gatttgaagg agctatcctg agatctgtac
      661 tgctatcact gtatatatgc cttatttcct gggtccatgg gaagcatgag tctgttggga
      721 cttgggacaa gaagaaaaca agacatcttc acaaggaaaa ccaagtacta aaaaaagtat
      781 cctcccaact ctgaagagat agaacacaaa catggccgac agtggactta gggaacctca
      841 agaggactct caaaaggatt tggaaaatga tccatcagta aattctcagg cgcaggagac
      901 cacaatcata gcaagtaatg ctgaagaagc tgagatccta cactctgcct gtggtcttag
      961 caaagaccac caagaggtag agacagaagg tccagaaagt gcagatacag gtgataaatc
     1021 agaaagtcca gatgaagcaa atgtggggaa acatccaaag gataaaacag aagatgagaa
     1081 caagcagagt tttctggatg gcggaaaagg gcatcacctc ccttcagaaa atctgggtaa
     1141 agaacccttg gatccagatc ccagccattc tccaagtgac aaggtaggaa gagcagatgc
     1201 acacttaggg agcagctctg tggccctccc taaggaagcg agtgacggaa ctggagcatc
     1261 tcaggaacca cctactacag actcccagga ggcccagagt cctggtcatt ccagtgcagg
     1321 gcaagagggt gaggatacac tgaggaggcg actgctggcc ccagaggctg gaagtcatcc
     1381 acaacaaaca caaaaattgg aagaaattaa agagaatgca caggacacca tgagacagat
     1441 taataaaaag ggtttttgga gctatggccc tgtgattctt gtcgtcctgg ttgtggctgt
     1501 tgtggcaagt tctgtgaata gctactattc ctctccagcc cagcaagtgc ccaaaaatcc
     1561 agctttggag gcctttttgg cccagtttag ccaattggaa gataaatttc caggccagag
     1621 ttccttcctg tggcagagag gacggaagtt tctccagaag cacctcaatg cttccaaccc
     1681 cactgagcca gccaccatca tatttacagc agctcgggag ggaagagaga ccctgaagtg
     1741 cctgagccac catgttgcag atgcctacac ctcttcccag aaagtctctc ccattcagat
     1801 tgatggggct ggaaggacct ggcaggacag tgacacggtc aagctgttgg ttgacctgga
     1861 gctgagctat gggtttgaga atggccagaa ggctgctgtg gtacaccact tcgaatcctt
     1921 ccctgccggc tccactttga tcttctataa gtattgtgat catgagaatg ctgcctttaa
     1981 agatgtggcc ctggtcctga ctgttctgct agaggaggaa acattagaag caagtgtagg
     2041 cccaagggaa acggaagaaa aagtgagaga cttactctgg gccaagttta ccaactctga
     2101 cactcccacc tccttcaacc acatggactc agacaaattg agtgggctgt ggagccgaat
     2161 ttcacacctg gtactgccag tccagccagt gagtagcata gaagaacagg ggtgcctttt
     2221 ctaaagctaa gcacagagtt ggttacagaa ggtatatgtt tatgaaaaag tttgtttaaa
     2281 gaccttccat ttatatggaa ggaggttgat aaaatagctt gaggaaatag cctgaaaaac
     2341 aaagatgagc ttattttaga aacaagtttt tattttttat tccttgtaaa atctttctaa
     2401 tctaagcctt gacaaagcta aaaattaacc tgactttttt tctttggacc aaatcaggtt
     2461 tgaaatatcg atgatatata tgagaatttt ttttaaattc taaaatatag caacattgca
     2521 caggaagata ctcttacttc ttagagtaac tacagagtga tttttttttt ttcttgagtg
     2581 agactctgaa gaaccttttc gataatgttt ggacttggac taaagcaatt agaattatga
     2641 agcaatgata acctttagaa aatttttcta tcacatgttg aatattttca aaccttactt
     2701 taataatcta aagttacggg attatatctt atattaattt tgcagttttg agtagtatga
     2761 taaaagaaat aagaattcaa accattaagt acctacctaa atactacatg taaggcactg
     2821 tgcttttatt tcattcagct gaggtataag cagctgtact caaatgttct taaaaatgag
     2881 aaccagtggg gaaattgttt ataatcattg gaaatgaaga aattccaatt ggctatatct
     2941 ttacttcagc ttttcttgaa caatttacag cattgatttt caaactgtgt ctactggcac
     3001 ccttcccctt tgtatcagag cagttctgct tttaactgtt ttatatgttg gggttctcta
     3061 tgagatttca ttggaacaaa gagtttcact gatattcgag tttgaaaacc attgattaag
     3121 tgaaaaaaca tcttagaaga taggaaatat gtttaaaaaa tgaatgtatt aaatcttatg
     3181 agtaggaaga tgaaatacag gtttattgta tagatacatt atttatgaag gataaagatc
     3241 tatacatgaa cagcagaatg tataagctag catttactag catgtctctg atgcttttgt
     3301 tcatttctgt taatcgtcat ttctgtcccc tctgcatgga attttatact tgtctagggt
     3361 aagagtttgt agactctttc agcagaacag attttaataa ccaatttatt tgttttattt
     3421 taaaaattta tttttgaata accaatttaa tagtaaattt tatatgaaca tttggcataa
     3481 ctttaccagt ttatttctat gcagtgatgg aacattatgt aatgcagctc atttcttgac
     3541 caactagtta tagaagtacc attaggttaa aaattagaga aatctaagag atgttatact
     3601 tagtgagagg aagcagaaat ggtgggtaga ttctcagagg ttttgatgtt cagtactgac
     3661 ggaccatgtt ctgtgattgt aagaaagatt gaaaacagtt tgtatggaga tagagttgat
     3721 tagcatttga gctctgaaag cagaactcta gtaaaatgat ctcgacctaa caaagggtct
     3781 gttccattat atagactatt accataatcc tggattattt caactgggtt ttggcctctc
     3841 cattatatga gatcatatgt atatagctaa gaagtctgat taaagtatgg aaagatttta
     3901 ggaaacacta agaagataca gggatcttta ctgataccta aaaagattac aattgagtaa
     3961 ttgctcaatt gagtgtaggg gcatacctga aggaagaatt tgcatttggg acttcgaagg
     4021 aagcttccaa gagatttggg aagagacctg aacaaaaagt taaagcatgg tgaatgtgat
     4081 atcactgtca atccagtata aaagcagagg aagttgaagg aaaatctgta tcccatatgc
     4141 acattttttc tgtcttttta gatcttagat gctagcgtta catccacaaa accagtgttg
     4201 ccttgtataa ctattatatt ggcctgctga cctgtgctac ctcagatctg tcaaggaacc
     4261 agtatgtcgc atattcttgt ttcttcattc agttgaatat ggtttttcat catttctctt
     4321 caaaataatt tagaaaaata aatttctaaa gtcataattt ttaatttagc ctttttaaaa
     4381 acattttccc ttccatgtat agtgcaatca attgagggtg ttgtcagttt tctgtctgct
     4441 atttcaaaag tctttttttt tttttttttt ttttgagatg gagtctcact ctgactccca
     4501 ggctgcagtg ctgtggcttg atcatagctc actgtagctt taaactcctg ggctcaagca
     4561 atcctcccac cttagcctcc tgagtagccg ggactacaag tgcagactac cacaccactc
     4621 taccacacta ttttgtatag agacagggtc ttactgtgtt gcctaggctg gtcttgaact
     4681 cctggcctca agtgatcctc ccacctcagc gtcccaaagt gtttggatta cagatgtgac
     4741 ccaatgcacc caaccaaact tctttttttt tttttttttt ttttgagaga aggtcttgct
     4801 ctgtcaccca ggctggaatg cagtgcagtg gcacaatctc atctcactgt aacctacacc
     4861 tcctgggttc aagtgattct tgtgcctcag cctcccaagt agctgggatt acaggcatgc
     4921 accacaatgc ccagctaatt attgtatttt taatagagac gaggttttgc tatgttgtcc
     4981 aggttggtct cgaactcctg gcctcaattg atccgcctgc cttggtcttt caaagtgcta
     5041 ggattatagg cacgagccac tgcacctggc ctcaaaaatc atttttaaaa gaagcagtat
     5101 attagctctg ggtcttctca tgactaaaat gactattttt aaacataaga ccatatttta
     5161 taaatgtaca gataattcaa atctattatc taatgtatta ggttaatttc tatttgttct
     5221 atactttttt tttttttttt ttttttgaga tggagtcttg ctctgttgcc caggctggag
     5281 tgcagtggtg caatcttggc tcactgcaag ctccgcctcc tgggttcatg ccattctcct
     5341 gcctcggcct tccaagtagc tgggactaca ggtgcccgcc ccgacacctg gctaattttt
     5401 aaaaaaatat ttttagtaga gacagggttt caccgtgtta gccaggatgg tctcgatctc
     5461 ctgacctcgt gatccgcccg ctttggcctc ccaaagtgct gggattacag gcgtgagcca
     5521 ccgcacccgg cctattgaca ttttttaagg tttcagattt tcttttgtgt gtctagtaat
     5581 tcgtctttta ttgtcaaaga taatttgctt atttgactta gaaaaatgat ttgtgggcat
     5641 acaatattgt atgtggtacc taaacgttgc catttagtta ctcttacaga acaactttca
     5701 ttacactgta tattaatata aattacttct tgagtaatcc cagaattgta gaaccaattg
     5761 gtagaatcag aaactgtctt tggacttgag gtttttcttc ccttagggta aattttaggt
     5821 tttctggtta gtttccagga gttggcggac aagttcatat cactaaaggt gttcatatca
     5881 ctaaaatagt aatgctaatt tgtttcatat ttctatttta aaaagcaatc aataaagaca
     5941 tttcaataca tttcatttgg aagcccccaa gtgtatggtg gttaataagg ctcagcatgc
     6001 tggtaaccca ccattctctt agctagtgac tccactaaat agtgctagcc gctgagatgg
     6061 ttttgaccct ttaacagcct tttttttttt ttgagacaga gtttcactct tgttatccag
     6121 gctggggtgc aatggtgcga tatctcggct cactgcaacc actgcctccc aggttcaagc
     6181 gattctcctg cctcagcctg ccaagtagct ggattacagg cacgtgccat cacgcccagc
     6241 taatttttgt atttttggta gagacggggt ttccccacgt tgaccaggct ggtctcgaac
     6301 tcctcacctc aagtgatcca cccgcctcgg cctcccaaag tgctgggatt acaggcgtga
     6361 gccaccgcga ctggcctaca cagcttttaa ttgcttgatt tatactttat taaagagagg
     6421 aagcacaatg agcagtgata ctaaaatata actaatatgg catgtgaaag tgatcattat
     6481 tcagatgatc ttcaccaaca ctgcatttgc atatatctga ccaaacttta tgcgacatag
     6541 gcaggtctct ggcacttcaa aaatgaatgt taaatagaaa ataataaata atagctgatt
     6601 agggtaatca tttatttaat cagaataaag attatatcca taaaatttac ttgcagagaa
     6661 gtactttctt tttgttttaa agacagggtc tcactctgtc acccaagcta tggtgcagtg
     6721 gcacaatcac agctcactgc agcctggacc tcctggcctc aaggggatga tcctcctact
     6781 tcaggaatta tgccaccatg cccggctagt tgagaagtac tttcaaatag caacatgaag
     6841 cctttccttt accatttgaa aataaaacat agttgtaaac ataaaccagt atgtctttgt
     6901 aaagccaata atatatcatt ttataggagc attgtcttct tgtgtttttc aagttgacta
     6961 tgtagttcaa tgtcagtctc cattttaata tcttgtttgt ttatcagcct gagcatattt
     7021 cattttaaaa tgtatttgtt gagaagtcat ggtggttttt tgtttttcac aagtcaagta
     7081 gcttgaacac tatcacttgt ccaatgggaa agttgatgct tatctttatg gcaaatgctt
     7141 ggttgaataa tatatttgca aagatgttaa ttctacagag agctaaataa agttaagata
     7201 cctgtaaaac agtttctcca gatgacttta aaataagcct tatttttgta aatttatgtt
     7261 aaattttagg tgttaagttg tgaaatacct aatgatgtgg gcctaaattt gcctcattca
     7321 gactgagaca gggctgttaa aattcatttc tagctaataa actgtgctat aacttcttta
     7381 ttattattat tattattatt attatagttt aagttctggg atacatgtgg agaacatgca
     7441 ggtttgttaa cataggtata cacgtgccat ggtggtttgc tgcacccatc aacccgtcat
     7501 ctacattagg tatttctcct aatgctatcc ctcccccagc cccccacccc ctgacaggcc
     7561 ccagtgtgtg atgttccctg ccctgtgtcc aagtgttttc tttgttcaat tcccacctat
     7621 gagtgagaac atgcgatgtt tggtaaactg tgctataact tctgtatctc tataggccaa
     7681 tccaaatggc ctgagaacat aatcagtatc ccctaatctg caaaaaggta aataccttag
     7741 tcttcagtac ctttccttcc agtattatct gcattatctg tgcccgcttg ctgtgatgtc
     7801 ttgaaaagcc cataaattgg ttcttatttt ggcaaatggt ctcctgcttt tcctcactga
     7861 ggcttataaa ctaaatttgc ctttggctaa gcgcagttac atgaaccaaa aagaacattt
     7921 tagacttggg aagcaacagg ctgagtcaca ttgtatgggg cagagttggc caagcccccg
     7981 gcagtcacag ccctactctc tgtgttcctt ctaggcctga ggacgcatca acacaaagct
     8041 ccaggcagtt gctcctggtt catcagagag cacaggaaat ttaaatctat ttgcctttcc
     8101 tgtcataaaa gaaacagcac actgactttc aaactcaatt gcattttgct tatttgtgct
     8161 taacaaaaaa tatgtgtgct ttgccaatac taacgtccca cttctctgca ctccctttct
     8221 gtataacagg gattgctttt gtatttgttt cttatagatg ctgatgatgt gccttattca
     8281 gattagttgg ccattaccag aataaagaat aaatctgaa
//
