LOCUS       NM_001001790             706 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens translocase of outer mitochondrial membrane 5 (TOMM5),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001001790 XM_933960 XM_933963 XM_945545 XM_945546
VERSION     NM_001001790.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 706)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 706)
  AUTHORS   Kato,H. and Mihara,K.
  TITLE     Identification of Tom5 and Tom6 in the preprotein translocase
            complex of human mitochondrial outer membrane
  JOURNAL   Biochem Biophys Res Commun 369 (3), 958-963 (2008)
   PUBMED   18331822
  REMARK    GeneRIF: The human counterparts of Tom5 and Tom6, together with the
            other components including Tom7, were identified in the preprotein
            translocase complex.
REFERENCE   3  (bases 1 to 706)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB451927.1, BC034247.1 and BC029423.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001001790.2.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the shortest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279834.3473.1,
                                           SRR1163655.670005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000321301.7/
                                                  ENSP00000313584.6
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DB451927.1         46-71
            27-701              BC034247.1         1-675
            702-706             BC029423.1         804-808
FEATURES             Location/Qualifiers
     source          1..706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.2"
     gene            1..706
                     /gene="TOMM5"
                     /gene_synonym="bA613M10.3; C9orf105; Tom5"
                     /note="translocase of outer mitochondrial membrane 5"
                     /db_xref="GeneID:401505"
                     /db_xref="HGNC:HGNC:31369"
                     /db_xref="MIM:616169"
     exon            1..186
                     /gene="TOMM5"
                     /gene_synonym="bA613M10.3; C9orf105; Tom5"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..221
                     /gene="TOMM5"
                     /gene_synonym="bA613M10.3; C9orf105; Tom5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial import receptor subunit TOM5 homolog;
                     mitochondrial outer membrane protein TOM5; translocase of
                     outer mitochondrial membrane 5 homolog"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM5
                     homolog isoform 1"
                     /protein_id="NP_001001790.1"
                     /db_xref="CCDS:CCDS43803.1"
                     /db_xref="GeneID:401505"
                     /db_xref="HGNC:HGNC:31369"
                     /db_xref="MIM:616169"
                     /translation="MFRIEGLAPKLDPEEMKRKMREDVISSIRNFLIYVALLRVTPFI
                     LKKLDSI"
     exon            187..706
                     /gene="TOMM5"
                     /gene_synonym="bA613M10.3; C9orf105; Tom5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      390..395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOMM5"
                     /gene_synonym="bA613M10.3; C9orf105; Tom5"
                     /note="hexamer: TATAAA"
     polyA_site      415
                     /gene="TOMM5"
                     /gene_synonym="bA613M10.3; C9orf105; Tom5"
                     /note="major polyA site"
     regulatory      684..689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOMM5"
                     /gene_synonym="bA613M10.3; C9orf105; Tom5"
                     /note="hexamer: AATAAA"
     polyA_site      706
                     /gene="TOMM5"
                     /gene_synonym="bA613M10.3; C9orf105; Tom5"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcgagg cggccaccgt ggagagcaga gcgcggcggc tggaagctgc taagtcagag
       61 ccgcgatgtt ccggattgag ggcctcgcgc cgaagctgga cccggaggag atgaaacgga
      121 agatgcgcga ggatgtgatc tcctccatac ggaactttct catctacgtg gccctcctgc
      181 gagtcactcc atttatctta aagaaattgg acagcatatg aagacaggac atcacatatg
      241 aatgcacgat atgaagagcc tggttacagt ttcgactcct ctctgcaagt gaataggccc
      301 agaaaggtgt aagagactct ttgaatggac ataaaattct gcttgttaag aacaagtttg
      361 gctctggtaa ctgaccttca aagctaaaat ataaaactat ttgggaagta tgaaacgatg
      421 tctcgtgatc tggtgtaccc ttatccctgt gacgtttggc ctctgacaat actggtataa
      481 ttgtaaataa tgtcaaactc cgttttctag caagtattaa gggagctgtg tctgaaatgg
      541 cactgtcttg tcagtcattt ctgtttacct ttttcttctg cccagagtgt atttgtgaag
      601 agtctcttat attatgtttt gtggaaatca gcacacaacc acaatgacat ttaagcacag
      661 gatcattatt agtctatgtt tttaataaac atatcaatta agaaaa
//
