LOCUS       NM_005425                619 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transition protein 2 (TNP2), mRNA.
ACCESSION   NM_005425
VERSION     NM_005425.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 619)
  AUTHORS   Amjad,S., Mushtaq,S., Rehman,R., Zahid,N., Munir,A. and
            Siddiqui,P.Q.R.
  TITLE     Spermatozoa retrieval in azoospermia and expression profile of
            JMJD1A, TNP2, and PRM2 in a subset of the Karachi population
  JOURNAL   Andrology 9 (6), 1934-1942 (2021)
   PUBMED   34235877
  REMARK    GeneRIF: Spermatozoa retrieval in azoospermia and expression
            profile of JMJD1A, TNP2, and PRM2 in a subset of the Karachi
            population.
REFERENCE   2  (bases 1 to 619)
  AUTHORS   Amor,H., Zeyad,A. and Hammadeh,M.E.
  TITLE     Tobacco smoking and its impact on the expression level of sperm
            nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2
  JOURNAL   Andrologia 53 (3), e13964 (2021)
   PUBMED   33440036
  REMARK    GeneRIF: Tobacco smoking and its impact on the expression level of
            sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2.
REFERENCE   3  (bases 1 to 619)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 619)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 619)
  AUTHORS   Savadi-Shiraz,E., Edalatkhah,H., Talebi,S., Heidari-Vala,H.,
            Zandemami,M., Pahlavan,S., Modarressi,M.H., Akhondi,M.M.,
            Paradowska-Dogan,A. and Sadeghi,M.R.
  TITLE     Quantification of sperm specific mRNA transcripts (PRM1, PRM2, and
            TNP2) in teratozoospermia and normozoospermia: New correlations
            between mRNA content and morphology of sperm
  JOURNAL   Mol Reprod Dev 82 (1), 26-35 (2015)
   PUBMED   25536093
  REMARK    GeneRIF: the quantity of PRM1, PRM2, and TNP2 transcripts and the
            PRM1/PRM2 mRNA ratio affect spermiogenesis, sperm morphology
REFERENCE   6  (bases 1 to 619)
  AUTHORS   Kundu,T.K. and Rao,M.R.
  TITLE     DNA condensation by the rat spermatidal protein TP2 shows GC-rich
            sequence preference and is zinc dependent
  JOURNAL   Biochemistry 34 (15), 5143-5150 (1995)
   PUBMED   7711033
REFERENCE   7  (bases 1 to 619)
  AUTHORS   Nelson,J.E. and Krawetz,S.A.
  TITLE     Characterization of a human locus in transition
  JOURNAL   J Biol Chem 269 (49), 31067-31073 (1994)
   PUBMED   7983046
REFERENCE   8  (bases 1 to 619)
  AUTHORS   Schluter,G., Kremling,H. and Engel,W.
  TITLE     The gene for human transition protein 2: nucleotide sequence,
            assignment to the protamine gene cluster, and evidence for its low
            expression
  JOURNAL   Genomics 14 (2), 377-383 (1992)
   PUBMED   1385303
REFERENCE   9  (bases 1 to 619)
  AUTHORS   Engel,W., Keime,S., Kremling,H., Hameister,H. and Schluter,G.
  TITLE     The genes for protamine 1 and 2 (PRM1 and PRM2) and transition
            protein 2 (TNP2) are closely linked in the mammalian genome
  JOURNAL   Cytogenet Cell Genet 61 (2), 158-159 (1992)
   PUBMED   1395729
REFERENCE   10 (bases 1 to 619)
  AUTHORS   Baskaran,R. and Rao,M.R.
  TITLE     Interaction of spermatid-specific protein TP2 with nucleic acids,
            in vitro. A comparative study with TP1
  JOURNAL   J Biol Chem 265 (34), 21039-21047 (1990)
   PUBMED   2250010
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009121.8, BX282422.1, X63758.1 and AI220577.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005425.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI220577.1, X63758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312693.4/ ENSP00000325738.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC009121.8         94678-94699
            23-63               BX282422.1         1-41
            64-594              X63758.1           1-531
            595-619             AI220577.1         3-27                c
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..619
                     /gene="TNP2"
                     /gene_synonym="TP2"
                     /note="transition protein 2"
                     /db_xref="GeneID:7142"
                     /db_xref="HGNC:HGNC:11952"
                     /db_xref="MIM:190232"
     exon            1..463
                     /gene="TNP2"
                     /gene_synonym="TP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..480
                     /gene="TNP2"
                     /gene_synonym="TP2"
                     /note="TP-2; transition protein 2 (during histone to
                     protamine replacement)"
                     /codon_start=1
                     /product="nuclear transition protein 2"
                     /protein_id="NP_005416.1"
                     /db_xref="CCDS:CCDS45410.1"
                     /db_xref="GeneID:7142"
                     /db_xref="HGNC:HGNC:11952"
                     /db_xref="MIM:190232"
                     /translation="MDTQTHSLPITHTQLHSNSQPQSRTCTRHCQTFSQSCRQSHRGS
                     RSQSSSQSPASHRNPTGAHSSSGHQSQSPNTSPPPKRHKKTMNSHHSPMRPTILHCRC
                     PKNRKNLEGKLKKKKMAKRIQQVYKTKTRSSGWKSN"
     exon            464..619
                     /gene="TNP2"
                     /gene_synonym="TP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      595..600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNP2"
                     /gene_synonym="TP2"
                     /note="hexamer: ATTAAA"
     polyA_site      619
                     /gene="TNP2"
                     /gene_synonym="TP2"
                     /note="major polyA site"
ORIGIN      
        1 gtaaagctag gcctgctggg agaggatgag gaggaggccc tgcccctcca aacgtggcct
       61 cctatggaca cccagactca cagccttcct atcacccaca ctcagctcca tagcaactct
      121 cagccccaaa gccgcacctg cacccgccat tgccaaacct tcagccagag ttgcagacag
      181 agccatcgtg gcagccggag ccagagctcc agccagagcc cggccagcca ccgcaaccca
      241 actggagccc acagctcatc cggccaccag agccagagtc ccaacactag tccaccacca
      301 aagcgccaca aaaagactat gaactcccac cactctccca tgcggcccac catcctgcac
      361 tgccgctgcc ccaagaacag aaagaacttg gaaggcaagc tgaaaaagaa aaaaatggcc
      421 aagaggatcc agcaggtgta caaaaccaag acgcggagct caggatggaa atccaactaa
      481 tgagaccgca ctccttggct tgttcctgcg tgtttcaccc aaaggagaaa atgctaggat
      541 gaagtcaatc ttcttgcagg aacatgttac tatggtgatt tctacgcaac actaattaaa
      601 gcttgtacct ggaagacta
//
