LOCUS       NM_001382218            4253 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens transportin 3 (TNPO3), transcript variant 6, mRNA.
ACCESSION   NM_001382218
VERSION     NM_001382218.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4253)
  AUTHORS   Sepulveda-Crespo,D., Jimenez-Sousa,M.A., Fernandez-Rodiguez,A.,
            Munoz-Fernandez,M.A., Jimenez,J.L., Moreno,S., Garcia,F.,
            Martinez,I., Benito,J.M., Rallon,N. and Resino,S.
  TITLE     IRF5-TNOP3 polymorphisms are associated with elite control of HIV
            infection: A retrospective study
  JOURNAL   J Med Virol 95 (6), e28841 (2023)
   PUBMED   37254791
  REMARK    GeneRIF: IRF5-TNOP3 polymorphisms are associated with elite control
            of HIV infection: A retrospective study.
REFERENCE   2  (bases 1 to 4253)
  AUTHORS   Zou,J., Yu,L., Zhu,Y., Yang,S., Zhao,J., Zhao,Y., Jiang,M., Xie,S.,
            Liu,H., Zhao,C. and Zhou,H.
  TITLE     Transportin-3 Facilitates Uncoating of Influenza A Virus
  JOURNAL   Int J Mol Sci 23 (8), 4128 (2022)
   PUBMED   35456945
  REMARK    GeneRIF: Transportin-3 Facilitates Uncoating of Influenza A Virus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4253)
  AUTHORS   Janssens,J., Blokken,J., Lampi,Y., De Wit,F., Zurnic Bonisch,I.,
            Nombela,I., Van de Velde,P., Van Remoortel,B., Gijsbers,R.,
            Christ,F. and Debyser,Z.
  TITLE     CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of
            Transportin-SR2 in HIV-1 Nuclear Import
  JOURNAL   Microbiol Spectr 9 (2), e0133621 (2021)
   PUBMED   34612665
  REMARK    GeneRIF: CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of
            Transportin-SR2 in HIV-1 Nuclear Import.
REFERENCE   4  (bases 1 to 4253)
  AUTHORS   Rice,B.L., Stake,M.S. and Parent,L.J.
  TITLE     TNPO3-Mediated Nuclear Entry of the Rous Sarcoma Virus Gag Protein
            Is Independent of the Cargo-Binding Domain
  JOURNAL   J Virol 94 (17), e00640-20 (2020)
   PUBMED   32581109
  REMARK    GeneRIF: TNPO3-Mediated Nuclear Entry of the Rous Sarcoma Virus Gag
            Protein Is Independent of the Cargo-Binding Domain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4253)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4253)
  AUTHORS   Lai,M.C., Kuo,H.W., Chang,W.C. and Tarn,W.Y.
  TITLE     A novel splicing regulator shares a nuclear import pathway with SR
            proteins
  JOURNAL   EMBO J 22 (6), 1359-1369 (2003)
   PUBMED   12628928
REFERENCE   7  (bases 1 to 4253)
  AUTHORS   Allemand,E., Dokudovskaya,S., Bordonne,R. and Tazi,J.
  TITLE     A conserved Drosophila transportin-serine/arginine-rich (SR)
            protein permits nuclear import of Drosophila SR protein splicing
            factors and their antagonist repressor splicing factor 1
  JOURNAL   Mol Biol Cell 13 (7), 2436-2447 (2002)
   PUBMED   12134081
  REMARK    GeneRIF: Results imply that the mechanism by which SR proteins are
            imported to the nucleus is conserved between Drosophila and humans
            and involves the nuclear import receptor transportin-SR
REFERENCE   8  (bases 1 to 4253)
  AUTHORS   Lai,M.C., Lin,R.I. and Tarn,W.Y.
  TITLE     Transportin-SR2 mediates nuclear import of phosphorylated SR
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 98 (18), 10154-10159 (2001)
   PUBMED   11517331
REFERENCE   9  (bases 1 to 4253)
  AUTHORS   Lai,M.C., Lin,R.I., Huang,S.Y., Tsai,C.W. and Tarn,W.Y.
  TITLE     A human importin-beta family protein, transportin-SR2, interacts
            with the phosphorylated RS domain of SR proteins
  JOURNAL   J Biol Chem 275 (11), 7950-7957 (2000)
   PUBMED   10713112
REFERENCE   10 (bases 1 to 4253)
  AUTHORS   Kataoka,N., Bachorik,J.L. and Dreyfuss,G.
  TITLE     Transportin-SR, a nuclear import receptor for SR proteins
  JOURNAL   J Cell Biol 145 (6), 1145-1152 (1999)
   PUBMED   10366588
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018639.8 and AC025594.5.
            
            Summary: The protein encoded by this gene is a nuclear import
            receptor for serine/arginine-rich (SR) proteins such as the
            splicing factors SFRS1 and SFRS2. The encoded protein has also been
            shown to be involved in HIV-1 infection, apparently through
            interaction with the HIV-1 capsid protein. Several protein-coding
            and non-coding transcript variants have been found for this gene.
            [provided by RefSeq, Apr 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.3293719.1,
                                           SRR18074967.2939527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               AC018639.8         71691-72151         c
            462-662             AC018639.8         34997-35197         c
            663-736             AC018639.8         34023-34096         c
            737-893             AC018639.8         32019-32175         c
            894-1037            AC025594.5         194167-194310       c
            1038-1213           AC025594.5         190210-190385       c
            1214-1352           AC025594.5         189580-189718       c
            1353-1499           AC025594.5         186540-186686       c
            1500-1607           AC025594.5         182958-183065       c
            1608-1699           AC025594.5         181150-181241       c
            1700-1839           AC025594.5         179112-179251       c
            1840-2031           AC025594.5         175880-176071       c
            2032-2123           AC025594.5         173319-173410       c
            2124-2200           AC025594.5         171399-171475       c
            2201-2261           AC025594.5         169122-169182       c
            2262-2402           AC025594.5         168134-168274       c
            2403-2519           AC025594.5         164970-165086       c
            2520-2614           AC025594.5         164019-164113       c
            2615-2771           AC025594.5         161577-161733       c
            2772-2939           AC025594.5         159299-159466       c
            2940-3052           AC025594.5         156431-156543       c
            3053-4253           AC025594.5         143336-144536       c
FEATURES             Location/Qualifiers
     source          1..4253
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..4253
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /note="transportin 3"
                     /db_xref="GeneID:23534"
                     /db_xref="HGNC:HGNC:17103"
                     /db_xref="MIM:610032"
     exon            1..461
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..3071
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /note="isoform 5 is encoded by transcript variant 6;
                     transportin-SR; importin 12; imp12; limb girdle muscular
                     dystrophy 1F (autosomal dominant)"
                     /codon_start=1
                     /product="transportin-3 isoform 5"
                     /protein_id="NP_001369147.1"
                     /db_xref="GeneID:23534"
                     /db_xref="HGNC:HGNC:17103"
                     /db_xref="MIM:610032"
                     /translation="MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAW
                     EISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSP
                     VIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLR
                     IGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNF
                     MANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTL
                     ETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHP
                     QYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEE
                     TDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKS
                     VDPENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMK
                     GLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTA
                     LVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGISSDPTVFLDRLAVIFRHTNP
                     IVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQ
                     PLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQN
                     GLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANCSVMRF
                     LRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEV
                     LWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHKQVTRNVFFN"
     exon            462..662
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            663..736
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            737..893
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1037
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1213
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1352
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1499
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1607
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1699
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1839
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2031
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2123
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2200
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2261
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2402
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2519
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2614
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2771
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2939
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3052
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..4253
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4206..4211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /note="hexamer: AACAAA"
     polyA_site      4226
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
     regulatory      4234..4239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /note="hexamer: AATAAA"
     polyA_site      4253
                     /gene="TNPO3"
                     /gene_synonym="IPO12; LGMD1F; LGMDD2; MTR10A; TRN-SR;
                     TRN-SR2; TRNSR"
                     /note="major polyA site"
ORIGIN      
        1 aaacgaacct taggtacact ggtgtgtggc ctcccaagat aggcttctga gggcaagtca
       61 gcgactgaag acgggagcgc cagaatctgt ggactcaaga gtctagaatc aagtggaaaa
      121 accggaaaaa aggccaggaa cctgaatacg acctaatagc tgtttccgag ggggcaactt
      181 ccacggagag ccttctgccc tggtaacggc caaagaggag gagatggcgc cagtcaggga
      241 gcggccgtgg cccagacagt gaggaagcgc gaaggcggag caaccgagga atcctccgga
      301 gaagaatcag agccgtcgct accgccacta ccgccaccac catggaagga gcaaagccga
      361 cattgcagct cgtgtaccag gcagtgcagg cgctttacca cgacccagat cccagcggaa
      421 aggagcgcgc ctctttttgg cttggggagc tgcagcgttc ggttcatgca tgggagatct
      481 cagaccagtt gttacagatc cggcaggatg tggagtcatg ctattttgct gcacagacca
      541 tgaaaatgaa gattcagacc tcattttatg agctccccac agactctcat gcctctttac
      601 gggactcatt gctaacccat atccagaact tgaaagactt gtcacctgtt attgtaacgc
      661 agctggcttt agcaatagca gatcttgccc tacagatgcc ttcctggaag ggatgtgtgc
      721 aaacactggt ggaaaaatac agcaatgatg tgacttcttt gccttttttg ctggagatcc
      781 ttacagtgtt acctgaagaa gtacatagtc gttccttacg aattggagct aatcggcgca
      841 cagaaattat agaagatttg gccttctact ctagtacagt agtatctcta ttgatgacct
      901 gtgtagaaaa agcaggaaca gatgagaaaa tgcttatgaa ggtttttcgc tgtttgggaa
      961 gttggtttaa cttgggagtt ttggacagta acttcatggc taacaataaa ttactagcac
     1021 tcctttttga ggttttgcaa caggataaga cctcgtctaa cctacatgaa gctgcttcgg
     1081 actgtgtatg ctcagctctc tatgccattg agaatgtgga gactaacttg ccattagcca
     1141 tgcaactttt tcagggagtg ctgacattgg agactgccta tcatatggcc gtggcacgtg
     1201 aagatttaga caaagttctg aattactgcc gtattttcac tgaactatgt gaaacttttc
     1261 ttgaaaaaat tgtttgtact ccaggccaag gtcttgggga ccttcgaact ctggagctgc
     1321 tgcttatctg tgcaggccat cctcaatatg aggtagtaga aatttcattt aacttttggt
     1381 accgactggg ggaacatttg tacaaaacta acgatgaagt tattcatggc atcttcaaag
     1441 cttacattca gaggctgctt cacgccttgg ctcgacactg ccagctggaa ccagaccatg
     1501 agggggttcc tgaggagact gatgactttg gggagtttcg catgagggta tcagacctgg
     1561 taaaggactt gattttcttg atagggtcta tggagtgttt tgctcagtta tattctactc
     1621 tgaaagaagg caacccaccc tgggaggtga cagaagcggt tctctttatc atggctgcta
     1681 tagcaaagag tgttgatccg gaaaacaatc caacacttgt ggaagtccta gaaggagttg
     1741 tccgcctccc ggagaccgta catacggctg tgcgatacac cagcattgaa ttggttggag
     1801 agatgagtga agtcgttgat cgaaatcctc agttccttga ccctgtgttg ggctatttga
     1861 tgaaaggcct gtgtgaaaag cccctggctt ctgctgcagc caaagccatt cataacattt
     1921 gctctgtctg ccgagatcac atggctcagc actttaatgg actcctggag attgcccgct
     1981 ccctcgattc cttcctgttg tctccagaag ctgctgtggg cttgctaaaa gggacagcac
     2041 ttgtcctagc ccgattacct ttggataaga ttaccgaatg tcttagtgaa ctatgttctg
     2101 ttcaggttat ggcattgaaa aagctgttgt ctcaagagcc cagcaatggc atatcctcag
     2161 atcccacagt gttcttagat cgccttgcag tgatatttag gcataccaat cccattgtgg
     2221 aaaatggaca gactcatccg tgtcagaaag tcatacagga aatatggcca gttttatccg
     2281 agactctaaa taagcaccga gctgataatc ggattgtaga gcgttgttgc aggtgcctgc
     2341 gctttgctgt tcgctgtgta ggcaaaggat ctgcagcact gctgcagcca ctagtcacac
     2401 agatggtgaa tgtgtaccac gtacatcagc attcctgctt cctgtacctt ggcagtatcc
     2461 ttgtggatga atatggcatg gaagaaggct gtcggcaggg actgctagac atgctccagg
     2521 cactgtgcat ccccaccttt cagctcctag aacagcagaa tggtctccag aatcaccctg
     2581 acactgtaga tgacctgttc cggctagcca ccaggtttat tcagcgtagc cctgtcacct
     2641 tgctgcggag ccaagtggtc atccctatct tacagtgggc cattgcctct actaccctgg
     2701 accaccggga tgccaattgt agtgtcatga ggtttctacg agacctcatt catacagggg
     2761 tagccaatga tcatgaagaa gactttgaat tacggaaaga actgattgga caggtgatga
     2821 accagcttgg acagcagctt gtcagccagc tgctgcacac ctgctgcttt tgcctccccc
     2881 cctataccct accagatgtg gctgaagtgc tctgggagat catgcaggtt gacagaccga
     2941 ctttttgtcg atggttagaa aattccttaa aaggtttgcc aaaggaaaca accgtgggag
     3001 ccgtcacagt gacacacaaa caacttacag acttccacaa gcaagtcact aggaatgtct
     3061 tttttaatta gaagacagga agaaaacaaa aaccagactg tgtcccacaa tcagaaacct
     3121 ccgttgtggc agaggggcct tcaccgccac cagggtgtcc cgccagacag ggagagactc
     3181 cagccttctg aggccatcct gaggagttcc tgtttggggg tgtgagggaa aatcagcgcg
     3241 gattttaaaa agatggctgt ggcctgcccg gcgtggtggg aggggagctg gtttcctggt
     3301 gaactttcta aaaggaaaaa taattttaag taaagaaaaa agaaaaaaaa ggaagactaa
     3361 acagaaacca gaactgaaac attcacctgg tagcaaatga cacatgcacg cacacacaca
     3421 tacacgcaca agcgccagtg cgcacgtgta cacagaaaaa caaaaggaca agctttctgt
     3481 gaaacaaaat atttacttag ggataatgtg gggattcaca tgaattaaat agctgcaatt
     3541 ggaagaagag ggtcagggtc atttgttcag gttttctatt gttttgtcct ctctttcctc
     3601 tcctaccctt ccttctcttt ctctctcccc tccttttaaa tgcaaatgag tagaaatttc
     3661 ttctaccttc cccagctgtt tcttcccacc tttagagttg tttagacaag gaggagtaag
     3721 caaggaactt gttctgcttt ctatcgtggt cacattggtg atgctcggga cctgccaggg
     3781 tcagaattta tggatatctg aaccctgacc ccgttcattc tctcagtcca cttccaatcc
     3841 acatcagttt gttgtctgcc ttggagagaa gagccaaaac tggggtgggc gggtgggtgg
     3901 ggagtgcagg atataaatgt gtaagttttt gttttttaag gtttttttct tagtgaatta
     3961 ttcacccaca gacatgagag aaaaaaagag ggagggtgtg tggagaaaaa atgtttacag
     4021 ggctaacaag ggatgatgtg tcatttagta tgttactaaa aagtgtggaa atgacttgat
     4081 tttaagggga gggtgaggcc gaagagggaa gcccaaagca gatcttaatg tttcaaagga
     4141 gtgcagccct tcacagccat cagatatgag ggcactgttc tgtctggtgt tgtagccatc
     4201 tcaagaacaa atcaacagca acaaaagaga aagaataaat ttttaaaatt taa
//
