LOCUS       NM_001365276           13097 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tenascin XB (TNXB), transcript variant 3, mRNA.
ACCESSION   NM_001365276
VERSION     NM_001365276.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13097)
  AUTHORS   Chen,J., Zeng,Q., Wang,X., Xu,R., Wang,W., Huang,Y., Sun,Q.,
            Yuan,W., Wang,P., Chen,D., Tong,P. and Jin,H.
  TITLE     Aberrant methylation and expression of TNXB promote chondrocyte
            apoptosis and extracullar matrix degradation in hemophilic
            arthropathy via AKT signaling
  JOURNAL   Elife 13, 93087 (2024)
   PUBMED   38819423
  REMARK    GeneRIF: Aberrant methylation and expression of TNXB promote
            chondrocyte apoptosis and extracullar matrix degradation in
            hemophilic arthropathy via AKT signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13097)
  AUTHORS   Sumioka,T., Matsumoto,K.I., Reinach,P.S. and Saika,S.
  TITLE     Tenascins and osteopontin in biological response in cornea
  JOURNAL   Ocul Surf 29, 131-149 (2023)
   PUBMED   37209968
  REMARK    GeneRIF: Tenascins and osteopontin in biological response in
            cornea.
REFERENCE   3  (bases 1 to 13097)
  AUTHORS   Ivo,C.R., Fitas,A.L., Madureira,I., Diamantino,C., Gomes,S.,
            Goncalves,J. and Lopes,L.
  TITLE     Congenital adrenal hyperplasia with a CYP21A2 deletion overlapping
            the tenascin-X gene: an atypical presentation
  JOURNAL   J Pediatr Endocrinol Metab 36 (1), 81-85 (2022)
   PUBMED   36259452
  REMARK    GeneRIF: Congenital adrenal hyperplasia with a CYP21A2 deletion
            overlapping the tenascin-X gene: an atypical presentation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13097)
  AUTHORS   Liang,G., Wang,S., Shao,J., Jin,Y.J., Xu,L., Yan,Y., Gunther,S.,
            Wang,L. and Offermanns,S.
  TITLE     Tenascin-X Mediates Flow-Induced Suppression of EndMT and
            Atherosclerosis
  JOURNAL   Circ Res 130 (11), 1647-1659 (2022)
   PUBMED   35443807
REFERENCE   5  (bases 1 to 13097)
  AUTHORS   Tee,M.K., Thomson,A.A., Bristow,J. and Miller,W.L.
  TITLE     Sequences promoting the transcription of the human XA gene
            overlapping P450c21A correctly predict the presence of a novel,
            adrenal-specific, truncated form of tenascin-X
  JOURNAL   Genomics 28 (2), 171-178 (1995)
   PUBMED   8530023
REFERENCE   6  (bases 1 to 13097)
  AUTHORS   Bristow,J., Tee,M.K., Gitelman,S.E., Mellon,S.H. and Miller,W.L.
  TITLE     Tenascin-X: a novel extracellular matrix protein encoded by the
            human XB gene overlapping P450c21B
  JOURNAL   J Cell Biol 122 (1), 265-278 (1993)
   PUBMED   7686164
REFERENCE   7  (bases 1 to 13097)
  AUTHORS   van Dijk,F.S., Ghali,N., Demirdas,S. and Baker,D.
  TITLE     TNXB-Related Classical-Like Ehlers-Danlos Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   36108117
REFERENCE   8  (bases 1 to 13097)
  AUTHORS   Hakim,A.
  TITLE     Hypermobile Ehlers-Danlos Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301456
REFERENCE   9  (bases 1 to 13097)
  AUTHORS   Gitelman,S.E., Bristow,J. and Miller,W.L.
  TITLE     Mechanism and consequences of the duplication of the human
            C4/P450c21/gene X locus
  JOURNAL   Mol Cell Biol 12 (5), 2124-2134 (1992)
   PUBMED   1373808
  REMARK    Erratum:[Mol Cell Biol. 1992 Jul;12(7):3313-4. doi:
            10.1128/mcb.12.7.3313-3314.1992.. PMID: 1620134]
REFERENCE   10 (bases 1 to 13097)
  AUTHORS   Morel,Y., Bristow,J., Gitelman,S.E. and Miller,W.L.
  TITLE     Transcript encoded on the opposite strand of the human steroid
            21-hydroxylase/complement component C4 gene locus
  JOURNAL   Proc Natl Acad Sci U S A 86 (17), 6582-6586 (1989)
   PUBMED   2475872
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662884.11, AL772248.5 and
            AL645922.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001365276.1.
            
            Summary: This gene encodes a member of the tenascin family of
            extracellular matrix glycoproteins. The tenascins have
            anti-adhesive effects, as opposed to fibronectin which is adhesive.
            This protein is thought to function in matrix maturation during
            wound healing, and its deficiency has been associated with the
            connective tissue disorder Ehlers-Danlos syndrome. This gene
            localizes to the major histocompatibility complex (MHC) class III
            region on chromosome 6. It is one of four genes in this cluster
            which have been duplicated. The duplicated copy of this gene is
            incomplete and is a pseudogene which is transcribed but does not
            encode a protein. The structure of this gene is unusual in that it
            overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends,
            respectively. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3). It should be noted
            that the exon combination of this variant lacks full-length
            transcript support in human; it is predicted based on a combination
            of partial human and homologous transcript alignments.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000644971.2/ ENSP00000496448.1
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AL662884.11        22008-22165         c
            159-569             AL662884.11        10623-11033         c
            570-2408            AL662884.11        8438-10276          c
            2409-2524           AL662884.11        7903-8018           c
            2525-2681           AL662884.11        2050-2206           c
            2682-2945           AL772248.5         6491-6754           c
            2946-3314           AL772248.5         3456-3824           c
            3315-3611           AL772248.5         2119-2415           c
            3612-3902           AL645922.12        178302-178592       c
            3903-4208           AL645922.12        177634-177939       c
            4209-4541           AL645922.12        175299-175631       c
            4542-4847           AL645922.12        169913-170218       c
            4848-5156           AL645922.12        168256-168564       c
            5157-5444           AL645922.12        166393-166680       c
            5445-5753           AL645922.12        165819-166127       c
            5754-6068           AL645922.12        165088-165402       c
            6069-6386           AL645922.12        164656-164973       c
            6387-6710           AL645922.12        163927-164250       c
            6711-7007           AL645922.12        161087-161383       c
            7008-7334           AL645922.12        158423-158749       c
            7335-7658           AL645922.12        157663-157986       c
            7659-7991           AL645922.12        154324-154656       c
            7992-8309           AL645922.12        152852-153169       c
            8310-8633           AL645922.12        152117-152440       c
            8634-8957           AL645922.12        149654-149977       c
            8958-9281           AL645922.12        148936-149259       c
            9282-9605           AL645922.12        146264-146587       c
            9606-9923           AL645922.12        145536-145853       c
            9924-10211          AL645922.12        144629-144916       c
            10212-10490         AL645922.12        144000-144278       c
            10491-10772         AL645922.12        142441-142722       c
            10773-11093         AL645922.12        141272-141592       c
            11094-11429         AL645922.12        140647-140982       c
            11430-11552         AL645922.12        140273-140395       c
            11553-11696         AL645922.12        140015-140158       c
            11697-11816         AL645922.12        139703-139822       c
            11817-11960         AL645922.12        139441-139584       c
            11961-12091         AL645922.12        139217-139347       c
            12092-12224         AL645922.12        138965-139097       c
            12225-12376         AL645922.12        138721-138872       c
            12377-12473         AL645922.12        138532-138628       c
            12474-12635         AL645922.12        138278-138439       c
            12636-12799         AL645922.12        138037-138200       c
            12800-13097         AL645922.12        137419-137716       c
FEATURES             Location/Qualifiers
     source          1..13097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33-p21.32"
     gene            1..13097
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /note="tenascin XB"
                     /db_xref="GeneID:7148"
                     /db_xref="HGNC:HGNC:11976"
                     /db_xref="MIM:600985"
     exon            1..158
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            159..569
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..12901
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; tenascin XB1; tenascin XB2; tenascin-X;
                     growth-inhibiting protein 45; hexabrachion-like protein"
                     /codon_start=1
                     /product="tenascin-X isoform 3 precursor"
                     /protein_id="NP_001352205.1"
                     /db_xref="CCDS:CCDS93886.1"
                     /db_xref="GeneID:7148"
                     /db_xref="HGNC:HGNC:11976"
                     /db_xref="MIM:600985"
                     /translation="MMPAQYALTSSLVLLVLLSTARAGPFSSRSNVTLPAPRPPPQPG
                     GHTVGAGVGSPSSQLYEHTVEGGEKQVVFTHRINLPPSTGCGCPPGTEPPVLASEVQA
                     LRVRLEILEELVKGLKEQCTGGCCPASAQAGTGQTDVRTLCSLHGVFDLSRCTCSCEP
                     GWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGWPSC
                     PGDCQGRGRCVQGVCVCRAGFSGPDCSQRSCPRGCSQRGRCEGGRCVCDPGYTGDDCG
                     MRSCPRGCSQRGRCENGRCVCNPGYTGEDCGVRSCPRGCSQRGRCKDGRCVCDPGYTG
                     EDCGTRSCPWDCGEGGRCVDGRCVCWPGYTGEDCSTRTCPRDCRGRGRCEDGECICDT
                     GYSGDDCGVRSCPGDCNQRGRCEDGRCVCWPGYTGTDCGSRACPRDCRGRGRCENGVC
                     VCNAGYSGEDCGVRSCPGDCRGRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRCV
                     DGRCVCNPGFTGEDCGSRRCPGDCRGHGLCEDGVCVCDAGYSGEDCSTRSCPGGCRGR
                     GQCLDGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSN
                     CHGRGRCEEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDCGQEE
                     PPASACPGGCGPRELCRAGQCVCVEGFRGPDCAIQTCPGDCRGRGECHDGSCVCKDGY
                     AGEDCGEEVPTIEGMRMHLLEETTVRTEWTPAPGPVDAYEIQFIPTTEGASPPFTARV
                     PSSASAYDQRGLAPGQEYQVTVRALRGTSWGLPASKTITTMIDGPQDLRVVAVTPTTL
                     ELGWLRPQAEVDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGR
                     AVSYPASVRANTGSSPLGLLGTTDEPPPSGPSTTQGAQAPLLQQRPQELGELRVLGRD
                     ETGRLRVVWTAQPDTFAYFQLRMRVPEGPGAHEEVLPGDVRQALVPPPPPGTPYELSL
                     HGVPPGGKPSDPIIYQGIMDKDEEKPGKSSGPPRLGELTVTDRTSDSLLLRWTVPEGE
                     FDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRHGPLVAEA
                     KILPQSDPSPGTPPHLGNLWVTDPTPDSLHLSWTVPEGQFDTFMVQYRDRDGRPQVVP
                     VEGPERSFVVSSLDPDHKYRFTLFGIANKKRYGPLTADGTTAPERKEEPPRPEFLEQP
                     LLGELTVTGVTPDSLRLSWTVAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLD
                     PDRKYKMNLYGLRGRQRVGPESVVAKTAPQEDVDETPSPTELGTEAPESPEEPLLGEL
                     TVTGSSPDSLSLFWTVPQGSFDSFTVQYKDRDGRPRAVRVGGKESEVTVGGLEPGHKY
                     KMHLYGLHEGQRVGPVSAVGVTAPQQEETPPATESPLEPRLGELTVTDVTPNSVGLSW
                     TVPEGQFDSFIVQYKDKDGQPQVVPVAADQREVTVYNLEPERKYKMNMYGLHDGQRMG
                     PLSVVIVTAPLPPAPATEASKPPLEPRLGELTVTDITPDSVGLSWTVPEGEFDSFVVQ
                     YKDRDGQPQVVPVAADQREVTIPDLEPSRKYKFLLFGIQDGKRRSPVSVEAKTVARGD
                     ASPGAPPRLGELWVTDPTPDSLRLSWTVPEGQFDSFVVQFKDKDGPQVVPVEGHERSV
                     TVTPLDAGRKYRFLLYGLLGKKRHGPLTADGTTEARSAMDDTGTKRPPKPRLGEELQV
                     TTVTQNSVGLSWTVPEGQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKL
                     LLYGLHHGKRVGPISAVAITAGREETETETTAPTPPAPEPHLGELTVEEATSHTLHLS
                     WMVTEGEFDSFEIQYTDRDGQLQMVRIGGDRNDITLSGLESDHRYLVTLYGFSDGKHV
                     GPVHVEALTVPEEEKPSEPPTATPEPPIKPRLGELTVTDATPDSLSLSWTVPEGQFDH
                     FLVQYRNGDGQPKAVRVPGHEEGVTISGLEPDHKYKMNLYGFHGGQRMGPVSVVGVTA
                     AEEETPSPTEPSMEAPEPAEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDR
                     DGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSAVGVTAPEEESPDA
                     PLAKLRLGQMTVRDITSDSLSLSWTVPEGQFDHFLVQFKNGDGQPKAVRVPGHEDGVT
                     ISGLEPDHKYKMNLYGFHGGQRVGPVSAVGLTAPGKDEEMAPASTEPPTPEPPIKPRL
                     EELTVTDATPDSLSLSWTVPEGQFDHFLVQYKNGDGQPKATRVPGHEDRVTISGLEPD
                     NKYKMNLYGFHGGQRVGPVSAIGVTAAEEETPSPTEPSMEAPEPPEEPLLGELTVTGS
                     SPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY
                     GLHEGRRVGPVSTVGVTAPQEDVDETPSPTEPGTEAPGPPEEPLLGELTVTGSSPDSL
                     SLSWTVPQGRFDSFTVQYKDRDGRPQAVRVGGQESKVTVRGLEPGRKYKMHLYGLHEG
                     RRLGPVSAVGVTEDEAETTQAVPTMTPEPPIKPRLGELTMTDATPDSLSLSWTVPEGQ
                     FDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIG
                     VTAAEEETPSPTELSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGHFDSFTVQY
                     KDRDGRPQVMRVRGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPEDEA
                     ETTQAVPTTTPEPPNKPRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPK
                     VVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPAPTEPST
                     EAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGRFDSFTVQYKDRDGRPQVVRVRGEE
                     SEVTVGGLEPGCKYKMHLYGLHEGQRVGPVSAVGVTAPKDEAETTQAVPTMTPEPPIK
                     PRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGL
                     EPDHKYKMNLYGFHGGQRVGPVSAIGVTEEETPSPTEPSTEAPEAPEEPLLGELTVTG
                     SSPDSLSLSWTVPQGRFDSFTVQYKDRDGQPQVVRVRGEESEVTVGGLEPGRKYKMHL
                     YGLHEGQRVGPVSTVGITAPLPTPLPVEPRLGELAVAAVTSDSVGLSWTVAQGPFDSF
                     LVQYRDAQGQPQAVPVSGDLRAVAVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAP
                     DTKPSPRLGELTVTDATPDSVGLSWTVPEGEFDSFVVQYKDKDGRLQVVPVAANQREV
                     TVQGLEPSRKYRFLLYGLSGRKRLGPISADSTTAPLEKELPPHLGELTVAEETSSSLR
                     LSWTVAQGPFDSFVVQYRDTDGQPRAVPVAADQRTVTVEDLEPGKKYKFLLYGLLGGK
                     RLGPVSALGMTAPEEDTPAPELAPEAPEPPEEPRLGVLTVTDTTPDSMRLSWSVAQGP
                     FDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRLGPLSAEG
                     TTGLAPAGQTSEESRPRLSQLSVTDVTTSSLRLNWEAPPGAFDSFLLRFGVPSPSTLE
                     PHPRPLLQRELMVPGTRHSAVLRDLRSGTLYSLTLYGLRGPHKADSIQGTARTLSPVL
                     ESPRDLQFSEIRETSAKVNWMPPPSRADSFKVSYQLADGGEPQSVQVDGQARTQKLQG
                     LIPGARYEVTVVSVRGFEESEPLTGFLTTVPDGPTQLRALNLTEGFAVLHWKPPQNPV
                     DTYDVQVTAPGAPPLQAETPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPASITFT
                     TGLEAPRDLEAKEVTPRTALLTWTEPPVRPAGYLLSFHTPGGQNQEILLPGGITSHQL
                     LGLFPSTSYNARLQAMWGQSLLPPVSTSFTTGGLRIPFPRDCGEEMQNGAGASRTSTI
                     FLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGN
                     EALHSLTQAGDYSMRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSY
                     HSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKG
                     FEFSVPFTEMKLRPRNFRSPAGGG"
     exon            570..2408
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2524
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2681
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2945
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3314
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3611
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..3902
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            3903..4208
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            4209..4541
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            4542..4847
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            4848..5156
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            5157..5444
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            5445..5753
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            5754..6068
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            6069..6386
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            6387..6710
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            6711..7007
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            7008..7334
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            7335..7658
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            7659..7991
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            7992..8309
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            8310..8633
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            8634..8957
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            8958..9281
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            9282..9605
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            9606..9923
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            9924..10211
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            10212..10490
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            10491..10772
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            10773..11093
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            11094..11429
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            11430..11552
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            11553..11696
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            11697..11816
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            11817..11960
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            11961..12091
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            12092..12224
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            12225..12376
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            12377..12473
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            12474..12635
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            12636..12799
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
     exon            12800..13097
                     /gene="TNXB"
                     /gene_synonym="EDS3; EDSCLL; EDSCLL1; HXBL; TENX; TN-X;
                     TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctcactg tcgctgccga gatccacagt cggttgtggc tcagcccctg ttgcagggga
       61 caagtgaggg agacttccct gtcctgccct gagacgccgc cctcccgggg ttggggacag
      121 agcaggtgca gaggcactgc agctgctcgg ttgcccagcc tcctgaatga tgccagccca
      181 gtatgctcta acctccagcc tggttctcct ggtgctgctg agcacagcca gagcaggccc
      241 cttctcttca cggtccaatg tgacactgcc agccccccgg ccccctcccc agccaggggg
      301 ccacacagtg ggggctggag tgggaagccc ctcttctcag ctttacgagc acacagtgga
      361 aggaggggag aagcaggtgg tattcaccca ccgcattaac ctgccccctt ccactggctg
      421 tggctgtccc ccaggcaccg agcccccagt ccttgcttca gaggtacagg ccctgagggt
      481 ccgtctagag atcctggagg agttggtgaa ggggctcaag gaacagtgca ctgggggatg
      541 ttgtcctgcc tctgcccaag ctggcacagg tcagacagat gtgcggaccc tctgcagtct
      601 ccatggtgtg tttgatctga gccgctgcac ctgttcctgt gagccaggct ggggtgggcc
      661 cacctgctca gaccccacag atgctgagat ccctccctct tccccaccct cagcctcggg
      721 gtcctgccca gatgactgca atgatcaggg tcgctgtgtc cgtggtcgtt gcgtgtgctt
      781 tcccggctac actggcccca gctgtggctg gccatcctgt cccggggact gccaaggccg
      841 tgggcgctgc gtgcagggcg tgtgtgtgtg ccgggcaggc ttctcaggcc ccgactgcag
      901 ccagcgctcc tgccctcgag gttgcagcca gaggggacgc tgtgagggtg ggcgctgcgt
      961 gtgtgaccca ggctacactg gtgacgactg tggcatgagg agctgccctc gcggttgcag
     1021 tcagaggggg cgctgtgaga atgggcgctg cgtgtgtaac cccggctaca ctggcgagga
     1081 ctgtggggtg aggagctgcc ctcggggctg cagccagcgg ggacgctgca aggacgggcg
     1141 ctgcgtgtgt gaccccggct acactggcga ggactgtggt acgcggagct gcccctggga
     1201 ctgtggcgag ggcgggcgct gcgtggacgg ccgctgcgtg tgctggcccg ggtacacagg
     1261 cgaggactgc agcacgcgga catgtccgag ggactgccgg ggccgcgggc gctgcgagga
     1321 cggcgaatgc atttgcgaca cgggctacag cggggacgac tgcggcgtgc gcagctgccc
     1381 tggcgactgc aaccaaaggg gccgctgcga ggacggccgc tgcgtgtgct ggccggggta
     1441 cactggaacc gattgcggct cgcgcgcctg cccacgcgac tgtagaggtc gcgggcgctg
     1501 cgagaacggc gtgtgtgttt gcaatgcggg ctacagcggc gaggactgcg gtgtgcgcag
     1561 ctgtcctggg gactgtcgtg gccggggccg ctgtgagagt ggccgctgca tgtgttggcc
     1621 ggggtacaca ggccgggact gcggcacgcg cgcctgtcct ggcgactgtc gcgggcgcgg
     1681 gcgctgcgtg gatggccgct gcgtgtgcaa cccgggcttc accggtgagg actgtgggag
     1741 ccgtcgctgt cccggggact gccgtgggca cggcctttgc gaggatggcg tgtgcgtgtg
     1801 tgacgcaggc tactcagggg aagactgcag cacgcgcagc tgccccgggg gctgccgagg
     1861 ccgcggccag tgcctagatg ggcggtgtgt gtgcgaggac ggctactctg gcgaggattg
     1921 cggtgtgagg cagtgcccga atgactgcag ccagcacggc gtgtgccagg acggtgtgtg
     1981 catctgttgg gaaggctacg tgagtgagga ctgcagcatc cgcacctgcc cctccaactg
     2041 ccacgggagg ggccgctgtg aggaagggcg ctgcctgtgc gacccaggct acaccggccc
     2101 tacctgtgcc acccgcatgt gcccggctga ctgccgggga cgtgggcggt gtgtgcaagg
     2161 agtgtgcctg tgccacgtgg gctatggcgg tgaggactgc gggcaggaag agcctccagc
     2221 cagcgcctgc cctggaggct gcgggccccg ggaactgtgc cgggcaggcc agtgtgtgtg
     2281 tgtagagggc ttccgaggcc ctgactgtgc catccagaca tgcccagggg actgccgtgg
     2341 ccgaggagag tgtcacgatg gcagctgtgt ctgcaaagat gggtatgctg gcgaagactg
     2401 cggagaagag gtgccaacca ttgagggcat gaggatgcat ctcttggagg agacaacagt
     2461 tcggacagag tggaccccgg ctcctggccc cgtggatgcc tatgaaattc agttcatccc
     2521 cacgacagag ggggcgagcc ccccattcac agcacgggtt ccaagctctg cctcagccta
     2581 tgaccagaga ggactggccc ctggacagga gtaccaggtc actgtccgag cccttcgagg
     2641 gaccagctgg ggccttcctg cctccaagac catcaccacc atgatcgatg ggccccagga
     2701 cctccgagtg gtggctgtga caccgacaac actggagctt ggctggctgc gtccccaggc
     2761 tgaggtggac cgatttgtgg tgtcctacgt cagtgccggc aaccagaggg tgaggctgga
     2821 agtgccccct gaagcagacg ggacgctgct gactgacctg atgccaggcg tagaatatgt
     2881 ggtgactgtc acagcggagc ggggccgggc agtcagctac ccagcttctg tcagggccaa
     2941 cacagggtcc tcacccttgg gcctcttggg gactaccgat gagcctcctc cctcaggccc
     3001 ctcgacgacg caaggggccc aggctcctct cctgcagcag cgcccccagg agctgggaga
     3061 gttgagggtg ctgggcagag atgagacagg gcgcctccgt gtggtctgga ccgcccagcc
     3121 tgacaccttt gcctacttcc aactgcgcat gcgggtgccc gaggggccgg gggcacatga
     3181 ggaagtgctg ccaggggacg tccgccaggc tctggtgcct ccaccccctc ctggaacccc
     3241 gtatgagctg tcacttcatg gggtccctcc tgggggcaag ccctctgacc ccatcatcta
     3301 ccaaggcatt atggacaagg atgaggagaa gcctgggaag tcctcaggcc caccacgcct
     3361 gggtgagctg acggtgacag acaggacctc cgactccttg ctcctgcgct ggacggtccc
     3421 cgagggcgag tttgactcct tcgtgatcca gtacaaagac agggacgggc agccccaggt
     3481 ggtgcccgtg gaaggacccc agcgctcggc cgtcatcacc tccctggatc ctggccgcaa
     3541 gtacaaattt gtcctgtatg ggtttgttgg caagaagagg catggtccgc tggtggctga
     3601 agccaagatc ttgcctcaga gtgacccaag tccagggact ccaccccacc tgggaaacct
     3661 gtgggtgaca gaccctaccc cagattcact gcacctctcc tggactgtcc ctgagggcca
     3721 gtttgacacc ttcatggtcc agtacaggga cagggatgga cggccccagg tggtacctgt
     3781 ggaagggccc gagcgttcat ttgttgtctc ctcactggac cctgaccaca agtacagatt
     3841 cactctgttt ggaattgcga acaagaagcg gtatggcccc ctcacggccg atggcaccac
     3901 tgctccagag aggaaagagg agcccccccg ccctgagttc ctggagcagc ccctcctggg
     3961 ggaactgaca gtgaccggcg tgaccccaga ctccttgcgt ctctcatgga cagtggccca
     4021 gggccccttc gactcattca tggtccagta caaggatgca caggggcagc cccaggcagt
     4081 gcctgttgcg ggggatgaga atgaggttac tgtccccggc ctggatcccg accggaagta
     4141 taagatgaac ctctacgggc ttcgtggcag gcagcgtgtg gggcccgagt ctgtggtggc
     4201 caagactgct cctcaggagg atgtggacga gacccccagc cccacagaac tgggcacgga
     4261 ggccccggag tcccccgagg agccgctcct gggggagctg acagtgacag gatcctcccc
     4321 tgattcgctg agcctcttct ggaccgtccc ccagggcagc ttcgactctt tcaccgtgca
     4381 gtacaaggac agggatgggc ggccccgggc ggtgcgtgtt gggggcaagg agagtgaggt
     4441 caccgtggga ggcctagagc ccgggcacaa gtacaagatg cacctgtacg gcctccacga
     4501 ggggcagcgc gtgggcccgg tgtccgccgt gggcgtgaca gccccacaac aagaagagac
     4561 ccctccagcc actgagtccc cgctggagcc acgcctagga gagctgacag tgacagatgt
     4621 gacccccaac tctgtgggcc tctcctggac agtccccgag ggccagtttg actccttcat
     4681 agtccagtac aaggacaagg acgggcagcc ccaggtggtg ccggtggcgg cagaccagcg
     4741 agaggtcaca gtctacaacc tggagcctga gagaaaatat aagatgaaca tgtatggact
     4801 acatgatggg caacgcatgg gccccctgtc tgtggtcatc gtgacggctc ccctcccacc
     4861 agccccagcc acagaggcct ccaagcctcc cctggagcca cgcctagggg agctgacagt
     4921 gacggatata acccctgact ctgtgggcct ctcatggaca gtccctgagg gtgaattcga
     4981 ctcctttgtg gttcagtaca aggacaggga cgggcagccc caggtggtgc ccgtggctgc
     5041 agatcagcgg gaggtcacta tccctgacct ggaaccctcc cgcaagtaca agttcctgct
     5101 ctttgggatc caggatggga aacgacgcag cccagtctct gtggaggcaa agacggttgc
     5161 ccgaggtgac gccagcccag gggccccacc ccgccttggg gagctgtggg tgacagaccc
     5221 caccccagac tcactgcgcc tctcctggac ggttcctgag ggccagttcg actcttttgt
     5281 ggtccagttc aaggacaaag acgggcccca ggtggtgccc gtggagggcc atgagcgctc
     5341 tgtcactgtc acccctctgg atgccggccg caagtacaga ttcctcctct atggcctcct
     5401 gggcaagaag cgccatggcc ctctcactgc cgacggcacc acggaagccc ggagtgctat
     5461 ggatgatact ggaacaaagc gtcccccaaa accccgtctg ggggaggagc tgcaggtgac
     5521 caccgtgacc cagaactccg tgggcctctc ctggacagtc cctgagggcc agtttgactc
     5581 ctttgtggtc cagtacaaag acagggacgg gcagccccag gtggtgcccg tggagggcag
     5641 cctcagggag gtcagcgtgc cgggcctgga ccctgcccac aggtacaagc tgctgctcta
     5701 cgggctgcac cacggcaagc gtgtgggccc catctcggcc gtcgccatta ctgccggcag
     5761 ggaagaaacg gaaactgaga ccacggcccc gacccctcca gcgcctgagc cccacctcgg
     5821 ggagttgaca gtggaggagg ccacgtcaca caccctgcat ctctcctgga tggtgactga
     5881 gggagaattt gactccttcg aaatccagta cacagataga gacgggcaac tccaaatggt
     5941 ccgcatagga ggtgaccgga atgacatcac cctctctggc ctggaatccg accacagata
     6001 cctggtgacc ctgtatggtt tcagtgatgg gaagcatgta ggtcctgtcc atgtcgaggc
     6061 cctgacagtc ccggaggagg agaagccttc agaacctccc accgcaaccc ccgagccccc
     6121 catcaagcct cgcctggggg agctgaccgt gacagatgcc acccctgact ccctcagcct
     6181 gtcctggaca gttcccgagg gacagtttga ccacttcctg gtccagtaca ggaatggaga
     6241 tgggcagccc aaggcagtga gggtgccagg gcacgaggaa ggggtcacca tctcgggcct
     6301 ggagccagac cataaataca agatgaacct gtacggcttc cacggtggcc agcgcatggg
     6361 ccctgtgtct gtcgtcgggg tgacagctgc agaggaagag acccccagcc ccacagaacc
     6421 cagcatggag gccccggagc ccgctgagga gccgctcctg ggggagctaa cagtgacagg
     6481 atcctcccct gactcgctga gcctctcctg gaccgtcccc cagggccgct tcgactcctt
     6541 caccgtgcag tacaaggaca gggacgggcg gccccaggtg gtgcgtgttg ggggcgagga
     6601 gagtgaagtc accgtggggg gcctggagcc tgggcgcaag tacaagatgc acctgtacgg
     6661 cctccacgag gggcggcgcg tgggcccagt gtctgctgtg ggcgtcacgg cccccgaaga
     6721 ggagtcccct gatgctcctc ttgcaaagct gcgcctaggg cagatgacag tgagagacat
     6781 cacctccgac tccctcagcc tctcctggac agtccccgag ggccagtttg accatttctt
     6841 ggtccagttt aagaatgggg acgggcagcc caaggcggtg cgggtgccgg gacacgagga
     6901 tggggtcacc atctcgggcc tggagccaga ccacaagtac aagatgaacc tgtacggctt
     6961 ccacggtggc cagcgcgtgg gccccgtgtc tgctgttggt ttaactgccc caggaaagga
     7021 tgaagaaatg gccccagcct cgacagaacc tcccacccct gaacccccca tcaagcctcg
     7081 cctggaggag ctgaccgtga cagatgcgac ccctgactcc ctcagcctgt cctggacggt
     7141 tcccgaggga cagtttgacc acttcctggt ccagtacaag aatggggatg ggcagcccaa
     7201 ggcaacacgg gtgccaggac atgaggacag ggtcaccatc tccggcctgg agccagacaa
     7261 caagtacaag atgaacctgt acggcttcca cggtggccag cgtgtgggcc ccgtgtctgc
     7321 catcggggtg acagctgcag aggaagagac ccccagcccc acagaaccca gcatggaggc
     7381 cccggagccc cctgaggagc cgctcctggg ggagctaaca gtgacaggat cctcccctga
     7441 ctcgctgagc ctctcctgga ccgtccccca gggccgcttc gactccttca ccgtgcagta
     7501 caaggacagg gacgggcggc cccaggtggt gcgtgttggg ggcgaggaga gcgaggtcac
     7561 cgtggggggc ctggagcctg ggcgcaaata caagatgcac ctgtatggcc tccacgaggg
     7621 gcggcgcgtg ggcccggtgt ccaccgtggg cgtgactgcc ccacaagagg atgtggacga
     7681 gacccccagc cctacagaac caggcacaga ggccccaggg ccccccgagg agcctctcct
     7741 gggggagctg acagtgacag gatcctcccc tgactcgctg agcctttcct ggaccgtccc
     7801 ccagggccgc tttgactcct tcaccgtgca gtacaaggac agggacgggc ggccccaggc
     7861 ggtgcgtgtt gggggccagg agagcaaggt cactgtgagg ggcctggagc ctgggcgcaa
     7921 gtacaagatg cacctgtacg gcctccacga ggggcggcgc ctgggcccgg tgtctgccgt
     7981 gggcgtcaca gaggatgaag ccgagaccac ccaagcagtg cctaccatga cccctgagcc
     8041 ccccatcaag cctcgcctgg gggagctgac catgacagat gccacccctg actccctcag
     8101 cctgtcctgg acggttcccg agggccagtt tgaccacttc ctggtccagt acaggaatgg
     8161 ggatgggcag cccaaggcgg tgcgggtgcc ggggcacgag gacggggtca ccatctcagg
     8221 cctggagcca gaccataaat acaagatgaa cctgtacggc ttccacggtg gccagcgcgt
     8281 gggccccatc tctgtcattg gggtgacggc tgcagaggaa gagaccccca gccccacgga
     8341 actcagcact gaggccccgg agccccctga ggagccgctc ctgggggagc tgacagtgac
     8401 aggatcctcc cctgactcgc tgagcctctc ctggaccatc ccccagggcc acttcgactc
     8461 cttcaccgtg cagtacaagg acagggacgg gcggccccag gtgatgcgtg tcaggggcga
     8521 ggagagcgag gtcaccgtgg ggggcctgga gcccgggcgc aaatacaaga tgcacctgta
     8581 cggcctccac gaggggcggc gtgtgggccc ggtgtccacc gtgggtgtga cagctccaga
     8641 ggatgaagca gagaccaccc aagcagtgcc caccacaacc cctgagcccc ccaacaagcc
     8701 tcgcctcggg gagctgaccg tgacagatgc cacccctgac tccctcagcc tgtcctggat
     8761 ggtccccgag ggccagtttg accacttcct ggtccagtac aggaatgggg atgggcagcc
     8821 caaggtggtg cgggtgccgg ggcacgagga cggggtcacc atctcaggcc tggagccaga
     8881 ccacaagtac aagatgaacc tgtacggctt ccacggtggc cagcgcgtgg gccccatctc
     8941 tgtcattggg gtgacagctg cagaggaaga aactcccgcc cccacagaac ccagcacgga
     9001 ggccccggag ccccctgagg agccgctcct gggggagctg acagtgacag gatcctcccc
     9061 tgactcgctg agcctctcct ggaccatccc ccagggccgc ttcgactcct tcactgtgca
     9121 gtacaaggac agggacgggc ggccccaggt ggtgcgtgtc aggggcgagg agagcgaggt
     9181 caccgtgggg ggcctggagc ccgggtgcaa atacaagatg cacctgtacg gcctccacga
     9241 ggggcagcgc gtgggcccag tgtccgctgt gggtgtgaca gctccaaagg atgaagccga
     9301 gaccacccaa gcagtgccta ccatgacccc tgagcccccc atcaagcctc gcctggggga
     9361 gctgaccgtg acagatgcca cccccgactc cctcagcctg tcctggatgg ttcccgaggg
     9421 ccagtttgac cacttcctgg tccagtacag gaatggggat gggcagccca aggcggtgcg
     9481 ggtgccgggg cacgaggacg gggtcaccat ctcaggcctg gagccagacc ataaatacaa
     9541 gatgaacctg tacggcttcc acggtggcca gcgcgtaggc cctgtgtctg ccattggggt
     9601 gacggaggaa gagaccccca gccccacaga acccagcact gaggccccgg aggcccctga
     9661 ggagccgctc ctgggggagt tgacagtgac aggatcctcc cctgactcgc tgagcctctc
     9721 ctggaccgtc ccccagggcc gcttcgactc cttcaccgtg cagtacaagg acagggacgg
     9781 gcagccccag gtggtgcgtg tcaggggcga ggagagcgag gtcaccgtgg ggggcctgga
     9841 gcccgggcgc aaatacaaga tgcatctgta cggcctccac gaggggcagc gcgtgggccc
     9901 agtgtccacc gtgggcatca cggcgcccct gcccacacca ctgccggtgg agccccgcct
     9961 gggggagctg gcggtggcgg ccgtgacctc ggactcagtg ggcctctcat ggacggtggc
    10021 ccagggcccc tttgactcct tcctggtaca gtacagggac gcgcaggggc agccccaggc
    10081 agtgcctgtg agcggagacc tccgagcggt cgccgtctcg gggctggacc cggcccgcaa
    10141 gtacaagttc ctgctctttg gactccagaa tgggaaacgc cacggcccag tccctgtgga
    10201 ggccaggacc gccccagaca ccaaaccgtc tccccgcctg ggggagctga ctgtgacaga
    10261 tgcgacccct gactccgtgg gcctctcgtg gacggtccct gagggcgaat tcgactcctt
    10321 cgtggtccag tacaaggata aggatggtcg gctccaggtg gtgccggtgg cagccaacca
    10381 gcgggaggtc acagtccagg gcctggagcc cagtaggaaa tacaggttcc tgctctatgg
    10441 tctgtcaggc aggaaacgac tgggccccat ctctgctgac agcaccacag ctcccctgga
    10501 gaaggagcta cctccccacc tgggggaact gaccgtggct gaggagacct ccagctctct
    10561 gcgcctgtcc tggacggtag cccagggccc ctttgactcc ttcgtggtcc agtacaggga
    10621 cacggacggg cagcccaggg cagtgcctgt ggccgcagac cagcgcacag tcaccgtaga
    10681 ggacctggag cctggcaaga aatacaagtt tctgctctac gggctccttg ggggaaagcg
    10741 cctgggcccg gtctctgccc tgggaatgac agccccagaa gaggacacac cagccccaga
    10801 gttagcccca gaggcccctg agcctcctga agagccccgc ctaggagtgc tgaccgtgac
    10861 cgacacaacc ccagactcca tgcgcctctc gtggagcgtg gcccagggcc cctttgattc
    10921 cttcgtggtc cagtatgagg acacgaacgg gcagccccag gccttgctcg tggacggcga
    10981 ccagagcaag atcctcatct caggcctgga gcccagcacc ccctacaggt tcctcctcta
    11041 tggcctccat gaagggaagc gcctggggcc cctctcagct gagggcacca cagggctggc
    11101 tcctgctggt cagacctcag aggagtcaag gccccgcctg tcccagctgt ctgtgactga
    11161 cgtgaccacc agttcactga ggctcaactg ggaggcccca ccgggggcct tcgactcctt
    11221 cctgctccgc tttggggttc catcaccaag cactctggag ccgcatccgc gtccactgct
    11281 gcagcgcgag ctgatggtgc cggggacgcg gcactcggcc gtgctccggg acctgcgttc
    11341 cgggactctg tacagcctga cactgtatgg gctgcgagga ccccacaagg ccgacagcat
    11401 ccagggaacc gcccgcaccc tcagcccagt tctggagagc ccccgtgacc tccaattcag
    11461 tgaaatcagg gagacctcag ccaaggtcaa ctggatgccc ccaccatccc gggcggacag
    11521 cttcaaagtc tcctaccagc tggcggacgg aggggagcct cagagtgtgc aggtggatgg
    11581 ccaggcccgg acccagaaac tccaggggct gatcccaggc gctcgctatg aggtgaccgt
    11641 ggtctcggtc cgaggctttg aggagagtga gcctctcaca ggcttcctca ccacggttcc
    11701 tgacggtccc acacagttgc gtgcactgaa cttgaccgag ggattcgccg tgctgcactg
    11761 gaagcccccc cagaatcctg tggacaccta tgacgtccag gtcacagccc ctggggcccc
    11821 gcctctgcag gcggagaccc caggcagcgc ggtggactac cccctgcatg accttgtcct
    11881 ccacaccaac tacaccgcca cagtgcgtgg cctgcggggc cccaacctca cttccccagc
    11941 cagcatcacc ttcaccacag ggctagaggc ccctcgggac ttggaggcca aggaagtgac
    12001 cccccgcacc gccctgctca cttggactga gcccccagtc cggcccgcag gctacctgct
    12061 cagcttccac acccctggtg gacagaacca ggagatcctg ctcccaggag ggatcacatc
    12121 tcaccagctc cttggcctct ttccctccac ctcctacaat gcacggctcc aggccatgtg
    12181 gggccagagc ctcctgccgc ccgtgtccac ctctttcacc acgggtgggc tgcggatccc
    12241 cttccccagg gactgcgggg aggagatgca gaacggagcc ggtgcctcca ggaccagcac
    12301 catcttcctc aacggcaacc gcgagcggcc cctgaacgtg ttttgcgaca tggagactga
    12361 tgggggcggc tggctggtgt tccagcgccg catggatgga cagacagact tctggaggga
    12421 ctgggaggac tatgcccatg gttttgggaa catctctgga gagttctggc tgggcaatga
    12481 ggccctgcac agcctgacac aggcaggtga ctactccatg cgcgtggacc tgcgggctgg
    12541 ggacgaggct gtgttcgccc agtacgactc cttccacgta gactcggctg cggagtacta
    12601 ccgcctccac ttggagggct accacggcac cgcaggggac tccatgagct accacagcgg
    12661 cagtgtcttc tctgcccgtg atcgggaccc caacagcttg ctcatctcct gcgctgtctc
    12721 ctaccgaggg gcctggtggt acaggaactg ccactacgcc aacctcaacg ggctctacgg
    12781 gagcacagtg gaccatcagg gagtgagctg gtaccactgg aagggcttcg agttctcggt
    12841 gcccttcacg gaaatgaagc tgagaccaag aaactttcgc tccccagcgg ggggaggctg
    12901 agctgctgcc cacctctctc gcaccccagt atgactgccg agcactgagg ggtcgccccg
    12961 agagaagagc cagggtcctt caccacccag ccgctggagg aagccttctc tgccagcgat
    13021 ctcgcagcac tgtgtttaca ggggggaggg gaggggttcg tacgggagca ataaaggaga
    13081 aactgaggta cccggct
//
