LOCUS       NM_005486               2168 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens target of myb1 like 1 membrane trafficking protein
            (TOM1L1), transcript variant 1, mRNA.
ACCESSION   NM_005486 XM_001723684 XM_001725529 XM_001726674
VERSION     NM_005486.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2168)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   2  (bases 1 to 2168)
  AUTHORS   Cabral-Dias,R., Lucarelli,S., Zak,K., Rahmani,S., Judge,G.,
            Abousawan,J., DiGiovanni,L.F., Vural,D., Anderson,K.E.,
            Sugiyama,M.G., Genc,G., Hong,W., Botelho,R.J., Fairn,G.D., Kim,P.K.
            and Antonescu,C.N.
  TITLE     Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate
            Akt signaling
  JOURNAL   J Cell Biol 221 (4) (2022)
   PUBMED   35238864
  REMARK    GeneRIF: Fyn and TOM1L1 are recruited to clathrin-coated pits and
            regulate Akt signaling.
REFERENCE   3  (bases 1 to 2168)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2168)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2168)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2168)
  AUTHORS   Li,W., Marshall,C., Mei,L., Dzubow,L., Schmults,C., Dans,M. and
            Seykora,J.
  TITLE     Srcasm modulates EGF and Src-kinase signaling in keratinocytes
  JOURNAL   J Biol Chem 280 (7), 6036-6046 (2005)
   PUBMED   15579470
  REMARK    GeneRIF: Srcasm plays a role in linking EGF receptor- and
            SFK-dependent signaling to differentiation in keratinocytes
REFERENCE   7  (bases 1 to 2168)
  AUTHORS   Katoh,Y., Shiba,Y., Mitsuhashi,H., Yanagida,Y., Takatsu,H. and
            Nakayama,K.
  TITLE     Tollip and Tom1 form a complex and recruit ubiquitin-conjugated
            proteins onto early endosomes
  JOURNAL   J Biol Chem 279 (23), 24435-24443 (2004)
   PUBMED   15047686
REFERENCE   8  (bases 1 to 2168)
  AUTHORS   Seykora,J.T., Mei,L., Dotto,G.P. and Stein,P.L.
  TITLE     'Srcasm: a novel Src activating and signaling molecule
  JOURNAL   J Biol Chem 277 (4), 2812-2822 (2002)
   PUBMED   11711534
REFERENCE   9  (bases 1 to 2168)
  AUTHORS   Seroussi,E., Kedra,D., Kost-Alimova,M., Sandberg-Nordqvist,A.C.,
            Fransson,I., Jacobs,J.F., Fu,Y., Pan,H.Q., Roe,B.A., Imreh,S. and
            Dumanski,J.P.
  TITLE     TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1
            and encode proteins similar to the endosomal proteins HGS and STAM
  JOURNAL   Genomics 57 (3), 380-388 (1999)
   PUBMED   10329004
REFERENCE   10 (bases 1 to 2168)
  CONSRTM   Ministerial Meeting on Population of the Non-Aligned Movement
            (1993: Bali)
  TITLE     Non-aligned movement support for South-South collaboration in the
            field of population and family planning
  JOURNAL   Integration (40), 37-42 (1994)
   PUBMED   12345679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN284148.1, AK315039.1, AK223125.1, AJ010071.1 and AW139144.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005486.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ010071.1, AK223125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000575882.6/ ENSP00000460823.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 CN284148.1         164-164
            2-5                 AK315039.1         1-4
            6-1839              AK223125.1         1-1834
            1840-2161           AJ010071.1         1856-2177
            2162-2168           AW139144.1         11-17               c
FEATURES             Location/Qualifiers
     source          1..2168
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..2168
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /note="target of myb1 like 1 membrane trafficking protein"
                     /db_xref="GeneID:10040"
                     /db_xref="HGNC:HGNC:11983"
                     /db_xref="MIM:604701"
     exon            1..72
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1445
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TOM1-like protein 1; target of Myb-like protein 1;
                     src-activating and signaling molecule protein"
                     /codon_start=1
                     /product="TOM1-like protein 1 isoform 1"
                     /protein_id="NP_005477.2"
                     /db_xref="CCDS:CCDS11582.1"
                     /db_xref="GeneID:10040"
                     /db_xref="HGNC:HGNC:11983"
                     /db_xref="MIM:604701"
                     /translation="MAFGKSHRDPYATSVGHLIEKATFAGVQTEDWGQFMHICDIINT
                     TQDGPKDAVKALKKRISKNYNHKEIQLTLSLIDMCVQNCGPSFQSLIVKKEFVKENLV
                     KLLNPRYNLPLDIQNRILNFIKTWSQGFPGGVDVSEVKEVYLDLVKKGVQFPPSEAEA
                     ETARQETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGKLHSELDMVKMNVRV
                     MSAILMENTPGSENHEDIELLQKLYKTGREMQERIMDLLVVVENEDVTVELIQVNEDL
                     NNAILGYERFTRNQQRILEQNKNQKEATNTTSEPSAPSQDLLDLSPSPRMPRATLGEL
                     NTMNNQLSGLNFSLPSSDVTNNLKPSLHPQMNLLALENTEIPPFAQRTSQNLTSSHAY
                     DNFLEHSNSVFLQPVSLQTIAAAPSNQSLPPLPSNHPAMTKSDLQPPNYYEVMEFDPL
                     APAVTTEAIYEEIDAHQHKGAQNDGD"
     exon            73..157
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            158..236
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            237..386
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            387..512
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            513..617
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            618..734
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            735..868
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            869..929
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1047
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1144
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1196
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1302
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1384
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1446
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..2168
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2148..2153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /note="hexamer: AATAAA"
     polyA_site      2168
                     /gene="TOM1L1"
                     /gene_synonym="SRCASM"
                     /note="major polyA site"
ORIGIN      
        1 cctctggcgc taccatggcg tttggcaaga gtcaccggga tccctacgcg acctccgtgg
       61 gccacctcat agaaaaggct acatttgctg gagttcagac tgaagattgg ggccagttca
      121 tgcacatctg tgacataatt aacactaccc aggatgggcc aaaagatgca gtgaaagctt
      181 tgaagaaaag gatttccaaa aactacaatc ataaagaaat ccaacttacc ttgtcactta
      241 ttgacatgtg tgtgcagaac tgtggtccaa gtttccagtc tctgattgtg aagaaggaat
      301 ttgttaaaga gaatttagtt aagctactga atcccagata caacttgcca ttagacattc
      361 agaatagaat cttgaatttc attaagactt ggtcacaggg cttcccagga ggtgtggatg
      421 taagcgaagt caaagaagta tacctcgacc tggttaagaa aggcgttcag tttcctccct
      481 cagaagcaga ggctgaaaca gcaagacaag agactgctca aatctcatca aatcctccaa
      541 catctgtccc tactgcacca gctctttctt ctgtaattgc tccaaagaac tcgactgtta
      601 cattggtccc agaacagatt ggaaaactgc acagtgaatt ggatatggtg aaaatgaatg
      661 tgcgagtgat gtccgccata ttgatggaga atactcctgg gtctgaaaac catgaagaca
      721 tagagcttct gcagaaactc tataaaacag gtcgggagat gcaggagagg atcatggacc
      781 tgcttgtggt ggtggagaac gaagatgtaa ctgttgagct aattcaggtg aatgaggatt
      841 tgaataatgc tatccttgga tatgagaggt ttactagaaa ccaacaaagg attttggagc
      901 aaaataagaa ccagaaggaa gccaccaata ctaccagtga gccttctgcc ccatctcaag
      961 atctcctcga cctaagtccc agtccccgga tgcctagggc cactctggga gaactcaaca
     1021 ccatgaataa tcaactttca ggcttaaatt tcagccttcc aagttctgat gtaacaaaca
     1081 acttaaaacc cagtcttcat ccacagatga acttgctagc cttggagaat acagagatac
     1141 ccccgtttgc ccaaaggacc agccaaaacc tcacctcaag ccacgcatat gataattttc
     1201 tggaacattc aaattcagtg tttctacagc cagttagtct acaaaccatt gcagcagcac
     1261 catcaaacca gagtctgcca cctttgccca gcaatcatcc agcgatgaca aaaagtgatc
     1321 tccagccacc taattactac gaggtaatgg agtttgatcc cttagctcct gctgtcacta
     1381 cagaagctat ttatgaagaa attgatgctc accagcacaa aggagctcaa aatgatggtg
     1441 actgagaaga aagtggatga tcagctcact accacatcaa aggtgccaac tctctaaaac
     1501 gtagactctg tgcagctttg aagcctggaa gacaatacct accaacatgt caaagccatg
     1561 gtggcacatt tctgctataa tgaagattaa atagaataac agttccagga taacactgat
     1621 tcctgacaac agcgtgagat ttcaacagaa cttgtttgga acaaatactc acttaaaact
     1681 tcagcagaag aaaaattact tagtccttag gccaaccaat ttaactgcag tgtcatgttt
     1741 cacaggcctt cctacattta gaaatcgtca cacagctgtg ataagagtag attattttac
     1801 tatgaaataa ttctgaatag atgaaagcat aaaatgtgag aaactgaatg tattattcag
     1861 gaagaatact gagtgccttc atttaactaa agttgaatgt aaaagtcaat ttgcacttct
     1921 ttataatcct ctggtttaga attataaatt gttaaaacct tgataattgt catttaatta
     1981 tatttcaggt gtcctgaaca ggtcactaga ctctacattg ggcagccttt aaatatgatt
     2041 ctttgtaatg ctaaatagcc tttttttctc tttttactgc aacttaatat ttctatttag
     2101 aacacagaaa atgaaaatat ttagaataag ttgtacattt gatgacaaat aaatcactat
     2161 taaaacaa
//
