LOCUS       NM_003281               6110 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens troponin I1, slow skeletal type (TNNI1), mRNA.
ACCESSION   NM_003281
VERSION     NM_003281.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6110)
  AUTHORS   Donkervoort,S., van de Locht,M., Ronchi,D., Reunert,J.,
            McLean,C.A., Zaki,M., Orbach,R., de Winter,J.M., Conijn,S.,
            Hoomoedt,D., Neto,O.L.A., Magri,F., Viaene,A.N., Foley,A.R.,
            Gorokhova,S., Bolduc,V., Hu,Y., Acquaye,N., Napoli,L., Park,J.H.,
            Immadisetty,K., Miles,L.B., Essawi,M., McModie,S., Ferreira,L.F.,
            Zanotti,S., Neuhaus,S.B., Medne,L., ElBagoury,N., Johnson,K.R.,
            Zhang,Y., Laing,N.G., Davis,M.R., Bryson-Richardson,R.J.,
            Hwee,D.T., Hartman,J.J., Malik,F.I., Kekenes-Huskey,P.M.,
            Comi,G.P., Sharaf-Eldin,W., Marquardt,T., Ravenscroft,G.,
            Bonnemann,C.G. and Ottenheijm,C.A.C.
  TITLE     Pathogenic TNNI1 variants disrupt sarcomere contractility resulting
            in hypo- and hypercontractile muscle disease
  JOURNAL   Sci Transl Med 16 (741), eadg2841 (2024)
   PUBMED   38569017
  REMARK    GeneRIF: Pathogenic TNNI1 variants disrupt sarcomere contractility
            resulting in hypo- and hypercontractile muscle disease.
REFERENCE   2  (bases 1 to 6110)
  AUTHORS   Barthel,B.L., Cox,D., Barbieri,M., Ziemba,M., Straub,V.,
            Hoffman,E.P. and Russell,A.J.
  TITLE     Elevation of fast but not slow troponin I in the circulation of
            patients with Becker and Duchenne muscular dystrophy
  JOURNAL   Muscle Nerve 64 (1), 43-49 (2021)
   PUBMED   33683712
  REMARK    GeneRIF: Elevation of fast but not slow troponin I in the
            circulation of patients with Becker and Duchenne muscular
            dystrophy.
REFERENCE   3  (bases 1 to 6110)
  AUTHORS   Sanders,R.D., Craigova,L., Schessler,B., Casey,C., White,M.,
            Parker,M., Kunkel,D., Blennow,K., Zetterberg,H., Pearce,R.A. and
            Lennertz,R.
  TITLE     Postoperative troponin increases after noncardiac surgery are
            associated with raised neurofilament light: a prospective
            observational cohort study
  JOURNAL   Br J Anaesth 126 (4), 791-798 (2021)
   PUBMED   33158499
  REMARK    GeneRIF: Postoperative troponin increases after noncardiac surgery
            are associated with raised neurofilament light: a prospective
            observational cohort study.
REFERENCE   4  (bases 1 to 6110)
  AUTHORS   Nie,S.F., Yu,M., Xie,T., Yang,F., Wang,H.B., Wang,Z.H., Li,M.,
            Gao,X.L., Lv,B.J., Wang,S.J., Zhang,X.B., He,S.L., Qiu,Z.H.,
            Liao,Y.H., Zhou,Z.H. and Cheng,X.
  TITLE     Cardiac Troponin I Is an Independent Predictor for Mortality in
            Hospitalized Patients With COVID-19
  JOURNAL   Circulation 142 (6), 608-610 (2020)
   PUBMED   32539541
  REMARK    GeneRIF: Cardiac Troponin I Is an Independent Predictor for
            Mortality in Hospitalized Patients With COVID-19.
REFERENCE   5  (bases 1 to 6110)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6110)
  AUTHORS   Corin,S.J., Juhasz,O., Zhu,L., Conley,P., Kedes,L. and Wade,R.
  TITLE     Structure and expression of the human slow twitch skeletal muscle
            troponin I gene
  JOURNAL   J Biol Chem 269 (14), 10651-10659 (1994)
   PUBMED   8144655
REFERENCE   7  (bases 1 to 6110)
  AUTHORS   Bhavsar,P.K., Dhoot,G.K., Cumming,D.V., Butler-Browne,G.S.,
            Yacoub,M.H. and Barton,P.J.
  TITLE     Developmental expression of troponin I isoforms in fetal human
            heart
  JOURNAL   FEBS Lett 292 (1-2), 5-8 (1991)
   PUBMED   1959627
REFERENCE   8  (bases 1 to 6110)
  AUTHORS   Hunkeler,N.M., Kullman,J. and Murphy,A.M.
  TITLE     Troponin I isoform expression in human heart
  JOURNAL   Circ Res 69 (5), 1409-1414 (1991)
   PUBMED   1934363
REFERENCE   9  (bases 1 to 6110)
  AUTHORS   Wade,R., Eddy,R., Shows,T.B. and Kedes,L.
  TITLE     cDNA sequence, tissue-specific expression, and chromosomal mapping
            of the human slow-twitch skeletal muscle isoform of troponin I
  JOURNAL   Genomics 7 (3), 346-357 (1990)
   PUBMED   2365354
REFERENCE   10 (bases 1 to 6110)
  AUTHORS   Suzuki,H., Kawarabayasi,Y., Kondo,J., Abe,T., Nishikawa,K.,
            Kimura,S., Hashimoto,T. and Yamamoto,T.
  TITLE     Structure and regulation of rat long-chain acyl-CoA synthetase
  JOURNAL   J Biol Chem 265 (15), 8681-8685 (1990)
   PUBMED   2341402
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC012600.1, AC096677.2 and
            AL832006.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003281.3.
            
            Summary: Troponin proteins associate with tropomyosin and regulate
            the calcium sensitivity of the myofibril contractile apparatus of
            striated muscles. Troponin I (TnI), along with troponin T (TnT) and
            troponin C (TnC), is one of 3 subunits that form the troponin
            complex of the thin filaments of striated muscle. TnI is the
            inhibitory subunit; blocking actin-myosin interactions and thereby
            mediating striated muscle relaxation. The TnI subfamily contains
            three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch,
            and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in
            fast-twitch and slow-twitch skeletal muscle fibers, respectively,
            while the TnI-cardiac gene is expressed exclusively in cardiac
            muscle tissue. This gene encodes the
            Troponin-I-skeletal-slow-twitch protein. This gene is expressed in
            cardiac and skeletal muscle during early development but is
            restricted to slow-twitch skeletal muscle fibers in adults. The
            encoded protein prevents muscle contraction by inhibiting
            calcium-mediated conformational changes in actin-myosin complexes.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL831975.1, BX510903.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361379.9/ ENSP00000354488.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1029              BC012600.1         5-1033
            1030-5522           AC096677.2         2370-6862           c
            5523-6110           AL832006.2         4239-4826
FEATURES             Location/Qualifiers
     source          1..6110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..6110
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /note="troponin I1, slow skeletal type"
                     /db_xref="GeneID:7135"
                     /db_xref="HGNC:HGNC:11945"
                     /db_xref="MIM:191042"
     exon            1..58
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /inference="alignment:Splign:2.1.0"
     exon            59..88
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..641
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /note="troponin I type 1 (skeletal, slow)"
                     /codon_start=1
                     /product="troponin I, slow skeletal muscle"
                     /protein_id="NP_003272.3"
                     /db_xref="CCDS:CCDS1411.1"
                     /db_xref="GeneID:7135"
                     /db_xref="HGNC:HGNC:11945"
                     /db_xref="MIM:191042"
                     /translation="MPEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRY
                     LAERIPTLQTRGLSLSALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVM
                     DLRGKFKRPPLRRVRVSADAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGD
                     WRKNVEAMSGMEGRKKMFDAAKSPTSQ"
     exon            89..92
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /inference="alignment:Splign:2.1.0"
     exon            93..134
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /inference="alignment:Splign:2.1.0"
     exon            135..266
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..356
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..533
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..643
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..6110
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1009..1014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /note="hexamer: ATTAAA"
     polyA_site      1032
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /note="major polyA site"
     regulatory      3555..3560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /note="hexamer: AATAAT"
     polyA_site      3579
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
     regulatory      5377..5382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /note="hexamer: AATAAA"
     polyA_site      5397
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
     regulatory      6090..6095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
                     /note="hexamer: AATACA"
     polyA_site      6110
                     /gene="TNNI1"
                     /gene_synonym="SSTNI; TNN1"
ORIGIN      
        1 acagtctgca gtctacggcg aggcacaggc cagcccagct ccacgaggac tgaacaaggt
       61 gctgtctcac tgccaccatg ccggaagtcg agagaaaacc caagatcact gcctcccgca
      121 aactcttgct gaagagcctg atgctggcca aggccaagga atgctgggag caggagcacg
      181 aggagcgcga ggctgagaag gtgcgctacc tggcagagcg catccccacg ctgcagaccc
      241 gtggcctgtc cctcagtgcc ctgcaggacc tgtgccggga gctgcacgcc aaggtggagg
      301 tggtggatga ggagcgatac gacattgagg ccaaatgcct ccacaacacc agggagatta
      361 aggacctgaa gctgaaggtg atggacctcc gtgggaagtt caagcgcccg cccctgcgtc
      421 gagtccgtgt ctcggctgac gccatgctcc gggccctgct gggctccaag cacaaggtgt
      481 ccatggatct gcgggccaac ctcaagtctg tgaagaagga agacacagag aaggagcggc
      541 ctgtggaggt gggtgactgg aggaagaacg tggaggccat gtctggcatg gaaggccgga
      601 agaagatgtt tgatgccgcc aagtctccga cctcacaata gaggccagct tgctgtgctg
      661 cgctctgagc tcctgcttca tgcttcttct ccaacccagc tcactcacct ctctgcctgt
      721 gtctggagca tcccttccca cctctccccc acttcttccc tccagcctgc atgccctcct
      781 ctggaactgg gattaaacag atacccaaga ggcaggaaaa acgcgagtgt ctgaagacct
      841 caccctggca gggtgggctt ctatccaccc atgaggcacc tggggcttct cagccacccc
      901 gtggtgtaac aagtggagga ggaggagggg gtgagaacac ctttcctcca gccctgtgcc
      961 acactccttc tatgtgtgta cagtgtccac aggcatcaca ccttcttcat taaaaaccca
     1021 gtttcctggt catttctgca gctctgactg tgagccctga gaagaaaggg aagacttggg
     1081 gcttgggaag agagggctgt gctgggctcc agtcaccctg tctgcagtcc ggagctcggg
     1141 atctgaaggg agggctaagg aattggtggc tgcttgccag ggtcccctgg ggccccttct
     1201 gcccagtccc tgtgacgtca cactgcacac actcaccacc caggatgctc agctcaccag
     1261 agccctgacc tccgagaaat gaccccgtcc tgcccctgac tctggccatc agaagaggcc
     1321 tctccattaa gagccgcttc tcctgccggc tttcatactc tccttcctct gcaaacctgg
     1381 attaactctc cctgatgtgt gctgggttga gaggtcaggg cactttcaat ccctcaccta
     1441 gtcctgctgc acagggcagg aggcctcaca gaagagatac ttgcagttcc aggcctggcc
     1501 accaggtgac gccttccttc tctcctgggc tctcctgtcc ctccggcctc tgctctcccc
     1561 acgttcaccc accctcctcc caattgtttc cccttcacac tcctgcactg gtcctatccc
     1621 ccaggactga ttctttcccg gagatggggt ggccacttat ctgtcctctg gatcaggtcc
     1681 tttctccatc ccactacctc ctgggtccaa agcctggtga gagcataggg ccttctgggg
     1741 tggaaggggg gtctggggca gcctctcttc ccccaacata ctcactagag tggctcctgt
     1801 gaagcagaga ccaaagttct gacttttctt tttccttttt tttttttttt tgagatggag
     1861 tctcgctgtg tcacccaggc tggagtgcag tgacgcgatc tcgactcact gcaacctccg
     1921 cctcccaggt tcaagcgatt ctcctgcttc aacctcctga gtagctggga ttacaggtgc
     1981 gtgccaccac accccgctaa tttttgtatt tttagtagag acagggtttc accatgttgg
     2041 tcaggctggt ctcgaactcc tgacctcgta atctgcccac ctcggcctcc caaagttctg
     2101 ggattacagg tgtgagcgac cacatccggt caagttctga cttttcaggg cagtgggatg
     2161 gtgacttctg agctaagcct gcaagggaag tggctgttcc cagacctggg gtcccttggc
     2221 ttttcgacca ccctagcact ggccctagga ggggctgagt tatcagagca gcaacccttc
     2281 tacccaccct actgagtccc cattctacct tcgaatccca tgtattatct tccataagtg
     2341 ccagaaattg gtacaaagtg cagtgccagc tgctccccag ggcatggtct ggctctctgg
     2401 gctgctgggc tgccagcccc tttcagaaag catggcagtg ggaaccagca acttgggcta
     2461 ccttagggga agcagcactc tgcccagggt tcttgctata aataggtcag tgggcagaga
     2521 ggcagatgtg tgcaaaaagc acaaccccaa tcacacacag aaacccgtag gcacggacac
     2581 acccagtctc aatgcacgaa gttggagaac ctgacagggc tggtccaggc cacagaggat
     2641 ggggttaggc ttcatgcctt catgcccagg cagccacaga aacccactct tccccgcctc
     2701 acagggctcc tccggttggc ctggatccaa agcgatctcc ttgtttcacc tctttccagc
     2761 tcttccctag agcctggccc caagttccag agtcaaatcc cagttttgca gtcaactatt
     2821 aacctggggc cctggcagat tggggtatcc acccagtcat gtaaaggcag gagacctgct
     2881 ctgggcctga ctcaaagcaa acacgtgggt gcagaagacc catgggagga ggaggtgggg
     2941 cccactcaac acacctaagc cagtggccct ctaggagggg cagaagagcc aaccagaggg
     3001 ttcctggagg tcatcgggtt cctccttctg cttccaggca gcaacagacc taattcatct
     3061 cctgtgagga tggagcaagg gcgaatatag gcatagacat atctggagcg caaggattga
     3121 gaggccctgt ggacaagggg aaggagagct tgggggtggg agagggatct atggaagggg
     3181 ctgttgtagc caagaatggg gcctgggctg ggggcctggc ctctggagag ccctgattct
     3241 actccagtct tctctcacca tggagacaac accagtagag ctgggagctg gggcctgcca
     3301 ctgagtaaca gctcacacat gtagcacact tatgcgtcag gcaccagcat gtacacctta
     3361 atttatttaa ctttcacaac aaccctagga gaaaggtaca gctactattc tcatggtaca
     3421 gtggggaaaa ctgaggcaca gagaggttag ggacttttca tgatcacaca gctaataagt
     3481 ggtggtccca ggattcaacc caagaagtct gttagaatcc atactcttat cgactatttt
     3541 aataacagca tttcaataat agtaatatgt gatgttaaat gctttatctg agttatatca
     3601 ttgcattctc acaaaaatgg tacatttgtt agctcaaatt tacagatgag gaaatggagg
     3661 cctggagagt tcaagtagct cactctaagt tacagggttt gctagctgca gactggagac
     3721 tagatctcag gtcactctgc cttggggttg cccttttctg agatcagact ggccttaaca
     3781 gagcccaact ttcttggaag gacacagctg ggggtcgagg gtcctgcata tgcacctggg
     3841 gagtccccac acacccgcac caaaggggaa acattcaaag gagatgcagg tgacatacag
     3901 atgggctaag gtgaggcctt cctccaacat ggggccctgg ctgagagtgg agggataggg
     3961 tgctacttgg gggatatcta ttactaatca gcacacaata gctgggtggg caccccctct
     4021 ctctgcagct ggtggagatg ggcctggtgc tcctctctgc ttggtaggaa tgaccagggc
     4081 aggatgccac ctgctacact cttgcctgtc ccagagccct tgggagacca gctgttgctc
     4141 ccacctttcc ccacagggtg cccggtcccc acggcgcaag gaggccaagc tcagctgtgt
     4201 gtctgagccc actcagcagc aggcatgatc agggcagggc ccagcgctaa gggctgctgg
     4261 ggctaaagtg ccttgctgaa ggaggggcag agttaaacat tagccacaat ggccccccgc
     4321 gaagtgagtc atactcccca caagtctctg ggctgggcag ccgggggcgg gggggttagc
     4381 ttcgttccag gtgggtgacc aagctgcgga agcccaggac agttcgctgg gaccagtgct
     4441 aatggcagct tctgctcctg acccccatca ggtctctttc ctcagacatc cccaaagctt
     4501 gtctgcctgt gggtctttca ttaaaggtga cgggcaaggg ttttctcttc cttccaagac
     4561 acacttctag gctggcttgt gggtcccctg agacgaaggc tgagcagggt gagcctcgaa
     4621 aaccccatag cactggccca gagcactgcg gtcaatgtcc gaaggaccag agagggaggg
     4681 tgacttgctc aaggtcacaa acctaactgg agctaggaag taggtcccca gactcccagt
     4741 ctgaggaaat tggatgtgga cagggctttg gtctcctggc cagaggcaaa cgcccaggga
     4801 tctgaacagg ctgcccatct ctggcctcaa ctcagcaccc caactggctc cagtgccaac
     4861 cattggcctc tctcactggt tggcacaggc tgggtgagcc tggccctttg ccctgggttc
     4921 aggagagagg tatggctttg cctggcagtc aggggaggtg ttccaacctg ggagcccctg
     4981 ggggaggagc gtgtgtgtga acgcttgtgc ctgttcatca gaaggggtga gcatggtgtg
     5041 tatgcgtggg catgcagaat gcagggtgat gacctgtctg cccgccctga gtgtcacaga
     5101 cacctgtgtg tcccctgtac tagtgcctcc cagatgctct tctcctgact ggctctttgt
     5161 gacctaaatt tcaactgctc caccccacaa ggaggaaacc agggccacaa atgtagtgag
     5221 attttcataa agctaaatgt attcagtgga aacgaccttc ctctgatcta aaagcatgca
     5281 tgcctttgtt ttattactgg agtattaaat tagcccttac ttatggaata ggaggacagt
     5341 aggtggcaat tgttttctaa tgctcttact tcacaaaata aaatggtggc agcacaatgt
     5401 cagtatttat attacacaat attattagtt tgtaaaaacc gaaagccagg gagcttactg
     5461 ccctggattc tttagggcgt gggtcttatc acctcattca tttcttccct tcccctaaga
     5521 gtgccacaag catggcagtt gctcagctga gacacatgaa tgggaacaga actgaaatat
     5581 caggatgtga cctcgagcca gctggttggg gctggggatc cccctggatc tccactctgt
     5641 cctgtccgag aaaggggaag ctgccctatg agtctttttt ctgggggatt ccagaggttg
     5701 aacgtctgtt ctgaggctcc tcagaacctc gagggagggg acgagagaga tgaccccttg
     5761 cccaaccact ggctgaaaaa tcttgaaatt ccctgacttt gaccagggaa ttcccagttg
     5821 tgctaagccc tgcctggtgg aatgtccctg gaggaagtaa ccaggacacg catacgtttt
     5881 taatgtacgt ataaagaatc gtaaagtgaa cacccatctg ccaaccactc attttaagaa
     5941 ctaggatatg gcacatactt ttgaagccct tatgcgtccc tccccaatca caaccccttc
     6001 ctctccacaa aggtaaatac aatcctcaat tttgtgtttg ttattctctt ggttctcttc
     6061 ataatgttac tacgtattta tgaattccta atacatcatt cagttttgga
//
