LOCUS       NM_014820               4100 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens translocase of outer mitochondrial membrane 70
            (TOMM70), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_014820
VERSION     NM_014820.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4100)
  AUTHORS   Lenhard,S., Gerlich,S., Khan,A., Rodl,S., Bokenkamp,J.E., Peker,E.,
            Zarges,C., Faust,J., Storchova,Z., Raschle,M., Riemer,J. and
            Herrmann,J.M.
  TITLE     The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein
            biogenesis
  JOURNAL   J Cell Biol 222 (10) (2023)
   PUBMED   37682539
  REMARK    GeneRIF: The Orf9b protein of SARS-CoV-2 modulates mitochondrial
            protein biogenesis.
REFERENCE   2  (bases 1 to 4100)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   3  (bases 1 to 4100)
  AUTHORS   Maruszczak,K.K., Jung,M., Rasool,S., Trempe,J.F. and Rapaport,D.
  TITLE     The role of the individual TOM subunits in the association of PINK1
            with depolarized mitochondria
  JOURNAL   J Mol Med (Berl) 100 (5), 747-762 (2022)
   PUBMED   35391620
REFERENCE   4  (bases 1 to 4100)
  AUTHORS   Li,X., Straub,J., Medeiros,T.C., Mehra,C., den Brave,F., Peker,E.,
            Atanassov,I., Stillger,K., Michaelis,J.B., Burbridge,E., Adrain,C.,
            Munch,C., Riemer,J., Becker,T. and Pernas,L.F.
  TITLE     Mitochondria shed their outer membrane in response to
            infection-induced stress
  JOURNAL   Science 375 (6577), eabi4343 (2022)
   PUBMED   35025629
  REMARK    GeneRIF: Mitochondria shed their outer membrane in response to
            infection-induced stress.
REFERENCE   5  (bases 1 to 4100)
  AUTHORS   Fan,A.C., Bhangoo,M.K. and Young,J.C.
  TITLE     Hsp90 functions in the targeting and outer membrane translocation
            steps of Tom70-mediated mitochondrial import
  JOURNAL   J Biol Chem 281 (44), 33313-33324 (2006)
   PUBMED   16968702
  REMARK    GeneRIF: suggests a novel active role for Hsp90 in import steps
            subsequent to Tom70 targeting.
REFERENCE   6  (bases 1 to 4100)
  AUTHORS   Chou,C.H., Lee,R.S. and Yang-Yen,H.F.
  TITLE     An internal EELD domain facilitates mitochondrial targeting of
            Mcl-1 via a Tom70-dependent pathway
  JOURNAL   Mol Biol Cell 17 (9), 3952-3963 (2006)
   PUBMED   16822835
  REMARK    GeneRIF: The internal EELD domain facilitates mitochondrial
            targeting of Mcl-1 via a Tom70-dependent pathway.
REFERENCE   7  (bases 1 to 4100)
  AUTHORS   Humphries,A.D., Streimann,I.C., Stojanovski,D., Johnston,A.J.,
            Yano,M., Hoogenraad,N.J. and Ryan,M.T.
  TITLE     Dissection of the mitochondrial import and assembly pathway for
            human Tom40
  JOURNAL   J Biol Chem 280 (12), 11535-11543 (2005)
   PUBMED   15644312
REFERENCE   8  (bases 1 to 4100)
  AUTHORS   Young,J.C., Hoogenraad,N.J. and Hartl,F.U.
  TITLE     Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the
            mitochondrial import receptor Tom70
  JOURNAL   Cell 112 (1), 41-50 (2003)
   PUBMED   12526792
REFERENCE   9  (bases 1 to 4100)
  AUTHORS   Edmonson,A.M., Mayfield,D.K., Vervoort,V., DuPont,B.R. and
            Argyropoulos,G.
  TITLE     Characterization of a human import component of the mitochondrial
            outer membrane, TOMM70A
  JOURNAL   Cell Commun Adhes 9 (1), 15-27 (2002)
   PUBMED   12200962
  REMARK    GeneRIF: TOMM70A is ubiquitously expressed in human tissues, maps
            on chromosome 3q13.1-q13.2 and consists of 12 coding exons spanning
            over 37 kb.
REFERENCE   10 (bases 1 to 4100)
  AUTHORS   Alvarez-Dolado,M., Gonzalez-Moreno,M., Valencia,A., Zenke,M.,
            Bernal,J. and Munoz,A.
  TITLE     Identification of a mammalian homologue of the fungal Tom70
            mitochondrial precursor protein import receptor as a thyroid
            hormone-regulated gene in specific brain regions
  JOURNAL   J Neurochem 73 (6), 2240-2249 (1999)
   PUBMED   10582581
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC065555.1, AB018262.1,
            AW044465.1 and AC093003.11.
            
            On May 17, 2019 this sequence version replaced NM_014820.4.
            
            Summary: This gene encodes an import receptor of the outer
            mitochondrial membrane that is part of the translocase of the outer
            membrane complex. This protein is involved in the import of
            mitochondrial precursor proteins. The protein interacts with the
            SARS-CoV and SARS-Cov-2 ORF9b proteins. [provided by RefSeq, Dec
            2021].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018262.1, BC065555.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related                :: involved in SARS-CoV-2
                                                  infection
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000284320.6/
                                                  ENSP00000284320.5
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BC065555.1         310-358
            50-4066             AB018262.1         1-4017
            4067-4072           AW044465.1         4-9                 c
            4073-4100           AC093003.11        67385-67412
FEATURES             Location/Qualifiers
     source          1..4100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.2"
     gene            1..4100
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /note="translocase of outer mitochondrial membrane 70"
                     /db_xref="GeneID:9868"
                     /db_xref="HGNC:HGNC:11985"
                     /db_xref="MIM:606081"
     exon            1..464
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1967
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /note="translocase of outer membrane 70 kDa subunit;
                     mitochondrial precursor proteins import receptor;
                     translocase of outer mitochondrial membrane 70 homolog A;
                     translocase of outer mitochondrial membrane protein 70"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM70"
                     /protein_id="NP_055635.3"
                     /db_xref="CCDS:CCDS33807.1"
                     /db_xref="GeneID:9868"
                     /db_xref="HGNC:HGNC:11985"
                     /db_xref="MIM:606081"
                     /translation="MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALA
                     VGAPLLLGAGAIYLWSRQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGP
                     GAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRA
                     AAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEG
                     FQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKG
                     EKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLL
                     RATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNM
                     AADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAY
                     TGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPD
                     NATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAID
                     MFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL"
     exon            465..638
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /inference="alignment:Splign:2.1.0"
     exon            639..765
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /inference="alignment:Splign:2.1.0"
     exon            766..875
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1024
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1232
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1367
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1475
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1592
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1690
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1813
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..4100
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2257
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
     regulatory      4051..4056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /note="hexamer: AATAAA"
     polyA_site      4068
                     /gene="TOMM70"
                     /gene_synonym="Tom70; TOMM70A"
                     /note="major polyA site"
ORIGIN      
        1 cttttctgtc gtccgctctc tctgcctagc gtgctcgctc gctcattgct ttccttccct
       61 ccctcggtct tccttcgcac gctgtttggt gattgtggcg ctcgcgacag acagggaggc
      121 ggtggcagag gacacttgtc atggccgcct ctaaacctgt ggaggcagcg gtggtcgcag
      181 ccgctgtacc gagctccggg agtggggtgg gcggcggcgg gactgcgggc ccgggcacgg
      241 gggggctgcc gcgatggcag ctggctctgg cggtcggggc acccctgctg ctgggcgcgg
      301 gtgccatata cctgtggagt cggcagcaac ggcgccggga ggccagaggc cggggcgacg
      361 ccagcggcct gaagcgcaac agcgaacgga agaccccgga gggcagggcc agtccggccc
      421 cgggcagcgg acaccctgaa ggtcccggtg ctcacttgga catgaactct cttgatagag
      481 cccaagcagc caagaataaa ggcaataaat attttaaagc aggaaaatat gaacaagcta
      541 ttcagtgcta tactgaggct attagcttgt gccctacaga gaagaatgtt gacctttcta
      601 cattttatca aaacagagct gctgcctttg aacagttgca aaaatggaaa gaagtggcac
      661 aagactgtac aaaagctgtt gaacttaatc ccaaatatgt gaaagctctc tttagacgtg
      721 caaaagccca tgagaagcta gacaataaga aggaatgttt agaagatgtc actgctgtgt
      781 gtatattaga agggttccaa aatcaacaaa gcatgctgtt agccgataaa gttcttaaac
      841 tccttggaaa agagaaagcc aaagaaaaat ataagaatcg tgaacctctg atgccatctc
      901 cacagtttat caaatcttac ttcagttctt tcacggatga tatcatttcc cagcccatgc
      961 ttaaaggaga gaaatctgat gaagataaag acaaggaagg ggaggcttta gaagtgaaag
     1021 aaaattctgg atacttaaag gccaaacagt atatggaaga agaaaactac gataaaatca
     1081 taagtgaatg ctcaaaagaa atagatgctg aaggcaaata catggcagaa gcattgctac
     1141 tacgagctac cttctacctg cttattggca atgccaatgc agccaaacca gatttagata
     1201 aagtcatcag tttgaaagaa gctaatgtga agcttcgagc aaatgctctc atcaaaagag
     1261 gcagcatgta catgcaacag cagcagcctt tgctgtccac tcaagatttt aacatggctg
     1321 ctgacatcga tcctcagaat gcagatgttt atcaccaccg aggacagctg aaaatactcc
     1381 ttgatcaagt tgaagaagca gtggcagatt ttgatgaatg tattaggtta agacctgagt
     1441 ctgctctggc acaagcacag aaatgttttg cattgtaccg ccaggcatat acgggaaaca
     1501 actcttcaca aatccaagca gctatgaaag gttttgaaga ggtcataaag aaatttccaa
     1561 ggtgtgccga aggctatgca ctatacgccc aggcattaac agatcaacaa cagtttggta
     1621 aagctgatga aatgtatgat aaatgtattg atttggaacc agataatgct acaacatatg
     1681 ttcataaagg tttacttcaa cttcagtgga agcaagatct ggatagaggt ttggaactta
     1741 tcagcaaggc tattgaaatt gacaataaat gtgattttgc ctatgaaacc atgggaacta
     1801 ttgaagtaca aagaggaaac atggagaaag ccattgacat gttcaacaaa gctattaacc
     1861 tggccaaatc ggaaatggag atggcccatc tgtattcact ttgcgatgcc gcccatgccc
     1921 agacagaagt tgcaaagaaa tacggattaa aaccaccaac attataaaac agggggaaag
     1981 cagactgacc ctctttttaa aagtttaccc cctcttcaac tgaaccctaa agacactgtc
     2041 atgaactgtg ttgaatggtg gaaatcagta tttctgtttg tggtgttgtt atttgttaca
     2101 tctgtttcat gtctaggtgt tgtgggtgtg gctgttgaag gaagtttgca gtcttgcagc
     2161 ttttattccc tgtgcaacaa aagattagaa catgttaaag ggatttttaa ataaagttgc
     2221 aaagagtaca aatgataatt ggccatgcaa ataaaaactg atttgttgat ttttttttta
     2281 aggggggttg gcagttgatt atgttctgga tgattccgtc tatatatgtg tgaataatgt
     2341 aagtatttta cagcatgttg atttttaaat taacgtagta aatgctgtaa aatagattta
     2401 tattcagtta accgctttca gttgattttt tgaaagaaac aaaggttaaa tgggggatta
     2461 aagtaaaatt gagagaccct ttaaaccatt gtcagcatgc acaatgcctc tgattctgca
     2521 gttttagaaa cttggtggca cttattaatc ctcttggccc ctttccactc taatggatag
     2581 tgtacattct tcttaaagtc cacaacagca gattttcttg cagtaaatta tgcagatgca
     2641 aaatattcta attgatatat gtgttggaag actgagtatt gatgggggag tggaccagac
     2701 aaagaggtaa gatgaaacag tagtgtgttt ataattgtct gtgactattt tctataataa
     2761 ttagtactat ttaatggtga gcttttaaaa atgtaggata gagggtacag tggcactgta
     2821 tatactattt atagtctcag ctactaggga ggctgaggca agaggcttga gaccaggagc
     2881 tcgaggctgt aatgtgccat gatgattgca cctgcgaata gccactgcac tccagcctgg
     2941 gcaatatagc aagaccccat cctttaaaaa attttagaac ttttttaaaa tcaaagtgca
     3001 gattgcttgt atgtaaaacc caaataaagg tagagtaagt gtgatatatg ggagtattaa
     3061 aatagcttaa aatttctcgt gaaggacatg tggctaaagg gtcaaaaagg atgtaagact
     3121 tggagccaga gcatagtatt tcctgaaata acaagtttag tgctttaact atggctacat
     3181 gtgcttaagg aattttgagc cacttatttt tgaagatgct gaggacatgt agagtgcttt
     3241 ttgtagtgag ctaaccttga tctctaagga ctaactaccc aggtccaggt cttcactagg
     3301 ggtactgaca gtgtttaagc tttactccac ctccttactt agaaatcact ttacgattta
     3361 tttccatttt ccacttttat agaccatcct tttgcttata tgctagattt ttctggtgag
     3421 ggaagggttg tgttcttcag gggtcttttg ttttgaaata ctcaggatgg ggagaggttt
     3481 atttaagaac gaattataat tatggtttac actgttggga gtaaaggagc atttttacac
     3541 cccttaaggg tgcttaattc tgttgaaacc aaaaagattt gtctacaaat gctatctttt
     3601 ttagaaacta ttagaaatga ctccctttca aagtcaatct ttggaaaata ttgaggaggt
     3661 cactaattag ttggtgcagt taatataatt caagatgatt tggatgatgg gaagtttgag
     3721 accgctgcat tttgttttta aattatgcac cttctgataa cccccaaata cagaaatgtt
     3781 ctacatctct gaatgacctc tgactttaaa aaagttttta tttgcatggc tgtatttaca
     3841 ttaacactga cattttcttc tactcttctc ccttctttca tcttggggtt gggtagagaa
     3901 acacaaagga aactgaagca tgtgccattc tatactgtca ttccaaattc tcatggacta
     3961 ttgcctgttg tgaaaatgtt tgaaactgca ctgaaagctg catctgtctg tatctttctt
     4021 ttgtaaatga cctcacatgt aaattcacca aataaatatt acattcaagc tcttctatct
     4081 attctttaaa tagaaagata
//
