LOCUS       NM_003284                407 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transition protein 1 (TNP1), mRNA.
ACCESSION   NM_003284
VERSION     NM_003284.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 407)
  AUTHORS   Amor,H., Zeyad,A. and Hammadeh,M.E.
  TITLE     Tobacco smoking and its impact on the expression level of sperm
            nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2
  JOURNAL   Andrologia 53 (3), e13964 (2021)
   PUBMED   33440036
  REMARK    GeneRIF: Tobacco smoking and its impact on the expression level of
            sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2.
REFERENCE   2  (bases 1 to 407)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 407)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 407)
  AUTHORS   Onishi,S., Adnan,E., Ishizaki,J., Miyazaki,T., Tanaka,Y.,
            Matsumoto,T., Suemori,K., Shudou,M., Okura,T., Takeda,H.,
            Sawasaki,T., Yasukawa,M. and Hasegawa,H.
  TITLE     Novel Autoantigens Associated with Lupus Nephritis
  JOURNAL   PLoS One 10 (6), e0126564 (2015)
   PUBMED   26098692
  REMARK    GeneRIF: Among Systemic lupus erythematosus patients, 63.6% and
            45.5% of those with lupus nephritis were positive for anti-RRP8 and
            anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic
            lupus erythematosus patients without nephritis, respectively.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 407)
  AUTHORS   Geller,F., Feenstra,B., Zhang,H., Shaffer,J.R., Hansen,T.,
            Esserlind,A.L., Boyd,H.A., Nohr,E.A., Timpson,N.J., Fatemifar,G.,
            Paternoster,L., Evans,D.M., Weyant,R.J., Levy,S.M., Lathrop,M.,
            Smith,G.D., Murray,J.C., Olesen,J., Werge,T., Marazita,M.L.,
            Sorensen,T.I. and Melbye,M.
  TITLE     Genome-wide association study identifies four loci associated with
            eruption of permanent teeth
  JOURNAL   PLoS Genet 7 (9), e1002275 (2011)
   PUBMED   21931568
REFERENCE   6  (bases 1 to 407)
  AUTHORS   Chirat,F., Martinage,A., Briand,G., Kouach,M., Van Dorsselaer,A.,
            Loir,M. and Sautiere,P.
  TITLE     Nuclear transition protein 1 from ram elongating spermatids. Mass
            spectrometric characterization, primary structure and
            phosphorylation sites of two variants
  JOURNAL   Eur J Biochem 198 (1), 13-20 (1991)
   PUBMED   2040274
REFERENCE   7  (bases 1 to 407)
  AUTHORS   Baskaran,R. and Rao,M.R.
  TITLE     Interaction of spermatid-specific protein TP2 with nucleic acids,
            in vitro. A comparative study with TP1
  JOURNAL   J Biol Chem 265 (34), 21039-21047 (1990)
   PUBMED   2250010
REFERENCE   8  (bases 1 to 407)
  AUTHORS   Luerssen,H., Mattei,M.G., Schroter,M., Grzeschik,K.H., Adham,I.M.
            and Engel,W.
  TITLE     Nucleotide sequence of the gene for human transition protein 1 and
            its chromosomal localization on chromosome 2
  JOURNAL   Genomics 8 (2), 324-330 (1990)
   PUBMED   2249851
REFERENCE   9  (bases 1 to 407)
  AUTHORS   Luerssen,H., Hoyer-Fender,S. and Engel,W.
  TITLE     The nucleotide sequence of human transition protein 1 cDNA
  JOURNAL   Nucleic Acids Res 16 (15), 7723 (1988)
   PUBMED   3412903
REFERENCE   10 (bases 1 to 407)
  AUTHORS   Kleene,K.C., Borzorgzadeh,A., Flynn,J.F., Yelick,P.C. and
            Hecht,N.B.
  TITLE     Nucleotide sequence of a cDNA clone encoding mouse transition
            protein 1
  JOURNAL   Biochim Biophys Acta 950 (2), 215-220 (1988)
   PUBMED   3382664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007557.3 and BC029516.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003284.3.
            
            Summary: Transition protein-1 is a spermatid-specific product of
            the haploid genome which replaces histone and is itself replaced in
            the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM
            182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM,
            Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU569792.1, BP371302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000236979.2/ ENSP00000236979.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC007557.3         73034-73038
            6-407               BC029516.1         5-406
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..407
                     /gene="TNP1"
                     /gene_synonym="TP1"
                     /note="transition protein 1"
                     /db_xref="GeneID:7141"
                     /db_xref="HGNC:HGNC:11951"
                     /db_xref="MIM:190231"
     exon            1..169
                     /gene="TNP1"
                     /gene_synonym="TP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..198
                     /gene="TNP1"
                     /gene_synonym="TP1"
                     /note="TP-1; STP-1; transition protein 1 (during histone
                     to protamine replacement)"
                     /codon_start=1
                     /product="spermatid nuclear transition protein 1"
                     /protein_id="NP_003275.1"
                     /db_xref="CCDS:CCDS2406.1"
                     /db_xref="GeneID:7141"
                     /db_xref="HGNC:HGNC:11951"
                     /db_xref="MIM:190231"
                     /translation="MSTSRKLKSHGMRRSKSRSPHKGVKRGGSKRKYRKGNLKSRKRG
                     DDANRNYRSHL"
     exon            170..407
                     /gene="TNP1"
                     /gene_synonym="TP1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      318
                     /gene="TNP1"
                     /gene_synonym="TP1"
     regulatory      386..391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNP1"
                     /gene_synonym="TP1"
                     /note="hexamer: AATAAA"
     polyA_site      407
                     /gene="TNP1"
                     /gene_synonym="TP1"
                     /note="major polyA site"
ORIGIN      
        1 gcaaagcccc tcattttggc agaacttacc atgtcgacca gccgcaaatt aaagagtcat
       61 ggcatgagga ggagcaagag ccgatctcct cacaagggag tcaagagagg tggcagcaaa
      121 agaaaatacc gtaagggcaa cctgaaaagt aggaaacggg gcgatgacgc caatcgcaat
      181 taccgctccc acttgtgagc ccccagcggg ctctgccctg gtgcgcttca cacagcacca
      241 agcagcaaca agaacagcag aaggggaact gccaaggaga cctgatgtta gatcaaagcc
      301 agagaggagc ctatggaatg tggatcaaat gccagttgtg acgaaatgag gaatgtatat
      361 gttggctgtt tttccccaac atctcaataa aactttgaaa gcagaaa
//
