LOCUS       NP_036602                923 aa            linear   PRI 30-APR-2025
DEFINITION  transportin-3 isoform 1 [Homo sapiens].
ACCESSION   NP_036602
VERSION     NP_036602.1
DBSOURCE    REFSEQ: accession NM_012470.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 923)
  AUTHORS   Sepulveda-Crespo,D., Jimenez-Sousa,M.A., Fernandez-Rodiguez,A.,
            Munoz-Fernandez,M.A., Jimenez,J.L., Moreno,S., Garcia,F.,
            Martinez,I., Benito,J.M., Rallon,N. and Resino,S.
  TITLE     IRF5-TNOP3 polymorphisms are associated with elite control of HIV
            infection: A retrospective study
  JOURNAL   J Med Virol 95 (6), e28841 (2023)
   PUBMED   37254791
  REMARK    GeneRIF: IRF5-TNOP3 polymorphisms are associated with elite control
            of HIV infection: A retrospective study.
REFERENCE   2  (residues 1 to 923)
  AUTHORS   Zou,J., Yu,L., Zhu,Y., Yang,S., Zhao,J., Zhao,Y., Jiang,M., Xie,S.,
            Liu,H., Zhao,C. and Zhou,H.
  TITLE     Transportin-3 Facilitates Uncoating of Influenza A Virus
  JOURNAL   Int J Mol Sci 23 (8), 4128 (2022)
   PUBMED   35456945
  REMARK    GeneRIF: Transportin-3 Facilitates Uncoating of Influenza A Virus.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 923)
  AUTHORS   Janssens,J., Blokken,J., Lampi,Y., De Wit,F., Zurnic Bonisch,I.,
            Nombela,I., Van de Velde,P., Van Remoortel,B., Gijsbers,R.,
            Christ,F. and Debyser,Z.
  TITLE     CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of
            Transportin-SR2 in HIV-1 Nuclear Import
  JOURNAL   Microbiol Spectr 9 (2), e0133621 (2021)
   PUBMED   34612665
  REMARK    GeneRIF: CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of
            Transportin-SR2 in HIV-1 Nuclear Import.
REFERENCE   4  (residues 1 to 923)
  AUTHORS   Rice,B.L., Stake,M.S. and Parent,L.J.
  TITLE     TNPO3-Mediated Nuclear Entry of the Rous Sarcoma Virus Gag Protein
            Is Independent of the Cargo-Binding Domain
  JOURNAL   J Virol 94 (17), e00640-20 (2020)
   PUBMED   32581109
  REMARK    GeneRIF: TNPO3-Mediated Nuclear Entry of the Rous Sarcoma Virus Gag
            Protein Is Independent of the Cargo-Binding Domain.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 923)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 923)
  AUTHORS   Lai,M.C., Kuo,H.W., Chang,W.C. and Tarn,W.Y.
  TITLE     A novel splicing regulator shares a nuclear import pathway with SR
            proteins
  JOURNAL   EMBO J 22 (6), 1359-1369 (2003)
   PUBMED   12628928
REFERENCE   7  (residues 1 to 923)
  AUTHORS   Allemand,E., Dokudovskaya,S., Bordonne,R. and Tazi,J.
  TITLE     A conserved Drosophila transportin-serine/arginine-rich (SR)
            protein permits nuclear import of Drosophila SR protein splicing
            factors and their antagonist repressor splicing factor 1
  JOURNAL   Mol Biol Cell 13 (7), 2436-2447 (2002)
   PUBMED   12134081
  REMARK    GeneRIF: Results imply that the mechanism by which SR proteins are
            imported to the nucleus is conserved between Drosophila and humans
            and involves the nuclear import receptor transportin-SR
REFERENCE   8  (residues 1 to 923)
  AUTHORS   Lai,M.C., Lin,R.I. and Tarn,W.Y.
  TITLE     Transportin-SR2 mediates nuclear import of phosphorylated SR
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 98 (18), 10154-10159 (2001)
   PUBMED   11517331
REFERENCE   9  (residues 1 to 923)
  AUTHORS   Lai,M.C., Lin,R.I., Huang,S.Y., Tsai,C.W. and Tarn,W.Y.
  TITLE     A human importin-beta family protein, transportin-SR2, interacts
            with the phosphorylated RS domain of SR proteins
  JOURNAL   J Biol Chem 275 (11), 7950-7957 (2000)
   PUBMED   10713112
REFERENCE   10 (residues 1 to 923)
  AUTHORS   Kataoka,N., Bachorik,J.L. and Dreyfuss,G.
  TITLE     Transportin-SR, a nuclear import receptor for SR proteins
  JOURNAL   J Cell Biol 145 (6), 1145-1152 (1999)
   PUBMED   10366588
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018639.8 and AC025594.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is a nuclear import
            receptor for serine/arginine-rich (SR) proteins such as the
            splicing factors SFRS1 and SFRS2. The encoded protein has also been
            shown to be involved in HIV-1 infection, apparently through
            interaction with the HIV-1 capsid protein. Several protein-coding
            and non-coding transcript variants have been found for this gene.
            [provided by RefSeq, Apr 2020].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068530.1, SRR11853561.26555.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265388.10/ ENSP00000265388.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     Protein         1..923
                     /product="transportin-3 isoform 1"
                     /note="transportin-SR; importin 12; imp12; limb girdle
                     muscular dystrophy 1F (autosomal dominant)"
                     /calculated_mol_wt=104073
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0007744|PubMed:19413330; propagated from
                     UniProtKB/Swiss-Prot (Q9Y5L0.3)"
     Region          33..96
                     /region_name="IBN_N"
                     /note="Importin-beta N-terminal domain; smart00913"
                     /db_xref="CDD:197981"
     Site            74
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9Y5L0.3)"
     Region          121..249
                     /region_name="Xpo1"
                     /note="Exportin 1-like protein; pfam08389"
                     /db_xref="CDD:462459"
     Site            896
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (Q9Y5L0.3)"
     CDS             1..923
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /coded_by="NM_012470.4:342..3113"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS5809.1"
                     /db_xref="GeneID:23534"
                     /db_xref="HGNC:HGNC:17103"
                     /db_xref="MIM:610032"
ORIGIN      
        1 megakptlql vyqavqalyh dpdpsgkera sfwlgelqrs vhaweisdql lqirqdvesc
       61 yfaaqtmkmk iqtsfyelpt dshaslrdsl lthiqnlkdl spvivtqlal aiadlalqmp
      121 swkgcvqtlv ekysndvtsl pflleiltvl peevhsrslr iganrrteii edlafysstv
      181 vsllmtcvek agtdekmlmk vfrclgswfn lgvldsnfma nnkllallfe vlqqdktssn
      241 lheaasdcvc salyaienve tnlplamqlf qgvltletay hmavaredld kvlnycrift
      301 elcetfleki vctpgqglgd lrtlelllic aghpqyevve isfnfwyrlg ehlyktndev
      361 ihgifkayiq rllhalarhc qlepdhegvp eetddfgefr mrvsdlvkdl ifligsmecf
      421 aqlystlkeg nppwevteav lfimaaiaks vdpennptlv evlegvvrlp etvhtavryt
      481 sielvgemse vvdrnpqfld pvlgylmkgl cekplasaaa kaihnicsvc rdhmaqhfng
      541 lleiarslds fllspeaavg llkgtalvla rlpldkitec lselcsvqvm alkkllsqep
      601 sngissdptv fldrlavifr htnpivengq thpcqkviqe iwpvlsetln khradnrive
      661 rccrclrfav rcvgkgsaal lqplvtqmvn vyhvhqhscf lylgsilvde ygmeegcrqg
      721 lldmlqalci ptfqlleqqn glqnhpdtvd dlfrlatrfi qrspvtllrs qvvipilqwa
      781 iasttldhrd ancsvmrflr dlihtgvand heedfelrke ligqvmnqlg qqlvsqllht
      841 ccfclppytl pdvaevlwei mqvdrptfcr wlenslkglp kettvgavtv thkqltdfhk
      901 qvtsaeeckq vcwalrdftr lfr
//
