LOCUS       XM_047421344            2413 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens DNA topoisomerase I mitochondrial (TOP1MT),
            transcript variant X15, mRNA.
ACCESSION   XM_047421344
VERSION     XM_047421344.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2413
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..2413
                     /gene="TOP1MT"
                     /note="DNA topoisomerase I mitochondrial; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 12 ESTs, 39 long SRA reads, 1 Protein, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 6 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:116447"
                     /db_xref="HGNC:HGNC:29787"
                     /db_xref="MIM:606387"
     CDS             442..2196
                     /gene="TOP1MT"
                     /codon_start=1
                     /product="DNA topoisomerase I, mitochondrial isoform X7"
                     /protein_id="XP_047277300.1"
                     /db_xref="GeneID:116447"
                     /db_xref="HGNC:HGNC:29787"
                     /db_xref="MIM:606387"
                     /translation="MLDHEYTTKEVFRKNFFNDWRKEMAVEEREVIKSLDKCDFTEIH
                     RYFVDKAAARKVLSREEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGR
                     GDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEVRSDNTVTWLAAWTESVQN
                     SIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALY
                     FIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYY
                     NRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASI
                     TLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAK
                     KEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENK
                     QVALGTSKLNYLDPRISIAWCVCLGSQFPPVAYGGPGFSRRPLFSPSIALVPCPLGSA
                     QALPVTGTHDAESCVISSPCPERSDGQGEVGVLTVAWDSEASGGPVELSLPTGSGRWL
                     SALLGGHLGHSRLSLTPR"
     polyA_site      2413
                     /gene="TOP1MT"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gaggggctgc tgtgggctgg acagcaggtg cttctgccgg tttctgcgtc ctggaagtgc
       61 tgctgtttgt aggggatgag gtagggggcc atctgagcct gtgtggtccc ttctccagag
      121 cagcagagcg tgtacttagg aaggacctgc taggtgcccc tgccctcaga ggctctggga
      181 gagagctgtg tgcaagccct gggcaggagt tcactggcct ggtcgtgtga cctgtggggc
      241 atcctgacag ccagccctgt gctgcagagg tgggagaagg agaagcacga agacggggtg
      301 aagtggagac agctggagca caagggcccg tacttcgcac ccccatacga gccccttccc
      361 gacggagtgc gtttcttcta tgaaggaagg cctgtgagat tgagcgtggc agcggaggag
      421 gtcgccactt tttatgggag gatgttagat catgaataca caacaaagga ggttttccgg
      481 aagaacttct tcaatgactg gcgaaaggaa atggcggtgg aagagaggga agtcatcaag
      541 agcctggaca agtgtgactt cacggagatc cacagatact ttgtggacaa ggccgcagcc
      601 cggaaagtcc tgagcaggga ggagaagcag aagctaaaag aagaggcaga aaaacttcag
      661 caagagttcg gctactgtat tttagatggt caccaagaaa aaataggcaa cttcaagatt
      721 gagccgcctg gcttgttccg tggccgtggc gaccatccca agatggggat gctgaagaga
      781 aggatcacgc cagaggatgt ggttatcaac tgcagcaggg actcgaagat ccccgagccg
      841 ccggcggggc accagtggaa ggaggtgcgc tccgataaca ccgtcacgtg gctggcagct
      901 tggaccgaga gcgttcagaa ctccatcaag tacatcatgc tgaacccttg ctcgaagctg
      961 aagggggaga cagcttggca gaagtttgaa acagctcgac gcctgcgggg atttgtggac
     1021 gagatccgct cccagtaccg ggctgactgg aagtctcggg aaatgaagac gagacagcgg
     1081 gcggtggccc tgtatttcat cgataagctg gcactgagag caggaaatga gaaggaggac
     1141 ggtgaggcgg ccgacaccgt gggctgctgt tccctccgcg tggagcacgt ccagctgcac
     1201 ccggaggccg atggctgcca acacgtggtg gaatttgact tcctggggaa ggactgcatc
     1261 cgctactaca acagagtgcc ggtggagaag ccggtgtaca agaacttaca gctctttatg
     1321 gagaacaagg acccccggga cgacctcttc gacaggctga ccacgaccag cctgaacaag
     1381 cacctccagg agctgatgga cgggctgacg gccaaggtgt tccggaccta caacgcctcc
     1441 atcactctgc aggagcagct gcgggccctg acgcgcgccg aggacagcat agcagctaag
     1501 atcttatcct acaaccgagc caaccgagtc gtggccattc tctgcaacca tcagcgagca
     1561 acccccagta cgttcgagaa gtcgatgcag aatctccaga cgaagatcca ggcaaagaag
     1621 gagcaggtgg ctgaggccag ggcagagctg aggagggcga gggctgagca caaagcccaa
     1681 ggggatggca agtccaggag tgtcctggag aagaagaggc ggctcctgga gaagctgcag
     1741 gagcagctgg cgcagctgag tgtgcaggcc acggacaagg aggagaacaa gcaggtggcc
     1801 ctgggcacgt ccaagctcaa ctacctggac cccaggatca gcattgcctg gtgcgtgtgc
     1861 ctggggtctc agttcccacc tgtggcctat ggggggcctg ggttttccag gaggcctctg
     1921 ttcagtccca gcattgccct tgtcccgtgt cccctggggt cagcacaggc cctccctgtg
     1981 acagggaccc atgatgctga gtcctgtgtc atcagctctc cctgccctga acgttcggat
     2041 ggacagggtg aagtgggggt gctgacagtg gcctgggact cggaggcatc aggagggcct
     2101 gtggagctca gcctgcccac agggagtggg aggtggctga gcgccctgct cggtggacac
     2161 ctaggccaca gcaggttgtc tttgacacct cgctgatgct ccagggtggc ggcatgcgtg
     2221 gggtggggtt ggcctagagg agcaggtccc agctacacca ggcggctctg gtgtctctgc
     2281 tgcatggagg acgctcgccc ttgccgagca ccctgacctg gccttcaagg tgggtgagtt
     2341 gcctgcttgc ctgggctgat gctgcctccc gcaggtgcaa gcggttcagg gtgccagtgg
     2401 agaagatcta cag
//
