LOCUS       NM_032865               4087 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens tensin 4 (TNS4), mRNA.
ACCESSION   NM_032865
VERSION     NM_032865.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4087)
  AUTHORS   Yang,J., Li,X., Chen,S., Li,G., Pu,P., Yang,Y., Wu,W., Geng,Y. and
            Liu,Y.
  TITLE     GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4
            via the JAK2-STAT3 pathway
  JOURNAL   Cancer Lett 598, 217067 (2024)
   PUBMED   38942137
  REMARK    GeneRIF: GPRC5A promotes gallbladder cancer metastasis by
            upregulating TNS4 via the JAK2-STAT3 pathway.
REFERENCE   2  (bases 1 to 4087)
  AUTHORS   Heo,H., Kim,H.J., Haam,K., Sohn,H.A., Shin,Y.J., Go,H., Jung,H.J.,
            Kim,J.H., Lee,S.I., Song,K.S., Kim,M.J., Lee,H., Kwon,E.S.,
            Kim,S.Y., Kim,Y.S. and Kim,M.
  TITLE     Epigenetic Activation of Tensin 4 Promotes Gastric Cancer
            Progression
  JOURNAL   Mol Cells 46 (5), 298-308 (2023)
   PUBMED   36896596
  REMARK    GeneRIF: Epigenetic Activation of Tensin 4 Promotes Gastric Cancer
            Progression.
REFERENCE   3  (bases 1 to 4087)
  AUTHORS   Wang,Y.X., Huang,C.Y., Chiu,H.J., Huang,P.H., Chien,H.T., Jwo,S.H.
            and Liao,Y.C.
  TITLE     Nuclear-localized CTEN is a novel transcriptional regulator and
            promotes cancer cell migration through its downstream target CDC27
  JOURNAL   J Physiol Biochem 79 (1), 163-174 (2023)
   PUBMED   36399312
  REMARK    GeneRIF: Nuclear-localized CTEN is a novel transcriptional
            regulator and promotes cancer cell migration through its downstream
            target CDC27.
REFERENCE   4  (bases 1 to 4087)
  AUTHORS   Liu,F., Gao,X., Liu,W. and Xue,W.
  TITLE     Mining TCGA and GEO databases for the prediction of poor prognosis
            in lung adenocarcinoma based on up-regulated expression of TNS4
  JOURNAL   Medicine (Baltimore) 101 (42), e31120 (2022)
   PUBMED   36281194
  REMARK    GeneRIF: Mining TCGA and GEO databases for the prediction of poor
            prognosis in lung adenocarcinoma based on up-regulated expression
            of TNS4.
REFERENCE   5  (bases 1 to 4087)
  AUTHORS   Lu,X., Zhou,B., Cao,M., Shao,Q., Pan,Y. and Zhao,T.
  TITLE     CTEN Inhibits Tumor Angiogenesis and Growth by Targeting VEGFA
            Through Down-Regulation of beta-Catenin in Breast Cancer
  JOURNAL   Technol Cancer Res Treat 20, 15330338211045506 (2021)
   PUBMED   34817293
  REMARK    GeneRIF: CTEN Inhibits Tumor Angiogenesis and Growth by Targeting
            VEGFA Through Down-Regulation of beta-Catenin in Breast Cancer.
REFERENCE   6  (bases 1 to 4087)
  AUTHORS   Lo,S.S., Lo,S.H. and Lo,S.H.
  TITLE     Cleavage of cten by caspase-3 during apoptosis
  JOURNAL   Oncogene 24 (26), 4311-4314 (2005)
   PUBMED   15806167
REFERENCE   7  (bases 1 to 4087)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   8  (bases 1 to 4087)
  AUTHORS   Sasaki,H., Yukiue,H., Kobayashi,Y., Fukai,I. and Fujii,Y.
  TITLE     Cten mRNA expression is correlated with tumor progression in
            thymoma
  JOURNAL   Tumour Biol 24 (5), 271-274 (2003)
   PUBMED   15001839
  REMARK    GeneRIF: Cten/GAPDH mRNA expression was correlated with evidence of
            tumor progression in thymoma.
REFERENCE   9  (bases 1 to 4087)
  AUTHORS   Sasaki,H., Moriyama,S., Mizuno,K., Yukiue,H., Konishi,A., Yano,M.,
            Kaji,M., Fukai,I., Kiriyama,M., Yamakawa,Y. and Fujii,Y.
  TITLE     Cten mRNA expression was correlated with tumor progression in lung
            cancers
  JOURNAL   Lung Cancer 40 (2), 151-155 (2003)
   PUBMED   12711115
  REMARK    GeneRIF: Increased cten mRNA expression was correlated with tumor
            progression in lung cancers
REFERENCE   10 (bases 1 to 4087)
  AUTHORS   Lo,S.H. and Lo,T.B.
  TITLE     Cten, a COOH-terminal tensin-like protein with prostate restricted
            expression, is down-regulated in prostate cancer
  JOURNAL   Cancer Res 62 (15), 4217-4221 (2002)
   PUBMED   12154022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018629.12, BM710196.1, AF417488.1, BC018706.1, AW937802.1 and
            AW378527.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032865.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF417488.1, AF370421.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254051.11/ ENSP00000254051.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC018629.12        156670-156690       c
            22-60               BM710196.1         1-39
            61-575              AF417488.1         2-516
            576-3038            BC018706.1         1-2463
            3039-3315           AW937802.1         235-511
            3316-3543           AF417488.1         3256-3483
            3544-3615           AW378527.1         67-138              c
            3616-4087           BC018706.1         3029-3500
FEATURES             Location/Qualifiers
     source          1..4087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..4087
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /note="tensin 4"
                     /db_xref="GeneID:84951"
                     /db_xref="HGNC:HGNC:24352"
                     /db_xref="MIM:608385"
     exon            1..90
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     exon            91..624
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2333
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /note="C terminal tensin like; C-terminal tensin-like
                     protein"
                     /codon_start=1
                     /product="tensin-4 precursor"
                     /protein_id="NP_116254.4"
                     /db_xref="CCDS:CCDS11368.1"
                     /db_xref="GeneID:84951"
                     /db_xref="HGNC:HGNC:24352"
                     /db_xref="MIM:608385"
                     /translation="MSQVMSSPLLAGGHAVSLAPCDEPRRTLHPAPSPSLPPQCSYYT
                     TEGWGAQALMAPVPCMGPPGRLQQAPQVEAKATCFLPSPGEKALGTPEDLDSYIDFSL
                     ESLNQMILELDPTFQLLPPGTGGSQAELAQSTMSMRKKEESEALDIKYIEVTSARSRC
                     HDGPQHCSSPSVTPPFGSLRSGGLLLSRDVPRETRSSSESLIFSGNQGRGHQRPLPPS
                     EGLSPRPPNSPSISIPCMGSKASSPHGLGSPLVASPRLEKRLGGLAPQRGSRISVLSA
                     SPVSDVSYMFGSSQSLLHSSNSSHQSSSRSLESPANSSSSLHSLGSVSLCTRPSDFQA
                     PRNPTLTMGQPRTPHSPPLAKEHASSCPPSITNSMVDIPIVLINGCPEPGSSPPQRTP
                     GHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTCPEGPARDMQPTMKFVMDTSKYWF
                     KPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPASAQSRPGEDSNDLI
                     RHFLIESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQRELGGADGAS
                     DSTDSPASCQKKSAGCHTLYLSSVSVETLTGALAVQKAISTTFERDILPTPTVVHFKV
                     TEQGITLTDVQRKVFFRRHYPLTTLRFCGMDPEQRKWQKYCKPSWIFGFVAKSQTEPQ
                     ENVCHLFAEYDMVQPASQVIGLVTALLQDAERM"
     exon            625..1048
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1473
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1560
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1686
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1779
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1857
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1926
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2095
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2164
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2191
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..4087
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4064..4069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /note="hexamer: AATAAA"
     polyA_site      4087
                     /gene="TNS4"
                     /gene_synonym="CTEN; PP14434"
                     /note="major polyA site"
ORIGIN      
        1 gcctctcctg actcttcacc tggactctga gtcgtcttgg tcccaggagc cagtagtgaa
       61 ggcaacagtc tgcccacctg tggacaccag atcctgggag ctcctggtta gcaagtgaga
      121 tctctgggat gtcagtgagg ctggttgaag accagaggta aactgcagag gtcaccaccc
      181 ccaccatgtc ccaggtgatg tccagcccac tgctggcagg aggccatgct gtcagcttgg
      241 cgccttgtga tgagcccagg aggaccctgc acccagcacc cagccccagc ctgccacccc
      301 agtgttctta ctacaccacg gaaggctggg gagcccaggc cctgatggcc cccgtgccct
      361 gcatggggcc ccctggccga ctccagcaag ccccacaggt ggaggccaaa gccacctgct
      421 tcctgccgtc ccctggtgag aaggccttgg ggaccccaga ggaccttgac tcctacattg
      481 acttctcact ggagagcctc aatcagatga tcctggaact ggaccccacc ttccagctgc
      541 ttcccccagg gactgggggc tcccaggctg agctggccca gagcaccatg tcaatgagaa
      601 agaaggagga atctgaagcc ttggacataa agtacatcga ggtgacctcc gccagatcaa
      661 ggtgccacga tggcccccag cactgctcca gcccctctgt caccccgccc ttcggctccc
      721 ttcgcagtgg tggcctcctc ctttccagag acgtcccccg agagacacga agcagcagtg
      781 agagcctcat cttctctggg aaccagggca gggggcacca gcgccctctg cccccctcag
      841 agggtctctc ccctcgaccc ccaaattccc ccagcatctc aatcccttgc atggggagca
      901 aggcctcgag cccccatggt ttgggctccc cgctggtggc ttctccaaga ctggagaagc
      961 ggctgggagg cctggcccca cagcggggca gcaggatctc tgtgctgtca gccagcccag
     1021 tgtctgatgt cagctatatg tttggaagca gccagtccct cctgcactcc agcaactcca
     1081 gccatcagtc atcttccaga tccttggaaa gtccagccaa ctcttcctcc agcctccaca
     1141 gccttggctc agtgtccctg tgtacaagac ccagtgactt ccaggctccc agaaacccca
     1201 ccctaaccat gggccaaccc agaacacccc actctccacc actggccaaa gaacatgcca
     1261 gcagctgccc cccatccatc accaactcca tggtggacat acccattgtg ctgatcaacg
     1321 gctgcccaga accagggtct tctccacccc agcggacccc aggacaccag aactccgttc
     1381 aacctggagc tgcttctccc agcaacccct gtccagccac caggagcaac agccagaccc
     1441 tgtcagatgc cccctttacc acatgcccag agggtcccgc cagggacatg cagcccacca
     1501 tgaagttcgt gatggacaca tctaaatact ggtttaagcc aaacatcacc cgagagcaag
     1561 caatcgagct gctgaggaag gaggagccag gggcttttgt cataagggac agctcttcat
     1621 accgaggctc cttcggcctg gccctgaagg tgcaggaggt tcccgcgtct gctcagagtc
     1681 gaccaggtga ggacagcaat gacctcatcc gacacttcct catcgagtcg tctgccaaag
     1741 gagtgcatct caaaggagca gatgaggagc cctactttgg gagcctctct gccttcgtgt
     1801 gccagcattc catcatggcc ctggccctgc cctgcaaact caccatccca cagagagaac
     1861 tgggaggtgc agatggggcc tcggactcta cagacagccc agcctcctgc cagaagaaat
     1921 ctgcgggctg ccacaccctg tacctgagct cagtgagcgt ggagaccctg actggagccc
     1981 tggccgtgca gaaagccatc tccaccacct ttgagaggga catcctcccc acgcccaccg
     2041 tggtccactt caaagtcaca gagcagggca tcactctgac tgatgtccag aggaaggtgt
     2101 ttttccggcg ccattaccca ctcaccaccc tccgcttctg tggtatggac cctgagcaac
     2161 ggaagtggca gaagtactgc aaaccctcct ggatctttgg gtttgtggcc aagagccaga
     2221 cagagcctca ggagaacgta tgccacctct ttgcggagta tgacatggtc cagccagcct
     2281 cgcaggtcat cggcctggtg actgctctgc tgcaggacgc agaaaggatg taggggagag
     2341 actgcctgtg cacctaacca acacctccag gggctcgcta aggagccccc ctccaccccc
     2401 tgaatgggtg tggcttgtgg ccatattgac agaccaatct atgggactag ggggattggc
     2461 atcaagttga cacccttgaa cctgctatgg ccttcagcag tcaccatcat ccagaccccc
     2521 cgggcctcag tttcctcaat catagaagaa gaccaataga caagatcagc tgttcttaga
     2581 tgctggtggg catttgaaca tgctcctcca tgattctgaa gcatgcacac ctctgaagac
     2641 ccctgcatga aaataacctc caaggaccct ctgaccccat cgacctgggc cctgcccaca
     2701 caacagtctg agcaagagac ctgcagcccc tgtttcgtgg cagacagcag gtgcctggcg
     2761 gtgacccacg gggctcctgg cttgcagctg gtgatggtca agaactgact acaaaacagg
     2821 aatggataga ctctatttcc ttccatatct gttcctctgt tccttttccc actttctggg
     2881 tggctttttg ggtccaccca gccaggatgc tgcaggccaa gctgggtgtg gtatttaggg
     2941 cagctcagca gggggaactt gtccccatgg tcagaggaga cccagctgtc ctgcaccccc
     3001 ttgcagatga gtatcacccc atcttttctt tccacttggt ttttattttt attttttttt
     3061 gagacagagt ctcactgtca cccaggctga actgcagtgg tgtgatctag gctcactgca
     3121 acctccacct cccaggttca agcaattatc ctgcctcagg ctcccaagta gctgggatta
     3181 caggcatgtg caactcaccc agctaatttt gtatttttag tagagacagg gtttcaccat
     3241 gttggccagg ctggtcttga actcctgacc gcaggtaatc cacctgcttc ggcctcccaa
     3301 agtgctggga ttacaggcgc aagccaccca gcccagcttc tttccattcc ttgataggcg
     3361 agtattccaa agctggtatc gtagctgccc taatgttgca tattaggcgg cgggggcaga
     3421 gataagggcc atctctctgt gattctgcct cagctcctgt cttgctgagc cctcccccaa
     3481 cccacgctcc aacacacaca cacacacaca cacacacaca cacacacaca cacacacaca
     3541 cacacacaca cgcccctcta ctgctatgtg gcttcaacca gcctcacagc cacacggggg
     3601 aagcagagag tcaagaatgc aaagaggccg cttccctaag aggcttggag gagctgggct
     3661 ctatcccaca cccaccccca ccccaccccc acccagcctc cagaagctgg aaccatttct
     3721 cccgcaggcc tgagttccta aggaaaccac cctaccgggg tggaagggag ggtcagggaa
     3781 gaaacccact cttgctctac gaggagcaag tgcctgcccc ctcccagcag ccagccctgc
     3841 caaagttgca ttatctttgg ccaaggctgg gcctgacggt tatgatttca gccctgggcc
     3901 tgcaggagag gctgagacca gcccacccag ccagtggtcg agcactgccc cgccgccaaa
     3961 gtctgcagaa tgtgagatga ggttctcaag gtcacaggcc ccagtcccag cctgggggct
     4021 ggcagaggcc cccatatact ctgctacagc tcctatcatg aaaaataaaa tgtttgtctt
     4081 tgcaaaa
//
