LOCUS       XM_047421340            2528 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens DNA topoisomerase I mitochondrial (TOP1MT),
            transcript variant X11, mRNA.
ACCESSION   XM_047421340
VERSION     XM_047421340.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..2528
                     /gene="TOP1MT"
                     /note="DNA topoisomerase I mitochondrial; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 13 ESTs, 39 long SRA reads, 1 Protein, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 6 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:116447"
                     /db_xref="HGNC:HGNC:29787"
                     /db_xref="MIM:606387"
     CDS             557..2311
                     /gene="TOP1MT"
                     /codon_start=1
                     /product="DNA topoisomerase I, mitochondrial isoform X7"
                     /protein_id="XP_047277296.1"
                     /db_xref="GeneID:116447"
                     /db_xref="HGNC:HGNC:29787"
                     /db_xref="MIM:606387"
                     /translation="MLDHEYTTKEVFRKNFFNDWRKEMAVEEREVIKSLDKCDFTEIH
                     RYFVDKAAARKVLSREEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGR
                     GDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEVRSDNTVTWLAAWTESVQN
                     SIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALY
                     FIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYY
                     NRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASI
                     TLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAK
                     KEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENK
                     QVALGTSKLNYLDPRISIAWCVCLGSQFPPVAYGGPGFSRRPLFSPSIALVPCPLGSA
                     QALPVTGTHDAESCVISSPCPERSDGQGEVGVLTVAWDSEASGGPVELSLPTGSGRWL
                     SALLGGHLGHSRLSLTPR"
     polyA_site      2528
                     /gene="TOP1MT"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gaggggctgc tgtgggctgg acagcaggtg cttctgccgg tttctgcgtc ctggaagtgc
       61 tgctgtttgt aggggatgag gtagggggcc atctgagcct gtgtggtccc ttctccagag
      121 cagcagagcg tgtacttagg aaggacctgc taggtgcccc tgccctcaga ggctctggga
      181 gagagctgtg tgcaagccct gggcaggagt tcactggcct ggtcgtgtga cctgtggggc
      241 atcctgacag ccagccctgt gctgcagaga cccttcagag acttcctgtt gctctgagga
      301 cactcatccc agccgaccag gcccaccagg cccccaacag cactacctgg ctggggtcac
      361 gtgcaggtct cctggctctg gcaggtggga gaaggagaag cacgaagacg gggtgaagtg
      421 gagacagctg gagcacaagg gcccgtactt cgcaccccca tacgagcccc ttcccgacgg
      481 agtgcgtttc ttctatgaag gaaggcctgt gagattgagc gtggcagcgg aggaggtcgc
      541 cactttttat gggaggatgt tagatcatga atacacaaca aaggaggttt tccggaagaa
      601 cttcttcaat gactggcgaa aggaaatggc ggtggaagag agggaagtca tcaagagcct
      661 ggacaagtgt gacttcacgg agatccacag atactttgtg gacaaggccg cagcccggaa
      721 agtcctgagc agggaggaga agcagaagct aaaagaagag gcagaaaaac ttcagcaaga
      781 gttcggctac tgtattttag atggtcacca agaaaaaata ggcaacttca agattgagcc
      841 gcctggcttg ttccgtggcc gtggcgacca tcccaagatg gggatgctga agagaaggat
      901 cacgccagag gatgtggtta tcaactgcag cagggactcg aagatccccg agccgccggc
      961 ggggcaccag tggaaggagg tgcgctccga taacaccgtc acgtggctgg cagcttggac
     1021 cgagagcgtt cagaactcca tcaagtacat catgctgaac ccttgctcga agctgaaggg
     1081 ggagacagct tggcagaagt ttgaaacagc tcgacgcctg cggggatttg tggacgagat
     1141 ccgctcccag taccgggctg actggaagtc tcgggaaatg aagacgagac agcgggcggt
     1201 ggccctgtat ttcatcgata agctggcact gagagcagga aatgagaagg aggacggtga
     1261 ggcggccgac accgtgggct gctgttccct ccgcgtggag cacgtccagc tgcacccgga
     1321 ggccgatggc tgccaacacg tggtggaatt tgacttcctg gggaaggact gcatccgcta
     1381 ctacaacaga gtgccggtgg agaagccggt gtacaagaac ttacagctct ttatggagaa
     1441 caaggacccc cgggacgacc tcttcgacag gctgaccacg accagcctga acaagcacct
     1501 ccaggagctg atggacgggc tgacggccaa ggtgttccgg acctacaacg cctccatcac
     1561 tctgcaggag cagctgcggg ccctgacgcg cgccgaggac agcatagcag ctaagatctt
     1621 atcctacaac cgagccaacc gagtcgtggc cattctctgc aaccatcagc gagcaacccc
     1681 cagtacgttc gagaagtcga tgcagaatct ccagacgaag atccaggcaa agaaggagca
     1741 ggtggctgag gccagggcag agctgaggag ggcgagggct gagcacaaag cccaagggga
     1801 tggcaagtcc aggagtgtcc tggagaagaa gaggcggctc ctggagaagc tgcaggagca
     1861 gctggcgcag ctgagtgtgc aggccacgga caaggaggag aacaagcagg tggccctggg
     1921 cacgtccaag ctcaactacc tggaccccag gatcagcatt gcctggtgcg tgtgcctggg
     1981 gtctcagttc ccacctgtgg cctatggggg gcctgggttt tccaggaggc ctctgttcag
     2041 tcccagcatt gcccttgtcc cgtgtcccct ggggtcagca caggccctcc ctgtgacagg
     2101 gacccatgat gctgagtcct gtgtcatcag ctctccctgc cctgaacgtt cggatggaca
     2161 gggtgaagtg ggggtgctga cagtggcctg ggactcggag gcatcaggag ggcctgtgga
     2221 gctcagcctg cccacaggga gtgggaggtg gctgagcgcc ctgctcggtg gacacctagg
     2281 ccacagcagg ttgtctttga cacctcgctg atgctccagg gtggcggcat gcgtggggtg
     2341 gggttggcct agaggagcag gtcccagcta caccaggcgg ctctggtgtc tctgctgcat
     2401 ggaggacgct cgcccttgcc gagcaccctg acctggcctt caaggtgggt gagttgcctg
     2461 cttgcctggg ctgatgctgc ctcccgcagg tgcaagcggt tcagggtgcc agtggagaag
     2521 atctacag
//
