LOCUS       NM_003285              12774 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tenascin R (TNR), transcript variant 1, mRNA.
ACCESSION   NM_003285
VERSION     NM_003285.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12774)
  AUTHORS   Hawi,Z., Yates,H., Pinar,A., Arnatkeviciute,A., Johnson,B.,
            Tong,J., Pugsley,K., Dark,C., Pauper,M., Klein,M., Heussler,H.S.,
            Hiscock,H., Fornito,A., Tiego,J., Finlay,A., Vance,A., Gill,M.,
            Kent,L. and Bellgrove,M.A.
  TITLE     A case-control genome-wide association study of ADHD discovers a
            novel association with the tenascin R (TNR) gene
  JOURNAL   Transl Psychiatry 8 (1), 284 (2018)
   PUBMED   30563984
  REMARK    GeneRIF: Study observed a genome-wide significant association
            between attention deficit hyperactivity disorder and rs6686722,
            mapped to the Tenascin R (TNR) gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12774)
  AUTHORS   Ashbrook,D.G., Williams,R.W., Lu,L. and Hager,R.
  TITLE     A cross-species genetic analysis identifies candidate genes for
            mouse anxiety and human bipolar disorder
  JOURNAL   Front Behav Neurosci 9, 171 (2015)
   PUBMED   26190982
  REMARK    GeneRIF: TNR is a novel candidate for Biopolar Disorder in humans
            and anxiety in mice
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12774)
  AUTHORS   Jakovcevski,I., Miljkovic,D., Schachner,M. and Andjus,P.R.
  TITLE     Tenascins and inflammation in disorders of the nervous system
  JOURNAL   Amino Acids 44 (4), 1115-1127 (2013)
   PUBMED   23269478
  REMARK    GeneRIF: TnC and TnR play important roles in nervous and immune
            systems. [Review]
            Review article
REFERENCE   4  (bases 1 to 12774)
  AUTHORS   Anlar,B. and Gunel-Ozcan,A.
  TITLE     Tenascin-R: role in the central nervous system
  JOURNAL   Int J Biochem Cell Biol 44 (9), 1385-1389 (2012)
   PUBMED   22634605
  REMARK    Review article
REFERENCE   5  (bases 1 to 12774)
  AUTHORS   Dufresne,D., Hamdan,F.F., Rosenfeld,J.A., Torchia,B.,
            Rosenblatt,B., Michaud,J.L. and Srour,M.
  TITLE     Homozygous deletion of Tenascin-R in a patient with intellectual
            disability
  JOURNAL   J Med Genet 49 (7), 451-454 (2012)
   PUBMED   22730557
REFERENCE   6  (bases 1 to 12774)
  AUTHORS   Leprini,A., Gherzi,R., Siri,A., Querze,G., Viti,F. and Zardi,L.
  TITLE     The human tenascin-R gene
  JOURNAL   J Biol Chem 271 (49), 31251-31254 (1996)
   PUBMED   8940128
REFERENCE   7  (bases 1 to 12774)
  AUTHORS   Carnemolla,B., Leprini,A., Borsi,L., Querze,G., Urbini,S. and
            Zardi,L.
  TITLE     Human tenascin-R. Complete primary structure, pre-mRNA alternative
            splicing and gene localization on chromosome 1q23-q24
  JOURNAL   J Biol Chem 271 (14), 8157-8160 (1996)
   PUBMED   8626505
REFERENCE   8  (bases 1 to 12774)
  AUTHORS   Xiao,Z.C., Taylor,J., Montag,D., Rougon,G. and Schachner,M.
  TITLE     Distinct effects of recombinant tenascin-R domains in neuronal cell
            functions and identification of the domain interacting with the
            neuronal recognition molecule F3/11
  JOURNAL   Eur J Neurosci 8 (4), 766-782 (1996)
   PUBMED   9081628
REFERENCE   9  (bases 1 to 12774)
  AUTHORS   Erickson,H.P.
  TITLE     Evolution of the tenascin family--implications for function of the
            C-terminal fibrinogen-like domain
  JOURNAL   Perspect Dev Neurobiol 2 (1), 9-19 (1994)
   PUBMED   7530148
  REMARK    Review article
REFERENCE   10 (bases 1 to 12774)
  AUTHORS   Erickson,H.P.
  TITLE     Tenascin-C, tenascin-R and tenascin-X: a family of talented
            proteins in search of functions
  JOURNAL   Curr Opin Cell Biol 5 (5), 869-876 (1993)
   PUBMED   7694605
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA804585.1, Z67996.1,
            DB068074.1, BC129830.1, AV650210.2 and Z94057.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003285.2.
            
            Summary: This gene encodes a member of the tenascin family of
            extracellular matrix glycoproteins. The encoded protein is
            restricted to the central nervous system. The protein may play a
            role in neurite outgrowth, neural cell adhesion and modulation of
            sodium channel function. It is a constituent of perineuronal nets.
            [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC129830.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367674.7/ ENSP00000356646.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-471               DA804585.1         22-492
            472-582             Z67996.1           19-129
            583-658             DB068074.1         452-527
            659-701             Z67996.1           206-248
            702-2627            BC129830.1         46-1971
            2628-3770           Z67996.1           2175-3317
            3771-3898           AV650210.2         287-414
            3899-4235           Z67996.1           3446-3782
            4236-4236           Z94057.1           47203-47203
            4237-5169           Z67996.1           3784-4716
            5170-12774          Z94057.1           54570-62174
FEATURES             Location/Qualifiers
     source          1..12774
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.1"
     gene            1..12774
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /note="tenascin R"
                     /db_xref="GeneID:7143"
                     /db_xref="HGNC:HGNC:11953"
                     /db_xref="MIM:601995"
     exon            1..370
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            371..471
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            472..1033
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             535..4611
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; janusin; restrictin"
                     /codon_start=1
                     /product="tenascin-R isoform 1 precursor"
                     /protein_id="NP_003276.3"
                     /db_xref="CCDS:CCDS1318.1"
                     /db_xref="GeneID:7143"
                     /db_xref="HGNC:HGNC:11953"
                     /db_xref="MIM:601995"
                     /translation="MGADGETVVLKNMLIGINLILLGSMIKPSECQLEVTTERVQRQS
                     VEEEGGIANYNTSSKEQPVVFNHVYNINVPLDNLCSSGLEASAEQEVSAEDETLAEYM
                     GQTSDHESQVTFTHRINFPKKACPCASSAQVLQELLSRIEMLEREVSVLRDQCNANCC
                     QESAATGQLDYIPHCSGHGNFSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQ
                     CICDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGRC
                     ANGTCLCEEGYVGEDCGQRQCLNACSGRGQCEEGLCVCEEGYQGPDCSAVAPPEDLRV
                     AGISDRSIELEWDGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYN
                     ISVYAVISNILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISFI
                     PKNNEGGVIAQVPSDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDGPT
                     QILVRDVSDTVAFVEWIPPRAKVDFILLKYGLVGGEGGRTTFRLQPPLSQYSVQALRP
                     GSRYEVSVSAVRGTNESDSATTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEVQEY
                     KVVYSTLAGEQYHEVLVPRGIGPTTRATLTDLVPGTEYGVGISAVMNSQQSVPATMNA
                     RTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGIASEVTVPKDRTSYT
                     LTDLEPGAEYIISVTAERGRQQSLESTVDAFTGFRPISHLHFSHVTSSSVNITWSDPS
                     PPADRLILNYSPRDEEEEMMEVSLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPI
                     VGSITTGIDPPKDITISNVTKDSVMVSWSPPVASFDYYRVSYRPTQVGRLDSSVVPNT
                     VTEFTITRLNPATEYEISLNSVRGREESERICTLVHTAMDNPVDLIATNITPTEALLQ
                     WKAPVGEVENYVIVLTHFAVAGETILVDGVSEEFRLVDLLPSTHYTATMYATNGPLTS
                     GTISTNFSTLLDPPANLTASEVTRQSALISWQPPRAEIENYVLTYKSTDGSRKELIVD
                     AEDTWIRLEGLLENTDYTVLLQAAQDTTWSSITSTAFTTGGRVFPHPQDCAQHLMNGD
                     TLSGVYPIFLNGELSQKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNV
                     EDEFWLGLDNIHRITSQGRYELRVDMRDGQEAAFASYDRFSVEDSRNLYKLRIGSYNG
                     TAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQG
                     INWYHWKGHEFSIPFVEMKMRPYNHRLMAGRKRQSLQF"
     exon            1034..1510
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1774
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1890
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2041
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2311
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2497
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2587
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2851
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..3121
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3241
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3388
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3508
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            3509..3652
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            3653..3783
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..3916
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4068
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4165
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4327
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            4328..4491
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     exon            4492..12774
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12754..12759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /note="hexamer: AATAAA"
     polyA_site      12774
                     /gene="TNR"
                     /gene_synonym="NEDSTO; TN-R"
                     /note="major polyA site"
ORIGIN      
        1 acgtcagagg caggaaccga ctgtgctaag gctgttggct caacacccag aggagacggg
       61 cagacccagg gagagtgaga gaagggggtc ctctctgacc caaggaatta ccactagtgg
      121 agtgaagcca cctgactttt tgatcttatt ttggttgcct cctcattctc cttccacccg
      181 tagccctgac agcttgggtt tcatttcttt cgtggagcct tgtctcttcc tcccagaata
      241 ggaggaaggg aagagaaggg aaagaggagg gctctctagg tgagcgcatc agctggctcc
      301 agcctgagca agcaagaatt ttcttcccag gaagctcctc tcgctccccg gccgcccacc
      361 cccagcctgg gtggctgtat cgttttaact gcatagaggg caggtctctt ttggaattag
      421 gattaaagaa agtgcagtaa agagaaagca tcgaagacac catcacaaaa gattcccaca
      481 actccatgct gtgtgctgca ggctggtcct gaacccagat ctctggctga gaggatgggg
      541 gcagatgggg aaacagtggt tctgaagaac atgctcattg gcatcaacct gatccttctg
      601 ggctccatga tcaagccttc agagtgtcag ctggaggtca ccacagaaag ggtccagaga
      661 cagtcagtgg aggaggaggg aggcattgcc aactacaaca catccagcaa agagcagcct
      721 gtggtcttca accacgtgta caacattaac gtgcccttgg acaacctctg ctcctcaggg
      781 ctagaggcct ctgctgagca ggaggtgagt gcagaagacg agactctggc agagtacatg
      841 ggccagacct cagaccacga gagccaggtc acctttacac acaggatcaa cttccccaaa
      901 aaggcctgtc catgtgccag ttcagcccag gtgctgcagg agctgctgag ccggatcgag
      961 atgctggaga gggaggtgtc ggtgctgcga gaccagtgca acgccaactg ctgccaagaa
     1021 agtgctgcca caggacaact ggactatatc cctcactgca gtggccacgg caactttagc
     1081 tttgagtcct gtggctgcat ctgcaacgaa ggctggtttg gcaagaattg ctcggagccc
     1141 tactgcccgc tgggttgctc cagccggggg gtgtgtgtgg atggccagtg catctgtgac
     1201 agcgagtaca gcggggatga ctgttccgaa ctccggtgcc caacagactg cagctcccgg
     1261 gggctctgcg tggacgggga gtgtgtctgt gaagagccct acactggcga ggactgcagg
     1321 gaactgaggt gccctgggga ctgttcgggg aaggggagat gtgccaacgg tacctgttta
     1381 tgcgaggagg gctacgttgg tgaggactgc ggccagcggc agtgtctgaa tgcctgcagt
     1441 gggcgaggac aatgtgagga ggggctctgc gtctgtgaag agggctacca gggccctgac
     1501 tgctcagcag ttgcccctcc agaggacttg cgagtggctg gtatcagcga caggtccatt
     1561 gagctggaat gggacgggcc gatggcagtg acggaatatg tgatctctta ccagccgacg
     1621 gccctggggg gcctccagct ccagcagcgg gtgcctggag attggagtgg tgtcaccatc
     1681 acggagctgg agccaggtct cacctacaac atcagcgtct acgctgtcat tagcaacatc
     1741 ctcagccttc ccatcactgc caaggtggcc acccatctct ccactcctca agggctacaa
     1801 tttaagacga tcacagagac caccgtggag gtgcagtggg agcccttctc attttccttc
     1861 gatgggtggg aaatcagctt cattccaaag aacaatgaag ggggagtgat tgctcaggtc
     1921 cccagcgatg ttacgtcctt taaccagaca ggactaaagc ctggggagga atacattgtc
     1981 aatgtggtgg ctctgaaaga acaggcccgc agccccccta cctcggccag cgtctccaca
     2041 gtcattgacg gccccacgca gatcctggtt cgcgatgtct cggacactgt ggcttttgtg
     2101 gagtggattc cccctcgagc caaagtcgat ttcattcttt tgaaatatgg cctggtgggc
     2161 ggggaaggtg ggaggaccac cttccggctg cagcctcccc tgagccaata ctcagtgcag
     2221 gccctgcggc ctggctcccg atacgaggtg tcagtcagtg ccgtccgagg gaccaacgag
     2281 agcgattctg ccaccactca gttcacaaca gagatcgatg cccccaagaa cttgcgagtt
     2341 ggttctcgca cagcaaccag ccttgacctc gagtgggata acagtgaagc cgaagttcag
     2401 gagtacaagg ttgtgtacag caccctggcg ggtgagcaat atcatgaggt actggtcccc
     2461 aggggcattg gtccaaccac cagggccacc ctgacagatc tggtacctgg cactgagtat
     2521 ggagttggaa tatctgccgt catgaactca cagcaaagcg tgccagccac catgaatgcc
     2581 aggactgaac ttgacagtcc ccgagacctc atggtgacag cctcctcgga gacctccatc
     2641 tccctcatct ggaccaaggc cagtggcccc attgaccact accgaattac ctttacccca
     2701 tcctctggga ttgcctcaga agtcaccgta cccaaggaca ggacctcata cacactaaca
     2761 gatctagagc ctggggcaga gtacatcatt tccgtcactg ctgagagggg tcggcagcag
     2821 agcttggagt ccactgtgga tgctttcaca ggcttccgtc ccatctctca tctgcacttt
     2881 tctcatgtga cctcctccag tgtgaacatc acttggagtg atccatctcc cccagcagac
     2941 agactcattc ttaactacag ccccagggat gaggaggaag agatgatgga ggtctccctg
     3001 gatgccacca agaggcatgc tgtcctgatg ggcctgcaac cagccacaga gtatattgtg
     3061 aaccttgtgg ctgtccatgg cacagtgacc tctgagccca ttgtgggctc catcaccaca
     3121 ggaattgatc ccccaaaaga catcacaatt agcaatgtga ccaaggactc agtgatggtc
     3181 tcctggagcc ctcctgttgc atctttcgat tactaccgag tatcatatcg acccacccaa
     3241 gtgggacgac tagacagctc agtggtgccc aacactgtga cagaattcac catcaccaga
     3301 ctgaacccag ctaccgaata cgaaatcagc ctcaacagcg tgcggggcag ggaggaaagc
     3361 gagcgcatct gtactcttgt gcacacagcc atggacaacc ctgtggatct gattgctacc
     3421 aatatcactc caacagaagc cctgctgcag tggaaggcac cagtgggtga ggtggagaac
     3481 tacgtcattg ttcttacaca ctttgcagtc gctggagaga ccatccttgt tgacggagtc
     3541 agtgaggaat ttcggcttgt tgacctgctt cctagcaccc actatactgc caccatgtat
     3601 gccaccaatg gacctctcac cagtggcacc atcagcacca acttttctac tctcctggac
     3661 cctccggcaa acctgacagc cagtgaagtc accagacaaa gtgccctgat ctcctggcag
     3721 cctcccaggg cagagattga aaattatgtc ttgacctaca aatccaccga tggaagccgc
     3781 aaggagctga ttgtggatgc agaagacacc tggattcgac tggagggcct gttggagaac
     3841 acagactaca cggtgctcct gcaggcagca caggacacca cgtggagcag catcacctcc
     3901 accgctttca ccacaggagg ccgggtgttc cctcatcccc aagactgtgc ccagcatttg
     3961 atgaatggag acactttgag tggggtttac cccatcttcc tcaatgggga gctgagccag
     4021 aaattacaag tgtactgtga tatgaccacc gacgggggcg gctggattgt attccagagg
     4081 cggcagaatg gccaaactga ttttttccgg aaatgggctg attaccgtgt tggcttcggg
     4141 aacgtggagg atgagttctg gctggggctg gacaatatac acaggatcac atcccagggc
     4201 cgctatgagc tgcgcgtgga catgcgggat ggccaagagg ccgccttcgc ctcctacgac
     4261 aggttctctg tcgaggacag cagaaacctg tacaaactcc gcataggaag ctacaacggc
     4321 actgcggggg actccctcag ctatcatcaa ggacgccctt tctccacaga ggatagagac
     4381 aatgatgttg cagtgactaa ctgtgccatg tcgtacaagg gagcatggtg gtataagaac
     4441 tgccaccgga ccaacctcaa tgggaagtac ggggagtcca ggcacagtca gggcatcaac
     4501 tggtaccatt ggaaaggcca tgagttctcc atcccctttg tggaaatgaa gatgcgcccc
     4561 tacaaccacc gtctcatggc agggagaaaa cggcagtcct tacagttctg agcagtgggc
     4621 ggctgcaagc caaccaatat tttctgtcat ttgtttgtat tttataatat gaaacaaggg
     4681 gggagggtaa tagcaatgtg ttttgcaaca tattaagagt atgtgaagga agcagggatg
     4741 tcgcaggaat ccgctggcta acatctgctc ttggtttctg ctgccctgga gcctgaccct
     4801 cagtctccat tctccctcct acccaggcct cctcaacctt cacctccttt cccaccaagg
     4861 aggagaagta ggaagttttc ttaaagggcc aattcaaagc caagtcgtgg ggtgcagatt
     4921 gttatggtga caggcacaca catttttcta cccttcttct gagatgtcct ctgccttcca
     4981 ggtatttgtg attttgtcac agcctgacat ggccaggttc tcacactggc ccagagaaaa
     5041 gagcctcagc aagagagttt tgccaacaat tccccttaaa aggaaacaga tcaactacac
     5101 cgcatcccaa caacccaggt tcttttcctt ccttccttcc ttcctccctt ccttctttcc
     5161 tgccttccct ccttccctcc tttctttctt gacagtatct cactcttgct cagtctggag
     5221 tgcagtggtg caatctcagc tcactacagc ctcgacttcc tgagcttaag tgatcctctc
     5281 gtctcagcct cttgagtagc tgggactaca ggcatgagcc accatacctg gctgattttt
     5341 cttttatttt ttgtagagat gggggtctca ctgtgttgtc caggctggtc acaaactcct
     5401 ggccttgaac aatcctccca cctcagcctc ccaaaatgct gggattacag gctacagcca
     5461 ctgcatccag ccccaagtcc tttataatgg gccaaagatt ctcatcttct gacactctta
     5521 ttataccagc cacatgtcct gttacctttc aagaacagtg gctcttttct ggccctgatg
     5581 gagtcttttg cctaatccca tcctgtctta gaccccagag cctcaaaagc ccaaccagca
     5641 ttttggaatc tagttcccaa ggcattgcct gctcctggcc ctgggtggca cagtggctat
     5701 gtgcctgtga gtcatcagcc actgccccca ccctcaggtc agacagacag tcactttctg
     5761 caaaggtagg agggggagat ggttgtagtt tttagcactt ttgggtcaag cattgaggaa
     5821 aggactgaag aagtcaaaat cagggcactg ccatagagat tatagtttcc atgggaaaca
     5881 cagatcttcc ctagccctgt tttctccatt tctggtccta tttgtcacag attctttttt
     5941 tctgaattgc aaaccgaagg cctcatatct atcttcaccc aagccctcct tagtgtaggt
     6001 ggcttaataa gagtcaggag aagaaggtat atgcccagag agctataccc ctgactgata
     6061 atcctggaaa gaggttgatt ttttttttct tttttggtcc tatgggaaac aggaatgacc
     6121 ttcttaatga ggtgagatca tgagaagcct ttccatcttc ttttattatt ctgccttgca
     6181 aaggaaaaat gacaatagcc aaaggaaatt acatccagaa atccaaaggt gaataggtga
     6241 taactgtggg cctacttccc attttatgag atgcactgtc ttcactagca caatttgatc
     6301 ttaagcccaa gagagctaga tgctctagaa gccgtgacct ttcaatttct cctccaaatc
     6361 caatatcagc aaccatcccc gcaacatctg cccagatcca tgcccagttc cctgagctgt
     6421 cttctccctt tcctctccca ttcctcaagg cccagcacca ttttctgtag tgcctatgtt
     6481 tgtctgacca gagcagtgtg tacctttgcc aaccagttac tggatgagcc ttagtgtcgg
     6541 caattttcta atggaaatat cctcactctt accaagcttt gagaaccaag atgaaaagtc
     6601 ccttgggctg accatcaggc ctcggacctc atggggatgc agccagccac cattgaatgg
     6661 aggcgcttcc cttgccgcag gcttctaggc tttgttcact gcggcagtgt ggatgtgaca
     6721 ggcataaccc tgaaaaacct aggcaccact tgcatttctc agttaaccat gggcttcaac
     6781 aaactgggag gaggaaaaaa cagaaacaga tcctttcaac aagcatgtaa attacagaag
     6841 acttacctag agacggggca acaatgaata gtaggaagca cattgcatgg gaaacttgag
     6901 ggccgaggta caggccaaca gctgtcatct tagctacgac atgacatcgg ctgggttgtt
     6961 tcacctctct gggccagttt cttcatctgt cagatgagag attagactag aatgagttct
     7021 aatttccctt tcagttttga cggtcaatga tgctaatctg tgatctgaaa acctaagtag
     7081 aaattggcat ggtgggacag cacaattagg taatgaaaat tcactagact ccctgtttaa
     7141 tgaggaaaga aggaaagaag gaaggaagga aggaaggaaa gaaggaaggg gagggaggga
     7201 gggaaagaaa agagagagat tgattcagga gtcataagta aaacacacac acacacacac
     7261 acacacacac gaaaatactg cagaaaagat catgccgagt gagaggctga actctttttg
     7321 tccataaaaa cagagaccag gtacctgggt ggtgccagca cgcccacttc atcaaggaag
     7381 ttgaaatgga aaaagattat gtgttgtcaa ttcaggtgaa agtcaagaaa catcagtgga
     7441 aacaaaaatc ttccttttat tgaaaccatt ctacactatg gaacattttt ataaatagta
     7501 ccagcggcat tgcatagctt tattttgaag caagaaagag acttcaaaga tcagcttatt
     7561 caaccctcta taaaaggatt tatagattcc ttttatttaa tagggtgatt ttctcatgag
     7621 ttttcaccat gtttaaaaga cactgtgccc cactctcatc ccaaggtcta tggtcaactt
     7681 gactcaatgc tcataacttt cctcgctgat tcctgcttat cctgctcctc caagcacaac
     7741 tgcatttccc aaaggtagat ccagtaagca atactctcaa agcacccacc ctatgcacac
     7801 cagtttccct caagggactc aaaaggaatc gaggtagacc cttctcagag gctgtttaac
     7861 tacagacaca tcaggatatg tactaatacc caaaaccaaa accaccacca atgactgcaa
     7921 tagattcact gtctagaccc aaggtccagg cagtttccct tttttgcatt tccccaacat
     7981 ataaagataa tttccaacat atcagatgca cattcaccag ggttatttct ggaaggtgaa
     8041 ggggtcaggt gtagaagagg tggcaagaat gacaagtctg tggaaaactg ttggccttga
     8101 gaccacagtg aactggtgga aggggacttg ctaagtgtgg ccacaaggtg gcagtcacct
     8161 cctgaaaccc cgtgtgaaac gtcagcgggg ttgagaaagg ccacgtctcc aagtttccag
     8221 gagagccaaa ccaggactca ggaaaaccgg ccagctgatt tgtatgggag attgatttgt
     8281 aaaagaacaa caacaacata tggcagcaag gaaatgcaaa gcaaacatct acaaatattt
     8341 gaatccacct gtccctcacc taccaacttc cccctctact actcataaag tggtaggact
     8401 cctaatgccc cgcttccttc cacctgagaa ccaaccagca ccctgatatt tcaaagccag
     8461 acctaaagaa ccatggttgc caataacctc aatgccaaac caaacaatcc taatcacatt
     8521 tttacttttc aaatccagtc tcagagcaga gctgtagatt aagggacaaa aagtcattgt
     8581 ggaatctttt caaatagctc ttgtaaaagc atcagttggg aaagagttta tgagttcctc
     8641 tttgtcctct cctctggaga aaagacagaa catgcaagaa cactagatac accaagctat
     8701 gggtgttgaa atagactagc tggtgacctg gatttgcaaa taccctaggg acatgaaaac
     8761 attttttctt tttctttttc ttttttgtaa cctccaccca gaatttcagg aaaggtgggg
     8821 ccacatgccc aggatatatg gtattctact gcttgctttc ttatcaccag aatactagtc
     8881 aatctgattt cttagttcca tgtcttttct tccaaggagg tagggcatgg ggttggggga
     8941 cactttccgc cttccttgca tctcactgtc cactcttaaa tttttattaa gaaacctctg
     9001 aaagattcaa aattcagttc agtttcaata atcccaaaga agttgggata atttgttttc
     9061 acttgcttca aacttgccac ggctgcagga ggagtctcag gacctcagag gaatggggca
     9121 gatgtgtgaa gtctgggagt ctgcctccca cccagatgcc aggagctgca tactcagctc
     9181 tgcctcactt ccctgatggt ctgctttcat ccaggttacc atgacagaga gggtctatcc
     9241 tctaaagaaa gctgagttac aggctggccc ctggggttgt tcctgtagcc tctctttgac
     9301 cacattcctg aagatgttta gctgaatgcc tcctcaaacc tttgcttctt ccataaccca
     9361 atcctacaca tatgtgataa agctttcttc aacaatactg ggtcatttgg acactaccag
     9421 tccagatgag aactcacaga ccaaatgaaa actttcaaaa gcaagcaggg aaagtaactc
     9481 ctatatgctt taagatgatg tattggtgta gattcaggtc caatttgaaa aaatgtctct
     9541 ggttctttct aattgtatcc actctggatt tgtttatgcc agttctacat tcatcaagcc
     9601 ttgagaaaca ggtggaaaga agaaaaatat aaaattaaga agaagctgat ggatcattgg
     9661 agattcaaaa caagccttct accggtggca ccacactgaa aggcagagac aaggcaggag
     9721 cggccatggg agaggaagca gcattggctt ctcacgttct ggcctccagc ctcccaccag
     9781 agcttctgcc attcacccac ttaacttgag gagaaactaa ggcaccaagg cctgtcactg
     9841 caccgaaaac cagaagcaga aggactttct ttctttgctc aaccagttct gcctggatct
     9901 gacttttgcg tcaccagtag tcacaagcct gatttgtcat ctccagcatt ctgtttattt
     9961 ttttaaggtc aatctttgcc tgaaacatga cttcattgca cctgcagcac ttcattgtcc
    10021 aaatgtcctt ggcaaacctc acagtctttg gacagtgttg cattttctcc aaaggggaaa
    10081 tcctctctcc ttcctcaagc ttaataaggc tcttgcagtg catccaaata acacagctct
    10141 tgttcctcag acacactcag ccccctctga taacttcata aaacagctcc ttattgtctg
    10201 ggccatgaag ccaggctaat gctaaagttc cagttcaaaa acatttaact ctattatcct
    10261 tatgaggcca gctctcctgg gtactggcac tcactcactg gcaccatgga ttcaggtcag
    10321 gtggtgcaaa catcttccct gagaagcaag ccatacaccc aacaggtcta gaacacctag
    10381 gtcacaagaa agggtttcag tccagatgca ctgtcagtaa gtgaacacaa ggacaagaat
    10441 gcatgaactg ttattttctt cccatcactg gtttagcagc ccctagggag accctgtgtt
    10501 gctctttaat attctgacat ggagcactaa tatgctcaac actgcctcca acaggcaaat
    10561 gttggaaata cactttcaga gctggatggg actcaagatc atctaatata atcctctcat
    10621 tttatttcct ctcaaggaaa ccaagggcaa gaaagtttag gcaatttgct cacattcaca
    10681 caggcaatta gtaacagagc tgagttcggg tctggtatag gctttttaat ttgattctcc
    10741 acaaatgaac actaagataa atagcattta ttgcataccc actatttacc agatactgtg
    10801 caaagggctt tacatatatt actttactaa atcctcacca taaactttaa gtcaggttta
    10861 accattttat agaagaggga agggagggcc aggaaggtta agtaacatgc tcaaagtcac
    10921 acagctacta aatagagcca taatctgaac ctttgtctaa ttttgaagcc cttgattttt
    10981 ccacttcatg aggctgctct ttatatttat ttagctgagt gaccaccatc ttggatttta
    11041 ctaatattct tacaaggggg ctttgatgcc acttcttctg acttttaaga aaaggaaatt
    11101 cttgcattat ttttgccatg tactccaggg gaccctcaat ctcatcatca tggggaataa
    11161 gaaacattct gacatctctt tccttttctt tctttttaaa tttggtagac gagggagagg
    11221 gtccccaaca gaatgagagg gggaagataa gaaccagaac ataaacccaa taccccccac
    11281 cccactcttt tgggaacatc ccaacattag aagagtggga tatccagtca tttttttcaa
    11341 gctggagcag gcagtgtagc caggattgag gaaggagaag ccacagaata aacatggcac
    11401 atgttctcag agcatcaatt ttactccaga atttgggaag aaaggattat attattagtg
    11461 tattcaaacc agtatggata gcacaaatgc agatatccta taaattttga ggctaactcc
    11521 agcaggttgt agactgattt aggctacctc cttccagact cccaggggta caaacacctt
    11581 cacagtcccc tgcgggagta catcagtgga aatatttggg gaatgaggct agaaggcagg
    11641 agatacattc agtttactta tccccctggt ttcttttccc cactccttac ctgccccaca
    11701 tccctagtgg gtgggaaggc atcagaagac agttggctac aatatcagct ttctctgcta
    11761 ctttggggaa tttagaagga aatcagtact tggcaacctg gtatttttag ctgccaggcc
    11821 aaaactccag acataaaccc cttcccttta attgaatgat gtttatatat aaaggaatag
    11881 atctccccaa gaaagaaccc cagaacactg gttccattcc agtgtggggg ctgcttgggc
    11941 agcagtgaca cctgtgcatt agatgcaata gacacttcaa ttcctgcaaa aatgtcggcc
    12001 aactaagtgc tcctttacca actgcggagg cccagactca caccatggtc ccacagactc
    12061 aaggtttaga atctatgtga gtctattttg gttaacacac aggctcctcc ttccaatcat
    12121 tcacacacac acacacacac acacacacac acacatgcac acacacacat gcatgcacac
    12181 atacacaggt gcacatgcac aaacacacac atctaatgat tccaacctcg aatactcccc
    12241 aggcccatgg ggatgcccaa gtaccctaag caaatcactg tgacactgag ggggtcatta
    12301 actggggctc cgagcagctg aaacccaccc tggtggtctc tagattgttg ttctgagaaa
    12361 tcataaacac caaatcctcc aatccctttg aatttgagtt tgtcatttta acctttaaca
    12421 gccttttcag gtaaaaataa caaagaccaa tttattgact ttgtagctac aatgagcttg
    12481 aaaaagcgct tacttaaaag aaagactgga aggaagaaaa aaaaaagaaa atggagtaca
    12541 tactcctcag acgatgcaca ctttaattag ctaaaataaa aataaaaatg tacagaggaa
    12601 gggagaggaa aaaccaactt ctctgatcct ttcatggcac tgtagctcaa agactggaat
    12661 ctctgcttgt taaccattgt taactagtat ttttagtcct ggttgctttt agcctctgta
    12721 tagttccttt tttaaacaca ttttctatac gttaataaaa gatcctgaaa gaaa
//
