LOCUS       XM_047436634            6155 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens DNA topoisomerase III alpha (TOP3A),
            transcript variant X2, mRNA.
ACCESSION   XM_047436634
VERSION     XM_047436634.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..6155
                     /gene="TOP3A"
                     /gene_synonym="MGRISCE2; PEOB5; TOP3; ZGRF7"
                     /note="DNA topoisomerase III alpha; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 29
                     ESTs, 407 long SRA reads, 2 Proteins, and 89% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 64 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:7156"
                     /db_xref="HGNC:HGNC:11992"
                     /db_xref="MIM:601243"
     CDS             697..2781
                     /gene="TOP3A"
                     /gene_synonym="MGRISCE2; PEOB5; TOP3; ZGRF7"
                     /codon_start=1
                     /product="DNA topoisomerase 3-alpha isoform X1"
                     /protein_id="XP_047292590.1"
                     /db_xref="GeneID:7156"
                     /db_xref="HGNC:HGNC:11992"
                     /db_xref="MIM:601243"
                     /translation="MATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIA
                     EKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNK
                     SDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVA
                     HGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIA
                     LMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPD
                     LRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTEL
                     AQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEAS
                     RDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPP
                     RASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNC
                     GQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGC
                     PPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCG
                     FFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQ
                     PGHTRPFCPQNR"
ORIGIN      
        1 agtttctgga catttactgg ctcatgattt ccagatgcag tttcgaaaat ggtcagtaca
       61 attctcaagg gaaggacttt cagattatag cagagctgca accctcttgt cctctttgaa
      121 gcagaaattg aaaagtactg cccagagaat tttgtagaca tcaagaaaac tttggaacga
      181 gagactcgcc agtgccaggc tctggtgatc tggactgact gtgatagaga aggcgaaaac
      241 atcgggtttg agattatcca cgtgtgtaag gctgtaaagc ccaatctgca ggtgttgcga
      301 gcccgattct ctgagatcac accccatgcc gtcaggacag cttgtgaaaa cctgaccgag
      361 cctgatcaga gggtgagcga tgctgtggat gtgaggcagg agctggacct gaggattgga
      421 gctgccttta ctaggttcca gaccctgcgg cttcagagga tttttcctga ggtgctggca
      481 gagcagctca tcagttacgg cagctgccag ttccccacac tgggctttgt ggtggagcgg
      541 ttcaaagcca ttcaggcttt tgtaccagaa atcttccaca gaattaaagt aactcatgac
      601 cacaaagatg gtatcgtaga attcaactgg aaaaggcatc gactctttaa ccacacggct
      661 tgcctagttc tctatcagtt gtgtgtggag gatcccatgg caactgtggt agaggtcaga
      721 tctaagccca agagcaagtg gcggcctcaa gccttggaca ctgtggagct tgagaagctg
      781 gcttctcgaa agttgagaat aaatgctaaa gaaaccatga ggattgctga gaagctctac
      841 actcaagggt acatcagcta tccccgaaca gaaacaaaca tttttcccag agacttaaac
      901 ctgacggtgt tggtggaaca gcagaccccc gatccacgct ggggggcctt tgcccagagc
      961 attctagagc ggggtggtcc caccccacgc aatgggaaca agtctgacca agctcaccct
     1021 cccattcacc ccaccaaata caccaacaac ttacagggag atgaacagcg actgtacgag
     1081 tttattgttc gccatttcct ggcttgctgc tcccaggatg ctcaggggca ggagaccaca
     1141 gtggagatcg acatcgctca ggaacgcttt gtggcccatg gcctcatgat tctggcccga
     1201 aactatctgg atgtgtatcc atatgatcac tggagtgaca agatcctccc tgtctatgag
     1261 caaggatccc actttcagcc cagcaccgtg gagatggtgg acggggagac cagcccaccc
     1321 aagctgctca ccgaggccga cctcattgcc ctcatggaga agcatggcat tggtacggat
     1381 gccactcatg cggagcacat cgagaccatc aaagcccgga tgtacgtggg cctcacccca
     1441 gacaagcggt tcctccctgg gcacctgggc atgggacttg tggaaggtta tgattccatg
     1501 ggctatgaaa tgtctaagcc tgacctccgg gctgaactgg aagctgatct gaagctgatc
     1561 tgtgatggca aaaaggacaa atttgtggtt ctaaggcagc aagtgcagaa atacaagcag
     1621 gttttcattg aagcggtggc taaagcaaag aaattggacg aggccttggc ccagtacttt
     1681 gggaatggga cagagttggc ccagcaagaa gatatctacc cagccatgcc agagcccatc
     1741 aggaagtgcc cacagtgcaa caaggacatg gtccttaaga ccaagaagaa tggcgggttc
     1801 tacctcagct gcatgggttt cccagagtgt cgctcagctg tgtggcttcc tgactcggtg
     1861 ctggaggcca gcagggacag cagtgtgtgt ccagtttgtc agccacaccc tgtgtacagg
     1921 ttaaagttaa agtttaagcg cggtagcctt cccccgacca tgcctctgga gtttgtttgc
     1981 tgcatcggcg gatgcgacga caccctgagg gagatcctgg acctgagatt ttcagggggc
     2041 ccccccaggg ctagccagcc ctctggccgc ctgcaggcta accagtccct gaacaggatg
     2101 gacaacagcc agcaccccca gcctgctgac agcagacaga ctgggtcctc aaaggctctg
     2161 gcccagaccc tcccaccacc cacggctgct ggtgaaagca attctgtgac ctgcaactgt
     2221 ggccaggagg ctgtgctgct cactgtccgt aaggagggcc ccaaccgggg ccggcagttc
     2281 tttaagtgca acggaggtag ctgcaacttc ttcctgtggg cagacagccc caatccggga
     2341 gcaggagggc ctcctgcctt ggcatataga cccctgggcg cctccctggg atgcccacca
     2401 ggcccaggga tccacctagg tgggtttggc aaccctggtg atggcagtgg tagtggcaca
     2461 tcctgccttt gcagccagcc ctccgtcaca cggactgtgc agaaggatgg acccaacaag
     2521 gggcgccagt tccacacatg tgccaagccg agagagcagc agtgtggctt tttccagtgg
     2581 gtcgatgaga acaccgctcc agggacttct ggagccccgt cctggacagg agacagagga
     2641 agaaccctgg agtcggaagc cagaagcaaa aggccccggg ccagttcctc agacatgggg
     2701 tccacagcaa agaaaccccg gaaatgcagc ctttgccacc agcctggaca cacccgtccc
     2761 ttttgtcctc agaacagatg agctcagggt agggtagaga acgccacttt ctcagacctg
     2821 tcccctttgt gtttagaaat gagttaacca ggaccaagtg gccatttagt gtcctggaaa
     2881 cttagaggac agtgttggcc tttggagtcg ggccttcttg tgttaagggg cacaaggtcc
     2941 agatcactct ggagcaggcc agctctgctg gacagtgacc ctcttcccag gcctcaggag
     3001 tgaccatagc cactgctgaa aagtcacgca gctgctccct cggacccccc aaggatggtt
     3061 gctgttagca gaggattggt gcagtcccag ctgaagccca ctgtgtgcca aaggaagaag
     3121 ctcccagggc tgcttccttc acctgcagaa agccccaagt gagccaccag cactcatggg
     3181 gcagtccctg tccaggctgc ccagggcttc tcatagacgt cctgagaagg acggtgtaat
     3241 gcaaggaaat ggctgtggta acactgatcc ttcagaagaa gcttcattcc ctcttaatct
     3301 agttaagcca ggacatccag aattcattgc tttaataaag aacccaggcc gggtgcagtg
     3361 gctcatgcct gtaatcccag cactttggga ggctgtgggg ggcggattgc ctgagctcag
     3421 gagttcgaga ccagccaggg caacatggtg aaaccctgtc tctactaaaa tacaaaaaat
     3481 tagccaggtg tggcggtgtg cgcctgtaga cccggctact caggaggctg aggcaggaga
     3541 attgcttgaa cccgggaggc ggaggttgca gttagctgag attgcgccac tggacgacag
     3601 agcgagactc agtctcaaaa aaaatttaaa aatttaaaaa aataaaaaga atccaacccc
     3661 ggcagggcgt ggaggctcac acctgtaatc cagcacttag ggaggccaag gctggaggat
     3721 tgcttgagat caggagttca agaccagcct gggcaacata gttagacctt gtctctattt
     3781 ttaaaaatat aacaagcaca gttgtacacg tctttagttc agctgctcag gaggctgaag
     3841 tgggaggatc ctttgaaccc aagagtttga ggctgcagca agccatgatc acaccactgc
     3901 actccagcct gggtgacaga gtaagaccct gtctcaaact ttttttaaaa tgaaagaatc
     3961 caaccttttt ttactctgac ctgcgagagt gcagagggtc tggggaacat ttgcagaagc
     4021 aacaggtacc agccagtgct ggaaggagct caccctggga ggtctcgtca gcctctgtcc
     4081 ttcatggctg tcccttgtgt cccatgtgga gagcccttcc tccctttcca catggtaagc
     4141 actgagccca atttcttctc accccacaga tggtccctca gagcagagat gtctaatgaa
     4201 aggttcagat tcagatcact aactttccat cttccacttt ttccagtggt ggccatgttc
     4261 ccccgtttgc cttcacaaaa accttgtgaa taatacaagc catatggact ctgatttaca
     4321 gtttagaaga tgagcagagg tgggtgtgag ttgcccagtc atgttgctag ttgttgaaga
     4381 aactaggatt gttctcaggt cttgggctcc tggcccatag accagtggct ctgtgttctg
     4441 atggggtatt ggggaggatt tttacaaatg caggttcctg agattgttcc tggaacatct
     4501 ccgagtgggt gtgggttgtg gccctgcgtg tgtgattttg cctatcccag ctccggggta
     4561 ccaccaacca ctttttgtct ctgtgggttt acctactctg gatattttgt ttaaatggaa
     4621 tcataccagg ctgggcacag tggctcacgc ctgtaatcct agcactttgg gaggccaagg
     4681 tgggcagatc acctgaggtc aggagttcga gaccagcctg accaatatga tgaaaccccg
     4741 tctctaaaaa aatacaaaaa ttagccgggc gtggtgtcag gcacctgtaa tcccagctac
     4801 tcaggaagca gaggttgcag tgagctgaga tcgggccatt gcactccagc ctgggcaaaa
     4861 agagtgaaac tctgtctcaa gaaaaaaaaa aaaatgaaat cctaccatac atgacatcct
     4921 gtgtctggtt tctttgactt ggctgatgtt tgtcaggctc atccacattg tagcatgtca
     4981 gtcctcgatg tttatgataa gctgatagcc cactgtatga atataccaca cgattatcca
     5041 tttgtcagtt gatggacatt gggttgtttc cactttttgg ctattgtgaa tagcactgtt
     5101 gtgaacattg gtgtatgagt gtctgatgac ttgttttcag ttattttggg catatgccga
     5161 ggaatggaat tgtagtttta taccataact ccatgttttg actttttgag gaacctacaa
     5221 attttccaca gtggatgcac cactttacac ccaccagcag cacaccaggg ttactgcttc
     5281 tccatatcct tgtgaacact tgttcctttc cttttcttgt attatagcca tcctagtgtt
     5341 ttgtcatcct agtgggtatg aagtggcgtg tcattgtggt tttgttttgc attttcctag
     5401 tcattaatga cattgaccat ctttccacag gcttactggc cattggtata cattctttgg
     5461 agaatgtcga tttaagttct tcacccattt tttatttttt attttttatt tttttttgag
     5521 atggagtttc gctcttgtgc ccaggctgga gtgcagtggt gcgatcttgg ctcactgcaa
     5581 cctctgcctc ctgggttcaa gcagttctcc tgcctcagcc tcccaagtag ctggaattac
     5641 aggcatctgc ctccacaccc agctaatttg tttagtattt ttagtaaaga cggggtttca
     5701 ccatgttggc caggctggtc tcaaactcgt gacctcaggt gatctaccag cctcggcctc
     5761 ccaaagtgct aggattaaca ggcaggagcc atcacacctg gtctcttccc ccatttttaa
     5821 attgtgttgt ctgtctttgt tgttgagttg taggagttct taatagtttc tggatatcag
     5881 atgcctttgt ggttttcaca tctctgcagg caactgtgtg tctcaaaagc aaactgcagg
     5941 attgggctgc accatggact gggccaggca tctgagatca gacagaccca ggctcagctc
     6001 ccacttcctg gcctcttctg ccaccctggg tgtgcagcct catccttgga gccccagttg
     6061 cctcatccgt aatggggtgt ccttgttcat attgaggctc tctagtgaag gcttacggtc
     6121 aggcacgact gcaaattaaa gcttcacaaa tcaaa
//
