LOCUS       NM_016272               4337 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transducer of ERBB2, 2 (TOB2), mRNA.
ACCESSION   NM_016272
VERSION     NM_016272.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4337)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 4337)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4337)
  AUTHORS   Wang,Y.H., Li,S.Y., Yuan,S.J., Pan,Y.X., Hua,Y. and Liu,J.Y.
  TITLE     MiR-375 promotes human periodontal ligament stem cells
            proliferation and osteogenic differentiation by targeting
            transducer of ERBB2, 2
  JOURNAL   Arch Oral Biol 117, 104818 (2020)
   PUBMED   32619704
  REMARK    GeneRIF: MiR-375 promotes human periodontal ligament stem cells
            proliferation and osteogenic differentiation by targeting
            transducer of ERBB2, 2.
REFERENCE   4  (bases 1 to 4337)
  AUTHORS   Chen,C.A., Strouz,K., Huang,K.L. and Shyu,A.B.
  TITLE     Tob2 phosphorylation regulates global mRNA turnover to reshape
            transcriptome and impact cell proliferation
  JOURNAL   RNA 26 (9), 1143-1159 (2020)
   PUBMED   32404348
  REMARK    GeneRIF: Tob2 phosphorylation regulates global mRNA turnover to
            reshape transcriptome and impact cell proliferation.
REFERENCE   5  (bases 1 to 4337)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4337)
  AUTHORS   Yoshida,Y., Hosoda,E., Nakamura,T. and Yamamoto,T.
  TITLE     Association of ANA, a member of the antiproliferative Tob family
            proteins, with a Caf1 component of the CCR4 transcriptional
            regulatory complex
  JOURNAL   Jpn J Cancer Res 92 (6), 592-596 (2001)
   PUBMED   11429045
REFERENCE   7  (bases 1 to 4337)
  AUTHORS   Hirosawa,M., Nagase,T., Murahashi,Y., Kikuno,R. and Ohara,O.
  TITLE     Identification of novel transcribed sequences on human chromosome
            22 by expressed sequence tag mapping
  JOURNAL   DNA Res 8 (1), 1-9 (2001)
   PUBMED   11258795
REFERENCE   8  (bases 1 to 4337)
  AUTHORS   Suzuki,T., Matsuda,S., Tsuzuku,J.K., Yoshida,Y. and Yamamoto,T.
  TITLE     A serine/threonine kinase p90rsk1 phosphorylates the
            anti-proliferative protein Tob
  JOURNAL   Genes Cells 6 (2), 131-138 (2001)
   PUBMED   11260258
REFERENCE   9  (bases 1 to 4337)
  AUTHORS   Ikematsu,N., Yoshida,Y., Kawamura-Tsuzuku,J., Ohsugi,M., Onda,M.,
            Hirai,M., Fujimoto,J. and Yamamoto,T.
  TITLE     Tob2, a novel anti-proliferative Tob/BTG1 family member, associates
            with a component of the CCR4 transcriptional regulatory complex
            capable of binding cyclin-dependent kinases
  JOURNAL   Oncogene 18 (52), 7432-7441 (1999)
   PUBMED   10602502
REFERENCE   10 (bases 1 to 4337)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM453650.1, AB051450.1, BC038957.1 and AI362988.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016272.3.
            
            Summary: TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM
            109580) family of antiproliferative proteins, which are involved in
            the regulation of cell cycle progression.[supplied by OMIM, Apr
            2004].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038957.1, AB051450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327492.4/ ENSP00000331305.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               BM453650.1         223-573
            352-1931            AB051450.1         333-1912
            1932-3126           BC038957.1         1927-3121
            3127-4333           AB051450.1         3108-4314
            4334-4337           AI362988.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..4337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..4337
                     /gene="TOB2"
                     /gene_synonym="APRO5; TOB4; TOBL; TROB2"
                     /note="transducer of ERBB2, 2"
                     /db_xref="GeneID:10766"
                     /db_xref="HGNC:HGNC:11980"
                     /db_xref="MIM:607396"
     exon            1..423
                     /gene="TOB2"
                     /gene_synonym="APRO5; TOB4; TOBL; TROB2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..4337
                     /gene="TOB2"
                     /gene_synonym="APRO5; TOB4; TOBL; TROB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             486..1520
                     /gene="TOB2"
                     /gene_synonym="APRO5; TOB4; TOBL; TROB2"
                     /note="protein Tob4; transducer of erbB-2 2"
                     /codon_start=1
                     /product="protein Tob2"
                     /protein_id="NP_057356.1"
                     /db_xref="CCDS:CCDS14015.1"
                     /db_xref="GeneID:10766"
                     /db_xref="HGNC:HGNC:11980"
                     /db_xref="MIM:607396"
                     /translation="MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLKKKYEGHW
                     YPEKPLKGSGFRCVHIGEMVDPVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQ
                     IGEKGAVKVLYLDDSEGCGAPELDKEIKSSFNPDAQVFVPIGSQDSSLSNSPSPSFGQ
                     SPSPTFIPRSAQPITFTTASFAATKFGSTKMKKGGGAASGGGVASSGAGGQQPPQQPR
                     MARSPTNSLLKHKSLSLSMHSLNFITANPAPQSQLSPNAKEFVYNGGGSPSLFFDAAD
                     GQGSGTPGPFGGSGAGTCNSSSFDMAQVFGGGANSLFLEKTPFVEGLSYNLNTMQYPS
                     QQFQPVVLAN"
     regulatory      4316..4321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOB2"
                     /gene_synonym="APRO5; TOB4; TOBL; TROB2"
                     /note="hexamer: ATTAAA"
     polyA_site      4337
                     /gene="TOB2"
                     /gene_synonym="APRO5; TOB4; TOBL; TROB2"
                     /note="major polyA site"
ORIGIN      
        1 gctcacttcg ggccggggcg cgggaaggtg cgggttgttg gctgaggcaa gccgtggctc
       61 gggcgacgcg gggccaggag ggcaggaccg tctgccggcg acagcccata ccgtctgccg
      121 ttgcgcgaca cgaaccaccc tccgatccgc catccccgcg tcgtcgccgc tagtccgccc
      181 gcccgccctc gggccccccg ctgccgagcc cgacctccta agagctgaaa gaaattattg
      241 agagtcatag tccatagccc cctgcttcgt cccccaaccc tcaacgacga aaaggacttc
      301 ggtcccctgg cccggcgacg cccgggaagg aaaggagagc gacctccgcc ccgcgctcag
      361 gccaccctgg agggagaagc cgccccgcgg ccggtagagc gccccgccgc cgcggagacc
      421 cgaagccgcc tggagcccaa ggctgtacac gtgccctgtg ctgattctct gcctaggaaa
      481 ggaccatgca gctagagatc aaagtggccc tgaacttcat catctcctac ttgtacaaca
      541 agctgccccg gcgccgggca gacctgtttg gggaggagct agagcggctt ttgaaaaaga
      601 aatatgaagg ccactggtac cctgagaagc cactgaaagg ctctggcttc cgctgtgttc
      661 acattgggga gatggtggac cccgtggtgg agctggccgc caagcggagt ggcctggcgg
      721 tggaagatgt gcgggccaat gtgcctgagg agctgagtgt ctggattgat ccctttgagg
      781 tgtcctacca gattggtgag aagggagctg tgaaagtgct gtacctggat gacagtgagg
      841 gttgcggtgc cccagagctg gacaaggaga tcaagagcag cttcaaccct gacgcccagg
      901 tgttcgtgcc cattggcagc caggacagct ccctgtccaa ctccccatcg ccatcctttg
      961 gccagtcacc cagccctacc ttcattcccc gctccgctca gcccatcacc ttcaccaccg
     1021 cctccttcgc tgccaccaaa tttggctcca ctaagatgaa gaaggggggc ggggcagcaa
     1081 gtggtggggg tgtagccagc agtggggcgg gtggccagca gccaccacag cagcctcgca
     1141 tggcccgctc acccaccaac agcctgctga agcacaagag cctctctctg tctatgcatt
     1201 cactgaactt catcacggcc aacccggccc ctcagtccca gctctcaccc aatgccaagg
     1261 agttcgtgta caacggtggt ggctcaccca gcctcttctt tgatgcggcc gatggccagg
     1321 gcagcggcac cccaggcccg tttggaggca gtggggctgg cacctgcaac agcagcagct
     1381 ttgacatggc ccaggtattt ggaggtggtg ccaacagcct cttcctggag aagacaccct
     1441 ttgtggaagg cctcagctac aacctgaaca ccatgcagta tcccagccag cagttccagc
     1501 ccgtggtgct ggccaactga ccatctacct gcccgtgggg ccaggagcac ccaagaccac
     1561 agaaaagaga aaggaaaggc caaaaaaaag aggaaaagaa aaatgtacaa aaagattttc
     1621 gatcttctca ctcttacttc tagaaaaaag atccagccca ggcacggaat gggagggccc
     1681 tgcaaagcac ccaagtgtgt ttcactcacc ccttaccgct cgcccaccgg cctgtgattt
     1741 atttggttgg tttgggtttt atatttcttt ttcttttttt tttttcttac atgtagtttt
     1801 ctatataaca tctttaatga gtggcttcct gtgctaagaa tggtccagat gtgaactgct
     1861 gctccctgct cctcccttcc tccttcacac tcctagttta ggattgatgt gtccaagctc
     1921 atagggaaga aagagctgca gctggagcct gaccctccct ggaacaggga gaggctggcc
     1981 cgtgtcactg cctctgtcac ccagctatcc tcgcactcaa agccatccaa cctcagcagg
     2041 ccttctcggg ccctgccacc tgaataggtc tgaccccagt ccccactccc tttcaggctg
     2101 ggccacaggg agttgctggc tggccacttg acaccctccc cctggagctg atgtctgtga
     2161 ctacagggag attagcactt cgtctagtga aactcctttc atctctgtcc tatggcccca
     2221 ccccaccatt ccctctaggc ccagaccatc atcatggccc tggccattga tgtgtatggg
     2281 ctttctttcc ctcatgcagc cccttcttcc ccaggctgga tgttgtgggt agggaggggt
     2341 gtgtgtgtgt gtatttggtt tgctgtcctt ttttaaagga ttccaagcca tgtgaaactt
     2401 cccttctgga tgtgattctg ggtcgcaagt ccttatttat atgtgaggct ggggaatggg
     2461 ctgggggtat tggcagtcct tttgcagggc agtgtgtgtg gtggggtgac accgctgtgg
     2521 cttagcccaa gacactccca gaggaaaaca ctgcagaagg aactggtttg cagactgtgg
     2581 aaggatctgc agttttgttt ttgaccaaaa aaataataat aagttagctc tgaagggcag
     2641 agggaatacc caagcccctg atgcctatga gaagtccctg gacttcaacc ctcctgttgt
     2701 ttggccttag cccagaggga gctgctcacc tgagcaccct tgggggtggg cagagaggca
     2761 gggtgggatt ttagagttag tgtctgtgcg ggggcagccc tgagcctgga gttgagactt
     2821 tggggtctct tagtttggag gtgttgagtg catttgtgcc cctgcctggt tgagagcttc
     2881 ttggtacctc ttgccacccc ttctcactgc cctgacccaa ccccactgga ccttgatgct
     2941 gcgaggagtg gtgtcctgac ggactcagca ctcccgcctg atgtattgga tcataggaga
     3001 gcacttgctc tcctgcctct gccaggagag ggcttgttcc tccaactcta ggaggccagg
     3061 caagcatgga caggagccaa gggagcaggg tcattaactt tttcttcttt gcaaagtggg
     3121 cacttggcat cagggtccca atcaccagaa agcaccaaag cccctggcac cccacccact
     3181 ccatcctacc cagggacccc aagtaggcaa ctgttatggc agtgggtcca gcccaggcca
     3241 gcactgccag cctcctctcc ctgcagtagg caccagctct acctcccccg gcaggcaatg
     3301 tcctggcttc tcagcccagc accatctgtt cccctagact tctcaggggc cagcccagtc
     3361 tgggccaccc tttgtttccc tcatcctcgg ctcccacaca ggtgacagac ccagcagata
     3421 gcttctctct gggaaaggtt ggatgctgcc ttacatcccc ttctagccct cctcccatcc
     3481 acacacacag gcacccaccc acaccaggtc ggcttgtttc tcacatgtag ggagagaggg
     3541 gagaccaacc cctttgtgtc ttttgaaata cgaagaaaaa tgtgtgttca ggagcatgac
     3601 tccagtgctg cgctcttggg cccagttcag tctgtcttgt ctcaaatcta ggcatttttg
     3661 cttcaatttt atttttttta agaatacaaa aacagaaatc tgcactaatt tacctggttt
     3721 cgtaggaaaa ctttttttta ttttttacat tttttggtgt ccgtttgtat tgaataattt
     3781 gctacatttg taaaatgtaa gaggtatata atatatgtat atttctaacg taaaaaacat
     3841 aatttttttc ttttcaagat tttttcttaa aaagatgaga gaaacatatt ttttcaggaa
     3901 aaacaaactt taaaaaaaaa agaggagaaa taaaaccttt tctccccttt ccccatcctc
     3961 tatctatccc tctttcccag gaacaaatca aaaggtggat tatcttctga agaatggaaa
     4021 ctgttagtcc agaatgatgt gtttttctca atgcagtgag ttatagattc tctagttttc
     4081 tccctaggga tgggaagggg gcattgaggc aagcctggag aggagcccgg ggagcagggt
     4141 catgaacttt tttctttagt gaaggaggaa tacaatcaag ggttttgtat tcagaatgtt
     4201 gtgcaatatt ttggaatggg acattggtgt gtttagagat tttagtttaa aaacaaaaca
     4261 aaaagattga tcaaatctgt acagtttcta ttgttccaga tttttttaag tttgtattaa
     4321 aagcatgata cataata
//
