LOCUS       NM_170754               4848 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens tensin 2 (TNS2), transcript variant 2, mRNA.
ACCESSION   NM_170754
VERSION     NM_170754.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4848)
  AUTHORS   Mitachi,K., Ariake,K., Shima,H., Sato,S., Miura,T., Maeda,S.,
            Ishida,M., Mizuma,M., Ohtsuka,H., Kamei,T., Igarashi,K. and Unno,M.
  TITLE     Novel candidate factors predicting the effect of S-1 adjuvant
            chemotherapy of pancreatic cancer
  JOURNAL   Sci Rep 11 (1), 6541 (2021)
   PUBMED   33753854
  REMARK    GeneRIF: Novel candidate factors predicting the effect of S-1
            adjuvant chemotherapy of pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4848)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4848)
  AUTHORS   Cheng,L.C., Chen,Y.L., Cheng,A.N., Lee,A.Y., Cho,C.Y., Huang,J.S.
            and Chuang,S.E.
  TITLE     AXL phosphorylates and up-regulates TNS2 and its implications in
            IRS-1-associated metabolism in cancer cells
  JOURNAL   J Biomed Sci 25 (1), 80 (2018)
   PUBMED   30419905
  REMARK    GeneRIF: Axl binds to and phosphorylates TNS2 and that
            Axl/TNS2/IRS-1 cross-talk may potentially play a critical role in
            glucose metabolism of cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4848)
  AUTHORS   Kim,E., Kim,D.H., Singaram,I., Jeong,H., Koh,A., Lee,J., Cho,W. and
            Ryu,S.H.
  TITLE     Cellular phosphatase activity of C1-Ten/Tensin2 is controlled by
            Phosphatidylinositol-3,4,5-triphosphate binding through the
            C1-Ten/Tensin2 SH2 domain
  JOURNAL   Cell Signal 51, 130-138 (2018)
   PUBMED   30092354
  REMARK    GeneRIF: Collectively,these findings suggest that the interaction
            between the C1-Ten/Tensin2 SH2 domain and PtdIns(3,4,5)P3 produces
            a negative feedback loop of insulin signaling through IRS-1.
REFERENCE   5  (bases 1 to 4848)
  AUTHORS   Lee,J., Koh,A., Jeong,H., Kim,E., Ha,T.S., Saleem,M.A. and Ryu,S.H.
  TITLE     C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy
            through mTORC1 activation
  JOURNAL   Sci Rep 7 (1), 12346 (2017)
   PUBMED   28955049
  REMARK    GeneRIF: Study observed significant increase in C1-Ten level in
            diabetic kidney and in high glucose-induced damaged podocytes.
            C1-Ten acts as a protein tyrosine phosphatase (PTPase) at the
            nephrin-PI3K binding site and renders PI3K for IRS-1, thereby
            activating mTORC1. These findings demonstrate the relationship
            between nephrin dephosphorylation and the mTORC1 pathway, mediated
            by C1-Ten PTPase activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4848)
  AUTHORS   Hafizi,S., Ibraimi,F. and Dahlback,B.
  TITLE     C1-TEN is a negative regulator of the Akt/PKB signal transduction
            pathway and inhibits cell survival, proliferation, and migration
  JOURNAL   FASEB J 19 (8), 971-973 (2005)
   PUBMED   15817639
  REMARK    GeneRIF: C1 domain-containing phosphatase and TENsin homologue
            (C1-TEN) appears to be a novel intracellular phosphatase that
            negatively regulates the Akt/Protein kinase B signaling cascade
REFERENCE   7  (bases 1 to 4848)
  AUTHORS   Hu,Y., Fang,X., Dunham,S.M., Prada,C., Stachowiak,E.K. and
            Stachowiak,M.K.
  TITLE     90-kDa ribosomal S6 kinase is a direct target for the nuclear
            fibroblast growth factor receptor 1 (FGFR1): role in FGFR1
            signaling
  JOURNAL   J Biol Chem 279 (28), 29325-29335 (2004)
   PUBMED   15117958
REFERENCE   8  (bases 1 to 4848)
  AUTHORS   Calderwood,D.A., Fujioka,Y., de Pereda,J.M., Garcia-Alvarez,B.,
            Nakamoto,T., Margolis,B., McGlade,C.J., Liddington,R.C. and
            Ginsberg,M.H.
  TITLE     Integrin beta cytoplasmic domain interactions with
            phosphotyrosine-binding domains: a structural prototype for
            diversity in integrin signaling
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2272-2277 (2003)
   PUBMED   12606711
REFERENCE   9  (bases 1 to 4848)
  AUTHORS   Hafizi,S., Alindri,F., Karlsson,R. and Dahlback,B.
  TITLE     Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1
            domain-containing protein with homology to tensin
  JOURNAL   Biochem Biophys Res Commun 299 (5), 793-800 (2002)
   PUBMED   12470648
  REMARK    GeneRIF: Interaction of Axl receptor tyrosine kinase with C1-TEN.
REFERENCE   10 (bases 1 to 4848)
  AUTHORS   Chen,H., Duncan,I.C., Bozorgchami,H. and Lo,S.H.
  TITLE     Tensin1 and a previously undocumented family member, tensin2,
            positively regulate cell migration
  JOURNAL   Proc Natl Acad Sci U S A 99 (2), 733-738 (2002)
   PUBMED   11792844
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF518729.1, BC054099.1,
            BX647126.1 and AC068888.35.
            
            On Nov 30, 2019 this sequence version replaced NM_170754.3.
            
            Summary: The protein encoded by this gene belongs to the tensin
            family. Tensin is a focal adhesion molecule that binds to actin
            filaments and participates in signaling pathways. This protein
            plays a role in regulating cell migration. Alternative splicing
            occurs at this locus and three transcript variants encoding three
            distinct isoforms have been identified. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) has a distinct 5' UTR and
            coding region, compared to variant 1, resulting in a protein
            (isoform 2) that is shorter and has a distinct N-terminus, compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150259.1, AB028998.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314250.11/ ENSP00000319684.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3857              AF518729.1         15-3871
            3858-4789           BC054099.1         2359-3290
            4790-4841           BX647126.1         4758-4809
            4842-4848           AC068888.35        3029-3035           c
FEATURES             Location/Qualifiers
     source          1..4848
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..4848
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /note="tensin 2"
                     /db_xref="GeneID:23371"
                     /db_xref="HGNC:HGNC:19737"
                     /db_xref="MIM:607717"
     exon            1..196
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..4351
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tensin-like C1 domain-containing phosphatase; C1
                     domain-containing phosphatase and tensin homolog; tensin
                     like C1 domain containing phosphatase (tensin 2)"
                     /codon_start=1
                     /product="tensin-2 isoform 2"
                     /protein_id="NP_736610.2"
                     /db_xref="CCDS:CCDS8843.1"
                     /db_xref="GeneID:23371"
                     /db_xref="HGNC:HGNC:19737"
                     /db_xref="MIM:607717"
                     /translation="MKSSGPVERLLRALGRRDSSRAASRPRKAEPHSFREKVFRKKPP
                     VCAVCKVTIDGTGVSCRVCKVATHRKCEAKVTSACQALPPVELRRNTAPVRRIEHLGS
                     TKSLNHSKQRSTLPRSFSLDPLMERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRE
                     LAHVLQSKHRDKYLLFNLSEKRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETW
                     LSADPQHVVVLYCKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKVATEL
                     QPSQRRYISYFSGLLSGSIRMNSSPLFLHYVLIPMLPAFEPGTGFQPFLKIYQSMQLV
                     YTSGVYHIAGPGPQQLCISLEPALLLKGDVMVTCYHKGGRGTDRTLVFRVQFHTCTIH
                     GPQLTFPKDQLDEAWTDERFPFQASVEFVFSSSPEKIKGSTPRNDPSVSVDYNTTEPA
                     VRWDSYENFNQHHEDSVDGSLTHTRGPLDGSPYAQVQRPPRQTPPAPSPEPPPPPMLS
                     VSSDSGHSSTLTTEPAAESPGRPPPTAAERQELDRLLGGCGVASGGRGAGRETAILDD
                     EEQPTVGGGPHLGVYPGHRPGLSRHCSCRQGYREPCGVPNGGYYRPEGTLERRRLAYG
                     GYEGSPQGYAEASMEKRRLCRSLSEGLYPYPPEMGKPATGDFGYRAPGYREVVILEDP
                     GLPALYPCPACEEKLALPTAALYGLRLEREAGEGWASEAGKPLLHPVRPGHPLPLLLP
                     ACGHHHAPMPDYSCLKPPKAGEEGHEGCSYTMCPEGRYGHPGYPALVTYSYGGAVPSY
                     CPAYGRVPHSCGSPGEGRGYPSPGAHSPRAGSISPGSPPYPQSRKLSYEIPTEEGGDR
                     YPLPGHLASAGPLASAESLEPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLHT
                     SSPVQGKESTRRQDTRSPTSAPTQRLSPGEALPPVSQAGTGKAPELPSGSGPEPLAPS
                     PVSPTFPPSSPSDWPQERSPGGHSDGASPRSPVPTTLPGLRHAPWQGPRGPPDSPDGS
                     PLTPVPSQMPWLVASPEPPQSSPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQQPGP
                     WGPEQASSPARGISHHVTFAPLLSDNVPQTPEPPTQESQSNVKFVQDTSKFWYKPHLS
                     RDQAIALLKDKDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPVEQLVRHFLI
                     ETGPKGVKIKGCPSEPYFGSLSALVSQHSISPISLPCCLRIPSKDPLEETPEAPVPTN
                     MSTAADLLRQGAACSVLYLTSVETESLTGPQAVARASSAALSCSPRPTPAVVHFKVSA
                     QGITLTDNQRKLFFRRHYPVNSITFSSTDPQDRRWTNPDGTTSKIFGFVAKKPGSPWE
                     NVCHLFAELDPDQPAGAIVTFITKVLLGQRK"
     exon            197..305
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..343
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..382
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..421
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..471
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..643
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..694
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..817
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..882
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..966
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1079
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1140
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1216
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1346
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1412
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1526
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..2738
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2889
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3479
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3480..3569
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3695
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3788
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3789..3866
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3867..3944
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3945..4113
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4114..4182
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4212
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4213..4848
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4818..4823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /note="hexamer: AATAAA"
     regulatory      4831..4836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /note="hexamer: TATAAA"
     polyA_site      4841
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /note="major polyA site"
     polyA_site      4848
                     /gene="TNS2"
                     /gene_synonym="C1-TEN; C1TEN; TENC1"
                     /note="major polyA site"
ORIGIN      
        1 agacagccta ccctccgccc aggggaagcg gctgcctccg ccaggccgct tccaggaagc
       61 cccgggccag gccccagcat tgttcaggcc ctggggccag caccccagcc agccgaacac
      121 catgaagtcc agcggccctg tggagaggct gctcagagcc ctggggagga gggacagcag
      181 ccgggccgca agcaggccta ggaaagctga gcctcatagc ttccgggaga aggttttccg
      241 gaagaaacct ccagtctgtg cagtatgtaa ggtgaccatc gatgggacag gcgtttcgtg
      301 cagagtctgc aaggtggcga cgcacagaaa atgtgaagca aaggtgactt cagcctgtca
      361 ggccttgcct cccgtggagt tgcggcgaaa cacggcccca gtcaggcgca tagagcacct
      421 gggatccacc aaatctctga accactcaaa gcagcgcagc actctgccca ggagcttcag
      481 cctggacccg ctcatggagc ggcgctggga cttagacctc acctacgtga cggagcgcat
      541 cttggccgcc gccttccccg cgcggcccga tgaacagcgg caccggggcc acctgcgcga
      601 gctggcccat gtgctgcaat ccaagcaccg ggacaagtac ctgctcttca acctttcaga
      661 gaaaaggcat gacctgaccc gcttaaaccc caaggttcaa gacttcggct ggcctgagct
      721 gcatgctcca cccctggaca agctgtgctc catctgcaaa gccatggaga catggctcag
      781 tgctgaccca cagcacgtgg tcgtactata ctgcaaggga aacaagggca agcttggggt
      841 catcgtttct gcctacatgc actacagcaa gatctctgca ggggcggacc aggcactggc
      901 cactcttacc atgcggaaat tctgcgagga caaggtggcc acagaactgc agccctccca
      961 gcgtcgatat atcagctact tcagtgggct gctatctggc tccatcagaa tgaacagcag
     1021 ccctctcttc ctgcactatg tgctcatccc catgctgcca gcctttgaac ctggcacagg
     1081 cttccagccc ttccttaaaa tctaccagtc catgcagctt gtctacacat ctggagtcta
     1141 tcacattgca ggccctggtc cccagcagct ttgcatcagc ctggagccag ccctcctcct
     1201 caaaggcgat gtcatggtaa catgttatca caagggtggc cggggcacag accggaccct
     1261 cgtgttccga gtccagttcc acacctgcac catccacgga ccacagctca ctttccccaa
     1321 ggaccagctt gacgaggcct ggactgatga gaggttcccc ttccaagcct ccgtggagtt
     1381 tgtcttctcc tccagccccg agaagatcaa aggcagcact ccacggaacg acccctcggt
     1441 ctctgtcgac tacaacacca ctgagccagc cgtgcgctgg gactcctatg agaacttcaa
     1501 ccagcaccac gaggacagtg tggatggctc cttgacccac acccggggtc ccctggatgg
     1561 cagtccttat gcccaggtgc agcggcctcc ccggcagacc cccccggcac cctctccaga
     1621 gcctccacca ccccccatgc tctctgtcag cagcgactca ggccattcct ccacgctgac
     1681 cacagagccg gctgctgagt cccctggccg gccgccccct acagctgctg aacggcagga
     1741 gctggatcgc ctcctaggag gctgcggagt ggccagtggg ggccggggag ctgggcgcga
     1801 gacggccatc ctagatgacg aagagcagcc cactgtgggc ggaggccccc acctcggagt
     1861 gtatccaggc cataggcctg gcctcagccg ccactgctcc tgccgccagg gctaccggga
     1921 gccctgcggg gttcccaatg ggggctacta ccggccagag ggaaccctgg agaggaggcg
     1981 actggcctac gggggctatg agggatcccc ccagggctac gccgaggcct cgatggagaa
     2041 gaggcgcctc tgccgatcgc tgtcagaggg gctatacccc tacccacctg agatggggaa
     2101 accagccact ggggactttg gctaccgcgc cccaggctac cgggaggtgg tcatcctgga
     2161 ggaccctggg ctgcctgccc tatacccatg cccagcctgc gaggagaagc tggcgctgcc
     2221 tacagcagcc ttgtatggac tgcggctgga gagggaggct ggagaagggt gggcaagtga
     2281 ggctggcaag cctctcctgc acccagtgcg gcctgggcac ccgctgcctc tgctcttgcc
     2341 tgcctgtggg catcaccatg ccccgatgcc tgactacagc tgcctgaagc cacccaaggc
     2401 aggcgaggaa gggcacgagg gctgctccta caccatgtgc cccgaaggca ggtatgggca
     2461 tccagggtac cctgccctgg tgacatacag ctatggagga gcagttccca gttactgccc
     2521 agcatatggc cgtgtgcctc atagctgtgg ctctccagga gagggcagag ggtatcccag
     2581 ccctggtgcc cactccccac gggctggctc catttccccg ggcagcccgc cctatccaca
     2641 atctaggaag ctgagctacg agatccctac ggaggaggga ggggacaggt acccattgcc
     2701 tgggcacctg gcctcagcag gacctttggc atctgcagag tcgctggagc cggtgtcctg
     2761 gagggagggc cccagtgggc acagcacact gcctcggtct ccccgagatg ccccatgcag
     2821 tgcttcgtca gagttgtctg gtccctccac gcccctgcac accagcagtc cagtccaggg
     2881 caaggaaagc acccggcgac aggacaccag gtcccccacc tcagcgccca ctcagagact
     2941 gagtcctggc gaggccttgc cccctgtttc ccaggcaggc accggaaagg cccctgagct
     3001 gccgtcggga agtgggcctg agcctctggc ccctagccca gtctctccga ccttccctcc
     3061 cagctcgccc agtgactggc ctcaggaaag gagtccaggg ggccactcag atggcgccag
     3121 tcctcggagc cctgtgccca ccacacttcc tggcctccgc cacgccccct ggcaaggccc
     3181 tcgaggcccc cccgacagcc cagatgggtc tcccctcact cctgtgcctt cccagatgcc
     3241 ctggcttgtg gccagcccag agccgcctca gagctcacct acacctgctt tccccctggc
     3301 tgcctcctat gacaccaatg gccttagcca gcccccactt cctgagaaac gccacctgcc
     3361 cgggccgggg caacagccag gaccctgggg cccagagcag gcatcatcgc cagccagagg
     3421 catcagtcac catgtcacct tcgcacctct gctctcagat aatgtccccc aaaccccaga
     3481 gcctcctaca caagagagcc aaagcaatgt caagtttgtc caggatacat ccaagttctg
     3541 gtacaagcca cacctgtccc gtgaccaagc cattgccctg ctgaaggaca aggaccctgg
     3601 ggccttcctg atcagggaca gtcattcatt ccaaggagct tatgggctgg ccctcaaggt
     3661 ggccacaccg ccacccagtg cccagccctg gaaaggggac cccgtggaac agctggtccg
     3721 ccatttcctc atcgagactg ggcccaaagg ggtgaagatc aagggctgcc ccagtgagcc
     3781 ctactttggc agcctgtccg ccttggtctc ccagcactcc atctccccca tctccctgcc
     3841 ctgctgcctg cgcattccca gcaaagatcc tctggaagag accccagagg ctccagtgcc
     3901 caccaacatg agcacagcgg cagacctcct gcgtcagggt gctgcctgca gcgtgctcta
     3961 cttgacctca gtggagacag agtcactgac gggcccccaa gctgtggccc gggccagctc
     4021 tgcagctctg agctgtagcc cccgcccgac accagctgtt gtccacttca aggtgtcagc
     4081 ccagggcatt acactgacgg acaaccaaag gaagctcttc tttcgccgcc attatccagt
     4141 gaacagcatc accttctcca gcactgaccc tcaagaccgg agatggacca acccagacgg
     4201 gaccacctcc aagatctttg gtttcgtggc caagaagccg ggaagcccct gggagaatgt
     4261 gtgtcacctc tttgcagagc ttgacccaga tcagcctgct ggcgccattg tcaccttcat
     4321 caccaaagtt ctactgggcc agagaaaatg aaggaaggcc acaagctcag agcccacatc
     4381 aacactgccc ccctcccagc accccacagc cctcacatcc cctggcctgg acccaggaga
     4441 cccaggagaa agcaccctcc cttaggaatg aggagtgggc atcaggcctg ggacactgct
     4501 ctccttcccc gcccccagcc tgctaagtta agtggacagg cccacaagat gaccttgcat
     4561 gtgagcagat ggcagagatg ggtgtgtgag gggtgaggag gcatcagcag ttgagccccg
     4621 aaggagatca ggcagcccca cctgcaggag aacgtcagcc ctccagggga tcagcccctg
     4681 ccagttccac ccagctgcag gtgccagcac ggcagggatg ggagaggggt ggggagcgag
     4741 tcactgcctc ctctgagcag agattcagag taggatcaca tgaatagggg aaaaaagaga
     4801 gtctattttt gtctaataat aaagaatttc tataaacttt agccgaaa
//
