LOCUS       XM_047447358            3703 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens DNA topoisomerase II binding protein 1
            (TOPBP1), transcript variant X6, mRNA.
ACCESSION   XM_047447358
VERSION     XM_047447358.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..3703
                     /gene="TOPBP1"
                     /gene_synonym="Dpb11; TOP2BP1"
                     /note="DNA topoisomerase II binding protein 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 52 ESTs, 364 long SRA reads, and 100% coverage
                     of the annotated genomic feature by RNAseq alignments,
                     including 41 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:11073"
                     /db_xref="HGNC:HGNC:17008"
                     /db_xref="MIM:607760"
     CDS             181..3546
                     /gene="TOPBP1"
                     /gene_synonym="Dpb11; TOP2BP1"
                     /codon_start=1
                     /product="DNA topoisomerase 2-binding protein 1 isoform
                     X6"
                     /protein_id="XP_047303314.1"
                     /db_xref="GeneID:11073"
                     /db_xref="HGNC:HGNC:17008"
                     /db_xref="MIM:607760"
                     /translation="MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITE
                     EEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVY
                     NMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAA
                     NLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEV
                     QQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFC
                     QDESIYKTEPRPEAKTMPNSSTPTSQINTIDNVSNISNINASCVSESICNSLNSKLEP
                     TLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVT
                     HVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVS
                     HKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFN
                     DSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNI
                     ANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPK
                     SNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKK
                     GMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEE
                     RSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVA
                     ASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPST
                     PLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKK
                     QSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDC
                     AQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEEND
                     VDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTS
                     LSRSGCNSASSTPDSTRSARSGRSRVLEALSCL"
ORIGIN      
        1 agtcggttcc cgttctgggc aatttccggg ttctccagcg tttgctttgg ggtaggggcg
       61 gcgccgagtc gggggagggg gctgtgcgcc gggctggcgc ccgaccccag ccaccgccct
      121 gcggccagcg cgtcccccga ctcgccgccc ggagaccccg aggctccaac gagttcagaa
      181 atgtccagaa atgacaaaga accgtttttt gtgaagtttt taaagtcttc agacaattcc
      241 aaatgttttt ttaaagctct cgagtccata aaagaattcc aatcagaaga atatcttcag
      301 attattacag aagaagaggc attgaagata aaggagaatg atagatcact ttatatctgt
      361 gaccctttta gtggcgttgt ctttgatcac ctcaaaaagc ttggctgcag aattgttggt
      421 cctcaagtag tcatattttg tatgcaccac cagcgatgtg tcccaagagc cgaacatcca
      481 gtttataata tggttatgtc tgatgtaacc atatcttgta caagtctgga aaaagaaaaa
      541 agggaagaag ttcataaata tgtacaaatg atgggcggac gagtatacag agaccttaat
      601 gtatcagtaa ctcaccttat tgcaggagaa gttggtagca aaaaatattt agttgctgca
      661 aacctgaaga aacctatttt gcttccctct tggataaaaa cactttggga gaagtcacaa
      721 gagaaaaaaa taactagata tactgatata aacatggaag atttcaagtg tcctattttt
      781 cttggttgca taatctgtgt gactggctta tgtggcttag acaggaaaga agttcagcaa
      841 ctcacagtta agcatggagg tcaatacatg ggacaattga aaatgaatga atgtacacac
      901 ctcattgtgc aagaaccaaa aggtcagaag tatgagtgtg ccaagagatg gaatgtacac
      961 tgtgtgacca cacagtggtt ttttgacagt attgagaaag gtttttgtca ggatgaatcc
     1021 atatacaaga cagaacctag accagaagca aagactatgc ccaattcttc aactcctacc
     1081 agccagatca acacaattga taatgtcagc aatatttcca acataaatgc aagttgcgta
     1141 agtgaatcaa tatgtaattc acttaacagc aaactggagc ctacacttga aaatctagaa
     1201 aatctggatg tcagtgcatt tcaagcacct gaagatttat tagatggttg tcggatatat
     1261 ctttgcggtt ttagtggcag aaagctagat aaactgagaa gacttattaa cagtggaggt
     1321 ggagttcgtt ttaaccagct aaatgaagat gtaactcatg ttattgtggg agattatgat
     1381 gatgaattga agcagttttg gaataaatca gcccacaggc ctcatgtagt gggagcaaag
     1441 tggttgctag agtgtttcag taaaggttat atgctttctg aagaaccata tatccatgct
     1501 aattaccagc cagtggaaat tccagtttca cataagcctg aaagtaaagc agctctttta
     1561 aaaaagaaga acagcagctt ctctaagaaa gactttgctc ctagtgaaaa gcatgagcaa
     1621 gctgatgaag atctgctctc tcaatatgaa aatggtagct ccacagtagt tgaggctaag
     1681 acgtctgaag ccaggccctt taatgattct actcatgctg agcccttgaa tgattctact
     1741 cacatttctt tgcaagaaga aaaccagtct tctgtcagtc attgtgtccc tgatgtttct
     1801 acaattactg aagaaggctt atttagccaa aagagtttcc ttgttttggg ttttagtaat
     1861 gaaaatgaat ctaacatcgc aaacatcata aaagaaaatg ctgggaaaat catgtccctt
     1921 ctgagcagaa ctgttgcgga ttatgctgtg gttcctctgc tggggtgtga agtggaagcc
     1981 actgtgggag aagttgttac aaatacatgg ctggttactt gcatagacta tcagactttg
     2041 tttgatccaa agtcgaatcc tctcttcaca ccagttccag taatgacagg aatgactcct
     2101 ttagaggatt gtgttatttc atttagccag tgtgctggag cagaaaaaga gtctttaaca
     2161 ttcctagcaa acctccttgg agcaagtgtt caagaatact ttgttcgcaa atccaatgca
     2221 aagaaaggca tgtttgccag tactcatctt atactgaaag aacgtggtgg ctctaaatat
     2281 gaagctgcaa agaagtggaa tttacctgcc gttactatag cttggctgtt ggagactgct
     2341 agaacgggaa agagagcaga cgaaagccat tttctgattg aaaattcaac taaagaagaa
     2401 cgaagtttgg aaacagaaat aacaaatgga atcaatctaa attcagatac tgcagagcat
     2461 cctggcacac gcctgcaaac tcacagaaaa accgtcgtta cacctttaga tatgaaccgc
     2521 tttcagagta aagctttccg tgctgtggtc tcacaacatg ccagacaggt cgcagcctcc
     2581 ccagcagtag gacaaccact tcagaaggag ccctcgttac acctggatac accatcaaaa
     2641 ttcctgtcca aggacaaact cttcaagcct tcctttgatg tgaaggatgc acttgcagcc
     2701 ttggaaactc caggacgtcc cagccaacag aaaaggaaac cgagtacgcc actctcagaa
     2761 gttattgtca aaaacttgca acttgctttg gcaaatagct ctcgaaatgc tgtcgctctt
     2821 tctgccagcc ctcaactgaa agaggcccag tcagagaagg aagaagcccc aaagccactt
     2881 cacaaagtag tggtatgtgt tagtaaaaaa ctcagtaaga agcagagtga actaaatggg
     2941 atcgcagcct ctctaggagc agattacagg tggagttttg atgaaacagt gactcatttc
     3001 atctatcaag ggcggccaaa tgacactaat cgggagtata aatctgtaaa agaaagagga
     3061 gtacacattg tttccgagca ctggctttta gattgtgccc aagagtgtaa acatcttcct
     3121 gaatctcttt atccacatac ttataatccc aaaatgagct tggatatcag cgcagtgcaa
     3181 gatggccggc tctgtaatag tcgactactc tcagctgtgt cttcaacaaa ggatgatgag
     3241 ccagatcctt tgattttaga agaaaatgat gtagacaata tggccaccaa taataaagag
     3301 tcagcaccat caaatggaag tggaaagaat gactctaaag gagttctgac acagacctta
     3361 gagatgagag agaactttca gaagcagtta caggagataa tgtctgcaac atcaatagtg
     3421 aaaccccaag ggcagaggac ttccctttca agaagtggtt gtaacagcgc atcttcaacc
     3481 cctgacagca ctcgctctgc tcgcagtgga cgaagtagag tcctagaggc actgagctgt
     3541 ctgtgatcct ggaaacatac gtgtgactga agctcccaaa cacccaatct ctgaagaact
     3601 ggaaactccc ataaaagaca gccacctgat ccctacgcct caagccccca gtattgcctt
     3661 tccactcgcc aacccccctg tggctccgca ccctagagaa aag
//
