LOCUS       NP_001073964            2968 aa            linear   PRI 12-JUN-2025
DEFINITION  trinucleotide repeat-containing gene 18 protein [Homo sapiens].
ACCESSION   NP_001073964 XP_376567
VERSION     NP_001073964.2
DBSOURCE    REFSEQ: accession NM_001080495.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 2968)
  AUTHORS   Zhao,S., Lu,J., Pan,B., Fan,H., Byrum,S.D., Xu,C., Kim,A., Guo,Y.,
            Kanchi,K.L., Gong,W., Sun,T., Storey,A.J., Burkholder,N.T.,
            Mackintosh,S.G., Kuhlers,P.C., Edmondson,R.D., Strahl,B.D.,
            Diao,Y., Tackett,A.J., Raab,J.R., Cai,L., Song,J. and Wang,G.G.
  TITLE     TNRC18 engages H3K9me3 to mediate silencing of endogenous
            retrotransposons
  JOURNAL   Nature 623 (7987), 633-642 (2023)
   PUBMED   37938770
REFERENCE   2  (residues 1 to 2968)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (residues 1 to 2968)
  AUTHORS   Zamariolli,M., Di-Battista,A., Moyses-Oliveira,M., de Mello,C.B.,
            de Paula Ramos,M.A., Liehr,T. and Melaragno,M.I.
  TITLE     Disruption of PCDH10 and TNRC18 Genes due to a Balanced
            Translocation
  JOURNAL   Cytogenet Genome Res 160 (6), 321-328 (2020)
   PUBMED   32535594
  REMARK    GeneRIF: Disruption of PCDH10 and TNRC18 Genes due to a Balanced
            Translocation.
REFERENCE   4  (residues 1 to 2968)
  AUTHORS   Brandler,W.M., Morris,A.P., Evans,D.M., Scerri,T.S., Kemp,J.P.,
            Timpson,N.J., St Pourcain,B., Smith,G.D., Ring,S.M., Stein,J.,
            Monaco,A.P., Talcott,J.B., Fisher,S.E., Webber,C. and Paracchini,S.
  TITLE     Common variants in left/right asymmetry genes and pathways are
            associated with relative hand skill
  JOURNAL   PLoS Genet 9 (9), e1003751 (2013)
   PUBMED   24068947
REFERENCE   5  (residues 1 to 2968)
  AUTHORS   Denis,N.J., Vasilescu,J., Lambert,J.P., Smith,J.C. and Figeys,D.
  TITLE     Tryptic digestion of ubiquitin standards reveals an improved
            strategy for identifying ubiquitinated proteins by mass
            spectrometry
  JOURNAL   Proteomics 7 (6), 868-874 (2007)
   PUBMED   17370265
REFERENCE   6  (residues 1 to 2968)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum Genet 100 (1), 114-122 (1997)
   PUBMED   9225980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092171.4, BX396597.2, AC093620.3, BC029940.1, AI738451.1,
            CR993399.1, CN295035.1, DR159642.1, AB058759.1, BC131808.1,
            U80753.1, DN990416.1 and AC093376.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 7, 2008 this sequence version replaced NP_001073964.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000430969.6/ ENSP00000395538.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2968
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     Protein         1..2968
                     /product="trinucleotide repeat-containing gene 18 protein"
                     /note="long CAG trinucleotide repeat-containing gene 79
                     protein"
                     /calculated_mol_wt=314389
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Region          139..261
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Region          <251..797
                     /region_name="PksD"
                     /note="Acyl transferase domain in polyketide synthase
                     (PKS) enzymes [Secondary metabolites biosynthesis,
                     transport and catabolism]; COG3321"
                     /db_xref="CDD:442550"
     Site            263
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O15417.3)"
     Region          304..356
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Region          381..488
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Site            611
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80WC3; propagated from
                     UniProtKB/Swiss-Prot (O15417.3)"
     Region          612..679
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Region          941..1002
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Region          1019..1055
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Region          1106..1190
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Site            1127
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O15417.3)"
     Site            1136
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O15417.3)"
     Region          1212..1236
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Region          1279..1306
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Region          1497..1566
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Site            1540
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O15417.3)"
     Region          1687..1855
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Site            1857
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Site            1863
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (O15417.3)"
     Region          1912..2148
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Site            2146
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (O15417.3)"
     Region          2220..2286
                     /region_name="Tudor_TNRC18"
                     /note="Tudor domain found in trinucleotide
                     repeat-containing gene 18 protein (TNRC18) and similar
                     proteins; cd20469"
                     /db_xref="CDD:410540"
     Site            order(2234,2240,2242,2264,2266,2268)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410540"
     Region          <2291..2531
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          2295..2771
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15417.3)"
     Site            2771
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O15417.3)"
     Region          2816..2960
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..2968
                     /gene="TNRC18"
                     /gene_synonym="CAGL79; TNRC18A"
                     /coded_by="NM_001080495.3:638..9544"
                     /db_xref="CCDS:CCDS47534.1"
                     /db_xref="GeneID:84629"
                     /db_xref="HGNC:HGNC:11962"
                     /db_xref="MIM:620902"
ORIGIN      
        1 mdgrdfgpqr svhgppppll sglamdshrv gaatagrlpa sglpgplppg kymaglnlhp
       61 hpgeaflgsf vasgmgpsas shgspvplps dlsfrsptps nlpmvqlwaa hahegfshlp
      121 sglypsylhl nhleppssgs pllsqlgqps ifdtqkgqgp ggdgfylpta gapgslhsha
      181 psartpgggh ssgapakgss srdgpakera grggeppplf gkkdprarge easgprgvvd
      241 ltqearaegr qdrgpprlae rlspflaesk tknaalqpsv ltmcnggagd vglpalvaea
      301 grggakeaar qdegarllrr tetllpgprp cpsplppppa ppkgppappa atpagvytvf
      361 reqgrehrvv aptfvpsvea fderpgpiqi asqardarar ereagrpgvl qappgsprpl
      421 drpeglrekn svirslkrpp padaptvrat raspdprayv pakellkpea dprpcerapr
      481 gpagpaaqqa aklfglepgr ppptgpehkw kpfelgnfaa tqmavlaaqh hhsraeeeaa
      541 vvaassskka yldpgavlpr saatcgrpva dmhsaahgsg easamqslik ysgsfardav
      601 avrpggcgkk spfgglgtmk pepaptsaga sraqarlphs ggpaagggrq lkrdperpes
      661 akafgregsg aqgeaevrhp pvgiavavar qkdsggsgrl gpglvdqers lslsnvkghg
      721 radedcvddr arhreerllg arldrdqekl lreskeladl arlhptscap nglnpnlmvt
      781 ggpalagsgr wsadpaahla thpwlprsgn asmwlaghpy glgppslhqg mapafppglg
      841 gslpsayqfv rdpqsgqlvv ipsdhlphfa elmeratvpp lwpalyppgr splhhaqqlq
      901 lfsqqhflrq qeflylqqqa aqalelqrsa qlvqerlkaq ehraemeekg skrgleaagk
      961 aglatagpgl lprkppglaa gpagtygkav spppsprasp vaalkakviq kledvskppa
     1021 yaypatpssh ptspppaspp ptpgitrkee apenvvekkd lelekeapsp fqalfsdipp
     1081 rypfqalpph ygrpypfllq ptaaadadgl apdvplpadg perlalsped kpirlspski
     1141 teplregpee eplaerevka evedmdegpt elpplesplp lpaaeamatp spaggcgggl
     1201 leaqalsatg qscaepsecp dfvegpeprv dspgrtepct aaldlgvqlt petlveakee
     1261 pvevpvavpv veavpeegla qvapsesqpt lemsdcdvpa gegqcpslep qeavpvlgst
     1321 cfleeassdq flpsledpla gmnalaaaae lpqarplpsp gaagaqalek leaaeslvle
     1381 qsflhgitll seiaeleler rsqemggaer alvarpsles llaagshmlr evldgpvvdp
     1441 lknlrlprel kpnkkyswmr kkeermyamk ssledmdale ldfrmrlaev qrqykekqre
     1501 lvklqrrrds edrreephrs larrgpgrpr krthapsals pprkrgksgh ssgklssksl
     1561 ltsddyelga girkrhkgse eehdaligmg kargrnqtwd eheassdfis qlkikkkkma
     1621 sdqeqlaskl dkalsltkqd klkspfkfsd saggksktsg gcgryltpyd sllgknrkal
     1681 akglglslks sregkhkraa ktrkmevgfk argqpksahs pfasevssys yntdseedee
     1741 flkdewpaqg pssskltpsl lcsmvaknsk aaggpkltkr glaaprtlkp kpatsrkqpf
     1801 clllreaear ssfsdssees fdqdesseee deeeeleeed easgggyrlg areralspgl
     1861 eesglgllar faasalpspt vgpslsvvql eakqkarkke erqsllgtef eytdsesevk
     1921 vrkrspagll rpkkglgepg pslaaptpga rgpdpsspdk aklavekgrk arklrgpkep
     1981 gfeagpeasd ddlwtrrrse riflhdasaa apapvstapa tktsrcakgg plsprkdagr
     2041 akdrkdprkk kkgkeagpga glppprapal psearaphas sltaakrska kakgkevkke
     2101 nrgkggavsk lmesmaaeed fepnqdssfs edehlprgga verpltpapr sciidkdelk
     2161 dglrvlipmd dkllyaghvq tvhspdiyrv vvegergnrp hiycleqllq eaiidvrpas
     2221 trflpqgtri aaywsqqyrc lypgtvvrgl ldleddgdli tvefddgdtg riplshirll
     2281 ppdykiqcae pspallvpsa krrsrktskd tgegkdggta gseepgakar grgrkpsaka
     2341 kgdraatlee gnptdevpst plalepsstp gskksppepv dkrakapkar pappqpspap
     2401 paftscpape pfaelpapat slapaplitm patrpkpkka raaeesgakg prrpgeeael
     2461 lvkldhegvt spkskkakea lllredpgag gwqepkslls lgsyppaags sepkapwpka
     2521 tdgdlaqepg pgltfedsgn pkspdkaqae qdgaeesess sssssgssss sssssssgse
     2581 tegeeegdkn gdggcgtggr ncsaassraa spasssssss ssssssssss ssssssssss
     2641 ssssssssss ssssssssss ssssssssss sttdedsscs sddeaapapt agpsaqaalp
     2701 tkatkqagka rpsahspgkk tpapqpqapp pqptqplqpk aqagaksrpk kregvhlptt
     2761 kelakrqrlp svenrpkiaa flparqlwkw fgkptqrrgm kgkarklfyk aivrgkemir
     2821 igdcavflsa grpnlpyigr iqsmweswgn nmvvrvkwfy hpeetspgkq fhqgqhwdqk
     2881 ssrslpaalr vssqrkdfme ralyqsshvd endvqtvshk clvvgleqye qmlktkkyqd
     2941 seglyylagt yepttgmifs tdgvpvlc
//
