LOCUS       NM_022093               5042 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tenascin N (TNN), mRNA.
ACCESSION   NM_022093 XM_040527
VERSION     NM_022093.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5042)
  AUTHORS   Lu,F., Liang,P., Fan,B., Zhu,Q., Xue,T., Liu,Z., Wang,R., Zhang,Y.,
            Zhang,X., Li,W., Wang,S., Chen,J. and Zha,D.
  TITLE     TNN is first linked to auditory neuropathy
  JOURNAL   Biochem Biophys Res Commun 632, 69-75 (2022)
   PUBMED   36206596
  REMARK    GeneRIF: TNN is first linked to auditory neuropathy.
REFERENCE   2  (bases 1 to 5042)
  AUTHORS   Zhang,P., Liu,G., Hu,J., Chen,S., Wang,B., Peng,P., Yu,X. and
            Guo,D.
  TITLE     Tenascin-C can Serve as an Indicator for the Immunosuppressive
            Microenvironment of Diffuse Low-Grade Gliomas
  JOURNAL   Front Immunol 13, 824586 (2022)
   PUBMED   35371015
  REMARK    GeneRIF: Tenascin-C can Serve as an Indicator for the
            Immunosuppressive Microenvironment of Diffuse Low-Grade Gliomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5042)
  AUTHORS   Hendaoui,I., Lahmar,A., Campo,L., Mebarki,S., Bichet,S., Hess,D.,
            Degen,M., Kchir,N., Charrada-Ben Farhat,L., Hefaiedh,R., Ruiz,C.,
            Terracciano,L.M., Tucker,R.P., Hendaoui,L. and Chiquet-Ehrismann,R.
  TITLE     Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers
  JOURNAL   Front Immunol 11, 630139 (2021)
   PUBMED   33692777
  REMARK    GeneRIF: Tenascin-W Is a Novel Stromal Marker in Biliary Tract
            Cancers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5042)
  AUTHORS   Degen,M., Scherberich,A. and Tucker,R.P.
  TITLE     Tenascin-W: Discovery, Evolution, and Future Prospects
  JOURNAL   Front Immunol 11, 623305 (2021)
   PUBMED   33603752
  REMARK    GeneRIF: Tenascin-W: Discovery, Evolution, and Future Prospects.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5042)
  AUTHORS   Han,Y.Y., Zhao,L.J., Lin,Y., He,H., Tian,Q., Zhu,W., Shen,H.,
            Chen,X.D. and Deng,H.W.
  TITLE     Multiple analyses indicate the specific association of NR1I3, C6
            and TNN with low hip BMD risk
  JOURNAL   J Genet Genomics 44 (6), 327-330 (2017)
   PUBMED   28629900
  REMARK    GeneRIF: specific association of NR1I3, C6 and TNN with low hip BMD
            risk
REFERENCE   6  (bases 1 to 5042)
  AUTHORS   Degen,M., Brellier,F., Schenk,S., Driscoll,R., Zaman,K., Stupp,R.,
            Tornillo,L., Terracciano,L., Chiquet-Ehrismann,R., Ruegg,C. and
            Seelentag,W.
  TITLE     Tenascin-W, a new marker of cancer stroma, is elevated in sera of
            colon and breast cancer patients
  JOURNAL   Int J Cancer 122 (11), 2454-2461 (2008)
   PUBMED   18306355
  REMARK    GeneRIF: results reveal a clear association between elevated levels
            of tenascin-W and the presence of colorectal cancer and breast
            cancer
REFERENCE   7  (bases 1 to 5042)
  AUTHORS   Degen,M., Brellier,F., Kain,R., Ruiz,C., Terracciano,L., Orend,G.
            and Chiquet-Ehrismann,R.
  TITLE     Tenascin-W is a novel marker for activated tumor stroma in
            low-grade human breast cancer and influences cell behavior
  JOURNAL   Cancer Res 67 (19), 9169-9179 (2007)
   PUBMED   17909022
  REMARK    GeneRIF: data imply that tenascin-W expression in the activated
            tumor stroma facilitates tumorigenesis by supporting the migratory
            behavior of breast cancer cells
REFERENCE   8  (bases 1 to 5042)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   9  (bases 1 to 5042)
  AUTHORS   Scherberich,A., Tucker,R.P., Degen,M., Brown-Luedi,M., Andres,A.C.
            and Chiquet-Ehrismann,R.
  TITLE     Tenascin-W is found in malignant mammary tumors, promotes alpha8
            integrin-dependent motility and requires p38MAPK activity for BMP-2
            and TNF-alpha induced expression in vitro
  JOURNAL   Oncogene 24 (9), 1525-1532 (2005)
   PUBMED   15592496
  REMARK    GeneRIF: The expression of tenascin-W is dependent on p38MAPK and
            JNK signaling pathways in mammary tumors. (tenascin-W)
REFERENCE   10 (bases 1 to 5042)
  AUTHORS   Neidhardt,J., Fehr,S., Kutsche,M., Lohler,J. and Schachner,M.
  TITLE     Tenascin-N: characterization of a novel member of the tenascin
            family that mediates neurite repulsion from hippocampal explants
  JOURNAL   Mol Cell Neurosci 23 (2), 193-209 (2003)
   PUBMED   12812753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z99297.1, AK127044.1, AL049689.1 and Z99715.1.
            
            On May 17, 2019 this sequence version replaced NM_022093.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127044.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239462.9/ ENSP00000239462.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                Z99297.1           46983-47007         c
            26-372              AK127044.1         1-347
            373-4903            AL049689.1         220-4750
            4904-5033           AK127044.1         4879-5008
            5034-5042           Z99715.1           18747-18755         c
FEATURES             Location/Qualifiers
     source          1..5042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.1"
     gene            1..5042
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /note="tenascin N"
                     /db_xref="GeneID:63923"
                     /db_xref="HGNC:HGNC:22942"
                     /db_xref="MIM:617472"
     exon            1..103
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            104..547
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..4038
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /note="TN-N; tenascin-W"
                     /codon_start=1
                     /product="tenascin-N precursor"
                     /protein_id="NP_071376.1"
                     /db_xref="CCDS:CCDS30943.1"
                     /db_xref="GeneID:63923"
                     /db_xref="HGNC:HGNC:22942"
                     /db_xref="MIM:617472"
                     /translation="MSLQEMFRFPMGLLLGSVLLVASAPATLEPPGCSNKEQQVTVSH
                     TYKIDVPKSALVQVDADPQPLSDDGASLLALGEAREEQNIIFRHNIRLQTPQKDCELA
                     GSVQDLLARVKKLEEEMVEMKEQCSAQRCCQGVTDLSRHCSGHGTFSLETCSCHCEEG
                     REGPACERLACPGACSGHGRCVDGRCLCHEPYVGADCGYPACPENCSGHGECVRGVCQ
                     CHEDFMSEDCSEKRCPGDCSGHGFCDTGECYCEEGFTGLDCAQVVTPQGLQLLKNTED
                     SLLVSWEPSSQVDHYLLSYYPLGKELSGKQIQVPKEQHSYEILGLLPGTKYIVTLRNV
                     KNEVSSSPQHLLATTDLAVLGTAWVTDETENSLDVEWENPSTEVDYYKLRYGPMTGQE
                     VAEVTVPKSSDPKSRYDITGLHPGTEYKITVVPMRGELEGKPILLNGRTEIDSPTNVV
                     TDRVTEDTATVSWDPVQAVIDKYVVRYTSADGDTKEMAVHKDESSTVLTGLKPGEAYK
                     VYVWAERGNQGSKKADTNALTEIDSPANLVTDRVTENTATISWDPVQATIDKYVVRYT
                     SADDQETREVLVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESKKADTNAPTDIDSPK
                     NLVTDRVTENMATVSWDPVQAAIDKYVVRYTSAGGETREVPVGKEQSSTVLTGLRPGM
                     EYMVHVWAQKGDQESKKADTKAQTDIDSPQNLVTDRVTENMATVSWDPVRATIDRYVV
                     RYTSAKDGETREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGAQESKKADTKAQTDID
                     SPQNLVTDWVTENTATVSWDPVQATIDRYVVHYTSANGETREVPVGKEQSSTVLTGLR
                     PGMEYTVHVWAQKGNQESKKADTKAQTEIDGPKNLVTDWVTENMATVSWDPVQATIDK
                     YMVRYTSADGETREVPVGKEHSSTVLTGLRPGMEYMVHVWAQKGAQESKKADTKAQTE
                     LDPPRNLRPSAVTQSGGILTWTPPSAQIHGYILTYQFPDGTVKEMQLGREDQRFALQG
                     LEQGATYPVSLVAFKGGRRSRNVSTTLSTVGARFPHPSDCSQVQQNSNAASGLYTIYL
                     HGDASRPLQVYCDMETDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLDK
                     LHNLTTGTPARYEVRVDLQTANESAYAIYDFFQVASSKERYKLTVGKYRGTAGDALTY
                     HNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGRYGETKHSEGVNWEPWKG
                     HEFSIPYVELKIRPHGYSREPVLGRKKRTLRGRLRTF"
     exon            548..922
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1186
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1372
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1462
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1726
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1993
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2257
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2524
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2788
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..3052
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3183
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3316
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3468
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3565
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3733
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3897
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..5042
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4717..4722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /note="hexamer: AATAAA"
     polyA_site      4745
                     /gene="TNN"
                     /gene_synonym="TN-W; TNW"
                     /note="major polyA site"
ORIGIN      
        1 gagacgagaa ccagggacga ccagcaagta ccaaggtctg cggcaggagg agaccggctc
       61 acaggagcag cagcattgga agaggcaccc agcagcctcc caggcatcct ggagggtctg
      121 ctccctgtct ttccaaggat gagtctccag gagatgttcc gcttccctat ggggctcctg
      181 cttggctctg tgctcctggt ggcttcggcc ccagccactc tggagcctcc cggctgcagc
      241 aacaaggagc aacaggtcac tgtcagccac acctacaaga tcgatgtgcc caagtctgcc
      301 ttggttcagg ttgacgctga ccctcagccc ctcagtgacg atggggcttc gctcttggcc
      361 ctgggggagg ccagggagga acagaacatc atcttcaggc acaacatccg ccttcagacg
      421 ccacagaagg actgcgagtt ggcaggcagt gtccaggacc tcctggcccg ggtgaagaag
      481 ctggaggaag agatggtgga gatgaaggaa cagtgtagtg cccagcgctg ctgccaggga
      541 gtcactgatc taagccgcca ctgcagcggc cacgggacct tctccctgga gacctgcagc
      601 tgccactgcg aagagggcag ggagggcccc gcctgcgagc ggctggcctg ccccggggcg
      661 tgcagcggcc acgggcgttg cgtggacggg cgctgcctgt gccatgagcc ctacgtgggt
      721 gccgactgcg gctacccggc ctgccctgag aactgcagcg gacacggcga gtgcgtgcgc
      781 ggcgtgtgcc agtgccacga agacttcatg tcggaggact gcagcgagaa gcgctgtccc
      841 ggcgactgca gcggccacgg cttctgtgac acgggcgagt gctactgcga ggagggcttc
      901 acaggcctgg actgtgccca ggtggtcacc ccacagggcc tgcagctgct caagaacacg
      961 gaggattctc tgctggtgag ctgggagccc tccagccagg tggatcacta cctcctcagc
     1021 tactaccccc tggggaagga gctctctggg aagcagatcc aagtgcccaa ggagcagcac
     1081 agctatgaga ttcttggttt gctgcctgga accaagtaca tagtcaccct gcgtaacgtc
     1141 aagaatgaag tttctagcag cccacagcat ctacttgcca ccacagacct tgctgtgctt
     1201 ggcactgcct gggtgacaga tgagactgag aactcccttg acgtggagtg ggaaaacccc
     1261 tcaactgagg tggactacta caagctgcga tatggcccca tgacaggaca ggaggtagct
     1321 gaggtcactg tgcccaagag cagtgacccc aagagccgat atgacatcac tggtctgcac
     1381 ccggggactg agtataagat cacggtggtg cccatgagag gagagctgga gggcaagccg
     1441 atcctcctga atggcaggac agaaattgac agtccaacca atgttgtcac tgatcgagtg
     1501 actgaagaca cagcaactgt ctcctgggac ccagtgcagg ctgtcataga caagtatgta
     1561 gtgcgctaca cttctgctga tggggacacc aaggaaatgg cagtgcacaa ggatgagagc
     1621 agcactgtcc tgacgggcct gaagccagga gaggcataca aggtctacgt gtgggctgaa
     1681 aggggcaacc aggggagcaa gaaagctgac accaatgccc tcacagaaat tgacagccca
     1741 gcaaacctgg tgactgaccg ggtgactgag aataccgcca ccatctcctg ggacccggta
     1801 caggccacca ttgacaagta cgtggtgcgc tacacctctg ctgacgacca agagaccaga
     1861 gaggttctgg tggggaagga gcagagcagc actgtcctga caggcctgag gccaggtgtg
     1921 gagtacacag tgcatgtctg ggcccagaag ggggaccgag agagcaagaa ggctgacacc
     1981 aacgccccga cagatattga cagccccaaa aacctggtga ctgaccgggt gacagagaat
     2041 atggccacgg tctcctggga cccggtgcag gccgccattg acaagtacgt ggtgcgctac
     2101 acctctgctg gtggagagac cagggaggtt ccggtgggga aggagcagag cagcacagtc
     2161 ctgacaggcc tgagaccggg tatggagtac atggtgcacg tgtgggccca gaagggggac
     2221 caggagagca agaaggccga caccaaggcc cagacagaca ttgacagccc ccaaaacctg
     2281 gtgaccgacc gggtgacaga gaatatggcc actgtctcct gggacccggt gcgggccacc
     2341 attgacaggt atgtggtgcg ctacacctct gccaaggacg gagagaccag ggaggttccg
     2401 gtggggaagg agcagagtag cactgtcctg acgggcctga ggccgggtgt ggagtacacg
     2461 gtgcacgtgt gggcccagaa gggggcccag gagagcaaga aggctgacac caaggcccag
     2521 acagacattg acagccccca aaacctggtc actgactggg tgacagagaa tacagccact
     2581 gtctcctggg acccggtgca ggccaccatt gacaggtatg tggtgcacta cacgtctgcc
     2641 aacggagaga ccagggaggt tccagtgggg aaggagcaga gcagcactgt cctgacgggc
     2701 ctgaggccgg gcatggagta cacggtgcac gtgtgggccc agaaggggaa ccaggagagc
     2761 aagaaggctg acaccaaggc ccagacagaa attgacggcc ccaaaaacct agtgactgac
     2821 tgggtgacgg agaatatggc cactgtctcc tgggacccgg ttcaggccac cattgacaag
     2881 tacatggtgc gctacacctc tgctgacgga gagaccaggg aggttccggt ggggaaggag
     2941 cacagcagca ctgtcctgac gggcctgaga ccaggcatgg agtacatggt gcacgtgtgg
     3001 gcccagaagg gggcccagga gagcaagaag gctgacacca aggcccagac agaactcgac
     3061 cctcccagaa accttcgtcc atctgctgta acgcagtctg gtggcatatt gacctggacg
     3121 cccccctctg ctcagatcca cggctacatt ctgacttacc agttcccaga tggcacagtt
     3181 aaggagatgc agctgggacg ggaagaccag aggtttgcgt tgcaaggcct tgagcaaggc
     3241 gccacctacc ctgtctccct tgttgccttt aagggtggtc gccggagcag aaatgtatcc
     3301 accaccctct ccacagttgg tgcccgtttc ccacaccctt cggactgcag tcaggttcag
     3361 cagaacagca atgccgccag tggtctgtac accatctacc tgcatggcga tgccagccgg
     3421 cccctgcagg tgtactgtga catggaaacg gacggaggtg gctggattgt cttccagagg
     3481 cggaacactg ggcagctgga tttcttcaag cgatggagga gctatgtgga aggctttggg
     3541 gaccccatga aggagttctg gcttggactt gacaagctac acaacctcac caccggcact
     3601 ccagcgcggt atgaggtgag agtggattta cagactgcca atgaatctgc ctatgctata
     3661 tatgatttct tccaagtggc ctccagcaag gagcggtata agctgacagt tgggaaatac
     3721 agaggcacgg caggggatgc tcttacttac cacaatggat ggaagtttac aacttttgac
     3781 agagacaatg atatcgcact cagcaactgt gccctgacac atcatggtgg ctggtggtat
     3841 aagaactgcc acttggccaa ccctaatggc agatatgggg agaccaagca cagtgagggg
     3901 gtgaactggg agccttggaa aggacatgaa ttctccattc cttacgtgga gttgaaaatc
     3961 cgccctcatg gctacagcag ggagcctgtc ctgggcagaa agaagcggac gctgagagga
     4021 aggctgcgaa cgttctgatg gcccgtgtga gcagtcctcg caggagacac caccagctgt
     4081 ggcagcttgg ggcggggtgg gtagtggtca ctgcggtctg ggagtgctca gatagcccgc
     4141 agaacaaatc atgtcaccaa gcttcaagcc atggaggttc cttccctctc acctgcattt
     4201 ttgcccgtct ttatgagggt cttgaaaatc aaaatagtag ttgcacagta tgtgtaggaa
     4261 agacagtact ggaacggcaa ggtttctcag cttatcttca gcaacatata tactggatta
     4321 gggcaagaga aggaatcacc cagcacttca ccagttggaa atctctggaa atttacatct
     4381 atgtatttaa agttctgcta atgcaaatct tttctctgga aagaagcaca gaggaggagt
     4441 tctgatgacc caggggttag ggctgagaca accggacgtt tgtcacctcc tttcccattg
     4501 ggtttttagg aaaacagtgt gaacctcccc cttttaattt ctggtgttat gaggaagaat
     4561 aaaggggata aaaggggcta agatggactc atgtttagct aagttctgac ttgtatccag
     4621 catgctggag accaaagctg ccgccttact gctattttta agtgccctct tttcagtcat
     4681 ttgcataatt gcgtccatag agctgcatat gttgtgaata aattctcact catttcaact
     4741 ttgaataatt tgactgtctt gataattggt tcctcccaaa gactcttctg caactcccat
     4801 tcatgcccac caggcctcag actccctctt ttccccgccc tgcactattg gagccctggg
     4861 ttttgtggga gtgctcagca ccgtgagtct tactgtttga tcggacagtt agcaagatca
     4921 gatccttttt gcttattttc tatcactttg gagggttttc tgtagcaaaa tcagtgacca
     4981 atgaagtaac ttaaattcct attgaagaaa aaaaataata aaccacttga tttaaaaaaa
     5041 aa
//
