LOCUS       NM_001382241            5051 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens transportin 2 (TNPO2), transcript variant 9, mRNA.
ACCESSION   NM_001382241
VERSION     NM_001382241.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5051)
  AUTHORS   Goodman,L.D., Cope,H., Nil,Z., Ravenscroft,T.A., Charng,W.L.,
            Lu,S., Tien,A.C., Pfundt,R., Koolen,D.A., Haaxma,C.A.,
            Veenstra-Knol,H.E., Wassink-Ruiter,J.S.K., Wevers,M.R., Jones,M.,
            Walsh,L.E., Klee,V.H., Theunis,M., Legius,E., Steel,D.,
            Barwick,K.E.S., Kurian,M.A., Mohammad,S.S., Dale,R.C., Terhal,P.A.,
            van Binsbergen,E., Kirmse,B., Robinette,B., Cogne,B., Isidor,B.,
            Grebe,T.A., Kulch,P., Hainline,B.E., Sapp,K., Morava,E., Klee,E.W.,
            Macke,E.L., Trapane,P., Spencer,C., Si,Y., Begtrup,A.,
            Moulton,M.J., Dutta,D., Kanca,O., Wangler,M.F., Yamamoto,S.,
            Bellen,H.J. and Tan,Q.K.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     TNPO2 variants associate with human developmental delays,
            neurologic deficits, and dysmorphic features and alter TNPO2
            activity in Drosophila
  JOURNAL   Am J Hum Genet 108 (9), 1669-1691 (2021)
   PUBMED   34314705
  REMARK    GeneRIF: TNPO2 variants associate with human developmental delays,
            neurologic deficits, and dysmorphic features and alter TNPO2
            activity in Drosophila.
REFERENCE   2  (bases 1 to 5051)
  AUTHORS   Moriyama,T., Yoneda,Y., Oka,M. and Yamada,M.
  TITLE     Transportin-2 plays a critical role in nucleocytoplasmic shuttling
            of oestrogen receptor-alpha
  JOURNAL   Sci Rep 10 (1), 18640 (2020)
   PUBMED   33122699
  REMARK    GeneRIF: Transportin-2 plays a critical role in nucleocytoplasmic
            shuttling of oestrogen receptor-alpha.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5051)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 5051)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5051)
  AUTHORS   Gong,L., Wen,T., Li,Z., Wang,Y., Wang,J., Che,X., Liu,Y. and Qu,X.
  TITLE     TNPO2 operates downstream of DYNC1I1 and promotes gastric cancer
            cell proliferation and inhibits apoptosis
  JOURNAL   Cancer Med 8 (17), 7299-7312 (2019)
   PUBMED   31605449
  REMARK    GeneRIF: TNPO2 operates downstream of DYNC1I1 and promotes gastric
            cancer cell proliferation and inhibits apoptosis.
REFERENCE   6  (bases 1 to 5051)
  AUTHORS   Guttinger,S., Muhlhausser,P., Koller-Eichhorn,R., Brennecke,J. and
            Kutay,U.
  TITLE     Transportin2 functions as importin and mediates nuclear import of
            HuR
  JOURNAL   Proc Natl Acad Sci U S A 101 (9), 2918-2923 (2004)
   PUBMED   14981248
  REMARK    GeneRIF: Transportin-2 mediates nuclear import of HuR protein in
            vitro
REFERENCE   7  (bases 1 to 5051)
  AUTHORS   Blanc,V., Kennedy,S. and Davidson,N.O.
  TITLE     A novel nuclear localization signal in the auxiliary domain of
            apobec-1 complementation factor regulates nucleocytoplasmic import
            and shuttling
  JOURNAL   J Biol Chem 278 (42), 41198-41204 (2003)
   PUBMED   12896982
REFERENCE   8  (bases 1 to 5051)
  AUTHORS   Shamsher,M.K., Ploski,J. and Radu,A.
  TITLE     Karyopherin beta 2B participates in mRNA export from the nucleus
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14195-14199 (2002)
   PUBMED   12384575
  REMARK    GeneRIF: Karyopherin beta 2B participates in mRNA export from the
            nucleus
REFERENCE   9  (bases 1 to 5051)
  AUTHORS   Siomi,M.C., Eder,P.S., Kataoka,N., Wan,L., Liu,Q. and Dreyfuss,G.
  TITLE     Transportin-mediated nuclear import of heterogeneous nuclear RNP
            proteins
  JOURNAL   J Cell Biol 138 (6), 1181-1192 (1997)
   PUBMED   9298975
REFERENCE   10 (bases 1 to 5051)
  AUTHORS   Lanfranchi,G., Muraro,T., Caldara,F., Pacchioni,B., Pallavicini,A.,
            Pandolfo,D., Toppo,S., Trevisan,S., Scarso,S. and Valle,G.
  TITLE     Identification of 4370 expressed sequence tags from a
            3'-end-specific cDNA library of human skeletal muscle by DNA
            sequencing and filter hybridization
  JOURNAL   Genome Res 6 (1), 35-42 (1996)
   PUBMED   8681137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018761.6.
            
            Transcript Variant: This variant (9), as well as variants 1, 8, and
            10, encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1667511.1,
                                           SRR14038192.2969594.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425528.6/ ENSP00000407182.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC018761.6         68488-68651         c
            165-281             AC018761.6         67968-68084         c
            282-393             AC018761.6         65598-65709         c
            394-469             AC018761.6         63980-64055         c
            470-619             AC018761.6         63748-63897         c
            620-726             AC018761.6         60352-60458         c
            727-860             AC018761.6         60124-60257         c
            861-942             AC018761.6         59962-60043         c
            943-1065            AC018761.6         59766-59888         c
            1066-1184           AC018761.6         59540-59658         c
            1185-1245           AC018761.6         56272-56332         c
            1246-1411           AC018761.6         56015-56180         c
            1412-1564           AC018761.6         55340-55492         c
            1565-1790           AC018761.6         51289-51514         c
            1791-1962           AC018761.6         50915-51086         c
            1963-2049           AC018761.6         50401-50487         c
            2050-2157           AC018761.6         50211-50318         c
            2158-2316           AC018761.6         49959-50117         c
            2317-2404           AC018761.6         48433-48520         c
            2405-2503           AC018761.6         48147-48245         c
            2504-2599           AC018761.6         47542-47637         c
            2600-2705           AC018761.6         46791-46896         c
            2706-2805           AC018761.6         46471-46570         c
            2806-2880           AC018761.6         46317-46391         c
            2881-3008           AC018761.6         46045-46172         c
            3009-5051           AC018761.6         43920-45962         c
FEATURES             Location/Qualifiers
     source          1..5051
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..5051
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /note="transportin 2"
                     /db_xref="GeneID:30000"
                     /db_xref="HGNC:HGNC:19998"
                     /db_xref="MIM:603002"
     exon            1..164
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            165..281
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            282..393
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..2988
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /note="isoform 1 is encoded by transcript variant 9;
                     karyopherin beta 2b, transportin; importin 3; transportin
                     2 (importin 3, karyopherin beta 2b); karyopherin beta-2b"
                     /codon_start=1
                     /product="transportin-2 isoform 1"
                     /protein_id="NP_001369170.1"
                     /db_xref="CCDS:CCDS45991.1"
                     /db_xref="GeneID:30000"
                     /db_xref="HGNC:HGNC:19998"
                     /db_xref="MIM:603002"
                     /translation="MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDF
                     NNYLIFVLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASS
                     LIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSEL
                     LDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHL
                     FALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACE
                     FWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIK
                     PRFHKSRTVTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELL
                     PHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKAL
                     VRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEA
                     CTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPL
                     IQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYT
                     QHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQ
                     SSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFISVCNNATWAIGEICMQMGAEM
                     QPYVQMVLNNLVEIINRPNTPKTLLENTGRLTSPSAIPAITIGRLGYVCPQEVAPMLQ
                     QFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWVSPKDDL
                     RDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV"
     exon            394..469
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            470..619
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..726
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..860
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            861..942
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1065
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1184
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1245
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1411
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1564
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1790
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1962
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2049
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2157
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2316
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2404
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2503
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2599
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2705
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2805
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2880
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..3008
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..5051
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5029..5034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /note="hexamer: AGTAAA"
     polyA_site      5051
                     /gene="TNPO2"
                     /gene_synonym="IDDHISD; IPO3; KPNB2B; TRN2"
                     /note="major polyA site"
ORIGIN      
        1 agtccagcgg aactggctac ctcggaatcc caactgctcc tttagggtgt cttccgcgat
       61 tctccgagtg gagttaggcg cctgccgaca cttccctaac cttggaggcc cgggacttga
      121 ttttcatgaa tgaacggagc cgggactgac tttgcctacg gcaaagaagg aaaaacggtg
      181 ccctactgtc ttcagacgtc gcaaggatca agaagatttc tttcttcatg accctgccct
      241 tgccagaatt tcctgcgctg ttccacctca ttcaacttca gcttgccttg cgccatggac
      301 tggcagccag acgagcaggg cctgcagcag gtcctgcagc tgctcaaaga ctcacagtcg
      361 cccaacacag ccactcagcg catcgtgcag gataaactca aacaactcaa tcagtttcct
      421 gacttcaaca actacctgat tttcgtcctg accagactca agtcagaaga tgagccaacg
      481 cgctctctca gtggcctcat cctcaagaac aacgtgaagg cacactatca gagcttccca
      541 ccccctgtgg cagacttcat caaacaggag tgtctcaaca acattggcga tgcctcctcg
      601 ctcatccgag ccaccattgg cattctcatc accaccatcg cttccaaggg tgagctgcag
      661 atgtggcccg agctgctgcc ccagctctgc aacctgctta actcggagga ttacaacact
      721 tgtgagggag cctttggagc cctgcagaag atctgtgaag actcatcaga gcttctggac
      781 agtgacgccc tcaacaggcc cctcaacatc atgatcccca agttcctgca gttcttcaag
      841 cactgcagtc ccaagatccg gtcccacgcc atcgcctgcg tgaaccagtt catcatggac
      901 cgggcccagg cgctgatgga caatattgac accttcatcg agcacctatt tgccctggct
      961 gtggatgatg accccgaggt gcggaagaat gtgtgccgtg ccctggtgat gcttctggaa
     1021 gtgcggattg acaggctcat cccccacatg cacagcatca tccagtacat gctgcagagg
     1081 acccaggacc atgatgagaa cgttgccctt gaggcctgtg agttctggct gacgctggcc
     1141 gagcagccca tctgcaagga agtcctggcc tcccatctgg tccagttgat ccccatcttg
     1201 gtgaatggga tgaagtactc ggaaattgac atcatcctgc tcaaggggga tgtggaggag
     1261 gatgaggctg tccccgacag tgagcaggac atcaagccac gcttccacaa gtcacgcacg
     1321 gtcacactgc cccacgaggc tgagcggcct gatggctccg aggacgcgga ggatgacgat
     1381 gatgatgatg ctctgtccga ctggaatttg aggaagtgct cagcggctgc actggacgtc
     1441 ctcgccaatg tcttccggga ggaactgctg ccccacctac tcccactact caaaggcctc
     1501 ctcttccacc ccgagtgggt ggtcaaggag tcgggcatcc tggtgctggg cgccattgct
     1561 gagggctgca tgcagggcat ggtgccctac ctgcctgagc tgatcccgca cctgatccag
     1621 tgcctgtcgg ataagaaggc cttggtccgc tccatcgcct gctggacgct gagccgctat
     1681 gcccactggg tggtcagcca gccacccgac atgcacctca agcccctgat gacagagctg
     1741 ctcaaacgca tcctggatgg caacaagagg gtacaggagg cggcctgcag tgcttttgcc
     1801 accctggagg aagaggcctg cacggagctg gtgccctacc tcagctacat cctggacacc
     1861 cttgtctttg cctttgggaa ataccagcac aagaacctgc tcatcctcta tgacgccatt
     1921 ggcaccctgg ccgactctgt aggccaccac ctcaaccagc cggaatacat ccagaagctg
     1981 atgcccccac tgatccagaa gtggaatgag ctcaaggacg aagacaagga cctcttcccc
     2041 ctgctggagt gtctgtcatc ggtggccacc gccctgcaga gtggcttcct gccttactgt
     2101 gagcccgtct accagcgctg tgtcaccctg gtgcagaaga cactggctca ggccatgatg
     2161 tacacccagc accctgagca gtatgaggct cccgacaagg acttcatgat cgtagcactg
     2221 gatctgctca gcggcctggc cgagggcctg ggtggtcacg tggagcagct ggtggcccgc
     2281 agcaacatca tgacattgct gttccagtgc atgcaggact cgatgcctga ggtccggcag
     2341 agctcctttg ccctcctggg agacctcacc aaagcctgct tcatccatgt caagccctgt
     2401 atcgccgagt tcatgcccat tctgggcacc aacctgaacc cagagttcat ctccgtctgc
     2461 aacaacgcca cctgggccat tggtgaaatc tgcatgcaga tgggggcaga gatgcagcct
     2521 tatgtgcaga tggtcctcaa caacctggtg gaaatcatta accgacccaa cacacccaag
     2581 acactgctgg aaaacacagg tcgcctgacg agtccctctg ccattccagc catcaccatc
     2641 ggccgcttgg gctacgtgtg cccccaggag gtggcaccca tgctgcagca gttcatccgg
     2701 ccttggtgca cgtccctcag gaacatcagg gacaacgagg agaaggactc agccttccgc
     2761 ggcatctgca tgatgatcgg tgtcaacccg gggggcgttg tgcaggactt tattttcttc
     2821 tgcgatgctg tagcctcctg ggtgagcccg aaggatgacc ttcgggacat gttttataag
     2881 attctccacg gcttcaaaga ccaagttggg gaagataact ggcagcagtt ctctgagcaa
     2941 ttcccgccgc tgctcaagga gaggctggcg gctttctatg gggtctaggt gatcatggag
     3001 actgccaggt ttctgtctgc gtcgtcgtcg gagggattac tggggagtgc gctgcatccg
     3061 gaagtcgctg tgccctggtt gaggggggtt agggaggagt gagtgggact caaatccaga
     3121 tgccttcccc gtccgtccgt ccgtccgtcc atccgtccac ttgccctcct ggcaggtggg
     3181 tggggccacc atgctcatcc tacaaacggg gaggtggggg ggacttctgg tgggcaaggg
     3241 cccctgggct ctaatagggt catctctggc agcccacttg ggccagctac gtgggaggga
     3301 ggaattacac agctgaccga atccggcttc ggatgaggtg agggaggagc aggtcaggag
     3361 gggggccctc gtagggacgc gtacactcac acggacacac atggccacac gcatgtgcgg
     3421 gtgccataac cggcgaggct gggccagccg ctccaccatt tccccgactg catggagaca
     3481 gtagaattag tgaacccctg agttaacccg taaggccttc cgtgtaacct gcatctagag
     3541 tttaagaagc ttctgctgtt ttgccggaat tggcggtgac tggggagggc tgggtgggtg
     3601 gggggcctca ggcgggatct cggggcgggg ggaggaggat ggtgaccttg ggagtcgccc
     3661 tgtcagcacg cacatgcttg ggacccactc cacacactcc ctgccagctt tgttgcagcc
     3721 tcagctggtg gtgtctccgt ccttatccta gcctagctcg cagggtgaga accactggag
     3781 tggctggggc tggccagagg tcaccgtttc tccttcctgt gtgctccagt ggcttttgaa
     3841 gacactgggt tgggaccttt ttcctgaaga gagctgggtg tagccagagc tactggcacc
     3901 taccccgagc atctctctct gtaagcagct tcaggggcag tccgtttctc tgtgcttctg
     3961 aaaccccctt ctcacgtttc aggccccagt tttaactcaa ggcctggggc aggggcgttt
     4021 aattgatgat gacagaggac acaggttttt gccagcaaaa aggaaaacca aggcttggtg
     4081 gaagggaaag gtggtgtgtc ccctgttccc tattccatct ccctgggact tcctgctcat
     4141 catagtaccc agtgagccca gagatcctac tagactgggt cagcaattct agagaacctt
     4201 ccggaatagt ctgggaacat ggtcaaggtg gaaggggctc ccctagagag ggtgggggtg
     4261 tagttacttc ccagttggcc agaaaactgg gccttgcaga cccccttagc attttttccc
     4321 tttttttcct tccctgcttt ctacttcttt ggggagcccc ttgtgttttg gagtctgact
     4381 ggagtctcgc atcctggggc ctgctccatc catccctcct gggcgccaga ccctccatcc
     4441 aagccctgtg tctttccata gtcagggtca ggccctgcat ctattccaag gggcactcag
     4501 tacacattcc ataaattagc tgggtgtccc tgcacgccca ccccatgaaa ctcgagcagg
     4561 tctctggaag ccatttgtta aaaaaaaaaa aaaaagtttt aaaaatacct tttaattttc
     4621 tggtaattcc agttctttga agcatcctct gctgggtctt ggggtgtgtg gatggattgg
     4681 ctgtctgatg ggattggtaa cccctcgcta ctcaagatgg ggggatacaa acaccttcag
     4741 ggaaggggag cctggttctt ctcgttttcc tttttttttt tttttttaaa aaaaaactat
     4801 ttaatttttt aatttatttt tggttgtttt ttgcacaatg aagtttcagc ttctcaacct
     4861 tctcccctac ccagggctgt ggacccagac tggccttgag ccacagtccc tctttccctc
     4921 ctcaccctct tccccctgcg ggctcccggg tctgtccatt tgttactgtg ctgtgctggg
     4981 gattggcgcc gaggtggcgt gagattccac ttgtgtagaa ctttgttgag taaagatcag
     5041 tttcttgtga a
//
