LOCUS       NM_005749               2238 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 1,
            mRNA.
ACCESSION   NM_005749
VERSION     NM_005749.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2238)
  AUTHORS   He,H., Dong,K., Chen,M., Wang,Y., Li,Y., Wang,D., Jia,M., Meng,X.,
            Sun,W., Fu,S. and Yu,J.
  TITLE     TOB1 inhibits the gastric cancer progression by focal adhesion
            pathway and ERK pathway based on transcriptional and metabolic
            sequencing
  JOURNAL   BMC Cancer 24 (1), 1130 (2024)
   PUBMED   39261761
  REMARK    GeneRIF: TOB1 inhibits the gastric cancer progression by focal
            adhesion pathway and ERK pathway based on transcriptional and
            metabolic sequencing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2238)
  AUTHORS   Zhang,J., Li,Y., Chen,J., Huang,T., Lin,J., Pi,Y., Hao,H., Wang,D.,
            Liang,X., Fu,S. and Yu,J.
  TITLE     TOB1 modulates neutrophil phenotypes to influence gastric cancer
            progression and immunotherapy efficacy
  JOURNAL   Front Immunol 15, 1369087 (2024)
   PUBMED   38617839
  REMARK    GeneRIF: TOB1 modulates neutrophil phenotypes to influence gastric
            cancer progression and immunotherapy efficacy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2238)
  AUTHORS   Dong,Z., Zhang,G., Lu,J., Guo,Y., Liang,J., Shen,S. and Guo,W.
  TITLE     Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates
            with Malignant Progression and Poor Prognosis of Esophageal
            Squamous Cell Carcinoma
  JOURNAL   Dig Dis Sci 68 (4), 1316-1331 (2023)
   PUBMED   36002674
  REMARK    GeneRIF: Methylation Mediated Downregulation of TOB1-AS1 and TOB1
            Correlates with Malignant Progression and Poor Prognosis of
            Esophageal Squamous Cell Carcinoma.
REFERENCE   4  (bases 1 to 2238)
  AUTHORS   Wang,D., Li,Y., Sui,S., Cai,M., Dong,K., Wang,P., Liang,X., Fu,S.
            and Yu,J.
  TITLE     Involvement of TOB1 on autophagy in gastric cancer AGS cells via
            decreasing the activation of AKT/mTOR signaling pathway
  JOURNAL   PeerJ 10, e12904 (2022)
   PUBMED   35186488
  REMARK    GeneRIF: Involvement of TOB1 on autophagy in gastric cancer AGS
            cells via decreasing the activation of AKT/mTOR signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2238)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 2238)
  AUTHORS   Yoshida,Y., Tanaka,S., Umemori,H., Minowa,O., Usui,M., Ikematsu,N.,
            Hosoda,E., Imamura,T., Kuno,J., Yamashita,T., Miyazono,K., Noda,M.,
            Noda,T. and Yamamoto,T.
  TITLE     Negative regulation of BMP/Smad signaling by Tob in osteoblasts
  JOURNAL   Cell 103 (7), 1085-1097 (2000)
   PUBMED   11163184
REFERENCE   7  (bases 1 to 2238)
  AUTHORS   Ikematsu,N., Yoshida,Y., Kawamura-Tsuzuku,J., Ohsugi,M., Onda,M.,
            Hirai,M., Fujimoto,J. and Yamamoto,T.
  TITLE     Tob2, a novel anti-proliferative Tob/BTG1 family member, associates
            with a component of the CCR4 transcriptional regulatory complex
            capable of binding cyclin-dependent kinases
  JOURNAL   Oncogene 18 (52), 7432-7441 (1999)
   PUBMED   10602502
REFERENCE   8  (bases 1 to 2238)
  AUTHORS   Pawlak,A., Chiannikulchai,N., Ansorge,W., Bulle,F., Weissenbach,J.,
            Gyapay,G. and Guellaen,G.
  TITLE     Identification and mapping of 26 human testis mRNAs containing
            CAG/CTG repeats
  JOURNAL   Mamm Genome 9 (9), 745-748 (1998)
   PUBMED   9716660
REFERENCE   9  (bases 1 to 2238)
  AUTHORS   Yoshida,Y., Matsuda,S. and Yamamoto,T.
  TITLE     Cloning and characterization of the mouse tob gene
  JOURNAL   Gene 191 (1), 109-113 (1997)
   PUBMED   9210596
REFERENCE   10 (bases 1 to 2238)
  AUTHORS   Matsuda,S., Kawamura-Tsuzuku,J., Ohsugi,M., Yoshida,M., Emi,M.,
            Nakamura,Y., Onda,M., Yoshida,Y., Nishiyama,A. and Yamamoto,T.
  TITLE     Tob, a novel protein that interacts with p185erbB2, is associated
            with anti-proliferative activity
  JOURNAL   Oncogene 12 (4), 705-713 (1996)
   PUBMED   8632892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA039934.1, BC098415.1 and
            BC031406.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005749.3.
            
            Summary: This gene encodes a member of the transducer of erbB-2
            /B-cell translocation gene protein family. Members of this family
            are anti-proliferative factors that have the potential to regulate
            cell growth. The encoded protein may function as a tumor
            suppressor. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.256920.1,
                                           SRR1163657.225214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000499247.3/ ENSP00000427695.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA039934.1         1-9
            10-404              BC098415.1         1-395
            405-1487            BC098415.1         397-1479
            1488-2238           BC031406.1         1052-1802
FEATURES             Location/Qualifiers
     source          1..2238
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..2238
                     /gene="TOB1"
                     /gene_synonym="APRO5; APRO6; PIG49; TOB; TROB; TROB1"
                     /note="transducer of ERBB2, 1"
                     /db_xref="GeneID:10140"
                     /db_xref="HGNC:HGNC:11979"
                     /db_xref="MIM:605523"
     exon            1..297
                     /gene="TOB1"
                     /gene_synonym="APRO5; APRO6; PIG49; TOB; TROB; TROB1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..2238
                     /gene="TOB1"
                     /gene_synonym="APRO5; APRO6; PIG49; TOB; TROB; TROB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             444..1481
                     /gene="TOB1"
                     /gene_synonym="APRO5; APRO6; PIG49; TOB; TROB; TROB1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transducer of erbB-2 1; proliferation-inducing gene 49;
                     protein Tob1"
                     /codon_start=1
                     /product="protein Tob1 isoform 1"
                     /protein_id="NP_005740.1"
                     /db_xref="CCDS:CCDS11576.1"
                     /db_xref="GeneID:10140"
                     /db_xref="HGNC:HGNC:11979"
                     /db_xref="MIM:605523"
                     /translation="MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHW
                     YPEKPYKGSGFRCIHIGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQ
                     IGEKGPVKVLYVDDNNENGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHS
                     AAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSNKVARTSPINLGLNVNDLLK
                     QKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKTSALSPNAKEFIF
                     PNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQY
                     SNQQFQPVMAN"
     regulatory      2215..2220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TOB1"
                     /gene_synonym="APRO5; APRO6; PIG49; TOB; TROB; TROB1"
                     /note="hexamer: ATTAAA"
     polyA_site      2238
                     /gene="TOB1"
                     /gene_synonym="APRO5; APRO6; PIG49; TOB; TROB; TROB1"
                     /note="major polyA site"
ORIGIN      
        1 agaaggagcg aagctctggc ccggcgtgta gcgggcgcac tacggggacg ctgggccggg
       61 caccgggctg tgtggagaag tgagcgcgct cgtctgaccc ccgtgcccgc caccccgagc
      121 cactaacggc gatctcccaa ggcctgcccg aggcctctgt cctctgtcct cagccccgca
      181 gcggcaacgt cttgcactcg gcgagctcgc cgctcccgac cctcccgcgc ccccgccctg
      241 ccgcgctgct ccccgcccag ccgcgggtct gtggtccaag ccgccccgaa gcagcccgaa
      301 caagatcact caaggtgaag gataatctac taataccagc actttgaatg aaaatttgtt
      361 tctctgccac aaactgaaca tctttttttt tttttttttt ttttggtggg ggagttgaaa
      421 cctaattttg tggcgtagca gctatgcagc ttgaaatcca agtagcacta aattttatta
      481 tttcgtattt gtacaataag cttcccagga gacgtgtcaa catttttggt gaagaacttg
      541 aaagacttct taagaagaaa tatgaagggc actggtatcc tgaaaagcca tacaaaggat
      601 cggggtttag atgtatacac ataggggaga aagtggaccc agtgattgaa caagcatcca
      661 aagagagtgg tttggacatt gatgatgttc gtggcaatct gccacaggat cttagtgttt
      721 ggatcgaccc atttgaggtt tcttaccaaa ttggtgaaaa gggaccagtg aaggtgcttt
      781 acgtggatga taataatgaa aatggatgtg agttggataa ggagatcaaa aacagcttta
      841 acccagaggc ccaggttttt atgcccataa gtgacccagc ctcatcagtg tccagctctc
      901 catcgcctcc ttttggtcac tctgctgctg taagccctac cttcatgccc cggtccactc
      961 agcctttaac ctttaccact gccacttttg ctgccaccaa gttcggctct accaaaatga
     1021 agaatagtgg ccgtagcaac aaggttgcac gtacttctcc catcaacctc ggcttgaatg
     1081 tgaatgacct cttgaagcag aaagccatct cttcctcaat gcactctctg tatgggcttg
     1141 gcttgggtag ccagcagcag ccacagcaac agcagcagcc agcccagccg ccaccgccac
     1201 caccaccacc acagcagcaa caacagcaga aaacctctgc tctttctcct aatgccaagg
     1261 aatttatttt tcctaatatg cagggtcaag gtagtagtac caatggaatg ttcccaggtg
     1321 acagccccct taacctcagt cctctccagt acagtaatgc ctttgatgtg tttgcagcct
     1381 atggaggcct caatgagaaa tcttttgtag atggcttgaa ttttagctta aataacatgc
     1441 agtattctaa ccagcaattc cagcctgtta tggctaacta aaaaaaagaa aatgtatcgt
     1501 acaagttaaa atgcacgggc ccaaggggga tttttttttt cacctccttg agaatttttt
     1561 tttttaagct tatagtaagg atacattcaa gcttggttaa aaaaataata ataaaacatg
     1621 catcattttt catttgccaa ccaagcacaa agttatttta tactgactgt atattttaaa
     1681 gtatactctc agatatggcc tcttacagta tttaagatat agcaaggaca tggctgattt
     1741 ttttttataa aaattggcac taataagtgg gtttattggt cttttctaat tgtataattt
     1801 aatttagtac aaagtttgta aaatatcaga ggatatatat atattgtttc tacgacatgg
     1861 tattgcattt atatcttttt actacagtga tctgtgacag cagcagcttc atgttgtatt
     1921 ttttttactg aaattgtaaa atatccatct taaagacatc aactattcta aaaattgtgt
     1981 acaggatatt cctttagtgg tggaattaaa atgtacgaat acttgctttt tcaaaaaaat
     2041 gtattttctg ttaaaagttt aaagattttt gctatatatt atggaagaaa aatgtaatcg
     2101 taaatattaa ttttgtacct atattgtgca atacttgaaa aaaacggtat aaaagtattt
     2161 tgagtcagtg tcttacatgt taagagggac tgaaatagtt tatattaagt ttgtattaaa
     2221 attctttaaa attaaaaa
//
