LOCUS       NM_001082968            5735 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens target of myb1 like 2 membrane trafficking protein
            (TOM1L2), transcript variant 3, mRNA.
ACCESSION   NM_001082968
VERSION     NM_001082968.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5735)
  AUTHORS   Shinde,S.R., Mick,D.U., Aoki,E., Rodrigues,R.B., Gygi,S.P. and
            Nachury,M.V.
  TITLE     The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes
            for retrieval from cilia
  JOURNAL   Dev Cell 58 (8), 677-693 (2023)
   PUBMED   37019113
  REMARK    GeneRIF: The ancestral ESCRT protein TOM1L2 selects ubiquitinated
            cargoes for retrieval from cilia.
REFERENCE   2  (bases 1 to 5735)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5735)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5735)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5735)
  AUTHORS   Medina-Gomez,C., Kemp,J.P., Dimou,N.L., Kreiner,E., Chesi,A.,
            Zemel,B.S., Bonnelykke,K., Boer,C.G., Ahluwalia,T.S., Bisgaard,H.,
            Evangelou,E., Heppe,D.H.M., Bonewald,L.F., Gorski,J.P.,
            Ghanbari,M., Demissie,S., Duque,G., Maurano,M.T., Kiel,D.P.,
            Hsu,Y.H., C J van der Eerden,B., Ackert-Bicknell,C., Reppe,S.,
            Gautvik,K.M., Raastad,T., Karasik,D., van de Peppel,J.,
            Jaddoe,V.W.V., Uitterlinden,A.G., Tobias,J.H., Grant,S.F.A.,
            Bagos,P.G., Evans,D.M. and Rivadeneira,F.
  TITLE     Bivariate genome-wide association meta-analysis of pediatric
            musculoskeletal traits reveals pleiotropic effects at the
            SREBF1/TOM1L2 locus
  JOURNAL   Nat Commun 8 (1), 121 (2017)
   PUBMED   28743860
  REMARK    GeneRIF: Variants in the TOM1L2/SREBF1 locus exert opposing effects
            of total-body lean mass (TB-LM) and total-body less head bone
            mineral density (TBLH-BMD) .
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5735)
  AUTHORS   Zhang,Y., Wolf-Yadlin,A., Ross,P.L., Pappin,D.J., Rush,J.,
            Lauffenburger,D.A. and White,F.M.
  TITLE     Time-resolved mass spectrometry of tyrosine phosphorylation sites
            in the epidermal growth factor receptor signaling network reveals
            dynamic modules
  JOURNAL   Mol Cell Proteomics 4 (9), 1240-1250 (2005)
   PUBMED   15951569
REFERENCE   7  (bases 1 to 5735)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   8  (bases 1 to 5735)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 5735)
  AUTHORS   Bi,W., Yan,J., Stankiewicz,P., Park,S.S., Walz,K., Boerkoel,C.F.,
            Potocki,L., Shaffer,L.G., Devriendt,K., Nowaczyk,M.J., Inoue,K. and
            Lupski,J.R.
  TITLE     Genes in a refined Smith-Magenis syndrome critical deletion
            interval on chromosome 17p11.2 and the syntenic region of the mouse
  JOURNAL   Genome Res 12 (5), 713-728 (2002)
   PUBMED   11997338
REFERENCE   10 (bases 1 to 5735)
  AUTHORS   Seranski,P., Heiss,N.S., Dhorne-Pollet,S., Radelof,U., Korn,B.,
            Hennig,S., Backes,E., Schmidt,S., Wiemann,S., Schwarz,C.E.,
            Lehrach,H. and Poustka,A.
  TITLE     Transcription mapping in a medulloblastoma breakpoint interval and
            Smith-Magenis syndrome candidate region: identification of 53
            transcriptional units and new candidate genes
  JOURNAL   Genomics 56 (1), 1-11 (1999)
   PUBMED   10036180
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA235267.1, AK124331.1,
            DA335727.1, AC122129.9 and BM976586.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001082968.1.
            
            Summary: This gene belongs to a small gene family whose members
            have an N-terminal VHS domain followed by a GAT domain; domains
            which typically participate in vesicular trafficking. The canonical
            protein encoded by this gene also has a C-terminal clathrin binding
            motif. This protein has been shown to interact with Tollip,
            clathrin and ubiquitin and is thought to play a role in endosomal
            sorting. This gene resides in the 3.7 Mb deletion of chromosome
            region 17p11.2 that is associated with Smith-Magenis syndrome.
            Alternative splicing results in multiple transcript variants
            encoding distinct proteins. [provided by RefSeq, Apr 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1057365.1,
                                           SRR14038194.252043.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379504.8/ ENSP00000368818.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DA235267.1         71-73
            4-272               AK124331.1         2-270
            273-558             DA335727.1         309-594
            559-2397            AK124331.1         557-2395
            2398-5271           AC122129.9         101713-104586       c
            5272-5735           BM976586.1         21-484              c
FEATURES             Location/Qualifiers
     source          1..5735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..5735
                     /gene="TOM1L2"
                     /note="target of myb1 like 2 membrane trafficking protein"
                     /db_xref="GeneID:146691"
                     /db_xref="HGNC:HGNC:11984"
                     /db_xref="MIM:615519"
     exon            1..139
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1611
                     /gene="TOM1L2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     TOM1-like protein 2; target of myb1-like 2; target of
                     Myb-like protein 2"
                     /codon_start=1
                     /product="TOM1-like protein 2 isoform 3"
                     /protein_id="NP_001076437.1"
                     /db_xref="CCDS:CCDS42270.1"
                     /db_xref="GeneID:146691"
                     /db_xref="HGNC:HGNC:11984"
                     /db_xref="MIM:615519"
                     /translation="MEFLLGNPFSTPVGQCLEKATDGSLQSEDWTLNMEICDIINETE
                     EGPKDAIRALKKRLNGNRNYREVMLALTVLETCVKNCGHRFHILVANRDFIDSVLVKI
                     ISPKNNPPTIVQDKVLALIQAWADAFRSSPDLTGVVHIYEELKRKGVEFPMADLDALS
                     PIHTPQRSVPEVDPAATMPRSQSQQRTSAGSYSSPPPAPYSAPQAPALSVTGPITANS
                     EQIARLRSELDVVRGNTKVMSEMLTEMVPGQEDSSDLELLQELNRTCRAMQQRIVELI
                     SRVSNEEVTEELLHVNDDLNNVFLRYERFERYRSGRSVQNASNGVLNEVTEDNLIDLG
                     PGSPAVVSPMVGNTAPPSSLSSQLAGLDLGTESVSGTLSSLQQCNPRDGFDMFAQTRG
                     NSLAEQRKTVTYEDPQAVGGLASALDNRKQSSEGIPVAQPSVMDDIEVWLRTDLKGDD
                     LEEGVTSEEFDKFLEERAKAAEMVPDLPSPPMEAPAPASNPSGRKKPERSEDALFAL"
     exon            140..224
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            225..303
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            304..453
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..588
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            589..747
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..864
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            865..998
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1047
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1171
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1289
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1365
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1425
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1462
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..5735
                     /gene="TOM1L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5718..5723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOM1L2"
                     /note="hexamer: AATAAA"
     polyA_site      5735
                     /gene="TOM1L2"
                     /note="major polyA site"
ORIGIN      
        1 gtcagtcagg acgggagtcc ggcgggttac agcggaggcc taggtggcag acagggggcc
       61 cgggccgctg cgtgttgtcc acccaagatg gagttcctcc tggggaaccc gttcagcaca
      121 ccagtggggc agtgcctcga aaaggcaaca gatggctccc tgcaaagtga ggattggacg
      181 ttgaatatgg agatctgtga catcatcaat gagacggagg aagggccaaa ggatgccatt
      241 cgagccctga agaagcggct caacgggaac cggaactaca gagaggtgat gctggcatta
      301 acagtgctgg agacatgtgt gaagaactgt ggccaccgct tccacatcct tgtggccaac
      361 cgagatttca tcgacagtgt tctggtcaaa attatatctc ccaagaacaa ccctcccacc
      421 attgtacagg acaaagtgct tgctctgatc caggcatggg ctgatgcctt tcgaagcagt
      481 cctgatctca ccggcgttgt gcacatatat gaggagctga agaggaaagg ggttgaattt
      541 cccatggcag acttggacgc tctgtctccc atacacacac cacagcggag tgtccctgaa
      601 gtggatccag ctgcgaccat gcccaggtcc caatcacagc agaggacaag tgctggttcc
      661 tattcctcgc cgcctcctgc tccctactcc gcaccgcagg ccccagctct gagtgtgact
      721 ggccccatca cagccaattc agaacagatt gccaggctgc ggagtgaact ggacgtcgtt
      781 cgaggaaaca caaaagtcat gtctgagatg ttaacagaaa tggtccctgg acaggaggat
      841 tcatctgatc tggagttgct gcaggagctc aacaggacct gtcgggccat gcagcagcgc
      901 atcgtggagc tcatctcccg cgtgtccaat gaggaggtca ccgaggagct gctgcatgtg
      961 aacgatgacc tcaacaacgt cttccttcga tacgagaggt tcgaacgata caggtctggc
     1021 cgatccgttc aaaatgccag taatggagta ctgaatgaag taaccgaaga caacttaata
     1081 gacctggggc cagggtctcc agccgtggtg agcccaatgg tggggaacac agcgccccca
     1141 tcttccctct cctcccagct tgcaggctta gacttgggga cagagagcgt cagtggcacc
     1201 ctcagttcac tccagcaatg taatccccgt gacggctttg acatgtttgc ccagacgaga
     1261 ggaaactcct tggctgagca gcgcaagacg gtaacctatg aggatcctca ggctgtcgga
     1321 ggacttgctt ctgcactaga caatcgaaaa cagagttcag aagggatccc cgttgcgcag
     1381 ccatctgtca tggacgacat tgaggtgtgg ctcaggaccg acctgaaggg tgatgatctg
     1441 gaggagggtg tcacaagtga agagtttgat aaattccttg aagaaagagc caaagctgct
     1501 gaaatggttc ccgacctccc ctcgcccccc atggaggctc ctgccccagc ctcaaaccct
     1561 tctggccgga agaagccaga gcggtcagag gatgccctct tcgccctgtg agcagctctg
     1621 tggtttgcct ccccagatgg cgggtccccg ctcgcacccc gtggacaccg ggcactggcc
     1681 actcctacat ccccagctcc acacggcctg cacacctgtg tttccatgga aatgccaccg
     1741 tgtctgctcc caggcctccc actagtcagg accagcttca gccacttctt ttctctgagt
     1801 ggtgggacaa ctgcagccag agactctctc ccctcccacc atgggcccct ctgcccatgt
     1861 ttcctcccag gaagagcggg cagagtggcc cagccccagg cagtgcttcc tgagcagacc
     1921 acccggactg tctttcctcc acccgcccat ggagaaagag cacgcccggc cccgccctgt
     1981 gctcacctct gcctggctca gcgaccttct caggcattct gccctcctgg gcccctctct
     2041 ccctgaaggg gctttgtggc atctctggaa gagcagggtg tgctgcactc atgggcctgg
     2101 tctcactcct tggacttgtc accttgtgac atttggctta tcagcatttg agaaggctct
     2161 gctgggtctc catggtgggg gtctctcacc ttcttgaccc tctctccatc attcagctgc
     2221 cagcccaggc ttcacaccca agctggctca gcagccgagc ctggcaccga gggtccctgc
     2281 aggctccctg ggcagggaga gggccaagga caattgggag ggcagcaggc agcccgcaga
     2341 tggtggccat gtggcacgct gctgagacga cactaccaat aaaccaaact gccacgcaca
     2401 cactgcaggc tcacacccgc acacctggtc ctggcttgtg gagggacttg cactggaggt
     2461 attgctctgg cttgcctggg gaagtgtcac agatgtgcac atgggccaca ctcagtgctg
     2521 tggcctggcc tgccgtagcc tcacacatct gcctcaagag ccagcagcaa acagctttgt
     2581 ggcatccttg gaggttccca gtgactgaga ggcctgggca gcactaaggc ccctgctctg
     2641 ctccctggca taggccttgg cctccttgca cagactctcc tgacagtctg gcctcctccc
     2701 acctcagagg tcctctggcc accaatttat actctctccc caagctgatc ctgaaggcag
     2761 gcagagcagc taggggctgg taacatgtat tcccatcccg tgtcctcact ggtgtgtctc
     2821 ctggccatgg gcaagggact cgggtcatcc caggccctgg tccagccaga cacctggccc
     2881 cacacctccc accaggctgc tgttgctcag aaggagaata ctgcagctgt atgcatcccc
     2941 gtgtgtcttg ggcccagctc gctgggtcag tctgctcctg tcccctccag catgcactgc
     3001 ctaggtcagc acaggttcct gatccatggt gtagttagcc cttcccacct ggcaggacgg
     3061 cccagaccac cagccaagca gggaaagggg gctgggcttg acgggagaag agaccagcga
     3121 catggtcgtt ggggagcatt caggatggcg acttcagctg ggggtcatgc tgagcaccaa
     3181 caggaactat tccagtgaag agcaagtgct gcccgaccca ggaccctgtg ccaggctagc
     3241 agccctccag ctccctccag agaggaaacc tctgtctggc tgagggtggg actagctggg
     3301 atgtctcact ccagttgctc aggttcaccc aggaagctcc tccgtggagt ggccagcctg
     3361 attctagccc tgtcctctct ggcagcacat gccacacctg cctgggcctt ctgctccctg
     3421 atgcttgatg agcccctgcc tcctcaatgt ttctcaaaga cagacccccc tgaggccagc
     3481 ttgaatgtga agactgctga agttagctgg cttcacttga gctgcagaaa aggtggctgg
     3541 gatggcccag gtgcacccag aggccccagc cctttggctg cctttgggtt gtgacttggg
     3601 ttgtctctga ggccctgcca gagctgggcc tgcgggtggt gggcggtccg acctcgggca
     3661 gtcagtgctc cgcagcctca gcactgcatc ccagacccag tgtcctcaga gggaagagcc
     3721 agcctccctg cctcatggaa ccaggagtcc caaaaagtca ggagcctgga ggctctgaaa
     3781 ggagcaggga ttccatagtg cgtgaagctg aaataggcgc cctcctgggg agcccccagc
     3841 aaaactgttt ttcataccca ctcccagaac tgccccgctc cagctccagc gccagcgcca
     3901 gctggttgcc aggcatcatt ggagaggcct ggctgcccca ggggcagcag ggagtggtgg
     3961 acctgtatgg gctggcagga ggccattggc catgctgaca agtgtcacct gccttcctag
     4021 cctggagcca cccctcaggt ggcctgcttg cacctcctat ccggaggtag cctgccccac
     4081 ctgtaggcag agggggctct tgcttgaggc ctgcacagga agcaagtata gccccggtgc
     4141 cccagagtgg gttccactta gccctggcga gatggcctgt cctgagatct ctgctcccag
     4201 accccaccat ctggggagca cagtccttag gctgcctggt ccaggaaggg ggtgcggctc
     4261 tgtcaggaaa cctggactct caaggcccac cagcctctcc gtgagtgtta gaaatcacag
     4321 atacagtata tacttaatta cactaaatta ttgctgggat tccttataag cactaattat
     4381 acctgattat aggttaaaat atttattttg tcaaaatatt ttcttgggaa tgtgtttaac
     4441 cctttctgcg ttcattgttg ctgagatgtg aaaactaacc attccctcct gcctaccttt
     4501 ttggccactg ggcggcagag aatggcgcta tgtgcagttg ggcccctggc accatgggcc
     4561 tttggcctgc ctgctgcaga gtagccctgc ctgggcagtc tccaggcact gagcaggcca
     4621 tctgtggcca ggctgagaga atgactggct cgcttaccag cgtgcatggg acaaggagct
     4681 ttggagcctc aaggggttgt tgctggcctg ggctagaggg aaaggtgacc atccgtctgt
     4741 cctcctgtct ttctattagc gcctccatgt gagtgatggt gccttggttc actagccttc
     4801 ccccaccacc ccaccatgcc acctggtggt cttggggcct gtgctgtcac tccagcccct
     4861 ggggaggaga ggacccagcc cggagagttg gggcaagggc tccacatggc ccaagggcaa
     4921 cagatgctcg cagggcagct gctgccgatg ctcacgctcc tgcccccctc cttcccgctg
     4981 ccacacccca ccctgggccc ccgcagacac gcatctctaa ctcagttggg cccagccttc
     5041 tggatggctt ggggtaggcc atgggcccac ctggggccag gccagcccct ggggcagctc
     5101 tggaagagca gtgtggagga gcacttgctt gcagcctggc ttcagcctct ggcactgctg
     5161 gagtggtccc tgggagcttc tgcactgtcg gctttgggga cgtctcaccc acttgggtta
     5221 cagtaggcct tccccaccca gagagaagtg tttccacccc agagacattg tctgtcagcc
     5281 cctgaagtgc tcgcctcccc cagtgcccgt caccagccct tcctatctgt ggggtccaag
     5341 tcaggcttcc cctgcggcca ccagccatag ggagcagcca tcagcccccg agtcagaact
     5401 gcttctgtct gtccatacct ccaggctctc ccggagaggg ggacggatat ttatttccta
     5461 aagtttgcac ttaattgtga ggattctcag gattgttggg ggctactgaa aagaggaatg
     5521 tgttgaatgt cgcgtttgct gtccactcgt cctagaagtt tagtgttttt gtcactgtca
     5581 tgtgtttctg tgggcagagc tggttctgga gggtgggtca gtgcacccga ggctcagagc
     5641 atccatccac cccactggcc ctccttccag ataccctctc tctaattggg ttcttgcatg
     5701 taaaatactc cacaataaat aaataattga acaaa
//
