LOCUS       NM_014765               3283 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens translocase of outer mitochondrial membrane 20
            (TOMM20), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_014765
VERSION     NM_014765.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3283)
  AUTHORS   Raimi,O.G., Ojha,H., Ehses,K., Dederer,V., Lange,S.M., Rivera,C.P.,
            Deegan,T.D., Chen,Y., Wightman,M., Toth,R., Labib,K.P.M.,
            Mathea,S., Ranson,N., Fernandez-Busnadiego,R. and Muqit,M.M.K.
  TITLE     Mechanism of human PINK1 activation at the TOM complex in a
            reconstituted system
  JOURNAL   Sci Adv 10 (23), eadn7191 (2024)
   PUBMED   38848361
REFERENCE   2  (bases 1 to 3283)
  AUTHORS   Mi,D., Yanatori,I., Zheng,H., Kong,Y., Hirayama,T. and Toyokuni,S.
  TITLE     Association of poly(rC)-binding protein-2 with sideroflexin-3
            through TOM20 as an iron entry pathway to mitochondria
  JOURNAL   Free Radic Res 58 (4), 261-275 (2024)
   PUBMED   38599240
  REMARK    GeneRIF: Association of poly(rC)-binding protein-2 with
            sideroflexin-3 through TOM20 as an iron entry pathway to
            mitochondria.
REFERENCE   3  (bases 1 to 3283)
  AUTHORS   Yin,L., Ye,Y., Zou,L., Lin,J., Dai,Y., Fu,Y., Liu,Y., Peng,Y.,
            Gao,Y., Fu,Y., Qi,X., Deng,T., Zhang,S. and Li,X.
  TITLE     AR antagonists develop drug resistance through TOMM20 autophagic
            degradation-promoted transformation to neuroendocrine prostate
            cancer
  JOURNAL   J Exp Clin Cancer Res 42 (1), 204 (2023)
   PUBMED   37563661
  REMARK    GeneRIF: AR antagonists develop drug resistance through TOMM20
            autophagic degradation-promoted transformation to neuroendocrine
            prostate cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3283)
  AUTHORS   Wu,C., Wang,L., Chen,S., Shi,L., Liu,M., Tu,P., Sun,J., Zhao,R.,
            Zhang,Y., Wang,J., Pan,Y., Ma,Y. and Guo,Y.
  TITLE     Iron induces B cell pyroptosis through Tom20-Bax-caspase-gasdermin
            E signaling to promote inflammation post-spinal cord injury
  JOURNAL   J Neuroinflammation 20 (1), 171 (2023)
   PUBMED   37480037
  REMARK    GeneRIF: Iron induces B cell pyroptosis through
            Tom20-Bax-caspase-gasdermin E signaling to promote inflammation
            post-spinal cord injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3283)
  AUTHORS   Micaily,I., Lee,S., Basu Mallick,A., Zhan,T., O'Neill,R.,
            Gargano,S., Hozack,B., Thapa,S., Martinez-Outschoorn,U., Abraham,J.
            and Jiang,W.
  TITLE     TOMM20 as a Potential Prognostic Biomarker in Chordoma: Results
            From a High-Volume, Single-Center Study
  JOURNAL   Am J Clin Pathol 159 (5), 492-501 (2023)
   PUBMED   36857736
  REMARK    GeneRIF: TOMM20 as a Potential Prognostic Biomarker in Chordoma:
            Results From a High-Volume, Single-Center Study.
REFERENCE   6  (bases 1 to 3283)
  AUTHORS   Schleiff,E. and Turnbull,J.L.
  TITLE     Characterization of the N-terminal targeting signal binding domain
            of the mitochondrial outer membrane receptor, Tom20
  JOURNAL   Biochemistry 37 (38), 13052-13058 (1998)
   PUBMED   9748310
REFERENCE   7  (bases 1 to 3283)
  AUTHORS   Schleiff,E., Shore,G.C. and Goping,I.S.
  TITLE     Interactions of the human mitochondrial protein import receptor,
            hTom20, with precursor proteins in vitro reveal pleiotropic
            specificities and different receptor domain requirements
  JOURNAL   J Biol Chem 272 (28), 17784-17789 (1997)
   PUBMED   9211931
REFERENCE   8  (bases 1 to 3283)
  AUTHORS   Schleiff,E., Shore,G.C. and Goping,I.S.
  TITLE     Human mitochondrial import receptor, Tom20p. Use of glutathione to
            reveal specific interactions between Tom20-glutathione
            S-transferase and mitochondrial precursor proteins
  JOURNAL   FEBS Lett 404 (2-3), 314-318 (1997)
   PUBMED   9119086
REFERENCE   9  (bases 1 to 3283)
  AUTHORS   Seki,N., Moczko,M., Nagase,T., Zufall,N., Ehmann,B., Dietmeier,K.,
            Schafer,E., Nomura,N. and Pfanner,N.
  TITLE     A human homolog of the mitochondrial protein import receptor Mom19
            can assemble with the yeast mitochondrial receptor complex
  JOURNAL   FEBS Lett 375 (3), 307-310 (1995)
   PUBMED   7498524
REFERENCE   10 (bases 1 to 3283)
  AUTHORS   Goping,I.S., Millar,D.G. and Shore,G.C.
  TITLE     Identification of the human mitochondrial protein import receptor,
            huMas20p. Complementation of delta mas20 in yeast
  JOURNAL   FEBS Lett 373 (1), 45-50 (1995)
   PUBMED   7589431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK289810.1, BC100286.1, D13641.1 and BC009886.2.
            
            On Nov 23, 2018 this sequence version replaced NM_014765.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13641.1, SRR14038195.118540.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000366607.5/
                                                  ENSP00000355566.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK289810.1         105-118
            15-1582             BC100286.1         1-1568
            1583-2659           D13641.1           1563-2639
            2660-3283           BC009886.2         1000-1623
FEATURES             Location/Qualifiers
     source          1..3283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.3"
     gene            1..3283
                     /gene="TOMM20"
                     /gene_synonym="MAS20; MOM19; TOM20"
                     /note="translocase of outer mitochondrial membrane 20"
                     /db_xref="GeneID:9804"
                     /db_xref="HGNC:HGNC:20947"
                     /db_xref="MIM:601848"
     exon            1..243
                     /gene="TOMM20"
                     /gene_synonym="MAS20; MOM19; TOM20"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..560
                     /gene="TOMM20"
                     /gene_synonym="MAS20; MOM19; TOM20"
                     /note="translocase of outer mitochondrial membrane 20
                     homolog type II; mitochondrial 20 kDa outer membrane
                     protein; outer mitochondrial membrane receptor Tom20"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM20
                     homolog"
                     /protein_id="NP_055580.1"
                     /db_xref="CCDS:CCDS1603.1"
                     /db_xref="GeneID:9804"
                     /db_xref="HGNC:HGNC:20947"
                     /db_xref="MIM:601848"
                     /translation="MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKK
                     QKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGEYEKGVDHLTNAIAVCGQ
                     PQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE"
     exon            244..290
                     /gene="TOMM20"
                     /gene_synonym="MAS20; MOM19; TOM20"
                     /inference="alignment:Splign:2.1.0"
     exon            291..372
                     /gene="TOMM20"
                     /gene_synonym="MAS20; MOM19; TOM20"
                     /inference="alignment:Splign:2.1.0"
     exon            373..515
                     /gene="TOMM20"
                     /gene_synonym="MAS20; MOM19; TOM20"
                     /inference="alignment:Splign:2.1.0"
     exon            516..3283
                     /gene="TOMM20"
                     /gene_synonym="MAS20; MOM19; TOM20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3264..3269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOMM20"
                     /gene_synonym="MAS20; MOM19; TOM20"
                     /note="hexamer: ATTAAA"
     polyA_site      3283
                     /gene="TOMM20"
                     /gene_synonym="MAS20; MOM19; TOM20"
                     /note="major polyA site"
ORIGIN      
        1 ctttctgtgt tcctggcccg cggccgtcgg gtgtgagctg cgccgaccgc tctgagggtt
       61 cgtggcccac cgctccttcg cggtccctgc cgccaccgtc cacgctcagc gttgtagaga
      121 agatggtggg tcggaacagc gccatcgccg ccggtgtatg cggggccctt ttcattgggt
      181 actgcatcta cttcgaccgc aaaagacgaa gtgaccccaa cttcaagaac aggcttcgag
      241 aacgaagaaa gaaacagaag cttgccaagg agagagctgg gctttccaag ttacctgacc
      301 ttaaagatgc tgaagctgtt cagaagttct tccttgaaga aatacagctt ggtgaagagt
      361 tactagctca aggtgaatat gagaagggcg tagaccatct gacaaatgca attgctgtgt
      421 gtggacagcc acagcagtta ctgcaggtct tacagcaaac tcttccacca ccagtgttcc
      481 agatgcttct gactaagctc ccaacaatta gtcagagaat tgtaagtgct cagagcttgg
      541 ctgaagatga tgtggaatga gaaacaaatg tcaacataat aaaatctcag ttaaaaatat
      601 tttaaaaatt cttggtagtt gagcagctct gggggaataa gggcaaatat gcttgttatg
      661 aactacactg aaatctacca aagttaatgt ttactttgtg tagatccatt tgtctatttt
      721 atttattttt cccagtgaaa agtgtatttt gatagagaac ttttcattct ataaatacac
      781 tatgagttac taaaatatca tggattttgt ttattcctga aacatagtta catagttaaa
      841 ctgtacatat gacatggctt atgttaaaaa tacccagtgc tcagttttga aagataggca
      901 aaaaaaaaaa agtataggag aaactgaaga atgtacactt ttttagaggg cacattttgc
      961 tgtaaatctg gaaatttgat agacttgact gtgtttgtga aaactgagca ttaaaggttt
     1021 tgattgatcc tttctttcca tttaatctct gagacgtaaa tatgtgaggt gtgctgctgt
     1081 gctgggttaa cagcttcctt ccctttctgt gtagcagtct tgaaatgttc tgtttaaatc
     1141 agtaggctta atgtgttctg ggtatttatc tccttgtatt ttaaatatat gtagttgcaa
     1201 atagcaccag gaattagatt tctgtacacc cctaatctag ccttgtgagc ttcgctagtt
     1261 aatgtgtgct cactttccct ccatttgtta cgtgagagaa tgcgtctgct gatcactgaa
     1321 gtgtcccttt tagcttctga ttcattgggt tctgttgggc atctttaaat ccaccttaac
     1381 ctgaggaatg tatgtgggca accaggccct gcattttttt atattctgaa ttttgcatgc
     1441 ttgcctgact tagtatttct gaattgatgt tttttttaat ggtataacta tcttgatttt
     1501 cactgaaatt atatggttct gtcactactc tgtaaattaa tccgaaactt ttaaggtaac
     1561 tgggatgatc tgcttgtaaa aatgcttgtt gccttttgct ttatcttcag tgtacctcct
     1621 taatcctgct tcaacttgat tatcttgtga aacgatgaga gtaagttgca accttgtgac
     1681 tgaaaacttg aaaagagtgg agcaggtggg acctcttatt ctcaaatagt gacatattct
     1741 ccgtagtcac agtttcagaa ctgagtaagg atccttggta cttggtggca tctgttgaac
     1801 tgaggagcat ttctcattgt aaagattgcc tttgttctgt ctaaaagtct ggagaaatcc
     1861 caaagacttt tcctatgtac taggcatttt attttgattg acttacaaac tcttcttaat
     1921 cattatcaat ctcggttttt ttgtggtgca gtggaaggag aaataggtct agtttctgcc
     1981 tctgattagc cgcacagcct tgaacaaatc acatttcatc tttgaactta cctctactgt
     2041 tagactaggc gactcacatt tgaggacttt tctcgggtat cttgagggtt tgtgatcctg
     2101 aacccttaaa cagtgctttt ttgttacaca ggagggcttt tttgggggga tgaccagtac
     2161 agacatgcca gttagtttta ctagtgggat cccaaatcca aagcagtgta gtggtgattg
     2221 gtcagtgact aaccaggcag ctaagaagtc ttaggcagca gcccagacat gtatagaggg
     2281 gcagttagag ggagaacagg ggtgggaaag ggagcaaggg gcagatagct cagcaaggaa
     2341 agaatgggct cagaaaaagg agggctggct ggaggagtga ggggcagctt aagtttgggg
     2401 agggtagaaa cgccgtttcc ttgggaactg gagtgcagta tgagctgggt gtcacttggc
     2461 tctgaacata ctggctttgc tgtaatgctt gaaaaggcgt tggtatcttc attttacagt
     2521 tcattaaccc aagtacgttt tcttatttaa atgacaactt tggtgcttta aaatgaggta
     2581 ccacttttta aagctagctg tgtcgagtta aagaaaaaat cagcagtttt ttctcccaga
     2641 aatgtaattg ccaaacacta ttcatcccca tcttaagttt tacaaggtga tgtaatcagc
     2701 ttgttgtagt gatgctggcc aaatggtgct cagcaggtga gaacaaaaaa accccagatc
     2761 tcagtgaact aatacacagc ttgagcgttt ccatgtgcta atgttgcaca cttactaaaa
     2821 aactttggaa atggaaaata atgtattagt gcaacagttg atgtgcttct ttgggcaaag
     2881 atatagtttt gttccacaat ttgtacttaa aagcgaaaga acattgaaaa catagactta
     2941 ctggctgtag caatgctggc ctgttaactg ataactagaa cttaggttca cgtttatgta
     3001 aagtgtgtaa aacctagtag agcttgcata gtcggcactc agtaaatgtt tggttccttt
     3061 tgccccttgg taagtttatt ttaccatcct cccacctgcc attctgactt tattaaatca
     3121 acatgtggac cagagtgtta atgagatgtt attgcagaag agattgagaa aattggtata
     3181 tcatgcagat aacatacaaa atctttttgt aacgtaaaaa atgcagtttt attattgctt
     3241 gtgcctcaac tgtttaagtg aatattaaag ggcttggaga aaa
//
