LOCUS       NM_199280               3548 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens TOG array regulator of axonemal microtubules 2
            (TOGARAM2), transcript variant 1, mRNA.
ACCESSION   NM_199280 XM_092437
VERSION     NM_199280.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3548)
  AUTHORS   Ramzan,M., Zafeer,M.F., Abad,C., Guo,S., Owrang,D., Alper,O.,
            Mutlu,A., Atik,T., Duman,D., Bademci,G., Vona,B., Kalcioglu,M.T.,
            Walz,K. and Tekin,M.
  TITLE     Genetic heterogeneity in hereditary hearing loss: Potential role of
            kinociliary protein TOGARAM2
  JOURNAL   Eur J Hum Genet 32 (6), 639-646 (2024)
   PUBMED   38374469
  REMARK    GeneRIF: Genetic heterogeneity in hereditary hearing loss:
            Potential role of kinociliary protein TOGARAM2.
REFERENCE   2  (bases 1 to 3548)
  AUTHORS   Das,A., Dickinson,D.J., Wood,C.C., Goldstein,B. and Slep,K.C.
  TITLE     Crescerin uses a TOG domain array to regulate microtubules in the
            primary cilium
  JOURNAL   Mol Biol Cell 26 (23), 4248-4264 (2015)
   PUBMED   26378256
REFERENCE   3  (bases 1 to 3548)
  AUTHORS   Simino,J., Sung,Y.J., Kume,R., Schwander,K. and Rao,D.C.
  TITLE     Gene-alcohol interactions identify several novel blood pressure
            loci including a promising locus near SLC16A9
  JOURNAL   Front Genet 4, 277 (2013)
   PUBMED   24376456
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3548)
  AUTHORS   Shi,J., Potash,J.B., Knowles,J.A., Weissman,M.M., Coryell,W.,
            Scheftner,W.A., Lawson,W.B., DePaulo,J.R. Jr., Gejman,P.V.,
            Sanders,A.R., Johnson,J.K., Adams,P., Chaudhury,S., Jancic,D.,
            Evgrafov,O., Zvinyatskovskiy,A., Ertman,N., Gladis,M., Neimanas,K.,
            Goodell,M., Hale,N., Ney,N., Verma,R., Mirel,D., Holmans,P. and
            Levinson,D.F.
  TITLE     Genome-wide association study of recurrent early-onset major
            depressive disorder
  JOURNAL   Mol Psychiatry 16 (2), 193-201 (2011)
   PUBMED   20125088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105398.3.
            
            On Jan 27, 2020 this sequence version replaced NM_199280.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous protein data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1737247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379558.5/ ENSP00000368876.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AC105398.3         18158-18398
            242-379             AC105398.3         31585-31722
            380-490             AC105398.3         35003-35113
            491-778             AC105398.3         36041-36328
            779-990             AC105398.3         39396-39607
            991-1181            AC105398.3         40352-40542
            1182-1228           AC105398.3         48315-48361
            1229-1395           AC105398.3         51255-51421
            1396-1546           AC105398.3         54014-54164
            1547-1711           AC105398.3         54652-54816
            1712-1862           AC105398.3         59018-59168
            1863-1968           AC105398.3         59946-60051
            1969-2204           AC105398.3         60999-61234
            2205-2363           AC105398.3         63713-63871
            2364-2481           AC105398.3         69794-69911
            2482-2576           AC105398.3         70329-70423
            2577-2769           AC105398.3         72324-72516
            2770-2986           AC105398.3         73401-73617
            2987-3073           AC105398.3         82184-82270
            3074-3548           AC105398.3         88616-89090
FEATURES             Location/Qualifiers
     source          1..3548
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.2"
     gene            1..3548
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /note="TOG array regulator of axonemal microtubules 2"
                     /db_xref="GeneID:165186"
                     /db_xref="HGNC:HGNC:33715"
                     /db_xref="MIM:620949"
     exon            1..241
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            242..379
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..3411
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM179A; crescerin-2; family with sequence
                     similarity 179 member A; TOG array regulator of axonemal
                     microtubules protein 2"
                     /codon_start=1
                     /product="TOG array regulator of axonemal microtubules
                     protein 2 isoform 1"
                     /protein_id="NP_954974.2"
                     /db_xref="CCDS:CCDS1769.2"
                     /db_xref="GeneID:165186"
                     /db_xref="HGNC:HGNC:33715"
                     /db_xref="MIM:620949"
                     /translation="MGTRDDVPEAKVLVPVAVYCGSIPRTSAGPRVLPPGSINSSLPH
                     GEGSLQPEPRALLNNEEPSQLLRGLGQLGGLKLDTPSKGWQARNGHPRNLRALSLGDQ
                     PLVLLPSPESEANSVARDTIQIKDKLKKRRLSEGLAASSRASLDPGGGPQGVPLHSTI
                     PRATSQRLLRVPRPMPLIQSIPTTPEASGVKEKGLDLPGSIPGPHELRPGAQEAQISW
                     QYLHCNDEKMQKSLGAIVIPPIPKARTVAATPSRVPGSLPSPLPPGQGVLTGLRAPRT
                     RLARGSGPREKTPASLEPKPLASPIRDRPAAAKKPALPFSQSAPTLTAFSFDCAREAC
                     PPLKEEDQKEIGTKIQVTISKSAREKMQLKQMKEMELLRRLEEPRTGQELTSQCLGSQ
                     RAFMKEGLLPLRGSGTLSVPTRLSGPCRNDVSIILRKWASRASLPSIPISRQEPRFAR
                     HASANSLPAVLTLGSPEWEEEEEMDLRACKELRPFSNPELGLRDALQCLNSSDWQMKE
                     KGLVSIQRLAACHSEVLTGKLHDVCLVVTGEVTNLRSKVSHLAISTLGDLFQALKKNM
                     DQEAEEIARCLLQKMADTNEFIQRAAGQSLRAMVENVTLARSLVVLTSAGVYHRNPLI
                     RKYAAEHLSAVLEQIGAEKLLSGTRDSTDMLVHNLVRLAQDSNQDTRFYGRKMVNILM
                     ANTKFDAFLKQSLPSYDLQKVMAAIKQQGIEDNDELPSAKGRKVLRSLVVCENGLPIK
                     EGLSCNGPRLVGLRSTLQGRGEMVEQLRELTRLLEAKDFRSRMEGVGQLLELCKAKTE
                     LVTAHLVQVFDAFTPRLQDSNKKVNQWALESFAKMIPLLRESLHPMLLSIIITVADNL
                     NSKNSGIYAAAVAVLDAMVESLDNLCLLPALAGRVRFLSGRAVLDVTDRLAVLVASVY
                     PRKPQAVERHVLPILWHFLNTATRNGTLPGPSGNIRGVVCRLSRSLQEHMGSRLLDFA
                     ASQPKHVLKTLQELLDSESLGGSRKATDRGVAPDSKTTGSSYPFQLD"
     exon            380..490
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            491..778
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            779..990
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1181
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1228
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1395
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1546
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1711
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1862
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1968
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2204
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2363
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2481
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2576
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2769
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2986
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3073
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3548
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3523..3528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /note="hexamer: AATAAA"
     polyA_site      3548
                     /gene="TOGARAM2"
                     /gene_synonym="FAM179A"
                     /note="major polyA site"
ORIGIN      
        1 gtttattcaa ggagagcttt gctgagagct ggagcacgcc agcagtggag ctcgtggcca
       61 cccagcccct gctcagacag gaggctgcgg cccaggactg tgtggctggt gggggccagg
      121 gtgggccagg cctggggctg ccccgtcctt gcctccctgg gcccatgagc atcaacgtct
      181 ctatagagac caaggaccct ggattcctcc agtgacaggg gtttggcctc tggacagaga
      241 ggtcccggat gttacaggtc agagccctcc agacccccaa ggactgtact cactgcccag
      301 aaatagctgc tgcctctggg caaccttgta ggcaccttct ccacccagga catgggcacc
      361 cgtgacgatg tccccgaagc caaggtcctg gtccccgtgg ccgtgtactg cgggagcatc
      421 cctcggacca gtgctgggcc ccgggtgctc ccgcctggaa gcatcaactc cagtctgcct
      481 catggagaag gttctctcca gcctgagcca agagccctgc tgaacaacga ggaaccgtca
      541 cagctcctgc gtggactcgg acagctgggt ggcctcaagc tggacacccc ttccaagggc
      601 tggcaggcaa ggaatggtca ccccaggaac ctcagggcct tgtctttggg ggaccagccc
      661 ctggtgctcc tcccttctcc ggagtcagag gccaacagcg tggccaggga caccatccag
      721 attaaggaca agctcaagaa aaggaggctc tcagagggct tggcagcgtc ttcccgagcc
      781 tctctggatc cagggggagg cccccaagga gttcccctgc acagcaccat cccccgagcc
      841 acctctcaga ggctgctgag ggtgcccagg ccgatgcctc tcatccagag catccctacc
      901 acccctgagg ccagcggagt caaagagaag ggcctggacc taccggggag cattccgggt
      961 cctcacgagt tgagacccgg tgctcaggag gcgcagatct cctggcaata cctgcactgc
     1021 aatgatgaga agatgcagaa gtccctgggc gccatcgtga tcccacccat cccaaaggcc
     1081 aggacggttg cagcgacccc ctcccgtgtg cctggctccc ttcccagccc gttacctcca
     1141 ggccagggag tcctcacagg cctgagggcc ccacgcacgc gattggctcg ggggagtggg
     1201 cctcgggaga agacccctgc atctctggag ccaaaacctt tggcctcacc catcagagac
     1261 aggcctgccg ctgccaagaa gcctgccctg cctttttctc agtctgctcc cacgctgaca
     1321 gccttctcct ttgactgtgc cagagaagcc tgccctccgc tgaaagaaga ggaccagaag
     1381 gagatcggca ccaagatcca agtcaccatc tccaagtctg cccgggagaa gatgcagctg
     1441 aagcagatga aggagatgga gctgcttcgg aggctggagg agcccaggac agggcaggag
     1501 ctcacttccc agtgcctggg ctcccagaga gccttcatga aggaaggcct ccttcccctc
     1561 cggggcagcg ggacactgtc tgtgcccact aggctgagcg gcccatgcag aaacgacgtc
     1621 agcatcatcc tgaggaagtg ggccagccgg gcctccctgc ccagcatccc catcagccgg
     1681 caggagcccc gctttgcccg ccacgcctca gctaactcat tacctgcggt gctcacgttg
     1741 gggtctcctg aatgggaaga agaggaggag atggatctta gagcctgtaa ggagttgagg
     1801 cctttctcga acccggagct ggggctgagg gatgcactcc agtgcctcaa cagcagtgac
     1861 tggcagatga aggagaaggg tctggtgagc atccagcgct tggcagcctg tcactcagag
     1921 gtcctcaccg ggaagctgca cgacgtgtgc ttggtggtga ctggggaggt caccaacctg
     1981 cggtccaagg tgtctcacct ggccatcagc accttgggag acctcttcca ggccttgaag
     2041 aagaatatgg accaggaggc cgaggagatc gcccgctgct tgctgcagaa gatggcggac
     2101 accaacgagt tcatccagag agcagccggc cagtctctga gggctatggt ggagaatgtg
     2161 acccttgccc gctccctggt ggtcctcacc tcggcgggtg tctaccaccg gaaccccttg
     2221 atccggaaat acgcggctga gcacctctca gctgtgctgg agcagatcgg cgctgagaag
     2281 cttctctcgg gcaccagaga cagcacagac atgttggtgc acaacctggt gaggctggca
     2341 caggactcca accaggacac cagattttat ggccggaaga tggtgaatat cttgatggcg
     2401 aacactaagt ttgatgcatt tctgaagcaa tctctcccat cttacgactt gcagaaggtc
     2461 atggcggcca ttaaacagca gggaatagaa gataatgatg aacttccctc tgccaaaggc
     2521 cgcaaggtgt tgaggagtct ggtggtgtgt gagaacgggc tgcccatcaa ggaggggctc
     2581 agctgcaatg gcccaaggct ggtggggctg cgctccacac tgcagggccg cggggagatg
     2641 gtggagcagc tacgggagct gacacggctg ctggaggcca aggacttccg gtcccggatg
     2701 gaaggcgtgg ggcagctcct ggagctctgc aaggccaaga cggagcttgt cactgcccac
     2761 ctggtccagg tctttgatgc tttcacccca aggcttcagg attccaacaa gaaagtgaac
     2821 cagtgggcgc tggagtcctt cgccaagatg atccccctcc tcagagagag cttacacccc
     2881 atgctgctct ccatcatcat cactgttgca gacaacctca actccaagaa ctcagggatt
     2941 tacgctgctg ccgtggctgt gctggatgcg atggttgaga gcctggacaa cctttgcctt
     3001 ctaccagcgc ttgctgggcg agtgcgtttc ctgagtggcc gtgcggtgct ggatgtcaca
     3061 gatcgcctgg cagtgctggt ggcctcagtt tacccccgga agcctcaagc tgtagagcgg
     3121 catgtccttc ccatcctctg gcacttcctg aacaccgcca ccaggaatgg caccctgcct
     3181 ggacccagcg ggaacatccg cggggtggtg tgccggctgt ccaggagcct ccaggagcac
     3241 atgggctccc gcctgctgga ctttgccgcc agccagccaa agcacgtcct caagacgctc
     3301 caggaactct tagactcaga gtccttggga ggcagccgca aggccactga cagaggggtg
     3361 gcccctgaca gcaagacaac tggcagctca tacccttttc agctggatta aagatggatc
     3421 tgaaatgggc aattattatt tatcttattt ttttgatgga ctattctcct ggttactttc
     3481 ccccttagag ttccagatgt acatggtata ttttgaagta gaaataaaag aattacttat
     3541 ttttctaa
//
