LOCUS       NM_019009               3627 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens toll interacting protein (TOLLIP), transcript variant
            1, mRNA.
ACCESSION   NM_019009
VERSION     NM_019009.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3627)
  AUTHORS   Nouri,H.R., Schaunaman,N., Kraft,M., Li,L., Numata,M. and Chu,H.W.
  TITLE     Tollip deficiency exaggerates airway type 2 inflammation in mice
            exposed to allergen and influenza A virus: role of the ATP/IL-33
            signaling axis
  JOURNAL   Front Immunol 14, 1304758 (2023)
   PUBMED   38124753
  REMARK    GeneRIF: Tollip deficiency exaggerates airway type 2 inflammation
            in mice exposed to allergen and influenza A virus: role of the
            ATP/IL-33 signaling axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3627)
  AUTHORS   Demir,A.B., Baris,E., Kaner,U.B., Alotaibi,H., Atabey,N. and Koc,A.
  TITLE     Toll-interacting protein may affect doxorubicin resistance in
            hepatocellular carcinoma cell lines
  JOURNAL   Mol Biol Rep 50 (10), 8551-8563 (2023)
   PUBMED   37644370
  REMARK    GeneRIF: Toll-interacting protein may affect doxorubicin resistance
            in hepatocellular carcinoma cell lines.
REFERENCE   3  (bases 1 to 3627)
  AUTHORS   Kowalewski,A., Jaworski,D., Borowczak,J., Maniewski,M.,
            Szczerbowski,K., Antosik,P., Durslewicz,J., Smolinska,M.,
            Ligmanowska,J., Grzanka,D. and Szylberg,L.
  TITLE     TOLLIP Protein Expression Predicts Unfavorable Outcome in Renal
            Cell Carcinoma
  JOURNAL   Int J Mol Sci 23 (23), 14702 (2022)
   PUBMED   36499030
  REMARK    GeneRIF: TOLLIP Protein Expression Predicts Unfavorable Outcome in
            Renal Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3627)
  AUTHORS   Venkatasubramanian,S., Pryor,R., Plumlee,C., Cohen,S.B.,
            Simmons,J.D., Warr,A.J., Graustein,A.D., Saha,A., Hawn,T.R.,
            Urdahl,K.B. and Shah,J.A.
  TITLE     TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide
            and Mycobacterium tuberculosis
  JOURNAL   J Immunol 209 (3), 435-445 (2022)
   PUBMED   35803695
  REMARK    GeneRIF: TOLLIP Optimizes Dendritic Cell Maturation to
            Lipopolysaccharide and Mycobacterium tuberculosis.
REFERENCE   5  (bases 1 to 3627)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 3627)
  AUTHORS   Jensen,L.E. and Whitehead,A.S.
  TITLE     IRAK1b, a novel alternative splice variant of interleukin-1
            receptor-associated kinase (IRAK), mediates interleukin-1 signaling
            and has prolonged stability
  JOURNAL   J Biol Chem 276 (31), 29037-29044 (2001)
   PUBMED   11397809
REFERENCE   7  (bases 1 to 3627)
  AUTHORS   Burns,K., Clatworthy,J., Martin,L., Martinon,F., Plumpton,C.,
            Maschera,B., Lewis,A., Ray,K., Tschopp,J. and Volpe,F.
  TITLE     Tollip, a new component of the IL-1RI pathway, links IRAK to the
            IL-1 receptor
  JOURNAL   Nat Cell Biol 2 (6), 346-351 (2000)
   PUBMED   10854325
REFERENCE   8  (bases 1 to 3627)
  AUTHORS   Volpe,F., Clatworthy,J., Kaptein,A., Maschera,B., Griffin,A.M. and
            Ray,K.
  TITLE     The IL1 receptor accessory protein is responsible for the
            recruitment of the interleukin-1 receptor associated kinase to the
            IL1/IL1 receptor I complex
  JOURNAL   FEBS Lett 419 (1), 41-44 (1997)
   PUBMED   9426216
REFERENCE   9  (bases 1 to 3627)
  AUTHORS   Cao,Z., Xiong,J., Takeuchi,M., Kurama,T. and Goeddel,D.V.
  TITLE     TRAF6 is a signal transducer for interleukin-1
  JOURNAL   Nature 383 (6599), 443-446 (1996)
   PUBMED   8837778
REFERENCE   10 (bases 1 to 3627)
  AUTHORS   Nilsen,K.H.
  TITLE     Malignant lymphoma and rheumatic symptoms
  JOURNAL   N Z Med J 83 (563), 320-322 (1976)
   PUBMED   1085432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB039994.1, AL136835.1 and
            AA861717.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019009.3.
            
            Summary: This gene encodes a ubiquitin-binding protein that
            interacts with several Toll-like receptor (TLR) signaling cascade
            components. The encoded protein regulates inflammatory signaling
            and is involved in interleukin-1 receptor trafficking and in the
            turnover of IL1R-associated kinase. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.450488.1,
                                           SRR1660805.26131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317204.11/ ENSP00000314733.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DB039994.1         32-54
            24-3612             AL136835.1         1-3589
            3613-3627           AA861717.1         9-23                c
FEATURES             Location/Qualifiers
     source          1..3627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..3627
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /note="toll interacting protein"
                     /db_xref="GeneID:54472"
                     /db_xref="HGNC:HGNC:16476"
                     /db_xref="MIM:606277"
     exon            1..167
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..959
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Toll-interacting protein; adapter protein"
                     /codon_start=1
                     /product="toll-interacting protein isoform 1"
                     /protein_id="NP_061882.2"
                     /db_xref="CCDS:CCDS7723.1"
                     /db_xref="GeneID:54472"
                     /db_xref="HGNC:HGNC:16476"
                     /db_xref="MIM:606277"
                     /translation="MATTVSTQRGPVYIGELPQDFLRITPTQQQRQVQLDAQAAQQLQ
                     YGGAVGTVGRLNITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNK
                     VIHCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLRQGKVEDKWYSLSGRQGD
                     DKEGMINLVMSYALLPAAMVMPPQPVVLMPTVYQQGVGYVPITGMPAVCSPGMVPVAL
                     PPAAVNAQPRCSEEDLKAIQDMFPNMDQEVIRSVLEAQRGNKDAAINSLLQMGEEP"
     exon            168..317
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            318..500
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            501..653
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            654..744
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            745..3627
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1346..1351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /note="hexamer: AATAGA"
     polyA_site      1375
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /note="major polyA site"
     regulatory      3575..3580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /note="hexamer: AATAAA"
     polyA_site      3595
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
     regulatory      3602..3607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /note="hexamer: AATAAA"
     polyA_site      3627
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
ORIGIN      
        1 gcggctgtca gctgactgtg gcggcggcgg cctcgaggtg acaactgtct ccgtcgcagg
       61 ctccggcggg ggcgcaggag gtcgcccggc gcgtcactgt cgggtcggcg agccacgggg
      121 gccgccgcag caccatggcg accaccgtca gcactcagcg cgggccggtg tacatcggtg
      181 agctcccgca ggacttcctc cgcatcacgc ccacacagca gcagcggcag gtccagctgg
      241 acgcccaggc ggcccagcag ctgcagtacg gaggcgcagt gggcaccgtg ggccgactga
      301 acatcacggt ggtacaggca aagttggcca agaattacgg catgacccgc atggacccct
      361 actgccgact gcgcctgggc tacgcggtgt acgagacgcc cacggcacac aatggcgcca
      421 agaatccccg ctggaataag gtcatccact gcacggtgcc cccaggcgtg gactctttct
      481 atctcgagat cttcgatgag agagccttct ccatggacga ccgcattgcc tggacccaca
      541 tcaccatccc ggagtccctg aggcagggca aggtggagga caagtggtac agcctgagcg
      601 ggaggcaggg ggacgacaag gagggcatga tcaacctcgt catgtcctac gcgctgcttc
      661 cagctgccat ggtgatgcca ccccagcccg tggtcctgat gccaacagtg taccagcagg
      721 gcgttggcta tgtgcccatc acagggatgc ccgctgtctg tagccccggc atggtgcccg
      781 tggccctgcc cccggccgcc gtgaacgccc agccccgctg tagcgaggag gacctgaaag
      841 ccatccagga catgttcccc aacatggacc aggaggtgat ccgctccgtg ctggaagccc
      901 agcgagggaa caaggatgcc gccatcaact ccctgctgca gatgggggag gagccataga
      961 gcctctgcct cgatgccgtt ttgcccccgc tctttggaca cgccgacccg gcgctcccca
     1021 aggaatgctg tcccaacaag attcccgtga aagagcaccc gtgtcgcccc ctcccgtgga
     1081 cttctgtgcc gccccgtcca cacctgttct tgggtgcatg tgggttttcg gttcctggcg
     1141 gtccaggacg gggcgggggc tcccctccca tctcgtgctg ggaggtctca gcgcgctctc
     1201 ctgtccctgg gacgtgcgtc tctccttctc atgccgttct ggaaaatgct cttgctgtag
     1261 agagcagctg cttctgccag ggtgttggag gtggtggagc gccttccgat tccattcatg
     1321 gcattttgtg atgtgatgta attggaatag agctgttgat ttaaggcaca cacaatccct
     1381 cacactgtgg gtttttttta gaacttccca gacgaaaact cacgcccttg ccctaacgcg
     1441 ctttgctgtg agcctggccc ctgcccaggg cttgggtctg gtgagctgag cagcttcctg
     1501 tggatggtgt ggggccggcc tctggcctgg ctcacctggc cactgtccag ccagccttgt
     1561 gacagactcc ggcctgaagg cagaatgaac ccacacctgg agtgaggaag ggggcctggc
     1621 acggttggcc aggctctgcc tgattgccag ccagcgggca tctgaagccg ggtccttcgc
     1681 ccgccggagg ctgccgtccg tctctcctgc tgcgctcgtg ccagctccgt gggtgtcctc
     1741 ccagggagct tctcttctca acaggccttg cgaggctggg gtgagaggtg atagaggcag
     1801 cactgtgcat gattccgaga gggtgtggtg gcactgccag ccgactgctg acagcttggg
     1861 agctgctgtg cccaggacgt gggttcagcg tgggcgagga aagcctggcg agcgtggccc
     1921 tgtaaaagct ttctgaggcg ggaggcgctc acttacctct gactgcctgg gcgctgcgtg
     1981 tagcatcttg gcctacagga cagattttag gtgacacctg gttatgacag tcagaaattt
     2041 gagaagcttc tcacaagtga tgcactttaa ataatctgca tgccattgag acacctgcat
     2101 gtctggtgtt tgtggttcaa gtgtcttgcc gccggccttc ggatgtaaac ccactgataa
     2161 cggacagaaa gagaatgccc acaagtgggt cttctgtgga agatgcagaa ggaggaagtt
     2221 agtgcttaca ttttagtctt tttctccctc aaaaaaatag gttaagtttc agtgccagct
     2281 agaaaatact gctttctgcc atcgattggg ggtggttttt gtcaaatata ctgttgataa
     2341 atatttattt ttgtaaactt gaagtgtgtg gtggccgtgg gggagggaca tgctggcagc
     2401 aggcgccttc ttcagctgtg ggtcctaaag gcctttgatc ctttgaagaa gaaagacatg
     2461 gtatttgttc agcagacgcc gaccactcag acggaggggc ccctgggatt ccctgtctca
     2521 gatggcctgg tcttacgcct gtgtagattt cttctccatt gggaatgaag gtgtcaggcg
     2581 ggactggaac gttctagatg gtatgttccg tgatattaac aactctaacc caggacagac
     2641 cacaagccac actcagaggc ctcactgtgc tgggggcttc ggtgtccagg cgcccaggtg
     2701 tggccaccag caccggtttc tgccttcgcg ttgctggggt gcagtgagac tgccacacgc
     2761 gtgcacatgt ggctctgtgg gtgtctccta gagaggacgt ggcccctgct gccagccctt
     2821 gagcagcccg tgtgggggcc cgagggaccc acacagtggg ggccagcctc gctggaggga
     2881 gagcaaccct ttgccgatga ccacgcttgc cgccatctct tagttttctt tttcacaagc
     2941 gctttatttt tttaatagac aaatcacatt ttgcaaggcc tttaattaaa taagattctt
     3001 ctttccttca ttttatgctt tatttcctgt ttgaaggctt actgtagaag tggcttactg
     3061 tagaagcagc ttgctgagcc cctccgagcg gtccccagaa ttagctggtt cacaaccccc
     3121 accctccccc gcccccgcct gtgtcaggtg tggatgaggt cgtcacactc agaaggacag
     3181 gcttgtctgc cagctcacaa ggggaggctg cagtgggttt gggagctggg tttaggcccc
     3241 tggtgtctga gggcccaggc cttgccagcc tctgctgctc ctgctcctgg gtttgaagat
     3301 gcaggccgat cgccagctcc gtggcagcgg tcactaagga cagcctgact gtgccatctt
     3361 ggagcctcag gcggggctcc ggagatagaa gacaggtcgc cggaggctcc ccctcctctc
     3421 ctctcccctc tgcagatgct ccctgggcgc taccctgcag ggtgccaggc aggagtggtc
     3481 tcagaacgtg cgcttctgat tattttactg gggtccattg tccagatttt tctttgattg
     3541 taaaatatat ttttactttt tagtcttcta atttaataaa tgatccatat aaaaatagag
     3601 aaataaagtc ctttaaggga aggttta
//
