LOCUS       NM_153188               8510 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens transportin 1 (TNPO1), transcript variant 2, mRNA.
ACCESSION   NM_153188
VERSION     NM_153188.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8510)
  AUTHORS   Mahajan,D., Madugula,V. and Lu,L.
  TITLE     Rab8 and TNPO1 are ciliary transport adaptors for GTPase Arl13b by
            interacting with its RVEP motif containing ciliary targeting
            sequence
  JOURNAL   J Biol Chem 299 (5), 104604 (2023)
   PUBMED   36907439
  REMARK    GeneRIF: Rab8 and TNPO1 are ciliary transport adaptors for GTPase
            Arl13b by interacting with its RVEP motif containing ciliary
            targeting sequence.
REFERENCE   2  (bases 1 to 8510)
  AUTHORS   Porschke,M., Rodriguez-Gonzalez,I., Parfentev,I., Urlaub,H. and
            Kehlenbach,R.H.
  TITLE     Transportin 1 is a major nuclear import receptor of the nitric
            oxide synthase interacting protein
  JOURNAL   J Biol Chem 299 (3), 102932 (2023)
   PUBMED   36690276
  REMARK    GeneRIF: Transportin 1 is a major nuclear import receptor of the
            nitric oxide synthase interacting protein.
REFERENCE   3  (bases 1 to 8510)
  AUTHORS   Fare,C.M., Rhine,K., Lam,A., Myong,S. and Shorter,J.
  TITLE     A minimal construct of nuclear-import receptor Karyopherin-beta2
            defines the regions critical for chaperone and disaggregation
            activity
  JOURNAL   J Biol Chem 299 (2), 102806 (2023)
   PUBMED   36529289
  REMARK    GeneRIF: A minimal construct of nuclear-import receptor
            Karyopherin-beta2 defines the regions critical for chaperone and
            disaggregation activity.
REFERENCE   4  (bases 1 to 8510)
  AUTHORS   Yang,T.J., Li,T.N., Huang,R.S., Pan,M.Y., Lin,S.Y., Lin,S.,
            Wu,K.P., Wang,L.H. and Hsu,S.D.
  TITLE     Tumor suppressor BAP1 nuclear import is governed by transportin-1
  JOURNAL   J Cell Biol 221 (6) (2022)
   PUBMED   35446349
  REMARK    GeneRIF: Tumor suppressor BAP1 nuclear import is governed by
            transportin-1.
REFERENCE   5  (bases 1 to 8510)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 8510)
  AUTHORS   Pollard,V.W., Michael,W.M., Nakielny,S., Siomi,M.C., Wang,F. and
            Dreyfuss,G.
  TITLE     A novel receptor-mediated nuclear protein import pathway
  JOURNAL   Cell 86 (6), 985-994 (1996)
   PUBMED   8808633
REFERENCE   7  (bases 1 to 8510)
  AUTHORS   Michael,W.M., Choi,M. and Dreyfuss,G.
  TITLE     A nuclear export signal in hnRNP A1: a signal-mediated,
            temperature-dependent nuclear protein export pathway
  JOURNAL   Cell 83 (3), 415-422 (1995)
   PUBMED   8521471
REFERENCE   8  (bases 1 to 8510)
  AUTHORS   Moroianu,J., Hijikata,M., Blobel,G. and Radu,A.
  TITLE     Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers:
            alpha 1 or alpha 2 subunit binds nuclear localization signal and
            beta subunit interacts with peptide repeat-containing nucleoporins
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6532-6536 (1995)
   PUBMED   7604027
REFERENCE   9  (bases 1 to 8510)
  AUTHORS   Bukrinsky,M.I., Haggerty,S., Dempsey,M.P., Sharova,N., Adzhubel,A.,
            Spitz,L., Lewis,P., Goldfarb,D., Emerman,M. and Stevenson,M.
  TITLE     A nuclear localization signal within HIV-1 matrix protein that
            governs infection of non-dividing cells
  JOURNAL   Nature 365 (6447), 666-669 (1993)
   PUBMED   8105392
REFERENCE   10 (bases 1 to 8510)
  AUTHORS   Bukrinsky,M.I., Sharova,N., Dempsey,M.P., Stanwick,T.L.,
            Bukrinskaya,A.G., Haggerty,S. and Stevenson,M.
  TITLE     Active nuclear import of human immunodeficiency virus type 1
            preintegration complexes
  JOURNAL   Proc Natl Acad Sci U S A 89 (14), 6580-6584 (1992)
   PUBMED   1631159
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008953.7, U70322.1, U72069.1
            and AC008972.8.
            
            On Nov 19, 2020 this sequence version replaced NM_153188.3.
            
            Summary: This gene encodes the beta subunit of the karyopherin
            receptor complex which interacts with nuclear localization signals
            to target nuclear proteins to the nucleus. The karyopherin receptor
            complex is a heterodimer of an alpha subunit which recognizes the
            nuclear localization signal and a beta subunit which docks the
            complex at nucleoporins. Alternate splicing of this gene results in
            several transcript variants encoding different proteins. [provided
            by RefSeq, Jun 2018].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1. Variants 2, 3, and
            4 all encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.22321.1,
                                           SRR14038197.1447923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC008953.7         56030-56142         c
            114-771             U70322.1           85-742
            772-2830            U72069.1           717-2775
            2831-8510           AC008972.8         82105-87784         c
FEATURES             Location/Qualifiers
     source          1..8510
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..8510
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /note="transportin 1"
                     /db_xref="GeneID:3842"
                     /db_xref="HGNC:HGNC:6401"
                     /db_xref="MIM:602901"
     exon            1..113
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            114..227
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2795
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /note="isoform 2 is encoded by transcript variant 2;
                     importin 2; karyopherin (importin) beta 2; importin beta
                     2; M9 region interaction protein; karyopherin beta-2"
                     /codon_start=1
                     /product="transportin-1 isoform 2"
                     /protein_id="NP_694858.1"
                     /db_xref="CCDS:CCDS4016.1"
                     /db_xref="GeneID:3842"
                     /db_xref="HGNC:HGNC:6401"
                     /db_xref="MIM:602901"
                     /translation="MEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYP
                     DFNNYLIFVLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDS
                     SPLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSA
                     EILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIE
                     NLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEA
                     CEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQD
                     IRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRD
                     ELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDK
                     KALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLE
                     EEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLM
                     PPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAM
                     LNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPE
                     VRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMG
                     IEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWC
                     TSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKI
                     LHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV"
     exon            228..303
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            304..453
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            454..560
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            561..694
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            695..776
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            777..899
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1018
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1079
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1248
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1401
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1627
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1799
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1886
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1994
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2153
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2241
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2340
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2436
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2512
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2612
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2687
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2830
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..8510
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4425..4430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /note="hexamer: AATAAA"
     polyA_site      4452
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
     regulatory      8491..8496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /note="hexamer: AATAAA"
     polyA_site      8510
                     /gene="TNPO1"
                     /gene_synonym="IPO2; KPNB2; MIP; MIP1; TRN"
                     /note="major polyA site"
ORIGIN      
        1 ccttgcgctc ggcggccgcg gcggcagcag cagcagacgc tggcggccgg gctgccagga
       61 gcagttccgc cgggtttcac tgtccgtgac ttccttcggg gcacctcagg cagcaaacca
      121 agatggagta tgagtggaaa cctgacgagc aagggcttca gcaaatcctg cagctgttga
      181 aggagtccca gtccccagac accaccatcc agagaaccgt gcaacaaaaa ctggaacaac
      241 ttaatcagta tccagacttt aacaactact tgatttttgt tcttacaaaa ttaaaatctg
      301 aagatgaacc cacaagatca ttgagtggtc ttatcttgaa gaataatgtg aaagcacact
      361 ttcagaactt cccaaatggt gtaacagact ttattaaaag tgaatgttta aataatattg
      421 gtgactcctc tcctctgatt agagccactg ttggtatttt gatcacaact atagcctcca
      481 agggagaatt gcagaattgg cctgacctct taccaaaact ctgtagcctg ttggattctg
      541 aagattataa tacctgtgag ggagcatttg gtgcccttca gaagatttgt gaagattctg
      601 ctgagatttt agacagtgat gttttagatc gtcctctcaa catcatgatt cccaaatttt
      661 tacagttctt caagcatagt agtccaaaaa taaggtctca cgctgttgca tgtgtcaatc
      721 agtttatcat cagtaggact caagctctaa tgttgcacat tgattctttt attgagaatc
      781 tctttgcatt agctggtgat gaagaaccag aggtacggaa aaatgtgtgc cgagcacttg
      841 tgatgttgct cgaagttcga atggatcgcc tgcttcctca catgcataat atagttgagt
      901 acatgctaca gaggactcaa gatcaagatg aaaatgtggc tttagaagcc tgtgaatttt
      961 ggctaacttt agctgaacag ccaatatgca aagatgtact cgtaaggcat cttcctaagt
     1021 tgattcctgt gttagtgaat ggcatgaagt actcagacat agatattatc ctacttaagg
     1081 gtgatgttga agaagacgaa acgattcctg atagtgaaca ggatatacgg ccacgttttc
     1141 accgatcgag gacggtggct cagcagcatg atgaagatgg aattgaagag gaagatgatg
     1201 atgatgatga aattgatgat gatgatacaa tttctgactg gaatctaaga aaatgttctg
     1261 ctgctgccct ggatgttctt gcaaatgtgt atcgtgatga actgctgcca catattttgc
     1321 cccttttgaa agaattactt tttcatcatg aatgggttgt taaagaatca ggcattttgg
     1381 ttttaggagc aattgctgaa ggttgcatgc agggcatgat tccatacttg cctgagctta
     1441 ttcctcacct tattcagtgc ctctctgata aaaaggctct tgtgcgttcc ataacatgct
     1501 ggactcttag ccgctatgca cactgggtgg tcagccagcc gccagacacg tacctgaagc
     1561 cattaatgac agaattgcta aagcgcatcc tggacagcaa caagagagta caagaagctg
     1621 cctgcagtgc ctttgctacc ctagaagagg aggcttgtac agaacttgtt ccttaccttg
     1681 cttatatact tgataccctg gtctttgcat ttagtaaata ccagcataag aacctgctca
     1741 ttctttacga tgccatagga acattagcag attcagtagg acatcattta aacaaaccag
     1801 aatatattca gatgctaatg cctccactga tccagaaatg gaacatgtta aaggatgaag
     1861 ataaagatct cttcccttta cttgagtgcc tatcttcagt tgccacagca ctgcagtctg
     1921 gattccttcc gtactgtgaa cctgtgtatc agcgttgtgt aaacctagta cagaagactc
     1981 ttgcacaagc catgctaaac aatgctcaac cagatcaata tgaagctcca gataaagatt
     2041 ttatgatagt ggctcttgat ttactgagtg gcctggctga aggacttgga ggcaacattg
     2101 aacagctggt agcccgaagt aacatcctga cactaatgta tcagtgcatg caggataaaa
     2161 tgccagaagt tcgacagagt tcttttgccc tgttaggtga cctcacaaaa gcttgctttc
     2221 agcatgttaa gccttgtata gctgatttca tgccaatatt gggaaccaac ctaaatccag
     2281 aattcatttc agtctgcaac aatgccacat gggcaattgg agaaatctcc attcaaatgg
     2341 gtatagagat gcagccttat attcctatgg tgttgcacca gcttgtagaa atcattaaca
     2401 gacccaacac accaaagacg ttgttagaga atacagcaat aacaattggt cgtcttggtt
     2461 acgtttgtcc tcaagaggtg gcccccatgc tacagcagtt tataagaccc tggtgcacct
     2521 ctctgagaaa cataagagac aatgaggaaa aggattcagc attccgtgga atttgtacca
     2581 tgatcagtgt gaatcccagt ggcgtaatcc aagattttat atttttttgt gatgccgttg
     2641 catcatggat taacccaaaa gatgatctca gagacatgtt ctgtaagatc cttcatggat
     2701 ttaaaaatca agttggcgat gaaaattgga ggcgtttctc tgaccagttt cctcttccct
     2761 taaaagagcg tcttgcagct ttttatggtg tttaatctaa tacacttaag ctgcagtccc
     2821 aaaattaggg gtccttcagt cttggagact ataagggagc ctctgcaccc agggaaaatg
     2881 ttacccttta caggggggaa gggtaaacca gtagggaata cagtacaatc ccaaccctac
     2941 tgggaggggc gggagggagg tgttgccgtc actgtattaa gtcgatgttg ggaaacgttt
     3001 taacatctgg agcctttgtg ggtggaaata tgtctccagt tacaactccg cagtggatgt
     3061 gaagaagcaa aaaaaaaaaa atctattcag tctactcaca aaacagtaca ttgtggaata
     3121 ttatggggaa ttgtaccaaa acaagaacca tataaatgat gcctagggac aagaaagagg
     3181 aacaattcta tagcgcacaa taaaggaaac ctaagaatgg gagttacaaa tagtaaagaa
     3241 gctttttttt tttttttaat ttaaagtttt tttatgtaag ttttcccaca tgatggggcc
     3301 ttgttttgca tgttgatgaa gaactacaca aagaaaacta atatagttaa aagtcagctt
     3361 gccttcccgt agtagaagca ggttcttgga agttacaatt taaggtaccc caaaaaagtt
     3421 ggaaataaaa caaaacaaac ataaacaatg aagcaccctg tgaaatgcca aatgagtcac
     3481 tccttttacc ttttttgggg tgggcaggga gggaggaata aatggggttg ggcatatcaa
     3541 actaaagatg acatcttaat tttgcattga acattaatgt agcggatata atttgatgat
     3601 tatacttcat tagatttaat ttctaggcca agatgttact ttttaaagtg cagtttaagg
     3661 ttcaggcatg cattctggct catagtggtt gaaagtaatt taaattagtg ggaaagtagc
     3721 atgcttgcat cacatagagt gagattggta ttcatttacc tatgttgcgc cagtttgtgt
     3781 tgcagtttac caattcaata tagccctgca tttaaagttc ctttttaaga tttgtggatt
     3841 ttatttttat taagaacata gatatataaa gtactgtagt ttacaggtag gccttgaaat
     3901 atctttttta ggatctgtta ggaataagat tgatattgta ttgtgtgtaa cctgcacaat
     3961 gtggaaagct gatatacctg tgcaaaatct ttgcctctgt gctgtcagtg tgatgtgctt
     4021 tctgcatggt tatatactac tagtgatttt atcaaaactt ctaaaattta aattacgtgg
     4081 taaaagatct gtaaaaggct gcataaatgt tagttggcac ataaagacaa ttgtagaagt
     4141 tgaaaaatga ttgctatatt tcaatgttta ttcccactca acatactgcc ttctaagctt
     4201 cccttttttt gttcaaagca tgatcttaaa gatatgttta agttaatgga tgtaatgcag
     4261 ggttcctaca ctgtattttg gcgcatgttg gtggccctct gtgccctaga tatatgcaca
     4321 cagggtgcaa gttaaaagct acagagtgaa agttggtttg gatcctcttc atttcatttg
     4381 tttagctttt ctgttatttt tctctactta catgtattcc tgtgaataaa tccttgttaa
     4441 gttaaccctt tacttttcct tccatgtgta ttttcttata tactgtgaat gtgaaaacct
     4501 aactggtaca cttgatcttg tgttcatatg aaagtgcaag tctttattaa tttggattgc
     4561 ctgaacagtg tatcccatga tgatgaagga aaatggagag atttttcttt ttaactctgc
     4621 tggtcagaga tgaagccacg cctttccatt tttcaatgct gcatatttaa tctgcaacaa
     4681 aaatgttaag ccataacagc ctttttatat tttagtttgt cacctttgca ttgcagaata
     4741 aatactgaat aaccattttt ataagcagtt gctcctcttt gcatggttct attctctaaa
     4801 agtgttgaat gatacagcca ttgcactgaa gtttgagctg tgtgcgtgtg aatttatact
     4861 gtttcaaaaa tttcaaatgc atggtagcat gtagaaaggt ttttgttact atgtgtgtgt
     4921 gtgtgttttg ttttgttttg ttctgttttt taacgttctt tcacctttcc tctactttgg
     4981 ctttgcaaat ttcagtctgt agagcctgaa attaaattat tttatagtgc ctgatatttt
     5041 taatattata agttggattc aaagggtata cagcattttg ttttctagta ccattgcttc
     5101 actgggagct caaaatttgc ctccctgtta gtctttaata actgagtaga gtagcttttt
     5161 tattcttaga ttatagtgat attctgtagt gcttcaaata cttagaattc taatatgaga
     5221 gatagtttaa tattctggaa tagagagtat tttaaattga aatgaccaaa ttcgatttaa
     5281 aacaaacaca taacaatctt cagtaaagtt atttgaacct gtggttgaca attctgtatt
     5341 gactaaaggc aatattgtca cctgtctcat taaaaattag tttccagtta ggcagatgaa
     5401 taacactatt aaaaatgcac ccagttttgt agtcacttga cttttttttt ttatttaaat
     5461 gaaatttaat ttgaaaatag aaaataaaat taggtaaata tgactggcaa cctgaatttg
     5521 agttgggatt ctttgtgtat ttttccccct tgaggttatt gtttcttcct aatttatatt
     5581 tcagatacat agtgtagaac aggaatttgc agaagccatt taagttatct tttgaggtaa
     5641 gctctgattt agcatttatt ctgataaaat ctaatacatc atgggatata tataaagcaa
     5701 cttaattctt gtggtgtagt cttaatagtt ttgaatgttg actgaatgtc tataaaattg
     5761 tgagtttgtc tttgttacat tccagtgttt ctgcctcttg gcatgcttaa agcacggctt
     5821 acttcatctg ctccttacac actaaaatgc tgttagtgtg ctcaactaca gaaatagccg
     5881 ctgctaagtg atgtagattt tctacttgaa tatttttatg ttgtaggaac ctcaggaggt
     5941 cagtgtttac tgttttatat atgccttctt tttcctgttt gagcttctct ctttgaagga
     6001 ttctaacaga acaaagctgc tgatcaacct aagttggaaa cagaaagtgt aattaatata
     6061 acttaaatgc atgtttggca gttccatgtt acagtccatt agcgagtgaa cttagtgcca
     6121 caggtattca tttattcagg aaagaatttt gctttttgta ttgtctaatc tcttcaatga
     6181 cttcatactg tgtaaaaaaa aatcactttt taatattttt tggttggtta tttcccaaat
     6241 aatcaacatg taaataatct tttaagagcc agttctgatg ctttacatta ttgctacttg
     6301 attttgttat gcaagttaga tttcagaaga atagatttta aaacacttaa ccaagccatt
     6361 acatcttaaa aacaaaacaa gtagcataca ttttgtaatt aacattgata aacactgtga
     6421 tttttttggt taagactttt tcattgatct gaattgctta aattgcatat attgtaaaat
     6481 aggatcagat gtatatttta aactaatttc aatggatttt cctcttgaaa tgctttgtct
     6541 actcagttat aaaatattca gatacaagtt ttatctcagg tgaatactct tgtattgttt
     6601 ttgctttggt gacatgctta taaagggtca tcctagttac attctttgtt ttttaagtgt
     6661 atttcattga gaatctttcc atttagtctg atttttttcc taatattcta gcaggctggg
     6721 gtggtataaa gccctcctga caagcctttt gcctacaggt ttacctgaaa atgagctaca
     6781 tatggtcgtc attttcttca aactctcaaa ataggaaagt ggaaattttt ctcccctata
     6841 taaaattatt ctgcctagca gaaatgccag aaataaatta attgcatctt agtctaaatt
     6901 taagtccttt gccatgagga aaaagtggtt ttttgcttca tatggtaaat ctatattatt
     6961 catattgaat gtattaacag ataatggtgc aaaagcattc ttcccagggg aagagtgtat
     7021 catgcataac tgcaatttaa gtccttcctt tgataatact tcaaaacata cacagctttg
     7081 cttactgaat tatttttgca aataatacaa ggaggggaaa ctaacttgct actagtgttg
     7141 ttaatgaagt ataggccttg gaacatttaa gaaaactggt cttcagatag ttaagggctt
     7201 gggataattt aagtgaaaag tgagatcagt aatgagctgt gttgttaaca atattatctg
     7261 gtaataatac catgcaatat agcgttgtat accaacttag tgcattttat actgtattaa
     7321 atatggagat acttctaatg cctctctaaa attaaatttt acataaaagt tagttttatt
     7381 cacctttagg ctttccaagt gaattgtgac taattttttc aatcttacat agatctttca
     7441 cccattagca ttacttacgt agataattct ttatgcctag ttattataca tattaatttt
     7501 taaggtatac atttaaatta cacaattgtt cattgtggtt tgtatcccag aatgtgttgt
     7561 gttttttaaa agatgcataa tagctgaatg tatgcatgac tttgaaagaa gttaaaatgg
     7621 tgattttttt tcacctcttg tacattttaa aaccaggcca aatctatttg ccaagcagtg
     7681 tatcactaat aagaaaagca gtttttcctt ttattgcagt ttttgtttat ctgccataga
     7741 atttccttat actgtggctt ggtattattc aagattagct atttcgctgg tattacatct
     7801 ttttaaaagc ctattataac atggttagcc tataaggcag tgttggtccc cttctaatat
     7861 tggcctcata aaggggttcc actgtacttt ccgcatatta ctgtgttgtt gttttccttt
     7921 gtggatatat aagcaaattg agcttgggtg atttttatgg agacaataat tagacaatac
     7981 tgtataatta gttttactta atagattatc atcttgtgag aagagatgtt taaacgtggt
     8041 aaatcacttc atattacaaa acagttttac acttaatatg ttaacattgg gtgcaataat
     8101 ttagtagcat tagctttagt tacaaatata actggatctt tctgctgaca acttaggttg
     8161 tatgagttat gcttaaaagc tttaaatctg atgtttcctg tacctgccac actatgttag
     8221 aatgtgtcct tcaaacatat cctcctgcaa cttctcaaac tgtactaaat tgatatttct
     8281 tgaagtctaa ctctgtgcta acagatctcc attttaaata gaatacggtt ttaatttttg
     8341 ataagctgct gaattttaaa gagagttttt tggggccacc aaatattttg gatcatgcag
     8401 agaatatata ttgtactgta gtaattttgt atttacattt gtatgatgtg acataataga
     8461 tgtgaatgtt aatcactgct tgactatgtt aataaagttg tttaactata
//
