LOCUS       NM_022748               7585 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens tensin 3 (TNS3), transcript variant 3, mRNA.
ACCESSION   NM_022748
VERSION     NM_022748.12
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7585)
  AUTHORS   Juilland,M., Alouche,N., Ubezzi,I., Gonzalez,M., Rashid,H.O.,
            Scarpellino,L., Erdmann,T., Grau,M., Lenz,G., Luther,S.A. and
            Thome,M.
  TITLE     Identification of Tensin-3 as a MALT1 substrate that controls B
            cell adhesion and lymphoma dissemination
  JOURNAL   Proc Natl Acad Sci U S A 120 (52), e2301155120 (2023)
   PUBMED   38109544
  REMARK    GeneRIF: Identification of Tensin-3 as a MALT1 substrate that
            controls B cell adhesion and lymphoma dissemination.
REFERENCE   2  (bases 1 to 7585)
  AUTHORS   Zhang,S., van de Peppel,J., Koedam,M., van Leeuwen,J.P.T.M. and van
            der Eerden,B.C.J.
  TITLE     Tensin-3 is involved in osteogenic versus adipogenic fate of human
            bone marrow stromal cells
  JOURNAL   Cell Mol Life Sci 80 (9), 277 (2023)
   PUBMED   37668682
  REMARK    GeneRIF: Tensin-3 is involved in osteogenic versus adipogenic fate
            of human bone marrow stromal cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7585)
  AUTHORS   Wu,Y., Zhang,H.Q., Tang,M., Guo,C., Liu,S., Li,J., Wang,Y., Xiao,L.
            and Yang,G.
  TITLE     Abnormal TNS3 gene methylation in patients with congenital
            scoliosis
  JOURNAL   BMC Musculoskelet Disord 23 (1), 797 (2022)
   PUBMED   35987623
  REMARK    GeneRIF: Abnormal TNS3 gene methylation in patients with congenital
            scoliosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7585)
  AUTHORS   Zuidema,A., Atherton,P., Kreft,M., Hoekman,L., Bleijerveld,O.B.,
            Nagaraj,N., Chen,N., Fassler,R. and Sonnenberg,A.
  TITLE     PEAK1 Y635 phosphorylation regulates cell migration through
            association with Tensin3 and integrins
  JOURNAL   J Cell Biol 221 (8) (2022)
   PUBMED   35687021
  REMARK    GeneRIF: PEAK1 Y635 phosphorylation regulates cell migration
            through association with Tensin3 and integrins.
REFERENCE   5  (bases 1 to 7585)
  AUTHORS   Park,G.C., Kim,J.M., Shin,S.C., Cheon,Y.I., Sung,E.S., Lee,M.,
            Lee,J.C. and Lee,B.J.
  TITLE     Tensin Regulates Fundamental Biological Processes by Interacting
            with Integrins of Tonsil-Derived Mesenchymal Stem Cells
  JOURNAL   Cells 11 (15), 2333 (2022)
   PUBMED   35954177
  REMARK    GeneRIF: Tensin Regulates Fundamental Biological Processes by
            Interacting with Integrins of Tonsil-Derived Mesenchymal Stem
            Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7585)
  AUTHORS   Liao,Y.C., Si,L., deVere White,R.W. and Lo,S.H.
  TITLE     The phosphotyrosine-independent interaction of DLC-1 and the SH2
            domain of cten regulates focal adhesion localization and growth
            suppression activity of DLC-1
  JOURNAL   J Cell Biol 176 (1), 43-49 (2007)
   PUBMED   17190795
REFERENCE   7  (bases 1 to 7585)
  AUTHORS   Maeda,I., Takano,T., Yoshida,H., Matsuzuka,F., Amino,N. and
            Miyauchi,A.
  TITLE     Tensin3 is a novel thyroid-specific gene
  JOURNAL   J Mol Endocrinol 36 (1), R1-R8 (2006)
   PUBMED   16461921
  REMARK    Review article
REFERENCE   8  (bases 1 to 7585)
  AUTHORS   Jones,R.B., Gordus,A., Krall,J.A. and MacBeath,G.
  TITLE     A quantitative protein interaction network for the ErbB receptors
            using protein microarrays
  JOURNAL   Nature 439 (7073), 168-174 (2006)
   PUBMED   16273093
REFERENCE   9  (bases 1 to 7585)
  AUTHORS   Cui,Y., Liao,Y.C. and Lo,S.H.
  TITLE     Epidermal growth factor modulates tyrosine phosphorylation of a
            novel tensin family member, tensin3
  JOURNAL   Mol Cancer Res 2 (4), 225-232 (2004)
   PUBMED   15140944
  REMARK    GeneRIF: Tensin3 may function as a platform for the disassembly of
            EGF-related signaling complexes at focal adhesions.
REFERENCE   10 (bases 1 to 7585)
  AUTHORS   Carson-Walter,E.B., Watkins,D.N., Nanda,A., Vogelstein,B.,
            Kinzler,K.W. and St Croix,B.
  TITLE     Cell surface tumor endothelial markers are conserved in mice and
            humans
  JOURNAL   Cancer Res 61 (18), 6649-6655 (2001)
   PUBMED   11559528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK092864.1, AC092000.3, AC073341.10, AF417489.1 and AF378756.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022748.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749644.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311160.14/ ENSP00000312143.9
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AK092864.1         34-51
            19-61               AC092000.3         134090-134132       c
            62-173              AC092000.3         81075-81186         c
            174-211             AC092000.3         58946-58983         c
            212-250             AC092000.3         33142-33180         c
            251-303             AC073341.10        177616-177668       c
            304-475             AC073341.10        175100-175271       c
            476-526             AC073341.10        172876-172926       c
            527-649             AC073341.10        170895-171017       c
            650-714             AC073341.10        163925-163989       c
            715-798             AC073341.10        159714-159797       c
            799-911             AC073341.10        150707-150819       c
            912-972             AC073341.10        149550-149610       c
            973-1048            AC073341.10        147340-147415       c
            1049-1178           AC073341.10        136397-136526       c
            1179-1244           AC073341.10        136005-136070       c
            1245-1349           AC073341.10        132412-132516       c
            1350-2539           AC073341.10        104044-105233       c
            2540-4704           AF417489.1         2224-4388
            4705-5290           AF378756.1         3752-4337
            5291-5291           AC073341.10        13061-13061         c
            5292-7585           AF378756.1         4339-6632
FEATURES             Location/Qualifiers
     source          1..7585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p12.3"
     gene            1..7585
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /note="tensin 3"
                     /db_xref="GeneID:64759"
                     /db_xref="HGNC:HGNC:21616"
                     /db_xref="MIM:606825"
     exon            1..61
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            62..173
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            174..211
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..250
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            251..303
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..475
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..4663
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     tensin-like SH2 domain containing 1; tumor endothelial
                     marker 6; thyroid specific PTB domain protein; tensin-like
                     SH2 domain-containing protein 1"
                     /codon_start=1
                     /product="tensin-3 isoform 3"
                     /protein_id="NP_073585.8"
                     /db_xref="CCDS:CCDS5506.2"
                     /db_xref="GeneID:64759"
                     /db_xref="HGNC:HGNC:21616"
                     /db_xref="MIM:606825"
                     /translation="MEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSK
                     HGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHV
                     VVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDKVSALMQPSQKRYV
                     QFLSGLLSGSVKMNASPLFLHFVILHGTPNFDTGGVCRPFLKLYQAMQPVYTSGIYNV
                     GPENPSRICIVIEPAQLLKGDVMVKCYHKKYRSATRDVIFRLQFHTGAVQGYGLVFGK
                     EDLDNASKDDRFPDYGKVELVFSATPEKIQGSEHLYNDHGVIVDYNTTDPLIRWDSYE
                     NLSADGEVLHTQGPVDGSLYAKVRKKSSSDPGIPGGPQAIPATNSPDHSDHTLSVSSD
                     SGHSTASARTDKTEERLAPGTRRGLSAQEKAELDQLLSGFGLEDPGSSLKEMTDARSK
                     YSGTRHVVPAQVHVNGDAALKDRETDILDDEMPHHDLHSVDSLGTLSSSEGPQSAHLG
                     PFTCHKSSQNSLLSDGFGSNVGEDPQGTLVPDLGLGMDGPYERERTFGSREPKQPQPL
                     LRKPSVSAQMQAYGQSSYSTQTWVRQQQMVVAHQYSFAPDGEARLVSRCPADNPGLVQ
                     AQPRVPLTPTRGTSSRVAVQRGVGSGPHPPDTQQPSPSKAFKPRFPGDQVVNGAGPEL
                     STGPSPGSPTLDIDQSIEQLNRLILELDPTFEPIPTHMNALGSQANGSVSPDSVGGGL
                     RASSRLPDTGEGPSRATGRQGSSAEQPLGGRLRKLSLGQYDNDAGGQLPFSKCAWGKA
                     GVDYAPNLPPFPSPADVKETMTPGYPQDLDIIDGRILSSKESMCSTPAFPVSPETPYV
                     KTALRHPPFSPPEPPLSSPASQHKGGREPRSCPETLTHAVGMSESPIGPKSTMLRADA
                     SSTPSFQQAFASSCTISSNGPGQRRESSSSAERQWVESSPKPMVSLLGSGRPTGSPLS
                     AEFSGTRKDSPVLSCFPPSELQAPFHSHELSLAEPPDSLAPPSSQAFLGFGTAPVGSG
                     LPPEEDLGALLANSHGASPTPSIPLTATGAADNGFLSHNFLTVAPGHSSHHSPGLQGQ
                     GVTLPGQPPLPEKKRASEGDRSLGSVSPSSSGFSSPHSGSTISIPFPNVLPDFSKASE
                     AASPLPDSPGDKLVIVKFVQDTSKFWYKADISREQAIAMLKDKEPGSFIVRDSHSFRG
                     AYGLAMKVATPPPSVLQLNKKAGDLANELVRHFLIECTPKGVRLKGCSNEPYFGSLTA
                     LVCQHSITPLALPCKLLIPERDPLEEIAESSPQTAANSAAELLKQGAACNVWYLNSVE
                     MESLTGHQAIQKALSITLVQEPPPVSTVVHFKVSAQGITLTDNQRKLFFRRHYPVNSV
                     IFCALDPQDRKWIKDGPSSKVFGFVARKQGSATDNVCHLFAEHDPEQPASAIVNFVSK
                     VMIGSPKKV"
     exon            476..526
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..649
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..714
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..798
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            799..911
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..972
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1048
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1178
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1244
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1349
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..2606
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2776
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2891
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..2975
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3147
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3782
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3869
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..4001
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4002..4097
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4098..4175
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4176..4253
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4422
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4423..4491
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4492..4518
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4519..7585
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7564..7569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /note="hexamer: AATAAA"
     polyA_site      7585
                     /gene="TNS3"
                     /gene_synonym="TEM6; TENS1"
                     /note="major polyA site"
ORIGIN      
        1 actcggagcc cagcctcgtt gcggccatcg ccctgccgga ccgcgcctca ggctccccca
       61 gccggaagaa ttaacctcga gtctgcacgc ttttaagaac aaggccttta aaaaatccaa
      121 agtgtgtgga gtttgcaaac aaattattga cggtcaaggt atttcatgcc gagcctgcaa
      181 gtattcctgc cacaagaaat gtgaagccaa ggtggtgatt ccctgcggtg tgcaagtccg
      241 actggaacag gctccaggga gttccacgct gtccagttct ctctgccgtg ataaacctct
      301 gcggcccgtc atcctgagtc ccaccatgga ggagggccat gggctggacc tcacttacat
      361 cacggagcgc atcatcgctg tgtccttccc tgccggctgc tctgaggagt cctacctgca
      421 caacctacag gaggtcacgc gcatgctcaa gtccaagcac ggggacaact acctggtatt
      481 aaacctttca gaaaagagat atgaccttac gaagcttaac ccaaagatca tggatgtggg
      541 ctggccagag ctccacgcac cgcccctgga taagatgtgt accatatgca aggcgcagga
      601 gtcctggctg aacagcaacc tccagcatgt ggtcgtcatt cactgcaggg gcgggaaagg
      661 acgcatagga gtggtcatat catcctacat gcatttcacc aacgtctcag ccagcgccga
      721 ccaggccctt gacaggtttg caatgaagaa gttttatgat gacaaagttt cagctttaat
      781 gcagccttcc caaaaacggt atgttcagtt cctcagtggg ctcctgtccg gatcggtgaa
      841 aatgaatgcc tctcccctgt tcctgcattt tgtcatcctc cacggcaccc ccaacttcga
      901 cacaggtgga gtgtgccggc cctttctgaa gctctaccaa gccatgcagc ctgtgtacac
      961 ctccgggatc tacaacgttg gcccagaaaa ccccagcagg atctgcatcg tcatcgagcc
     1021 ggcccagctt ctgaagggag atgtcatggt gaaatgctac cacaagaaat accgctcggc
     1081 cacccgtgac gtcattttcc gcctgcagtt tcacactggg gctgtgcagg gctacgggct
     1141 ggtgtttggg aaggaggatc tggacaatgc cagcaaagat gaccgttttc ctgactatgg
     1201 gaaggttgaa ttagtcttct ctgccacgcc tgagaagatt caagggtccg aacacttgta
     1261 caacgaccac ggtgtgattg tggactacaa cacaacagac ccactgatac gctgggactc
     1321 gtacgagaac ctcagtgcag atggagaagt gctacacacg cagggccctg tcgatggcag
     1381 cctttacgcg aaggtgagga agaaaagctc ctcggatcct ggcatcccag gtggccccca
     1441 ggcaatcccg gccaccaaca gcccagacca cagtgaccac accttgtctg tcagcagtga
     1501 ctccggccac tctacagcct ctgccaggac ggataagacg gaagagcgcc tggccccagg
     1561 aaccaggagg ggcctgagtg cccaggagaa ggcagagttg gaccagctgc tcagtggctt
     1621 tggcctggaa gatcctggaa gctccctcaa ggaaatgact gatgctcgaa gcaagtacag
     1681 tgggacccgc cacgtggtgc cagcccaggt tcacgtgaat ggagacgctg ctctgaagga
     1741 tcgggagaca gacattctgg atgacgagat gccccaccac gacctgcaca gtgtggacag
     1801 ccttgggacc ctgtcctcct cggaagggcc tcagtcggcc cacctgggtc ccttcacctg
     1861 ccacaagagc agccagaact cactcctatc tgacggtttt ggcagcaacg ttggtgaaga
     1921 tccgcagggc accctcgttc cggacctggg ccttggcatg gacggcccct atgagcggga
     1981 gcggactttt gggagtcgag agcccaagca gccccagccc ctgctgagaa agccctcagt
     2041 gtccgcccag atgcaggcct atgggcagag cagctactcc acacagacct gggtgcgcca
     2101 gcagcagatg gttgtagctc accagtatag cttcgcccca gatggggagg cccggctggt
     2161 gagccgctgc cctgcagaca atcctggcct cgtccaggcc cagcccagag tgccactcac
     2221 ccccacccga gggaccagca gtagggtggc tgtccagagg ggtgtaggca gtgggccaca
     2281 tccccctgac acacagcagc cctctcccag caaagcgttc aaacccaggt ttccaggaga
     2341 ccaggttgtg aatggagccg gcccagagct gagcacaggc ccctccccag gctcgcccac
     2401 cctggacatc gaccagtcca tcgagcagct caacaggctg atcctggagc tggatcccac
     2461 cttcgagccc atccctaccc acatgaacgc cctcggtagc caggccaatg gctctgtgtc
     2521 tccagacagc gtgggaggtg ggctccgggc aagcagcagg ctgcctgaca caggagaggg
     2581 ccccagcagg gccaccgggc ggcaaggctc ctctgctgaa cagcccctgg gcgggagact
     2641 caggaagctg agcctggggc agtacgacaa cgatgctggg gggcagctgc ccttctccaa
     2701 atgtgcatgg ggaaaggctg gtgtggacta tgccccaaac ctgccgccat tcccctcacc
     2761 agcggacgtc aaagagacga tgacccctgg ctatccccag gacctcgata ttatcgatgg
     2821 cagaatttta agtagcaagg agtccatgtg ttcaactcca gcatttcctg tgtctccaga
     2881 gacaccgtat gtgaaaacag cgctgcgcca tcctccgttc agcccacctg agcccccgct
     2941 gagcagccca gccagtcagc acaaaggagg acgtgaacca cgaagctgcc ctgagacgct
     3001 cactcacgct gtggggatgt cagagagccc catcggaccc aaatccacga tgctccgggc
     3061 tgatgcgtcc tcgacgccct cctttcagca ggcttttgct tcttcctgca ccatttccag
     3121 caacggccct gggcagagga gagagagctc ctcttctgca gaacgccagt gggtggagag
     3181 cagccccaag cccatggttt ccctgctggg gagcggccgg cccaccggaa gtcccctcag
     3241 cgctgagttc tccggtacca ggaaggactc cccagtgctg tcctgcttcc cgccgtcaga
     3301 gctccaggct cctttccaca gccatgagct gtccctagca gagccaccgg actccctggc
     3361 gcctcccagc agccaggcct tcctgggctt cggcaccgcc ccagtgggaa gtggccttcc
     3421 gcccgaggag gacctggggg ccttgctggc caattctcat ggagcgtcac cgacccccag
     3481 catcccgctg acagcgacag gggctgccga caatggcttc ctgtcccaca actttctcac
     3541 ggtggcgcct ggacacagca gccaccacag tccaggcctg cagggccagg gtgtgaccct
     3601 gcccgggcag ccacccctcc ctgagaagaa gcgggcctcg gagggggatc gttctttggg
     3661 ctcagtctct ccctcctcca gtggcttctc cagcccgcac agcgggagca ccatcagtat
     3721 ccccttccca aatgtccttc ccgacttttc caaggcttca gaagcggcct cacctctgcc
     3781 agatagtcca ggtgataaac ttgtgatcgt gaaatttgtt caagacactt ccaagttctg
     3841 gtacaaggcg gatatttcaa gagaacaagc catcgccatg ttgaaggaca aggagccggg
     3901 ctcattcatt gttcgagaca gccattcctt ccgaggggcc tatggcctgg ccatgaaggt
     3961 ggccacgccc ccaccttcag tcctgcagct gaacaagaaa gctggagatt tggccaatga
     4021 actcgtccgg cactttttga tcgagtgtac cccgaaggga gtgcggttga aagggtgctc
     4081 gaatgaacca tatttcggga gcctgacggc cttggtgtgc cagcattcca tcacgccctt
     4141 ggccttgccg tgcaagctgc ttatcccaga gagagatcca ttggaggaaa tagcagaaag
     4201 ttctccccag acggcagcca attcagcagc tgagctgttg aagcaggggg cagcctgcaa
     4261 tgtgtggtac ttgaactctg tggagatgga gtccctcacc ggccaccagg cgatccagaa
     4321 ggccctgagc atcaccctgg tccaggagcc tccacctgtg tccacagttg tgcacttcaa
     4381 ggtgtcagcc cagggcatca ccctgacaga caatcagagg aagctcttct tccggaggca
     4441 ttaccccgtg aacagtgtga ttttctgtgc cttggaccca caagacagga agtggatcaa
     4501 agatggccct tcctcaaaag tctttggatt tgtggcccgg aagcagggca gtgccacgga
     4561 taatgtgtgc cacctgtttg cagagcatga ccctgagcag cctgccagtg ccattgtcaa
     4621 cttcgtatca aaggtcatga ttggttcccc aaagaaggtc tgagaactcc cctccctccc
     4681 tggacccacc gatgcctctc gaagccctgg agacagccgt tgggtgaggg tggggccccc
     4741 actttttacc aaactagtaa acctgacatt ccaggcccat gaggggaaag aggatcttcc
     4801 agctctgcaa aaacaagaac aaacaacatc accgtgaatt ggcctttcct gaaagtgact
     4861 tatctgacac atctctgtag ccacatgctt tttgggtaga agaagctggg catgggtgca
     4921 ccccaccccc tagggtcccc atgggaaagg gacatgcaag gaaacagcac agaacacgag
     4981 gtggtcccca tgtccctggc acactagcat tccgggggat gaggaatccc cagcccttga
     5041 ggcagaggtg ccgagtgact gccatgcttc gcccgtccgc atgggcgctt ctgtccagct
     5101 gcacccgagg ccgggggttt ccctcacctc ggtcttccca agatggagat gctaacgaaa
     5161 ctgagaaggg ggcgtatgtt tgacgaaggt ttgtgcaagt caggcccttc tggaacacag
     5221 cagggcctac aacgaggggc ctttgcgatg ggctgtgagg atgggggtgg tgggaagaat
     5281 tggccacgtt ggagacccca tgccacccca ccatggtgag tgctctgtgc ctcctgctca
     5341 cctgtggtga gctgggcgag ctgggcgagc tgggcgagct gggctgggga gagcctgtga
     5401 ggaccgagag gagaaatgag aagaaggaac aaaaatatta tttctatgta atttatattt
     5461 tacttatgcc aaattattta tgataatttg ccattgctat actgtaccag tgtcaaatgc
     5521 tgcagcctgc caagctgtga ttttgtgagg cttgtcccta tgtaggatgc accgcaggcc
     5581 cctggccact gaaagagtgt gcagtggact gtgggtctcc catatgcggt gccgcccaaa
     5641 ggtggctttg cctcaagcaa cctaccctga tgttttactc attggaatgt ttttccccga
     5701 ttgtggatga cttcttttct gatggagaga gtccaggagg gatggaaaac tcctggattt
     5761 aagctcagca tcccccacat gggcttttcg atcatcttca ggcctgaagc tgcacgacct
     5821 gaagttcgcc tgcatttatc agccctcttt gtgctgctcc ttgccacctt ggggttcctg
     5881 ctggggacca tgtgtggttg tggcatgtgt gagcagaagg gaggatgagg aaaaagagaa
     5941 gaaaccccgg tactgacaag ctgtttttga gtgccactgt ttgccatcat ctaagccact
     6001 gaatcaagtg tatttcaggc ttatttcaac attccaatgc cctggttttc ctgcttgaat
     6061 ctgttcgtgg tcaaaggttt gggggaattt gtgaccctgg aacatcccca gagtgaaaga
     6121 tggagctggg ccacatcaga ataaggcctt ggccccatcc tctcacagcc taggtgctct
     6181 gcaggcatgc tgactgtcct gattgcgatc cagcccgaaa ttccctcctc tgctttcaaa
     6241 agtcaaatcc cccattctta ggccacactg gtgtcacaag ctcctgtcag ggagctgggg
     6301 tttgggaatg tgctttgtga actctgcttt aaagtgaggg gccgaggaaa acttagaaac
     6361 aggcagagtt ggaagcagcc aaatcacagt gggtgttgtg tgtgtgtgcg tgtgtgcatg
     6421 cgtgcgtgta tgcgtgtgtg aaagcaggtg gaccattcca ctttttagct cctattgatg
     6481 caccaaacca agtgcctcat ttctgtgcca aatgtttgcc ttggtcgttg tggacctcct
     6541 tctctaactt gcggtggcat gactgtcagg aggtgctggc attttcagca gatcctcatg
     6601 tgttgaccct gatgtcttta gcagaggcct ctagcatctc ggtttttcat ccactgcagg
     6661 aatgtggcca cagggagcag aggtttgtac tttccccaag aggtcctcat cctgagacgg
     6721 tctctaccca tgtttaaccc aaagagtgca ggccaggttc cttatccttc tgatgaagga
     6781 tgagagagct catttagaag tcagagcaaa ctagggtctc agtattgaga aacgcagcct
     6841 gccagggaat cacagagaca tcggggtgcc cgcgatggcc ctcatgaagc catgcctcga
     6901 cggcattcag gaagccctgc aaacgtgctt tttgaactca ttggccaggt gtgattttta
     6961 cacaaggtaa acgtggtcaa gggcatcggg gaatttgctc caagcagata gctccctctg
     7021 aggaaccaaa ggaagcaagt ttccacgatt tctgaagagc tggtatagga agtttctttc
     7081 ttccttttgt gttacatgtg cattaaacag aacaagctgt gtgtcatcac agattgtact
     7141 gtgggctcag aaaccgtgag agagccccca ccgtggacac cggctctagg gccacaggaa
     7201 aaggaacgtt tccaggcatt ttgtctccag ggctcccgct ggacaggcac gtactgccct
     7261 ggggagtaaa tgcggagagt tcacgaactg tgcccaacgc atgttatagc cagggtccta
     7321 ctaactactc agtaaaagaa cgtattgttg tattcctcca gtgttaagct atagccatgt
     7381 taaaagtcac tgtgcattta ttctcagcat caaatacctt gtaacgtctt ctctgccttg
     7441 ttagtgcata tttttacttt tctgatactg taaagaatat atccagtatg taaatgaatg
     7501 ttctataaat cttttgtata gtcattttct ctgctcctta aatatcatct ctattcagag
     7561 tataataaaa ttatgaactt ggtaa
//
