LOCUS       XM_047421341            2321 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens DNA topoisomerase I mitochondrial (TOP1MT),
            transcript variant X12, mRNA.
ACCESSION   XM_047421341
VERSION     XM_047421341.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..2321
                     /gene="TOP1MT"
                     /note="DNA topoisomerase I mitochondrial; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 12 ESTs, 39 long SRA reads, 1 Protein, and 99%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 69 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:116447"
                     /db_xref="HGNC:HGNC:29787"
                     /db_xref="MIM:606387"
     CDS             350..2104
                     /gene="TOP1MT"
                     /codon_start=1
                     /product="DNA topoisomerase I, mitochondrial isoform X7"
                     /protein_id="XP_047277297.1"
                     /db_xref="GeneID:116447"
                     /db_xref="HGNC:HGNC:29787"
                     /db_xref="MIM:606387"
                     /translation="MLDHEYTTKEVFRKNFFNDWRKEMAVEEREVIKSLDKCDFTEIH
                     RYFVDKAAARKVLSREEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGR
                     GDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEVRSDNTVTWLAAWTESVQN
                     SIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALY
                     FIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYY
                     NRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASI
                     TLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAK
                     KEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENK
                     QVALGTSKLNYLDPRISIAWCVCLGSQFPPVAYGGPGFSRRPLFSPSIALVPCPLGSA
                     QALPVTGTHDAESCVISSPCPERSDGQGEVGVLTVAWDSEASGGPVELSLPTGSGRWL
                     SALLGGHLGHSRLSLTPR"
     polyA_site      2321
                     /gene="TOP1MT"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 cacaagccgc atggatccag tggccctggt ggccgttggt ggtcccaggc gctttcctgg
       61 aggacatgtg agaagccctg ccggcgcata ctgggcctgg ggtagccgca tggggatggg
      121 tctctgcgca tgaaatgctg gagtttccga agagctggag agttgacagc ctcactggtg
      181 ggagaaggag aagcacgaag acggggtgaa gtggagacag ctggagcaca agggcccgta
      241 cttcgcaccc ccatacgagc cccttcccga cggagtgcgt ttcttctatg aaggaaggcc
      301 tgtgagattg agcgtggcag cggaggaggt cgccactttt tatgggagga tgttagatca
      361 tgaatacaca acaaaggagg ttttccggaa gaacttcttc aatgactggc gaaaggaaat
      421 ggcggtggaa gagagggaag tcatcaagag cctggacaag tgtgacttca cggagatcca
      481 cagatacttt gtggacaagg ccgcagcccg gaaagtcctg agcagggagg agaagcagaa
      541 gctaaaagaa gaggcagaaa aacttcagca agagttcggc tactgtattt tagatggtca
      601 ccaagaaaaa ataggcaact tcaagattga gccgcctggc ttgttccgtg gccgtggcga
      661 ccatcccaag atggggatgc tgaagagaag gatcacgcca gaggatgtgg ttatcaactg
      721 cagcagggac tcgaagatcc ccgagccgcc ggcggggcac cagtggaagg aggtgcgctc
      781 cgataacacc gtcacgtggc tggcagcttg gaccgagagc gttcagaact ccatcaagta
      841 catcatgctg aacccttgct cgaagctgaa gggggagaca gcttggcaga agtttgaaac
      901 agctcgacgc ctgcggggat ttgtggacga gatccgctcc cagtaccggg ctgactggaa
      961 gtctcgggaa atgaagacga gacagcgggc ggtggccctg tatttcatcg ataagctggc
     1021 actgagagca ggaaatgaga aggaggacgg tgaggcggcc gacaccgtgg gctgctgttc
     1081 cctccgcgtg gagcacgtcc agctgcaccc ggaggccgat ggctgccaac acgtggtgga
     1141 atttgacttc ctggggaagg actgcatccg ctactacaac agagtgccgg tggagaagcc
     1201 ggtgtacaag aacttacagc tctttatgga gaacaaggac ccccgggacg acctcttcga
     1261 caggctgacc acgaccagcc tgaacaagca cctccaggag ctgatggacg ggctgacggc
     1321 caaggtgttc cggacctaca acgcctccat cactctgcag gagcagctgc gggccctgac
     1381 gcgcgccgag gacagcatag cagctaagat cttatcctac aaccgagcca accgagtcgt
     1441 ggccattctc tgcaaccatc agcgagcaac ccccagtacg ttcgagaagt cgatgcagaa
     1501 tctccagacg aagatccagg caaagaagga gcaggtggct gaggccaggg cagagctgag
     1561 gagggcgagg gctgagcaca aagcccaagg ggatggcaag tccaggagtg tcctggagaa
     1621 gaagaggcgg ctcctggaga agctgcagga gcagctggcg cagctgagtg tgcaggccac
     1681 ggacaaggag gagaacaagc aggtggccct gggcacgtcc aagctcaact acctggaccc
     1741 caggatcagc attgcctggt gcgtgtgcct ggggtctcag ttcccacctg tggcctatgg
     1801 ggggcctggg ttttccagga ggcctctgtt cagtcccagc attgcccttg tcccgtgtcc
     1861 cctggggtca gcacaggccc tccctgtgac agggacccat gatgctgagt cctgtgtcat
     1921 cagctctccc tgccctgaac gttcggatgg acagggtgaa gtgggggtgc tgacagtggc
     1981 ctgggactcg gaggcatcag gagggcctgt ggagctcagc ctgcccacag ggagtgggag
     2041 gtggctgagc gccctgctcg gtggacacct aggccacagc aggttgtctt tgacacctcg
     2101 ctgatgctcc agggtggcgg catgcgtggg gtggggttgg cctagaggag caggtcccag
     2161 ctacaccagg cggctctggt gtctctgctg catggaggac gctcgccctt gccgagcacc
     2221 ctgacctggc cttcaaggtg ggtgagttgc ctgcttgcct gggctgatgc tgcctcccgc
     2281 aggtgcaagc ggttcagggt gccagtggag aagatctaca g
//
