LOCUS       NM_019059                434 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens translocase of outer mitochondrial membrane 7 (TOMM7),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_019059
VERSION     NM_019059.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 434)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 434)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 434)
  AUTHORS   Bhagawati,M., Arroum,T., Webeling,N., Montoro,A.G., Mootz,H.D. and
            Busch,K.B.
  TITLE     The receptor subunit Tom20 is dynamically associated with the TOM
            complex in mitochondria of human cells
  JOURNAL   Mol Biol Cell 32 (20), br1 (2021)
   PUBMED   34347503
  REMARK    GeneRIF: The receptor subunit Tom20 is dynamically associated with
            the TOM complex in mitochondria of human cells.
REFERENCE   4  (bases 1 to 434)
  AUTHORS   Sekine,S., Wang,C., Sideris,D.P., Bunker,E., Zhang,Z. and
            Youle,R.J.
  TITLE     Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and
            Activation of PINK1
  JOURNAL   Mol Cell 73 (5), 1028-1043 (2019)
   PUBMED   30733118
  REMARK    GeneRIF: Mitochondrial membrane potential loss-dependent PINK1
            import arrest does not result solely from Tim23 inactivation but
            also through an actively regulated 'tug of war' between Tom7 and
            OMA1.
REFERENCE   5  (bases 1 to 434)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 434)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 434)
  AUTHORS   Humphries,A.D., Streimann,I.C., Stojanovski,D., Johnston,A.J.,
            Yano,M., Hoogenraad,N.J. and Ryan,M.T.
  TITLE     Dissection of the mitochondrial import and assembly pathway for
            human Tom40
  JOURNAL   J Biol Chem 280 (12), 11535-11543 (2005)
   PUBMED   15644312
REFERENCE   8  (bases 1 to 434)
  AUTHORS   Johnston,A.J., Hoogenraad,J., Dougan,D.A., Truscott,K.N., Yano,M.,
            Mori,M., Hoogenraad,N.J. and Ryan,M.T.
  TITLE     Insertion and assembly of human tom7 into the preprotein
            translocase complex of the outer mitochondrial membrane
  JOURNAL   J Biol Chem 277 (44), 42197-42204 (2002)
   PUBMED   12198123
  REMARK    GeneRIF: Levels of Tom22 in mitochondria accelerate the rate of
            Tom7 assembly into the mature TOM complex.
REFERENCE   9  (bases 1 to 434)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   10 (bases 1 to 434)
  AUTHORS   Lee,J.S.
  TITLE     Cloning and characterization of the human novel gene encoding 6.2
            kDa protein highly expressed upon ultraviolet irradiation in
            DNA-PK-deleted human glioma M059J cells
  JOURNAL   DNA Seq 10 (3), 195-198 (1999)
   PUBMED   10647823
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005682.2.
            
            On Apr 24, 2020 this sequence version replaced NM_019059.4.
            
            Summary: This gene encodes a subunit of the translocase of the
            outer mitochondrial membrane. The encoded protein regulates the
            assembly and stability of the translocase complex. [provided by
            RefSeq, Oct 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and is the protein-coding variant.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD388375.1, DT218110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000358435.9/
                                                  ENSP00000351214.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC005682.2         144447-144619
            174-222             AC005682.2         149248-149296
            223-434             AC005682.2         154111-154322
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..434
                     /gene="TOMM7"
                     /gene_synonym="GMPGS; TOM7"
                     /note="translocase of outer mitochondrial membrane 7"
                     /db_xref="GeneID:54543"
                     /db_xref="HGNC:HGNC:21648"
                     /db_xref="MIM:607980"
     exon            1..173
                     /gene="TOMM7"
                     /gene_synonym="GMPGS; TOM7"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..238
                     /gene="TOMM7"
                     /gene_synonym="GMPGS; TOM7"
                     /note="translocase of outer membrane 7 kDa subunit
                     homolog; translocase of outer mitochondrial membrane 7
                     homolog"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM7
                     homolog"
                     /protein_id="NP_061932.1"
                     /db_xref="CCDS:CCDS5376.1"
                     /db_xref="GeneID:54543"
                     /db_xref="HGNC:HGNC:21648"
                     /db_xref="MIM:607980"
                     /translation="MVKLSKEAKQRLQQLFKGSQFAIRWGFIPLVIYLGFKRGADPGM
                     PEPTVLSLLWG"
     exon            174..222
                     /gene="TOMM7"
                     /gene_synonym="GMPGS; TOM7"
                     /inference="alignment:Splign:2.1.0"
     exon            223..434
                     /gene="TOMM7"
                     /gene_synonym="GMPGS; TOM7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      415..420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOMM7"
                     /gene_synonym="GMPGS; TOM7"
                     /note="hexamer: AATAAA"
     polyA_site      434
                     /gene="TOMM7"
                     /gene_synonym="GMPGS; TOM7"
                     /note="major polyA site"
ORIGIN      
        1 cctttccctt tcggattccc gacgctgtgg ttgctgtaag gggtcctccc tgcgccacac
       61 ggccgtcgcc atggtgaagc tgagcaaaga ggccaagcag agactacagc agctcttcaa
      121 ggggagccag tttgccattc gctggggctt tatccctctt gtgatttacc tgggatttaa
      181 gaggggtgca gatcccggaa tgcctgaacc aactgttttg agcctacttt ggggataaag
      241 gattatttgg tcttctggat ttggaggcaa tcagcggaca gcatggaaga tgtgtgctct
      301 ggctcggata agagatggga catcattcag tcactagttg gatggcacaa ggctcttcac
      361 agacgcatct gtagcagagt ggaacttgta ctaacttatg atagaatgta tcagaataaa
      421 tgtttttaac agtg
//
