LOCUS       NM_001382294             565 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens translocase of outer mitochondrial membrane 6 (TOMM6),
            transcript variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001382294
VERSION     NM_001382294.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 565)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 565)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 565)
  AUTHORS   Kato,H. and Mihara,K.
  TITLE     Identification of Tom5 and Tom6 in the preprotein translocase
            complex of human mitochondrial outer membrane
  JOURNAL   Biochem Biophys Res Commun 369 (3), 958-963 (2008)
   PUBMED   18331822
  REMARK    GeneRIF: The human counterparts of Tom5 and Tom6, together with the
            other components including Tom7, were identified in the preprotein
            translocase complex.
REFERENCE   4  (bases 1 to 565)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   5  (bases 1 to 565)
  AUTHORS   Gevaert,K., Staes,A., Van Damme,J., De Groot,S., Hugelier,K.,
            Demol,H., Martens,L., Goethals,M. and Vandekerckhove,J.
  TITLE     Global phosphoproteome analysis on human HepG2 hepatocytes using
            reversed-phase diagonal LC
  JOURNAL   Proteomics 5 (14), 3589-3599 (2005)
   PUBMED   16097034
REFERENCE   6  (bases 1 to 565)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 565)
  AUTHORS   Chassin,D., Benifla,J.L., Delattre,C., Fernandez,H., Ginisty,D.,
            Janneau,J.L., Prade,M., Contesso,G., Caillou,B., Tournaire,M. et
            al.
  TITLE     Identification of genes overexpressed in tumors through
            preferential expression screening in trophoblasts
  JOURNAL   Cancer Res 54 (19), 5217-5223 (1994)
   PUBMED   7923143
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL365205.35.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU681511.1, BC067252.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000398881.4/
                                                  ENSP00000381856.3
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AL365205.35        57978-58109
            133-237             AL365205.35        59516-59620
            238-565             AL365205.35        59852-60179
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..565
                     /gene="TOMM6"
                     /gene_synonym="OBTP; TOM6"
                     /note="translocase of outer mitochondrial membrane 6"
                     /db_xref="GeneID:100188893"
                     /db_xref="HGNC:HGNC:34528"
                     /db_xref="MIM:616168"
     exon            1..132
                     /gene="TOMM6"
                     /gene_synonym="OBTP; TOM6"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..229
                     /gene="TOMM6"
                     /gene_synonym="OBTP; TOM6"
                     /note="over-expressed breast tumor protein; translocase of
                     outer mitochondrial membrane 6 homolog; overexpressed
                     breast tumor protein; translocase of outer membrane 6 kDa
                     subunit homolog"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM6
                     homolog"
                     /protein_id="NP_001369223.1"
                     /db_xref="CCDS:CCDS47424.1"
                     /db_xref="GeneID:100188893"
                     /db_xref="HGNC:HGNC:34528"
                     /db_xref="MIM:616168"
                     /translation="MASSTVPVSAAGSANETPEIPDNVGDWLRGVYRFATDRNDFRRN
                     LILNLGLFAAGVWLARNLSDIDLMAPQPGV"
     exon            133..237
                     /gene="TOMM6"
                     /gene_synonym="OBTP; TOM6"
                     /inference="alignment:Splign:2.1.0"
     exon            238..565
                     /gene="TOMM6"
                     /gene_synonym="OBTP; TOM6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      543..548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOMM6"
                     /gene_synonym="OBTP; TOM6"
                     /note="hexamer: AATAAA"
     polyA_site      565
                     /gene="TOMM6"
                     /gene_synonym="OBTP; TOM6"
                     /note="major polyA site"
ORIGIN      
        1 cactatggct tccagcactg tcccggtgag cgctgctggc tcggctaatg aaactcccga
       61 aataccggac aacgtgggag attggcttcg gggcgtctac cgctttgcca ctgataggaa
      121 tgacttccgg aggaacttga tactaaattt gggactcttt gctgcgggag tttggctggc
      181 caggaacttg agtgacattg acctcatggc acctcagcca ggggtgtagc caagtagaca
      241 aatggaatcc tgtgctgaac ccgaatcttc caaaaaacag cctacaatct gtgaccacca
      301 caagatgtgc cctgatggca gctgaagttt gattcagatg ggcacttttc ttccccttcc
      361 ctgcctagtt tccttttgtt ccttgagtcc acgcagaatt ccattctctg gtcagcagac
      421 aggcttaagc taaagtattg cctctattct gtaaagttct gtacatagtt cccaagcttc
      481 tgcagggggt gatttttgct cttgtcctga gaaataacag tgctgtttta aaaaacattt
      541 gaaataaata ccgcacacaa aggca
//
