LOCUS       NM_006809               1973 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens translocase of outer mitochondrial membrane 34
            (TOMM34), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_006809
VERSION     NM_006809.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1973)
  AUTHORS   Shi,Q., Zhang,P., Hu,Q., Zhang,T., Hou,R., Yin,S., Zou,Y., Chen,F.,
            Jiao,S., Si,L., Zheng,B., Chen,Y., Zhan,T., Liu,Y., Zhu,W. and
            Qi,N.
  TITLE     Role of TOMM34 on NF-kappaB activation-related hyperinflammation in
            severely ill patients with COVID-19 and influenza
  JOURNAL   EBioMedicine 108, 105343 (2024)
   PUBMED   39276680
  REMARK    GeneRIF: Role of TOMM34 on NF-kappaB activation-related
            hyperinflammation in severely ill patients with COVID-19 and
            influenza.
REFERENCE   2  (bases 1 to 1973)
  AUTHORS   Huang,Y., Chen,Z., Chen,X., Chen,X. and Xu,M.
  TITLE     TOMM34 promotes cell proliferation, migration, and invasion of OSCC
            and modulates mitochondrial function
  JOURNAL   J Oral Pathol Med 52 (1), 47-55 (2023)
   PUBMED   36367442
  REMARK    GeneRIF: TOMM34 promotes cell proliferation, migration, and
            invasion of OSCC and modulates mitochondrial function.
REFERENCE   3  (bases 1 to 1973)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1973)
  AUTHORS   Cai,M., Tan,R., Huang,Y., Chen,X., Kong,Q., Guo,K. and Xu,M.
  TITLE     High Expression of Tomm34 and Its Correlations With
            Clinicopathology in Oral Squamous Cell Carcinoma
  JOURNAL   Pathol Oncol Res 27, 641042 (2021)
   PUBMED   34257607
  REMARK    GeneRIF: High Expression of Tomm34 and Its Correlations With
            Clinicopathology in Oral Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1973)
  AUTHORS   Trcka,F., Durech,M., Vankova,P., Vandova,V., Simoncik,O., Kavan,D.,
            Vojtesek,B., Muller,P. and Man,P.
  TITLE     The interaction of the mitochondrial protein importer TOMM34 with
            HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3
            adaptors
  JOURNAL   J Biol Chem 295 (27), 8928-8944 (2020)
   PUBMED   32371396
  REMARK    GeneRIF: The interaction of the mitochondrial protein importer
            TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and
            binding to 14-3-3 adaptors.
REFERENCE   6  (bases 1 to 1973)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   7  (bases 1 to 1973)
  AUTHORS   Fossey,S.C., Mychaleckyj,J.C., Pendleton,J.K., Snyder,J.R.,
            Bensen,J.T., Hirakawa,S., Rich,S.S., Freedman,B.I. and Bowden,D.W.
  TITLE     A high-resolution 6.0-megabase transcript map of the type 2
            diabetes susceptibility region on human chromosome 20
  JOURNAL   Genomics 76 (1-3), 45-57 (2001)
   PUBMED   11549316
REFERENCE   8  (bases 1 to 1973)
  AUTHORS   Chewawiwat,N., Yano,M., Terada,K., Hoogenraad,N.J. and Mori,M.
  TITLE     Characterization of the novel mitochondrial protein import
            component, Tom34, in mammalian cells
  JOURNAL   J Biochem 125 (4), 721-727 (1999)
   PUBMED   10101285
REFERENCE   9  (bases 1 to 1973)
  AUTHORS   Young,J.C., Obermann,W.M. and Hartl,F.U.
  TITLE     Specific binding of tetratricopeptide repeat proteins to the
            C-terminal 12-kDa domain of hsp90
  JOURNAL   J Biol Chem 273 (29), 18007-18010 (1998)
   PUBMED   9660753
REFERENCE   10 (bases 1 to 1973)
  AUTHORS   Nuttall,S.D., Hanson,B.J., Mori,M. and Hoogenraad,N.J.
  TITLE     hTom34: a novel translocase for the import of proteins into human
            mitochondria
  JOURNAL   DNA Cell Biol 16 (9), 1067-1074 (1997)
   PUBMED   9324309
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI560064.1, BC006573.2,
            BC001763.1 and BC007423.2.
            
            On Nov 23, 2018 this sequence version replaced NM_006809.4.
            
            Summary: The protein encoded by this gene is involved in the import
            of precursor proteins into mitochondria. The encoded protein has a
            chaperone-like activity, binding the mature portion of unfolded
            proteins and aiding their import into mitochondria. This protein,
            which is found in the cytoplasm and sometimes associated with the
            outer mitochondrial membrane, has a weak ATPase activity and
            contains 6 TPR repeats. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007423.2, AB085681.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000372813.4/
                                                  ENSP00000361900.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BI560064.1         94-95
            3-11                BC006573.2         1-9
            12-1880             BC001763.1         1-1869
            1881-1973           BC007423.2         1870-1962
FEATURES             Location/Qualifiers
     source          1..1973
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1973
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
                     /note="translocase of outer mitochondrial membrane 34"
                     /db_xref="GeneID:10953"
                     /db_xref="HGNC:HGNC:15746"
                     /db_xref="MIM:616049"
     exon            1..191
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..994
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
                     /note="outer mitochondrial membrane translocase (34kD);
                     translocase of outer membrane 34 kDa subunit"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM34"
                     /protein_id="NP_006800.2"
                     /db_xref="CCDS:CCDS13340.1"
                     /db_xref="GeneID:10953"
                     /db_xref="HGNC:HGNC:15746"
                     /db_xref="MIM:616049"
                     /translation="MAPKFPDSVEELRAAGNESFRNGQYAEASALYGRALRVLQAQGS
                     SDPEEESVLYSNRAACHLKDGNCRDCIKDCTSALALVPFSIKPLLRRASAYEALEKYP
                     MAYVDYKTVLQIDDNVTSAVEGINRMTRALMDSLGPEWRLKLPSIPLVPVSAQKRWNS
                     LPSENHKEMAKSKSKETTATKNRVPSAGDVEKARVLKEEGNELVKKGNHKKAIEKYSE
                     SLLCSNLESATYSNRALCYLVLKQYTEAVKDCTEALKLDGKNVKAFYRRAQAHKALKD
                     YKSSFADISNLLQIEPRNGPAQKLRQEVKQNLH"
     exon            192..291
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            292..444
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            445..614
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            615..762
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            763..889
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1973
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1862..1867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
                     /note="hexamer: ATTAAA"
     polyA_site      1886
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
                     /note="major polyA site"
     regulatory      1945..1950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
                     /note="hexamer: AATAAA"
     polyA_site      1973
                     /gene="TOMM34"
                     /gene_synonym="HTOM34P; TOM34; URCC3"
ORIGIN      
        1 aaggtgtgcc gcaccacacg ggggaggaag gaaggagctc ccaactcgcc ggcctggcca
       61 cgggatggcc cccaaattcc cagactctgt ggaggagctc cgcgccgccg gcaatgagag
      121 tttccgcaac ggccagtacg ccgaggcctc cgcgctctac ggccgcgcgc tgcgggtgct
      181 gcaggcgcaa ggttcttcag acccagaaga agaaagtgtt ctctactcca accgagcagc
      241 atgtcacttg aaggatggaa actgcagaga ctgcatcaaa gattgcactt cagcactggc
      301 cttggttccc ttcagcatta agcccctgct gcggcgagca tctgcttatg aggctctgga
      361 gaagtaccct atggcctatg ttgactataa gactgtgctg cagattgatg ataatgtgac
      421 gtcagccgta gaaggcatca acagaatgac cagagctctc atggactcgc ttgggcctga
      481 gtggcgcctg aagctgccct caatcccctt ggtgcctgtt tcagctcaga agaggtggaa
      541 ttccttgcct tcggagaacc acaaagagat ggctaaaagc aaatccaaag aaaccacagc
      601 tacaaagaac agagtgcctt ctgctgggga tgtggagaaa gccagagttc tgaaggaaga
      661 aggcaatgag cttgtaaaga agggaaacca taagaaagct attgagaagt acagtgaaag
      721 cctcttgtgt agtaacctgg aatctgccac gtacagcaac agagcactct gctatttggt
      781 cctgaagcag tacacagaag cagtgaagga ctgcacagaa gccctcaagc tggatggaaa
      841 gaacgtgaag gcattctaca gacgggctca agcccacaaa gcactcaagg actataaatc
      901 cagctttgca gacatcagca acctcctaca gattgagcct aggaatggtc ctgcacagaa
      961 gttgcggcag gaagtgaagc agaacctaca ctaaaaaccc aacagggcaa ctggaacccc
     1021 tgcctgacct tacccagaga agccatgggc cacctgctct gtgcccgctc ctgaaaccca
     1081 gcatgcccca agtgagctct gaagccccct cctcaatccc ttgatggcct cccaccctgt
     1141 aagaggcttt gcttgttcaa attaaactca gtgtagtcaa acacagacat ggttgttgca
     1201 ccagaaaggt ccccactaga gctaagcgtg aagctgaagc tctgtcccta ttcccccagc
     1261 ccagctagct gatcacacca acagatcctc atcagcaaag catttggctt tgtcctgccc
     1321 aagtgggctg cagactgagt gctgcccttg tagcttcccc agaccccaac tcactgcagt
     1381 tcatctgaac aacctgagct cctgggccgg ggtggaagga gggggataaa cctaaggccc
     1441 tgatccaaag cagcctgttg agctggttct ccagggctgc agtctctcca ggtgtacagc
     1501 tgctgtccct gccctgtcct gtccttgcac agtctcctat gtctgagccc cagtgccttc
     1561 tgttcgggcc ctcctttggt gggaaggcag agccctgacc cttgaatggt tgtccttgac
     1621 tctgtgctgc tgccttctgc agagaggcac ctaagctgtt taaagagccc agtgattgtg
     1681 gctgctcctc ctagaggtgg gagggggcaa gaggcctcct tggtcagtgt ccatgctttc
     1741 tgggcaggga cttggttttt tgttccaaca gtggccttct ccgggcttca tagttctttg
     1801 taatatgttg aagttaattt gaattgactg attttgttga actgtgtgtt taagctgttg
     1861 cattaaaaag ctttcttcta catcaatatc tgctgtgctt tcatttatgc cttttcagct
     1921 ttgcacctgg aactctgtag taataataaa agttattgct tattgggcat tca
//
