LOCUS       XM_047421330            2503 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens DNA topoisomerase I mitochondrial (TOP1MT),
            transcript variant X1, mRNA.
ACCESSION   XM_047421330
VERSION     XM_047421330.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..2503
                     /gene="TOP1MT"
                     /note="DNA topoisomerase I mitochondrial; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 13 ESTs, 39 long SRA reads, 1 Protein, and 99%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 7 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:116447"
                     /db_xref="HGNC:HGNC:29787"
                     /db_xref="MIM:606387"
     CDS             118..2286
                     /gene="TOP1MT"
                     /codon_start=1
                     /product="DNA topoisomerase I, mitochondrial isoform X1"
                     /protein_id="XP_047277286.1"
                     /db_xref="GeneID:116447"
                     /db_xref="HGNC:HGNC:29787"
                     /db_xref="MIM:606387"
                     /translation="MRFAPGPFFPELAFSLPFSSPGVVTCLPSPGSLCWQPPCNTSDP
                     SETSCCSEDTHPSRPGPPGPQQHYLAGVTCRSPGSGRWEKEKHEDGVKWRQLEHKGPY
                     FAPPYEPLPDGVRFFYEGRPVRLSVAAEEVATFYGRMLDHEYTTKEVFRKNFFNDWRK
                     EMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQKLKEEAEKLQQEFGYCI
                     LDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQ
                     WKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIR
                     SQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHP
                     EADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLN
                     KHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNH
                     QRATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRL
                     LEKLQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCVCLGSQFPPVAYGGP
                     GFSRRPLFSPSIALVPCPLGSAQALPVTGTHDAESCVISSPCPERSDGQGEVGVLTVA
                     WDSEASGGPVELSLPTGSGRWLSALLGGHLGHSRLSLTPR"
     polyA_site      2503
                     /gene="TOP1MT"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gctcgggcct tcccggcgtc tccgcgcagg cctcggggaa gcggggtccg ggggagccgt
       61 ggtgcggtgg gaccgcgtgg gtcctggaag agctgcagag gagagtgacg gctttggatg
      121 cgctttgccc cagggccttt cttcccggag ttggcctttt ccctgccctt ctcttctcct
      181 ggcgtggtga cctgcctccc ttctcctgga tcgctttgct ggcagccacc ttgtaacacc
      241 tcagaccctt cagagacttc ctgttgctct gaggacactc atcccagccg accaggccca
      301 ccaggccccc aacagcacta cctggctggg gtcacgtgca ggtctcctgg ctctggcagg
      361 tgggagaagg agaagcacga agacggggtg aagtggagac agctggagca caagggcccg
      421 tacttcgcac ccccatacga gccccttccc gacggagtgc gtttcttcta tgaaggaagg
      481 cctgtgagat tgagcgtggc agcggaggag gtcgccactt tttatgggag gatgttagat
      541 catgaataca caacaaagga ggttttccgg aagaacttct tcaatgactg gcgaaaggaa
      601 atggcggtgg aagagaggga agtcatcaag agcctggaca agtgtgactt cacggagatc
      661 cacagatact ttgtggacaa ggccgcagcc cggaaagtcc tgagcaggga ggagaagcag
      721 aagctaaaag aagaggcaga aaaacttcag caagagttcg gctactgtat tttagatggt
      781 caccaagaaa aaataggcaa cttcaagatt gagccgcctg gcttgttccg tggccgtggc
      841 gaccatccca agatggggat gctgaagaga aggatcacgc cagaggatgt ggttatcaac
      901 tgcagcaggg actcgaagat ccccgagccg ccggcggggc accagtggaa ggaggtgcgc
      961 tccgataaca ccgtcacgtg gctggcagct tggaccgaga gcgttcagaa ctccatcaag
     1021 tacatcatgc tgaacccttg ctcgaagctg aagggggaga cagcttggca gaagtttgaa
     1081 acagctcgac gcctgcgggg atttgtggac gagatccgct cccagtaccg ggctgactgg
     1141 aagtctcggg aaatgaagac gagacagcgg gcggtggccc tgtatttcat cgataagctg
     1201 gcactgagag caggaaatga gaaggaggac ggtgaggcgg ccgacaccgt gggctgctgt
     1261 tccctccgcg tggagcacgt ccagctgcac ccggaggccg atggctgcca acacgtggtg
     1321 gaatttgact tcctggggaa ggactgcatc cgctactaca acagagtgcc ggtggagaag
     1381 ccggtgtaca agaacttaca gctctttatg gagaacaagg acccccggga cgacctcttc
     1441 gacaggctga ccacgaccag cctgaacaag cacctccagg agctgatgga cgggctgacg
     1501 gccaaggtgt tccggaccta caacgcctcc atcactctgc aggagcagct gcgggccctg
     1561 acgcgcgccg aggacagcat agcagctaag atcttatcct acaaccgagc caaccgagtc
     1621 gtggccattc tctgcaacca tcagcgagca acccccagta cgttcgagaa gtcgatgcag
     1681 aatctccaga cgaagatcca ggcaaagaag gagcaggtgg ctgaggccag ggcagagctg
     1741 aggagggcga gggctgagca caaagcccaa ggggatggca agtccaggag tgtcctggag
     1801 aagaagaggc ggctcctgga gaagctgcag gagcagctgg cgcagctgag tgtgcaggcc
     1861 acggacaagg aggagaacaa gcaggtggcc ctgggcacgt ccaagctcaa ctacctggac
     1921 cccaggatca gcattgcctg gtgcgtgtgc ctggggtctc agttcccacc tgtggcctat
     1981 ggggggcctg ggttttccag gaggcctctg ttcagtccca gcattgccct tgtcccgtgt
     2041 cccctggggt cagcacaggc cctccctgtg acagggaccc atgatgctga gtcctgtgtc
     2101 atcagctctc cctgccctga acgttcggat ggacagggtg aagtgggggt gctgacagtg
     2161 gcctgggact cggaggcatc aggagggcct gtggagctca gcctgcccac agggagtggg
     2221 aggtggctga gcgccctgct cggtggacac ctaggccaca gcaggttgtc tttgacacct
     2281 cgctgatgct ccagggtggc ggcatgcgtg gggtggggtt ggcctagagg agcaggtccc
     2341 agctacacca ggcggctctg gtgtctctgc tgcatggagg acgctcgccc ttgccgagca
     2401 ccctgacctg gccttcaagg tgggtgagtt gcctgcttgc ctgggctgat gctgcctccc
     2461 gcaggtgcaa gcggttcagg gtgccagtgg agaagatcta cag
//
